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1. 发明授权

US09498570B2 Bladder syringe fluid delivery system 有权
标题翻译：膀胱注射器液体输送系统
公开(公告)号：US09498570B2
公开(公告)日：2016-11-22
申请号：US13453335
申请日：2012-04-23
申请人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III , Barry L. Tucker , Jaroslaw Wlodarczyk
发明人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III , Barry L. Tucker , Jaroslaw Wlodarczyk
IPC分类号： A61M5/00 , A61M5/145 , A61M5/148 , A61M5/24 , A61M5/315 , A61M5/168 , A61M5/31
CPC分类号： A61M5/31 , A61M5/002 , A61M5/007 , A61M5/1452 , A61M5/14546 , A61M5/148 , A61M5/16827 , A61M5/2425 , A61M5/31511 , A61M5/31515 , A61M2005/14553 , A61M2005/3123 , A61M2005/31516 , A61M2207/10 , B29C45/1418 , B29C45/14336 , B29K2023/12 , B29L2031/7544
摘要： A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.
摘要翻译：用于流体输送系统的膀胱注射器包括圆柱体，囊 - 囊组件，设置在圆柱体中的柱塞元件和用于将囊 - 囊组件固定到圆柱体上的安装组件。圆柱体具有远端和近端并限定通孔。盖囊组件适于连接到圆柱体的远端，并且包括帽体和囊。盖体限定内腔和远端排出导管，并适于接合圆柱体的远端。盘状囊体设置在内腔内，通常包括中央膜部分。柱塞元件设置在圆柱形主体的通孔中并且被排气以便能够排出柱塞元件和圆柱体中的囊 - 囊组件之间的空间。

2. 发明授权

US10046106B2 Bladder syringe fluid delivery system 有权
公开(公告)号：US10046106B2
公开(公告)日：2018-08-14
申请号：US13881072
申请日：2011-10-25
申请人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III , Bernard J. Hobi , Vincent S. Rossitto , Jaroslaw Wlodarczyk , Matthew Schrauder
发明人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III , Bernard J. Hobi , Vincent S. Rossitto , Jaroslaw Wlodarczyk , Matthew Schrauder
IPC分类号： A61M37/00 , A61M5/00 , A61M5/145 , A61M5/148 , A61M5/24 , A61M5/315
CPC分类号： A61M5/007 , A61M5/1452 , A61M5/148 , A61M5/2425 , A61M5/31511
摘要： A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.

3. 发明申请

US20130211248A1 BLADDER SYRINGE FLUID DELIVERY SYSTEM 审中-公开
标题翻译： BLADDER SYRINGE流体输送系统
公开(公告)号：US20130211248A1
公开(公告)日：2013-08-15
申请号：US13881072
申请日：2011-10-25
申请人： Kevin P. Cowan , Raymond C. Hoffman , Charles A. Lang , Mark Trocki , Arthur E. Uber, III , Joseph C. Mator , Edward P. Liscio , Bernard J. Hobi , L. Robert Crouthamel , Glen P. Williams , Vincent S. Rossitto , Jaroslaw Wlodarczyk , Matthew Schrauder
发明人： Kevin P. Cowan , Raymond C. Hoffman , Charles A. Lang , Mark Trocki , Arthur E. Uber, III , Joseph C. Mator , Edward P. Liscio , Bernard J. Hobi , L. Robert Crouthamel , Glen P. Williams , Vincent S. Rossitto , Jaroslaw Wlodarczyk , Matthew Schrauder
IPC分类号： A61M5/00
CPC分类号： A61M5/007 , A61M5/1452 , A61M5/148 , A61M5/2425 , A61M5/31511
摘要： A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.
摘要翻译：用于流体输送系统的膀胱注射器包括圆柱体，囊 - 囊组件，设置在圆柱体中的柱塞元件和用于将囊 - 囊组件固定到圆柱体上的安装组件。圆柱体具有远端和近端并限定通孔。盖囊组件适于连接到圆柱体的远端，并且包括帽体和囊。盖体限定内腔和远端排出导管，并适于接合圆柱体的远端。盘状囊体设置在内腔内，通常包括中央膜部分。柱塞元件设置在圆柱形主体的通孔中并且被排气以便能够排出柱塞元件和圆柱体中的囊 - 囊组件之间的空间。

4. 发明申请

US20130126559A1 Displacement Syringe 审中-公开
标题翻译：置换注射器
公开(公告)号：US20130126559A1
公开(公告)日：2013-05-23
申请号：US13695189
申请日：2011-05-02
申请人： Kevin P. Cowan , Mark Trocki , Barry L. Tucker , Edward J. Rhinehart , Raymond C. Hoffman , David H. Berry , Arthur E. Uber, III
发明人： Kevin P. Cowan , Mark Trocki , Barry L. Tucker , Edward J. Rhinehart , Raymond C. Hoffman , David H. Berry , Arthur E. Uber, III
IPC分类号： B65D88/54 , G01F11/00
CPC分类号： B65D83/0005 , A61M5/204 , A61M5/315 , A61M5/31505 , A61M5/31513 , A61M5/31525 , A61M5/31573 , A61M5/3158 , A61M5/31591 , A61M5/31595 , A61M2005/3101 , A61M2005/3121 , A61M2005/3128 , A61M2005/31598
摘要： A displacement syringe having a housing with a distal tip and a proximal end; a moveable outer plunger within the housing having an elongated passageway; at least one moveable inner plunger within the passageway of the outer plunger; at least one first seal between the outer plunger and the housing; and at least one second seal between the inner plunger and the outer plunger is disclosed herein. The syringe may have a lock at the proximal end of the housing and/or a valve at the distal tip of the housing. The syringe may also have a plurality of inner plungers of various diameters. A transfer system and delivery system are also disclosed herein. Methods to accurately and efficiently deliver small volumes using the displacement syringe are also disclosed.
摘要翻译：一种置换式注射器，其具有具有远侧末端和近端的壳体; 壳体内的可移动外柱塞具有细长通道; 在所述外柱塞的通道内的至少一个可动内柱塞; 所述外柱塞和所述壳体之间的至少一个第一密封; 并且本文公开了内柱塞和外柱塞之间的至少一个第二密封。注射器可以在壳体的近端处具有锁定和/或在壳体的远侧末端处的阀。注射器还可以具有多个各种直径的内部柱塞。本文还公开了传送系统和传送系统。还公开了使用位移注射器精确和有效地递送小体积的方法。

5. 发明申请

US20080294096A1 Delivery of Agents Such as Cells to Tissue 有权
标题翻译：将细胞递送给组织
公开(公告)号：US20080294096A1
公开(公告)日：2008-11-27
申请号：US12092448
申请日：2006-11-06
申请人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
发明人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
IPC分类号： A61M5/168
CPC分类号： A61M5/142 , A61M5/1452 , A61M5/1723 , A61M5/3291 , A61M25/007 , A61M25/04 , A61M31/005 , A61M2025/0089 , A61M2025/009 , A61M2025/0092
摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be pregenitor cells or stem cells.
摘要翻译：一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。通信系统适于向控制系统提供信息。控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。细胞可以例如是前体细胞或干细胞。

6. 发明授权

US08182444B2 Delivery of agents such as cells to tissue 有权
标题翻译：将细胞递送至组织
公开(公告)号：US08182444B2
公开(公告)日：2012-05-22
申请号：US12092448
申请日：2006-11-06
申请人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , David M. Reilly , Kevin P. Cowan , Barry L. Tucker , David Mishler
发明人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , David M. Reilly , Kevin P. Cowan , Barry L. Tucker , David Mishler
IPC分类号： A61M5/168
CPC分类号： A61M5/142 , A61M5/1452 , A61M5/1723 , A61M5/3291 , A61M25/007 , A61M25/04 , A61M31/005 , A61M2025/0089 , A61M2025/009 , A61M2025/0092
摘要： A system for delivering a fluid comprising cells to tissue of a patient includes a container holding an injection fluid and a powered drive. A sensor system provides a measurement indicative of at least shear forces on the cells to a control system. Based at least in part on this measurement, the control system is adapted to transmit a control signal to the powered drive for pressurizing the contents of the container to deposit cells within the tissue of a patient via a fluid path and a patient interface. As an example, the cells can be pregenitor or stem cells.
摘要翻译：用于将包含细胞的流体输送到患者的组织的系统包括容纳注射流体和动力驱动器的容器。传感器系统提供至少指示细胞上的至少剪切力到控制系统的测量。至少部分地基于该测量，控制系统适于将控制信号传输到动力驱动器，用于对容器的内容物进行加压，以经由流体路径和患者接口将细胞沉积在患者组织内。例如，细胞可以是祖细胞或干细胞。

7. 发明申请

US20120209111A1 BLADDER SYRINGE FLUID DELIVERY SYSTEM 有权
标题翻译： BLADDER SYRINGE流体输送系统
公开(公告)号：US20120209111A1
公开(公告)日：2012-08-16
申请号：US13453335
申请日：2012-04-23
申请人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III
发明人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III
IPC分类号： A61M5/315
CPC分类号： A61M5/31 , A61M5/002 , A61M5/007 , A61M5/1452 , A61M5/14546 , A61M5/148 , A61M5/16827 , A61M5/2425 , A61M5/31511 , A61M5/31515 , A61M2005/14553 , A61M2005/3123 , A61M2005/31516 , A61M2207/10 , B29C45/1418 , B29C45/14336 , B29K2023/12 , B29L2031/7544
摘要： A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.
摘要翻译：用于流体输送系统的膀胱注射器包括圆柱体，囊 - 囊组件，设置在圆柱体中的柱塞元件和用于将囊 - 囊组件固定到圆柱体上的安装组件。圆柱体具有远端和近端并限定通孔。盖囊组件适于连接到圆柱体的远端，并且包括帽体和囊。盖体限定内腔和远端排出导管，并适于接合圆柱体的远端。盘状囊体设置在内腔内，通常包括中央膜部分。柱塞元件设置在圆柱形主体的通孔中并且被排气以便能够排出柱塞元件和圆柱体中的囊 - 囊组件之间的空间。

8. 发明申请

US20100063481A1 CONNECTOR SYSTEM HAVING A COMPRESSIBLE SEALING ELEMENT AND A FLARED FLUID PATH ELEMENT TO REDUCE FLUID FLOW RESTRICTIONS 有权
标题翻译：具有可压缩密封元件的连接器系统和用于减少流体流动限制的FLLED流体路径元件
公开(公告)号：US20100063481A1
公开(公告)日：2010-03-11
申请号：US12206123
申请日：2008-09-08
申请人： Raymond C. Hoffman , Edward J. Rhinehart , Kevin P. Cowan , Barry L. Tucker
发明人： Raymond C. Hoffman , Edward J. Rhinehart , Kevin P. Cowan , Barry L. Tucker
IPC分类号： A61M39/10
CPC分类号： A61M39/10 , A61M39/1011 , A61M2206/11
摘要： A system for connecting a conduit to a fluid path element, includes a length of conduit, a compressible sealing element positioned on a distal end of the length of conduit to be attached to the fluid path element, a first cooperating connector positioned around the length of conduit proximal to the sealing element and a second cooperating connector. The first cooperating connector includes a first cooperating connection mechanism and the second cooperating connector includes a second cooperating connection mechanism. The first cooperating connection mechanism and the second cooperating connection mechanism are adapted to form a connection between the first cooperating connector and the second cooperating connector. The connection causes the compression of the sealing element. The second cooperating connector further includes a passage therein in fluid connection with a connection for the fluid path element. Another system for connecting to a fluid path section includes a connector including a connection mechanism to connect the connector to the fluid path section and a passage therethrough. The passage is in fluid connection with a first fluid path element downstream of the connector. The first fluid path element includes a lumen therethrough. The diameter of the lumen is flared outward to a larger diameter at a proximal end of the fluid path element. The proximal end of the first fluid path element can abut a surface of the connector in which the distal end of the fluid path is formed. The inner diameter of the proximal end is greater than the diameter of the passage of the second cooperating connector. The outer diameter of the proximal end of the first fluid path element can also be flared outward
摘要翻译：一种用于将导管连接到流体路径元件的系统，包括一段导管，一个可压缩的密封元件，该可密封的密封元件定位在待连接到流体路径元件的管道长度的远端上;第一协作连接器，靠近密封元件的导管和第二协作连接器。第一配合连接器包括第一配合连接机构，第二配合连接器包括第二配合连接机构。第一配合连接机构和第二配合连接机构适于在第一配合连接器和第二配合连接器之间形成连接。连接导致密封元件的压缩。第二配合连接器还包括与流体路径元件的连接件流体连接的通道。用于连接到流体路径部分的另一系统包括连接器，该连接器包括将连接器连接到流体路径部分的连接机构和通过其的通道。通道与连接器下游的第一流体路径元件流体连接。第一流体路径元件包括其中的内腔。在流体路径元件的近端处，管腔的直径向外扩张到更大的直径。第一流体路径元件的近端可邻接形成流体路径的远端的连接器的表面。近端的内径大于第二配合连接器的通道的直径。第一流体路径元件的近端的外径也可以向外张开

9. 发明授权

US08551074B2 Connector system having a compressible sealing element and a flared fluid path element 有权
标题翻译：连接器系统具有可压缩的密封元件和扩张的流体路径元件
公开(公告)号：US08551074B2
公开(公告)日：2013-10-08
申请号：US12206123
申请日：2008-09-08
申请人： Raymond C. Hoffman , Edward J. Rhinehart , Kevin P. Cowan , Barry L. Tucker
发明人： Raymond C. Hoffman , Edward J. Rhinehart , Kevin P. Cowan , Barry L. Tucker
IPC分类号： A61M25/18
CPC分类号： A61M39/10 , A61M39/1011 , A61M2206/11
摘要： Systems for connecting a conduit to an injection needle may include a sealing element positioned on a distal end of the conduit, a first cooperating connector positioned around the length of conduit proximal to the sealing element and a second cooperating connector. The first cooperating connector includes a first cooperating connection mechanism and the second cooperating connector includes a second cooperating connection mechanism having a passage therein. The first cooperating connection mechanism and the second cooperating connection mechanism are adapted to form a connection between the first cooperating connector and the second cooperating connector. The connection causes the compression of the sealing element. The injection needle has a lumen with a diameter flared outward to a larger diameter at a proximal end. The second cooperating connector has a mounting hole connected to the passage and a sleeve around the injection needle so that the sleeve and the injection needle are received within the mounting hole.
摘要翻译：用于将导管连接到注射针的系统可以包括定位在导管的远端上的密封元件，位于靠近密封元件的导管长度周围的第一配合连接器和第二配合连接器。第一配合连接器包括第一配合连接机构，第二配合连接器包括在其中具有通道的第二配合连接机构。第一配合连接机构和第二配合连接机构适于在第一配合连接器和第二配合连接器之间形成连接。连接导致密封元件的压缩。注射针头具有直径向外扩张到更近的直径的内腔。第二配合连接器具有连接到通道的安装孔和围绕注射针的套筒，使得套筒和注射针被容纳在安装孔内。

10. 发明申请

US20110178359A1 Systems For Integrated Radiopharmaceutical Generation, Preparation, Transportation and Administration 有权
标题翻译：综合放射性药物生成，制备，运输和管理系统
公开(公告)号：US20110178359A1
公开(公告)日：2011-07-21
申请号：US12595165
申请日：2007-12-28
申请人： Alan D. Hirschman , Arthur E. Uber, III , Kevin P. Cowan , David M. Reilly , Edward J. Rhinehart , John Kalafut , Bronwyn Uber , Frederick W. Trombley, III , Steven J. Remis , Paul D. Levin , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths
发明人： Alan D. Hirschman , Arthur E. Uber, III , Kevin P. Cowan , David M. Reilly , Edward J. Rhinehart , John Kalafut , Bronwyn Uber , Frederick W. Trombley, III , Steven J. Remis , Paul D. Levin , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths
IPC分类号： A61M36/06
CPC分类号： A61N5/1001 , A61B5/0205 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/0478 , A61B6/107 , A61B6/4057 , A61B6/4258 , A61B6/4423 , A61B6/507 , A61B6/508 , A61B6/5288 , A61B6/548 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/16827 , A61M5/16881 , A61M5/1723 , A61M5/1785 , A61M2205/3576 , A61N5/1071 , A61N2005/1021 , A61N2005/1094 , G06F19/00 , G06F19/3468 , G16H20/17 , G21F5/015 , G21G4/08
摘要： An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.
摘要翻译：公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

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