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1. 发明授权

US07094419B2 Method of obtaining immune cells from an animal 失效
标题翻译：从动物获得免疫细胞的方法
公开(公告)号：US07094419B2
公开(公告)日：2006-08-22
申请号：US10602785
申请日：2003-06-24
申请人： Kevor S. TenHuisen , Joel Rosenblatt , Ilya S. Koyfman
发明人： Kevor S. TenHuisen , Joel Rosenblatt , Ilya S. Koyfman
IPC分类号： A61K9/00 , A61F2/00
CPC分类号： A61K9/0024 , A61K9/0092 , A61K2039/515 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/466 , Y02A50/48 , Y02A50/491
摘要： The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines (e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.
摘要翻译：本发明涉及一种可植入的免疫调节装置，其可用于在多孔壳内调节包含多个纤维的哺乳动物中的免疫应答。根据应用，纤维填充物装载有单个或多个抗原，以及任选的一种或多种生物活性化合物，例如细胞因子（例如淋巴因子，趋化因子等），附着因子，基因，肽，蛋白质，核苷酸，碳水化合物或细胞。

2. 发明授权

US06958158B2 Immune modulation device for use in animals 有权
标题翻译：用于动物的免疫调节装置
公开(公告)号：US06958158B2
公开(公告)日：2005-10-25
申请号：US10103087
申请日：2002-03-21
申请人： Kevor S. TenHuisen , Joel Rosenblatt , Ilya S. Koyfman
发明人： Kevor S. TenHuisen , Joel Rosenblatt , Ilya S. Koyfman
IPC分类号： C12N5/06 , A61K9/00 , A61K9/22 , A61K35/14 , A61K39/00 , A61K47/34 , A61P37/02 , A61P37/04 , A61F2/00 , A61M31/00
CPC分类号： A61K9/0024 , A61K9/0092 , A61K2039/515 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/466 , Y02A50/48 , Y02A50/491
摘要： The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines (e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.
摘要翻译：本发明涉及一种可植入的免疫调节装置，其可用于在多孔壳内调节包含多个纤维的哺乳动物中的免疫应答。根据应用，纤维填充物装载有单个或多个抗原，以及任选的一种或多种生物活性化合物，例如细胞因子（例如淋巴因子，趋化因子等），附着因子，基因，肽，蛋白质，核苷酸，碳水化合物或细胞。

3. 发明授权

US06648849B2 Medicinal implant and device and method for loading and delivering implants containing drugs and cells 有权
公开(公告)号：US06648849B2
公开(公告)日：2003-11-18
申请号：US09892342
申请日：2001-06-27
申请人： Kevor S. Tenhuisen , Joel Rosenblatt , John McAllen, III
发明人： Kevor S. Tenhuisen , Joel Rosenblatt , John McAllen, III
IPC分类号： A61M3100
CPC分类号： A61M37/0069
摘要： A system for injecting controlled release medicinal implants has a syringe-like injector body with a lumen and plunger. A needle is attached to the injector body and receives therein an injectable implant with an internal hollow. The implant is retained in the needle by friction, which is overcome by the plunger upon dispensing. As the plunger moves from the retracted position to the deployed position, it forces a medicament previously loaded into the injector body into the implant hollow and then pushes the implant out of the needle into the creature into which the needle has been inserted. The implant may contain a filler to absorb flowable medicaments to aid in their retention within the implant. As in known implants, the medicament is released gradually depending upon the dissolution rate of the implant body which is formed from a biodegradable material. Because the medicament is loaded into the implant at the time of injection, issues concerning the reaction of the medicament with the implant material during preparation and storage are eliminated.

4. 发明授权

US08951577B2 Antimicrobial hydrochloric acid catheter lock solution and method of use 有权
标题翻译：抗菌盐酸导管锁解决方案及使用方法
公开(公告)号：US08951577B2
公开(公告)日：2015-02-10
申请号：US12849665
申请日：2010-08-03
申请人： Nisha Gupta , Elaine Steinke , Joel Rosenblatt
发明人： Nisha Gupta , Elaine Steinke , Joel Rosenblatt
IPC分类号： A01N59/00 , A61K33/18 , A61L29/16 , A61L2/00 , A61L29/14 , A61K31/18 , A61K31/727
CPC分类号： A01N59/00 , A61K31/18 , A61K31/727 , A61L2/00 , A61L2/18 , A61L29/02 , A61L29/14 , A61L29/16 , A61L2300/104 , A61L2300/106 , A61L2300/204 , A61L2300/404 , A61L2300/42 , A61M25/0017 , A61K2300/00
摘要： A catheter lock solution includes a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar. This hydrochloric acid solution may be used to lock a catheter and/or salvage an infected catheter.
摘要翻译：导管锁定溶液包括浓度为0.3摩尔至1.0摩尔浓度的盐酸溶液。该盐酸溶液可用于锁定导管和/或挽救受感染的导管。

5. 发明授权

US08545459B2 Stabilized enzyme compositions 有权
标题翻译：稳定的酶组合物
公开(公告)号：US08545459B2
公开(公告)日：2013-10-01
申请号：US12392544
申请日：2009-02-25
申请人： Nisha Gupta , Joel Rosenblatt
发明人： Nisha Gupta , Joel Rosenblatt
IPC分类号： A61M25/00 , B05D3/00
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/206 , A61L2300/236 , A61L2300/254 , A61L2300/404 , A61L2300/42 , C08L5/02
摘要： A medical device includes a base material having an immobilized fibrinolytic enzyme and dextran sulfate. The dextran sulfate has a molecular weight that is less than 40 kilo dalton (kDa). The medical device is formed from at least a base material. A fibrinolytic enzyme is immobilized on the base material. The fibrinolytic enzyme is stabilized with a dextran sulfate having a molecular weight of less than 40 (kDa).
摘要翻译：医疗装置包括具有固定的纤维蛋白溶解酶和硫酸葡聚糖的基材。硫酸葡聚糖的分子量小于40千道尔顿（kDa）。医疗装置至少由基材形成。纤维蛋白溶解酶固定在基材上。纤维蛋白溶解酶用分子量小于40（kDa）的硫酸葡聚糖稳定。

6. 发明授权

US08496970B2 Conformable tissue repair implant capable of injection delivery 有权
标题翻译：能够注射输送的适应性组织修复植入物
公开(公告)号：US08496970B2
公开(公告)日：2013-07-30
申请号：US13406230
申请日：2012-02-27
申请人： Francois Binette , Joseph J. Hammer , Krish Mukhopadhyay , Joel Rosenblatt
发明人： Francois Binette , Joseph J. Hammer , Krish Mukhopadhyay , Joel Rosenblatt
IPC分类号： A61K35/32
CPC分类号： A61L27/3604 , A61L27/3683 , A61L27/38 , A61L27/3852 , A61L27/58
摘要： A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.
摘要翻译：提供适合组织植入物用于修复或增加组织缺损或损伤部位。组织植入物包含组织载体基质，其包含多个生物相容的生物可再吸收的颗粒和与颗粒结合的至少一个组织片段。组织片段含有一种或多种活细胞，其可以从组织迁移并填充组织载体基质。还提供了用于可注射地递送组织植入物的方法。

7. 发明申请

US20120258238A1 Polymer for Controlling Delivery of Bioactive Agents and Method of Use 审中-公开
标题翻译：用于控制生物活性剂递送的聚合物和使用方法
公开(公告)号：US20120258238A1
公开(公告)日：2012-10-11
申请号：US13525762
申请日：2012-06-18
申请人： Hiep Do , Joel Rosenblatt
发明人： Hiep Do , Joel Rosenblatt
IPC分类号： B05D7/00 , B05D5/00
CPC分类号： A61L29/16 , A61L29/06 , A61L2300/206 , A61L2300/404 , C08L83/04
摘要： A medical device includes a base material and chlorhexidine or a pharmaceutically acceptable salt thereof disposed in the base material sufficient to reduce microbial growth. The base material includes a polymer having a silicone monomer and a urethane monomer. To make the medical device having an antimicrobial agent, a silicone-urethane-carbonate polymer is dissolved in Dimethylformamide/Tetrahydrofuran (DMF/THF) to generate a coating solution, a chlorhexidine or a pharmaceutically acceptable salt thereof is mixed into the coating solution, a base material is coated with the coating solution, and the coating solution is dried to remove the solvent. The chlorhexidine is present in concentration sufficient to reduce microbial growth.
摘要翻译：医疗装置包括基材和设置在基材中的氯己定或其药学上可接受的盐，足以减少微生物生长。基材包括具有硅氧烷单体和聚氨酯单体的聚合物。为了使具有抗微生物剂的医疗装置，将硅氧烷 - 氨基甲酸酯 - 碳酸酯聚合物溶解在二甲基甲酰胺/四氢呋喃（DMF / THF）中以产生涂布溶液，洗必泰或其药学上可接受的盐混合到涂布溶液中，将基材涂布在涂布溶液中，并将涂布溶液干燥以除去溶剂。洗必泰以足以减少微生物生长的浓度存在。

8. 发明申请

US20080075754A1 COMPOSITIONS AND MEDICAL DEVICES UTILIZING BIOABSORBABLE LIQUID POLYMERS 有权
标题翻译：使用生物可溶性液体聚合物的组合物和医疗器械
公开(公告)号：US20080075754A1
公开(公告)日：2008-03-27
申请号：US11952232
申请日：2007-12-07
申请人： Aruna Nathan , Joel Rosenblatt , Steven Arnold
发明人： Aruna Nathan , Joel Rosenblatt , Steven Arnold
IPC分类号： A61F2/00 , A61K47/30
CPC分类号： A61K9/0024 , A61K9/1647 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , C08L67/08
摘要： The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.
摘要翻译：本发明涉及包含合成的，生物可吸收的生物相容性液体聚合物的医疗装置和药物组合物，其是多元酸或其衍生物，多元醇和脂肪酸的反应产物，液体聚合物的熔点小于约 40℃，通过差示扫描量热法测定。

9. 发明授权

US07316822B2 Conformable tissue repair implant capable of injection delivery 有权
标题翻译：能够注射输送的适应性组织修复植入物
公开(公告)号：US07316822B2
公开(公告)日：2008-01-08
申请号：US10723982
申请日：2003-11-26
申请人： Francois Binette , Joseph J. Hammer , Krish Mukhopadhyay , Joel Rosenblatt
发明人： Francois Binette , Joseph J. Hammer , Krish Mukhopadhyay , Joel Rosenblatt
IPC分类号： A61K35/32
CPC分类号： A61L27/3604 , A61L27/3683 , A61L27/38 , A61L27/3852 , A61L27/58
摘要： A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.
摘要翻译：提供适合组织植入物用于修复或增加组织缺损或损伤部位。组织植入物包含组织载体基质，其包含多个生物相容的生物可再吸收的颗粒和与颗粒结合的至少一个组织片段。组织片段含有一种或多种活细胞，其可以从组织迁移并填充组织载体基质。还提供了用于可注射地递送组织植入物的方法。

10. 发明申请

US20070129690A1 Catheter with polymeric coating 审中-公开
标题翻译：导管与聚合物涂层
公开(公告)号：US20070129690A1
公开(公告)日：2007-06-07
申请号：US11293056
申请日：2005-12-02
申请人： Joel Rosenblatt , Jeff Vitullo , Mike Bouchard
发明人： Joel Rosenblatt , Jeff Vitullo , Mike Bouchard
IPC分类号： A61M25/00 , A61M5/32
CPC分类号： A61L29/16 , A61L2300/206 , A61L2300/404 , A61M25/007 , A61M2025/0056
摘要： A catheter including a main body having a first end, a second end, a lumen extending between the first end and the second end, a first section located proximal the first end of the main body and second section located proximal the second end of the main body. An inhibitory polymer is disposed at the first section. The inhibitory polymer includes one or more members selected from the group consisting of antiproliferatives, antithrombotics, thrombolytics, and fibrinolytics. An antimicrobial agent is disposed at the second section. The main body has a length such that when the catheter is at least partially implanted the first end accesses a body vessel and at least a portion of the second section is disposed within a subcutaneous space of a patient.
摘要翻译：一种包括主体的导管，其具有第一端，第二端，在所述第一端和所述第二端之间延伸的内腔，位于所述主体的第一端附近的第一部分和位于所述主体的第二端附近的第二部分身体。在第一部分设置抑制性聚合物。抑制性聚合物包括选自抗增生剂，抗血栓药，溶栓剂和纤维蛋白溶解剂中的一种或多种。抗微生物剂设置在第二部分。主体具有这样的长度，使得当导管至少部分植入时，第一端进入体血管，并且第二部分的至少一部分设置在患者的皮下空间内。

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