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1. 发明授权

US07094419B2 Method of obtaining immune cells from an animal 失效
标题翻译：从动物获得免疫细胞的方法
公开(公告)号：US07094419B2
公开(公告)日：2006-08-22
申请号：US10602785
申请日：2003-06-24
申请人： Kevor S. TenHuisen , Joel Rosenblatt , Ilya S. Koyfman
发明人： Kevor S. TenHuisen , Joel Rosenblatt , Ilya S. Koyfman
IPC分类号： A61K9/00 , A61F2/00
CPC分类号： A61K9/0024 , A61K9/0092 , A61K2039/515 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/466 , Y02A50/48 , Y02A50/491
摘要： The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines (e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.
摘要翻译：本发明涉及一种可植入的免疫调节装置，其可用于在多孔壳内调节包含多个纤维的哺乳动物中的免疫应答。根据应用，纤维填充物装载有单个或多个抗原，以及任选的一种或多种生物活性化合物，例如细胞因子（例如淋巴因子，趋化因子等），附着因子，基因，肽，蛋白质，核苷酸，碳水化合物或细胞。

2. 发明授权

US06958158B2 Immune modulation device for use in animals 有权
标题翻译：用于动物的免疫调节装置
公开(公告)号：US06958158B2
公开(公告)日：2005-10-25
申请号：US10103087
申请日：2002-03-21
申请人： Kevor S. TenHuisen , Joel Rosenblatt , Ilya S. Koyfman
发明人： Kevor S. TenHuisen , Joel Rosenblatt , Ilya S. Koyfman
IPC分类号： C12N5/06 , A61K9/00 , A61K9/22 , A61K35/14 , A61K39/00 , A61K47/34 , A61P37/02 , A61P37/04 , A61F2/00 , A61M31/00
CPC分类号： A61K9/0024 , A61K9/0092 , A61K2039/515 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/466 , Y02A50/48 , Y02A50/491
摘要： The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines (e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.
摘要翻译：本发明涉及一种可植入的免疫调节装置，其可用于在多孔壳内调节包含多个纤维的哺乳动物中的免疫应答。根据应用，纤维填充物装载有单个或多个抗原，以及任选的一种或多种生物活性化合物，例如细胞因子（例如淋巴因子，趋化因子等），附着因子，基因，肽，蛋白质，核苷酸，碳水化合物或细胞。

3. 发明授权

US09636207B2 Implantable repair device 有权
公开(公告)号：US09636207B2
公开(公告)日：2017-05-02
申请号：US13075351
申请日：2011-03-30
申请人： Robert A. Rousseau , David C. Lindh, Sr. , John R. Jacobs , Ilya S. Koyfman , Gaoyuan Gavin Chen , Donald G. Hill
发明人： Robert A. Rousseau , David C. Lindh, Sr. , John R. Jacobs , Ilya S. Koyfman , Gaoyuan Gavin Chen , Donald G. Hill
IPC分类号： A61F2/02 , A61F2/00
CPC分类号： A61F2/02 , A61F2/0063 , A61F2002/0068 , A61F2210/0004
摘要： An implantable prosthesis for repairing or reinforcing a tissue or muscle wall defect including a first composite structure including at least one layer of a non-absorbable material, wherein the first composite structure has a central portion sized and shaped to cover at least a portion of the tissue or muscle wall defect, and has an outer periphery. The prosthesis further includes a second structure having a reinforced central region and an outer peripheral edge, a reinforcing element positioned between the first and second structures, and having an outer periphery and a stiffness greater than that of the first and second structures, and at least one pulling element coupled to the reinforced central region of the second structure. The second structure is coupled to the first structure substantially only at their respective peripheries.

4. 发明授权

US08409296B2 Brow lift implant and method 有权
标题翻译：眉笔提升植入物和方法
公开(公告)号：US08409296B2
公开(公告)日：2013-04-02
申请号：US12639177
申请日：2009-12-16
申请人： David Knize , Ilya S. Koyfman , J. Jenny Yuan , Michael Hoffman , Donald G. Hill
发明人： David Knize , Ilya S. Koyfman , J. Jenny Yuan , Michael Hoffman , Donald G. Hill
IPC分类号： A61F2/02
CPC分类号： A61F2/0059 , A61B2017/00004 , A61F2210/0004 , A61F2250/0018
摘要： A substantially flat implant for repositioning a patient's eyebrow that may allow for a gradient lift across the eyebrow. The implant may be geometrically non-symmetrical, and/or may have non-symmetric physical properties. The implant may include a foot portion that extends along a first longitudinal axis and has a length, and a vertical strip portion that extends outwardly from the foot portion along a second longitudinal axis. The strip portion has a length and a width that is smaller than the length of the foot. The second longitudinal axis is offset from the center of the length of the foot portion.
摘要翻译：用于重新定位患者眉毛的基本上平坦的植入物，其可允许跨越眉毛的梯度升高。植入物可以是几何上不对称的，和/或可以具有非对称的物理性质。植入物可以包括沿着第一纵向轴线延伸并且具有长度的足部部分和从第一纵向轴线从脚部向外延伸的垂直条带部分。带状部分的长度和宽度小于脚的长度。第二纵向轴线从脚部的长度的中心偏移。

5. 发明申请

US20110144750A1 BROW LIFT IMPLANT AND METHOD 有权
标题翻译： BROW LIFT植入物和方法
公开(公告)号：US20110144750A1
公开(公告)日：2011-06-16
申请号：US12639177
申请日：2009-12-16
申请人： David Knize , Ilya S. Koyfman , J. Jenny Yuan , Michael Hoffman , Donald G. Hill
发明人： David Knize , Ilya S. Koyfman , J. Jenny Yuan , Michael Hoffman , Donald G. Hill
IPC分类号： A61F2/02
CPC分类号： A61F2/0059 , A61B2017/00004 , A61F2210/0004 , A61F2250/0018
摘要： A substantially flat implant for repositioning a patient's eyebrow that may allow for a gradient lift across the eyebrow. The implant may be geometrically non-symmetrical, and/or may have non-symmetric physical properties. The implant may include a foot portion that extends along a first longitudinal axis and has a length, and a vertical strip portion that extends outwardly from the foot portion along a second longitudinal axis. The strip portion has a length and a width that is smaller than the length of the foot. The second longitudinal axis is offset from the center of the length of the foot portion.
摘要翻译：用于重新定位患者眉毛的基本上平坦的植入物，其可允许跨越眉毛的梯度升高。植入物可以是几何上不对称的，和/或可以具有非对称的物理性质。植入物可以包括沿着第一纵向轴线延伸并且具有长度的足部部分和从第一纵向轴线从脚部向外延伸的垂直条带部分。带状部分的长度和宽度小于脚的长度。第二纵向轴线从脚部的长度的中心偏移。

6. 发明授权

US08500759B2 Hernia mesh support device 有权
公开(公告)号：US08500759B2
公开(公告)日：2013-08-06
申请号：US11904200
申请日：2007-09-26
申请人： Ilya S. Koyfman , Uri Herzberg
发明人： Ilya S. Koyfman , Uri Herzberg
IPC分类号： A61B17/08 , A61F2/02
CPC分类号： A61F2/0063 , A61F2/0095
摘要： A hernia mesh support device includes an outer ring, an inner ring and a plurality of ring support members extending between and interconnected to the outer ring and inner ring. On a first axial side of the outer ring and inner ring is situated a layer of mesh material. On a second axial side of the outer ring and inner ring is situated an anti-adhesion barrier. A plurality of barbed pins or hollow needles extend from the first axial side of the outer ring. A removable protective cover covers the plurality of barbed pins or hollow needles.

7. 发明授权

US6045560A Surgical stapling apparatus with biocompatible surgical fabric 失效
标题翻译：具有生物兼容手术织物的手术吻合装置
公开(公告)号：US6045560A
公开(公告)日：2000-04-04
申请号：US664658
申请日：1996-06-17
申请人： Wanda L. McKean , Matthew Hain , Ilya S. Koyfman
发明人： Wanda L. McKean , Matthew Hain , Ilya S. Koyfman
IPC分类号： A61B17/00 , A61B17/072 , A61B17/10
CPC分类号： A61B17/07207 , A61B17/07292 , A61B2017/00004 , A61B2017/07214
摘要： A surgical stapling apparatus having tissue bolstering material releasably attached thereto for application of the material and staples to body tisuse is disclosed. The tissue bolstering material is preferably releasably held to surfaces of the stapling apparatus through pins, clips or similar securing structures. The tissue bolstering material can be either planar or tubular in configuration. Preferably, both the anvil portion and the fastener ejecting portion of the stapler are at least partially covered with the tissue bolstering material. In use, tissue is disposed between the anvil portion and the stapling portion of the instrument and the instrument is fired. The tissue bolstering material is thereby secured to the tissue and releasably detaches from the stapler upon withdrawal of the stapler from the surgical site.
摘要翻译：公开了一种具有可释放地附接到其上的组织支撑材料以将材料和钉钉施加到身体小便的外科缝合装置。组织支撑材料优选通过销，夹子或类似的固定结构可释放地保持在缝合装置的表面。组织支撑材料可以是平面的或管状的。优选地，订书机的砧座部分和紧固件弹出部分至少部分地被组织支撑材料覆盖。在使用中，组织设置在砧座部分和器械的装订部分之间，并且仪器被点燃。因此，当将缝合器从外科手术部位撤出时，组织支撑材料被固定到组织上并可释放地脱离订书机。

8. 发明授权

US5542594A Surgical stapling apparatus with biocompatible surgical fabric 失效
标题翻译：具有生物兼容手术织物的手术吻合装置
公开(公告)号：US5542594A
公开(公告)日：1996-08-06
申请号：US132601
申请日：1993-10-06
申请人： Wanda L. McKean , Matthew Hain , Ilya S. Koyfman
发明人： Wanda L. McKean , Matthew Hain , Ilya S. Koyfman
IPC分类号： A61B17/00 , A61B17/072
CPC分类号： A61B17/07207 , A61B17/07292 , A61B2017/00004 , A61B2017/07214
摘要： A surgical stapling apparatus having biocompatible surgical fabric releasably attached thereto for application of the fabric and staples to body tisuse is disclosed. The fabric is releasably held to surfaces of the stapling apparatus through pins, clips or similar securing structures. The biocompatible surgical fabric can be either planar or tubular in configuration. Preferably, both the anvil portion and the fastener ejecting portion of the stapler are at least partially covered with the biocompatible surgical fabric. In use, tissue is disposed between the anvil portion and the stapling portion of the instrument and the instrument is fired. The biocompatible surgical fabric is thereby secured to the tissue and releasably detaches from the stapler upon withdrawal of the stapler from the surgical site.
摘要翻译：公开了一种外科缝合装置，其具有可释放地附接到其上的生物相容性外科用织物，用于将织物和钉钉施加到身体小腿上。织物通过销，夹子或类似的固定结构可释放地保持在缝合装置的表面。生物相容的手术织物可以是平面的或管状的。优选地，吻合器的砧部分和紧固件弹出部分都至少部分地被生物相容的手术织物覆盖。在使用中，组织设置在砧座部分和器械的装订部分之间，并且仪器被点燃。由此，生物相容的手术织物固定到组织上，并且在将吻合器从外科手术部位撤回时可释放地从吻合器脱离。

9. 发明授权

US5261886A Cabled core and braided suture made therefrom 失效
标题翻译：由其制成的电缆芯和编织缝线
公开(公告)号：US5261886A
公开(公告)日：1993-11-16
申请号：US855682
申请日：1992-06-17
申请人： Michael P. Chesterfield , Ilya S. Koyfman , Donald S. Kaplan , Matthew E. Hermes
发明人： Michael P. Chesterfield , Ilya S. Koyfman , Donald S. Kaplan , Matthew E. Hermes
IPC分类号： A61B17/00 , A61B17/06 , A61L17/00
CPC分类号： D04C1/12 , A61B17/06166 , A61L17/005 , A61B2017/00004 , A61L2300/406 , A61L2300/412 , A61L2300/418
摘要： A braided suture possesses a cable core which resists any tendency to protrude through the surrounding braid structure.
摘要翻译： PCT No.PCT / US91 / 09137 371日期：1992年6月17日 102（e）日期1992年6月17日PCT 1991年12月4日提交。编织缝线具有防止任何倾向穿过周围编织结构的电缆芯。

10. 发明授权

US08388633B2 Implantable repair device 有权
公开(公告)号：US08388633B2
公开(公告)日：2013-03-05
申请号：US13075442
申请日：2011-03-30
申请人： Robert A. Rousseau , David C. Lindh, Sr. , John R. Jacobs , Ilya S. Koyfman , Gaoyuan Gavin Chen , Donald G. Hill
发明人： Robert A. Rousseau , David C. Lindh, Sr. , John R. Jacobs , Ilya S. Koyfman , Gaoyuan Gavin Chen , Donald G. Hill
IPC分类号： A61B17/08
CPC分类号： A61F2/02 , A61F2/0063 , A61F2002/0068 , A61F2210/0004
摘要： An implantable prosthesis for repairing or reinforcing a tissue or muscle wall defect including a first composite structure including at least one layer of a non-absorbable material, wherein the first composite structure has a central portion sized and shaped to cover at least a portion of the tissue or muscle wall defect, and has an outer periphery. The prosthesis further includes a second structure having a reinforced central region and an outer peripheral edge, a reinforcing element positioned between the first and second structures, and having an outer periphery and a stiffness greater than that of the first and second structures, and at least one pulling element coupled to the reinforced central region of the second structure. The second structure is coupled to the first structure substantially only at their respective peripheries.

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