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1. 发明授权

US09511171B2 Biocompatible scaffolds with tissue fragments 有权
标题翻译：具有组织碎片的生物相容性支架
公开(公告)号：US09511171B2
公开(公告)日：2016-12-06
申请号：US12951205
申请日：2010-11-22
申请人： Francois Binette , Julia Hwang , Sridevi Dhanaraj , Anna Gosiewska
发明人： Francois Binette , Julia Hwang , Sridevi Dhanaraj , Anna Gosiewska
IPC分类号： A61F2/00 , A61L27/36 , A61F2/08
CPC分类号： A61L27/3612 , A61F2/02 , A61F2/08 , A61F2310/0097 , A61L27/18 , A61L27/36 , A61L27/3616 , A61L27/3817 , A61L27/3895 , A61L27/58 , A61L2400/18 , A61L2430/06 , A61L2430/10 , A61L2430/34 , C12N5/0068 , C12N5/0655
摘要： A biocompatible tissue repair implant or scaffold device is provided for use in repairing a variety of tissue injuries, particularly injuries to cartilage, ligaments, tendons, and nerves. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair. The biocompatible tissue repair implants include a biocompatible scaffold and particles of living tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
摘要翻译：提供生物相容性组织修复植入物或支架装置，用于修复各种组织损伤，特别是软骨，韧带，腱和神经的损伤。修复程序可以用包含有助于愈合或组织修复的生物成分的植入物进行。生物相容性组织修复植入物包括生物相容性支架和活组织颗粒，使得组织和支架变得相关联。活组织的颗粒含有一个或多个活细胞，其可从组织迁移并填充支架。

2. 发明申请

US20120302958A1 CHONDROCYTE CONTAINER AND METHOD OF USE 失效
标题翻译： CHONDROCYTE CONTAINER和使用方法
公开(公告)号：US20120302958A1
公开(公告)日：2012-11-29
申请号：US13567322
申请日：2012-08-06
申请人： Brooks J. Story , Francois Binette , M. E. Liesbeth Brown
发明人： Brooks J. Story , Francois Binette , M. E. Liesbeth Brown
IPC分类号： A61M5/00 , A61M5/142 , A61M5/14
CPC分类号： A61M31/002 , A61K9/0024 , A61K35/32 , A61L27/3817 , A61L27/54 , A61L2300/602 , A61M5/00 , A61M5/142 , A61M5/145 , A61M5/1452 , A61M39/22 , C12N5/0655 , C12N2533/76
摘要： Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).
摘要翻译：提供用于递送通过遗传改变的软骨细胞产生的治疗剂的装置和方法。更具体地，该装置包括壳体，其限定被配置为保持大体积的软骨细胞的细胞室，同时选择性地释放通过这些被捕获的细胞产生的治疗剂。在一个示例性实施例中，细胞室可以被配置成使得细胞的一部分可以位于与装置的外壁至少约1.5mm（即离开外部营养物质约1.5mm）处。例如，电池室可以具有长度和直径的管状构造，其中这些尺寸中的每个尺寸至少为约3mm（由此到室的中心芯离开装置的外壁至少约1.5mm）。

3. 发明授权

US08257963B2 Chondrocyte container and method of use 失效
标题翻译：软骨细胞容器及使用方法
公开(公告)号：US08257963B2
公开(公告)日：2012-09-04
申请号：US12123650
申请日：2008-05-20
申请人： Francois Binette , Brooks J. Story , M. E. Liesbeth Brown
发明人： Francois Binette , Brooks J. Story , M. E. Liesbeth Brown
IPC分类号： C12N5/00 , C12M1/00 , C12M1/12 , C12M1/36 , A01N37/18
CPC分类号： A61M31/002 , A61K9/0024 , A61K35/32 , A61L27/3817 , A61L27/54 , A61L2300/602 , A61M5/00 , A61M5/142 , A61M5/145 , A61M5/1452 , A61M39/22 , C12N5/0655 , C12N2533/76
摘要： Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).
摘要翻译：提供用于递送通过遗传改变的软骨细胞产生的治疗剂的装置和方法。更具体地，该装置包括壳体，其限定被配置为保持大体积的软骨细胞的细胞室，同时选择性地释放通过这些被捕获的细胞产生的治疗剂。在一个示例性实施例中，细胞室可以被配置成使得细胞的一部分可以位于与装置的外壁至少约1.5mm（即离开外部营养物质约1.5mm）处。例如，电池室可以具有长度和直径的管状构造，其中这些尺寸中的每个尺寸至少为约3mm（由此到室的中心芯离开装置的外壁至少约1.5mm）。

4. 发明申请

US20110097381A1 CONFORMABLE TISSUE REPAIR IMPLANT CAPABLE OF INJECTION DELIVERY 有权
标题翻译：可配套的组织修复植入物
公开(公告)号：US20110097381A1
公开(公告)日：2011-04-28
申请号：US12980544
申请日：2010-12-29
申请人： Francois Binette , Joseph J. Hammer , Krish Mukhopadhyay , Joel Rosenblatt
发明人： Francois Binette , Joseph J. Hammer , Krish Mukhopadhyay , Joel Rosenblatt
IPC分类号： A61K9/14 , A61K35/12 , A61K39/395 , A61K35/76 , A61K35/14 , A61K35/32 , A61K35/28 , A61P17/00 , A61P19/04 , A61P19/08 , A61P19/02 , A61P21/00
CPC分类号： A61L27/3604 , A61L27/3683 , A61L27/38 , A61L27/3852 , A61L27/58
摘要： A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.
摘要翻译：提供适合组织植入物用于修复或增加组织缺损或损伤部位。组织植入物包含组织载体基质，其包含多个生物相容的生物可再吸收的颗粒和与颗粒结合的至少一个组织片段。组织片段含有一种或多种活细胞，其可以从组织迁移并填充组织载体基质。还提供了用于可注射地递送组织植入物的方法。

5. 发明申请

US20110091517A1 BIOCOMPATIBLE SCAFFOLDS WITH TISSUE FRAGMENTS 审中-公开
标题翻译：生物成分与组织片
公开(公告)号：US20110091517A1
公开(公告)日：2011-04-21
申请号：US12951205
申请日：2010-11-22
申请人： Francois Binette , Julia Hwang , Sridevi Dhanaraj , Anna Gosiewska
发明人： Francois Binette , Julia Hwang , Sridevi Dhanaraj , Anna Gosiewska
IPC分类号： A61F2/00 , A61K35/12 , A61K35/32 , A61K35/36 , A61K35/34 , A61K35/30 , A61K35/23 , A61K35/28 , A61K35/407 , A61K35/22 , A61K35/39
CPC分类号： A61L27/3612 , A61F2/02 , A61F2/08 , A61F2310/0097 , A61L27/18 , A61L27/36 , A61L27/3616 , A61L27/3817 , A61L27/3895 , A61L27/58 , A61L2400/18 , A61L2430/06 , A61L2430/10 , A61L2430/34 , C12N5/0068 , C12N5/0655
摘要： A biocompatible tissue repair implant or scaffold device is provided for use in repairing a variety of tissue injuries, particularly injuries to cartilage, ligaments, tendons, and nerves. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair. The biocompatible tissue repair implants include a biocompatible scaffold and particles of living tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
摘要翻译：提供生物相容性组织修复植入物或支架装置，用于修复各种组织损伤，特别是软骨，韧带，腱和神经的损伤。修复程序可以用包含有助于愈合或组织修复的生物成分的植入物进行。生物相容性组织修复植入物包括生物相容性支架和活组织颗粒，使得组织和支架变得相关联。活组织的颗粒含有一个或多个活细胞，其可从组织迁移并填充支架。

6. 发明授权

US07897384B2 Chondrocyte therapeutic delivery system 有权
标题翻译：软骨细胞治疗递送系统
公开(公告)号：US07897384B2
公开(公告)日：2011-03-01
申请号：US10657516
申请日：2003-09-08
申请人： Francois Binette , Brooks J. Story
发明人： Francois Binette , Brooks J. Story
IPC分类号： C12N5/00 , C12N5/02 , C12P21/06 , C12P21/04 , A61K48/00
CPC分类号： C12N5/0655 , A61K35/12 , C12N2510/00 , C12N2533/74 , C12N2533/76
摘要： Methods and compositions for producing therapeutic agents using chondrocytes are provided. The genetically engineered chondrocytes can be used to express the therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.
摘要翻译：提供了使用软骨细胞产生治疗剂的方法和组合物。基因工程软骨细胞可用于在受试者中表达治疗剂，包括在通常与软骨细胞相关的环境中以及通常不与软骨细胞相关的环境中。

7. 发明授权

US07824701B2 Biocompatible scaffold for ligament or tendon repair 有权
标题翻译：生物相容性支架用于韧带或肌腱修复
公开(公告)号：US07824701B2
公开(公告)日：2010-11-02
申请号：US10374754
申请日：2003-02-25
申请人： Francois Binette , Julia Hwang , Mark Zimmerman , Mora Carolynne Melican
发明人： Francois Binette , Julia Hwang , Mark Zimmerman , Mora Carolynne Melican
IPC分类号： A61F2/00
CPC分类号： A61L27/3683 , A61F2/08 , A61L27/3604 , A61L27/3662 , A61L2430/10
摘要： A biocompatible ligament repair implant or scaffold device is provided for use in repairing a variety of ligament tissue injuries. The repair procedures may be conducted with ligament repair implants that contain a biological component that assists in healing or tissue repair. The biocompatible ligament repair implants include a biocompatible scaffold and particles of viable tissue derived from ligament tissue or tendon tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
摘要翻译：提供生物相容性韧带修复植入物或支架装置用于修复各种韧带组织损伤。修复过程可以用韧带修复植入物进行，其包含有助于愈合或组织修复的生物成分。生物相容性韧带修复植入物包括衍生自韧带组织或腱组织的生物相容性支架和活组织颗粒，使得组织和支架变得相关联。活组织的颗粒含有一个或多个活细胞，其可从组织迁移并填充支架。

8. 发明授权

US07794408B2 Tissue collection device and methods 有权
标题翻译：组织采集装置及方法
公开(公告)号：US07794408B2
公开(公告)日：2010-09-14
申请号：US10402266
申请日：2003-03-28
申请人： Francois Binette , Julia Hwang , Keith M. Orr , Steve Lepke , Eric Hyman , Ashley Perkins
发明人： Francois Binette , Julia Hwang , Keith M. Orr , Steve Lepke , Eric Hyman , Ashley Perkins
IPC分类号： A61B10/00
CPC分类号： A61L27/36 , A61B10/0096 , A61F2/4644 , A61F2002/2835
摘要： A biological tissue collection device is provided having a housing with a fluid-retaining inner chamber adapted to retain a bioimplantable, fluid permeable tissue scaffold. The scaffold is preferably retained in the housing in such a way that the scaffold separates the fluid-retaining inner chamber into a first chamber and a second chamber. The collection device further includes a driver mechanism coupled to the housing and effective to create a force within the housing to displace fluid disposed within the second chamber to the first chamber. As the fluid is displaced, any biological tissue deposited on the tissue scaffold is dispersed within the fluid. Removal of the force enables the fluid to return to the second chamber and thereby deposit the tissue onto the tissue scaffold. In an exemplary embodiment, the tissue is deposited evenly onto the tissue scaffold.
摘要翻译：提供了一种生物组织收集装置，其具有壳体，其具有适于保持生物可植入的，可流体渗透的组织支架的流体保持内室。支架优选地保持在壳体中，使得支架将流体保持内室分离成第一室和第二室。收集装置还包括联接到壳体并且有效地在壳体内产生力以将置于第二室内的流体置换到第一室的驱动器机构。当流体移动时，沉积在组织支架上的任何生物组织分散在流体内。去除力使得流体返回到第二室，从而将组织沉积到组织支架上。在示例性实施例中，组织均匀地沉积在组织支架上。

9. 发明申请

US20080071385A1 CONFORMABLE TISSUE REPAIR IMPLANT CAPABLE OF INJECTION DELIVERY 有权
标题翻译：可配套的组织修复植入物
公开(公告)号：US20080071385A1
公开(公告)日：2008-03-20
申请号：US11947384
申请日：2007-11-29
申请人： Francois Binette , Joseph Hammer , Krish Mukhopadhyay , Joel Rosenblatt
发明人： Francois Binette , Joseph Hammer , Krish Mukhopadhyay , Joel Rosenblatt
IPC分类号： A61F2/08
CPC分类号： A61L27/3604 , A61L27/3683 , A61L27/38 , A61L27/3852 , A61L27/58
摘要： A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.
摘要翻译：提供适合组织植入物用于修复或增加组织缺损或损伤部位。组织植入物包含组织载体基质，其包含多个生物相容的生物可再吸收的颗粒和与颗粒结合的至少一个组织片段。组织片段含有一种或多种活细胞，其可以从组织迁移并填充组织载体基质。还提供了用于可注射地递送组织植入物的方法。

10. 发明申请

US20060045903A1 Musculo-skeletal implant having a bioactive gradient 有权
标题翻译：肌肉骨骼植入物具有生物活性梯度
公开(公告)号：US20060045903A1
公开(公告)日：2006-03-02
申请号：US11189691
申请日：2005-07-26
申请人： Sudhakar Kadiyala , Francois Binette , Cynthia Coleman , Terri Kapur
发明人： Sudhakar Kadiyala , Francois Binette , Cynthia Coleman , Terri Kapur
IPC分类号： A61F2/00
CPC分类号： A61K9/0024 , A61F2/08 , A61F2002/0894 , A61F2250/0035 , A61F2250/0068 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/432 , A61L2300/45 , A61L2300/602
摘要： This invention relates to an implant for a musculoskeletal defect having a bioactive agent having a concentration gradient.
摘要翻译：本发明涉及具有浓度梯度的生物活性剂的肌骨骼缺损植入物。

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