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1. 发明授权

US08765189B2 Organophosphorous and multivalent metal compound compositions and methods 有权
标题翻译：有机磷和多价金属化合物组成及方法
公开(公告)号：US08765189B2
公开(公告)日：2014-07-01
申请号：US13469806
申请日：2012-05-11
申请人： Venkat R. Garigapati , Kevor S. TenHuisen
发明人： Venkat R. Garigapati , Kevor S. TenHuisen
IPC分类号： A61K47/24
CPC分类号： A61L24/04 , A61K9/0024 , A61K31/661 , A61K31/675 , A61K33/06 , A61K33/26 , A61K33/42 , A61K47/593 , A61K47/60 , C09J11/06 , A61K2300/00
摘要： Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least multivalent metal compound, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments which exhibit bond strength upon curing with the possible usage as bone cement for bone filler applications.
摘要翻译：本文公开了将它们用于粘附各种材料的组合物和方法。组合物至少包含多价金属化合物，有效量的结构上类似于磷酸丝氨酸的化合物，并且可以与水溶液混合。组合物在湿和干燥环境中提供粘合和内聚强度，其在固化时表现出粘合强度，可用作骨填料应用的骨水泥。

2. 发明授权

US07257897B2 Trimmer for cutting a coiled strand 有权
标题翻译：切割卷曲线的修剪器
公开(公告)号：US07257897B2
公开(公告)日：2007-08-21
申请号：US10302535
申请日：2002-11-22
申请人： Zhigang Li , Yufu Li , Ronald W Marsh , Kevor S. Tenhuisen
发明人： Zhigang Li , Yufu Li , Ronald W Marsh , Kevor S. Tenhuisen
IPC分类号： B26B13/00
CPC分类号： A61B17/8863 , A61B17/0467 , A61B17/32 , A61F2/88 , B21F11/005 , B21F45/008 , B23D29/023 , Y10S83/907
摘要： A cutting device for trimming a coiled strand, such as an arterial, urinary or other intraluminal stent made from metal or plastic wire, has a pair of articulating arms connected at a pivot joint. One of the arms has a holding jaw for holding the coiled strand. A second of the arms has a jaw with a cutter. The holding jaw has a passageway through which the coiled strand may be threaded to aid in holding the coiled strand for cutting by the cutter. The holding jaw preferably has a guide channel formed by a pair of tapered walls that slide between adjacent turns of the coiled strand. In accordance with a method of the invention, an end of the coiled strand is introduced through the passageway in the holding jaw. The coiled strand is rotated to advance the coiled strand through the passageway until the coiled strand is positioned beneath the cutting jaw at the selected location. The lever portions and the jaw portions are then urged together, cutting the coiled strand at the selected location.
摘要翻译：用于修整卷绕股线的切割装置，例如由金属或塑料线制成的动脉，尿液或其他管腔内支架，具有连接在枢转关节处的一对关节臂。其中一个臂具有用于固定线圈的保持爪。第二个手臂有一个钳子与一个钳子。保持爪具有通道，通过该通道可以使卷绕的线可以被螺纹连接以帮助保持卷绕的线以便切割器进行切割。保持夹爪优选地具有由一对锥形壁形成的引导通道，所述一对锥形壁在螺旋绞线的相邻匝之间滑动。根据本发明的方法，卷绕股线的端部通过保持夹爪中的通道被引入。旋转线圈以使线圈股线通过通道，直到线圈股线在选定位置处位于切割钳口下方。杠杆部分和钳口部分然后被推到一起，在所选择的位置切割线圈股。

3. 发明授权

US07169187B2 Biodegradable stent 有权
标题翻译：可生物降解支架
公开(公告)号：US07169187B2
公开(公告)日：2007-01-30
申请号：US10602338
申请日：2003-06-24
申请人： Arindam Datta , Shawn Thayer Huxel , Dennis D. Jamiolkowski , Yufu Li , Kevor S. TenHuisen
发明人： Arindam Datta , Shawn Thayer Huxel , Dennis D. Jamiolkowski , Yufu Li , Kevor S. TenHuisen
IPC分类号： A61F2/04 , A61F2/06
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： The present invention is directed to stents that are formed into a helical structure having a plurality of coils, a longitudinal axis, an internal longitudinal passage, a distal section and a proximal section having different diameters; where the structure is made from a fiber having a cross-section and including an inner core having an exterior surface made from a biodegradable polymer having a first degradation rate and an outer section made from a blend of a first biodegradable polymer component and a second biodegradable polymer component covering the exterior surface of the inner core and having a second degradation rate; where the second degradation rate is lower than the first degradation rate.
摘要翻译：本发明涉及形成具有多个线圈，纵向轴线，内部纵向通道，远端部分和具有不同直径的近端部分的螺旋结构的支架; 其中结构由具有横截面的纤维制成，并且包括具有由具有第一降解速率的生物可降解聚合物制成的外表面的内芯和由第一可生物降解的聚合物组分和第二可生物降解的共混物制成的外部部分聚合物组分覆盖内芯的外表面并具有第二降解速率; 其中第二降解速率低于第一降解速率。

4. 发明授权

US08337904B2 Magnesium-substituted hydroxyapatites 有权
标题翻译：镁取代羟基磷灰石
公开(公告)号：US08337904B2
公开(公告)日：2012-12-25
申请号：US12768715
申请日：2010-04-27
申请人： Richard E. Riman , Wojciech Suchanek , Pavel Shuk , Kevor S. TenHuisen , Chun-Wei Chen
发明人： Richard E. Riman , Wojciech Suchanek , Pavel Shuk , Kevor S. TenHuisen , Chun-Wei Chen
IPC分类号： A61K33/42
CPC分类号： C01B25/32 , A61K6/0215 , A61K6/033 , A61K8/24 , A61Q11/00 , C04B35/447 , C04B35/62615 , C04B2235/3206 , C04B2235/3208 , C04B2235/3212 , C04B2235/44 , C04B2235/442 , C04B2235/443 , C04B2235/444 , C04B2235/447 , Y10T428/12 , Y10T428/2982
摘要： A stable, phase-pure magnesium-substituted crystalline hydroxyapatite containing from about 2.0 to about 29 wt % magnesium, wherein at least 75 wt % of the magnesium content is substituted for calcium ions in the hydroxyapatite lattice structure.
摘要翻译：含有约2.0〜约29重量％的镁的稳定的相纯镁取代的结晶羟基磷灰石，其中至少75重量％的镁含量代替羟基磷灰石晶格结构中的钙离子。

5. 发明申请

US20120288446A1 ORGANOPHOSPHOROUS & MULTIVALENT METAL COMPOUND COMPOSITIONS & METHODS 有权
标题翻译：有机和多元金属化合物组合物和方法
公开(公告)号：US20120288446A1
公开(公告)日：2012-11-15
申请号：US13469806
申请日：2012-05-11
申请人： Venkat R. Garigapati , Kevor S. TenHuisen
发明人： Venkat R. Garigapati , Kevor S. TenHuisen
IPC分类号： A61L24/02 , A61K47/24 , A61K49/00 , A61F2/28 , A61K9/00 , A61P19/00 , C09J11/04 , A61K47/04 , A61K33/42
CPC分类号： A61L24/04 , A61K9/0024 , A61K31/661 , A61K31/675 , A61K33/06 , A61K33/26 , A61K33/42 , A61K47/593 , A61K47/60 , C09J11/06 , A61K2300/00
摘要： Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least multivalent metal compound, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments which exhibit bond strength upon curing with the possible usage as bone cement for bone filler applications.
摘要翻译：本文公开了将它们用于粘附各种材料的组合物和方法。组合物至少包含多价金属化合物，有效量的结构上类似于磷酸丝氨酸的化合物，并且可以与水溶液混合。组合物在湿和干燥环境中提供粘合和内聚强度，其在固化时表现出粘合强度，可用作骨填料应用的骨水泥。

6. 发明授权

US06497707B1 Graft fixation device combination 有权
公开(公告)号：US06497707B1
公开(公告)日：2002-12-24
申请号：US09535183
申请日：2000-03-27
申请人： Steven M. Bowman , Victor F. Janas , Kevor S. Tenhuisen
发明人： Steven M. Bowman , Victor F. Janas , Kevor S. Tenhuisen
IPC分类号： A61B1756
CPC分类号： A61B17/0401 , A61B17/0642 , A61B17/068 , A61B17/92 , A61B2017/00004 , A61B2017/0409 , A61B2017/0412 , A61B2017/0419 , A61B2017/0427 , A61B2017/0445 , A61B2017/0646 , A61B2017/0647 , A61F2/2846
摘要： A graft fixation device combination. The device is useful for affixing a tissue graft to a bone or other body surface. The combination has a fixation device having two implantation members connected by a connecting member. The implantation members have longitudinal passageways therethrough. The combination also has an insertion member in engagement with the distal end of each implantation member.

7. 发明授权

US06364884B1 Method of securing a graft using a graft fixation device 有权
标题翻译：使用移植物固定装置固定移植物的方法
公开(公告)号：US06364884B1
公开(公告)日：2002-04-02
申请号：US09535187
申请日：2000-03-27
申请人： Steven M. Bowman , Victor F. Janas , Kevor S. Tenhuisen
发明人： Steven M. Bowman , Victor F. Janas , Kevor S. Tenhuisen
IPC分类号： A61F504
CPC分类号： A61B17/0401 , A61B17/0642 , A61B17/068 , A61B17/92 , A61B2017/00004 , A61B2017/0409 , A61B2017/0412 , A61B2017/0419 , A61B2017/0427 , A61B2017/0445 , A61B2017/0646 , A61B2017/0647 , A61F2/2846
摘要： A method of affixing a graft to bone using a the combination of a graft fixation device and an insertion member. The fixation device is useful for affixing a tissue graft to a bone or other body surface. The graft fixation device comprises two implantation members connected by a connecting member. The implantation members have longitudinal passageways therethrough. The insertion device member similarly has a longitudinal passage.
摘要翻译：使用移植物固定装置和插入构件的组合将移植物固定在骨上的方法。固定装置可用于将组织移植物固定到骨骼或其他身体表面。移植物固定装置包括通过连接构件连接的两个植入构件。植入构件具有穿过其的纵向通道。插入装置构件类似地具有纵向通道。

8. 发明授权

US07094419B2 Method of obtaining immune cells from an animal 失效
标题翻译：从动物获得免疫细胞的方法
公开(公告)号：US07094419B2
公开(公告)日：2006-08-22
申请号：US10602785
申请日：2003-06-24
申请人： Kevor S. TenHuisen , Joel Rosenblatt , Ilya S. Koyfman
发明人： Kevor S. TenHuisen , Joel Rosenblatt , Ilya S. Koyfman
IPC分类号： A61K9/00 , A61F2/00
CPC分类号： A61K9/0024 , A61K9/0092 , A61K2039/515 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/466 , Y02A50/48 , Y02A50/491
摘要： The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines (e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.
摘要翻译：本发明涉及一种可植入的免疫调节装置，其可用于在多孔壳内调节包含多个纤维的哺乳动物中的免疫应答。根据应用，纤维填充物装载有单个或多个抗原，以及任选的一种或多种生物活性化合物，例如细胞因子（例如淋巴因子，趋化因子等），附着因子，基因，肽，蛋白质，核苷酸，碳水化合物或细胞。

9. 发明授权

US06916321B2 Self-tapping resorbable two-piece bone screw 有权
标题翻译：自攻可回收两片骨螺钉
公开(公告)号：US06916321B2
公开(公告)日：2005-07-12
申请号：US09969779
申请日：2001-09-28
申请人： Kevor S. TenHuisen , Victor F. Janas , Kevin L. Cooper , David W. Overaker , J. Jenny Yuan
发明人： Kevor S. TenHuisen , Victor F. Janas , Kevin L. Cooper , David W. Overaker , J. Jenny Yuan
IPC分类号： A61B17/58 , A61B17/00 , A61B17/86 , A61F2/08
CPC分类号： A61F2/0811 , A61B17/8635 , A61B17/864 , A61B17/8645 , A61B17/866 , A61B17/8685 , A61B2017/00004 , A61F2/0805 , A61F2002/0829 , A61F2002/0841 , A61F2002/0858 , A61F2002/0882 , A61F2250/0019 , A61F2250/003 , Y10S606/909
摘要： An orthopedic interference screw has a hard, self-threading front section and a bioabsorbable rear section. The two sections are conjoined and threaded such that the hard front section cuts threads into the bone and the softer rear section follows the threads into the bone. Preferably, the screw has an axial bore for matingly receiving a turning tool such as a hex wrench.
摘要翻译：矫形干涉螺钉具有硬的自动穿线前部和生物可吸收的后部。两个部分结合和螺纹，使得硬的前部将螺纹切入骨头，并且较软的后部部分跟随进入骨的线。优选地，螺杆具有用于配合地接收诸如六角扳手的转动工具的轴向孔。

10. 发明授权

US06451059B1 Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds 失效
标题翻译：用于生产可吸收陶瓷纤维和支架的粘性悬浮纺丝工艺
公开(公告)号：US06451059B1
公开(公告)日：2002-09-17
申请号：US09439656
申请日：1999-11-12
申请人： Victor F. Janas , Kevor S. TenHuisen
发明人： Victor F. Janas , Kevor S. TenHuisen
IPC分类号： A61F228
CPC分类号： C04B35/62268 , A61F2/28 , A61F2/30767 , A61F2/3094 , A61F2002/2817 , A61F2002/2835 , A61F2002/30011 , A61F2002/30062 , A61F2002/30199 , A61F2002/3093 , A61F2002/30968 , A61F2002/4648 , A61F2210/0004 , A61F2230/0063 , A61F2250/0023 , A61F2310/00293 , A61F2310/0097 , A61L27/12 , C03B37/011 , C04B30/02 , C04B35/447 , C04B2111/00836 , C04B14/46 , C04B38/06 , C04B40/0268 , C04B41/4582 , C04B41/48
摘要： The present invention provides a hard tissue scaffold comprising a resorbable ceramic. The scaffold is formed by first creating unfired (green) bioresorbable ceramic fibers via the viscous suspension spinning process (VSSP). Then, using common textile techniques, a structure in which the size and distribution of interconnected pores are controlled, is created. Heat treating the structure to remove the organic phase and sintering the ceramic yields a hard tissue scaffold.
摘要翻译：本发明提供一种包含可再吸收陶瓷的硬组织支架。支架通过首先通过粘性悬浮纺丝工艺（VSSP）创建未烧（绿色）生物可吸收陶瓷纤维而形成。然后，使用普通的纺织技术，形成其中控制互连孔的尺寸和分布的结构。热处理结构以除去有机相并烧结陶瓷产生硬组织支架。

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