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1. 发明申请

US20130211248A1 BLADDER SYRINGE FLUID DELIVERY SYSTEM 审中-公开
标题翻译： BLADDER SYRINGE流体输送系统
公开(公告)号：US20130211248A1
公开(公告)日：2013-08-15
申请号：US13881072
申请日：2011-10-25
申请人： Kevin P. Cowan , Raymond C. Hoffman , Charles A. Lang , Mark Trocki , Arthur E. Uber, III , Joseph C. Mator , Edward P. Liscio , Bernard J. Hobi , L. Robert Crouthamel , Glen P. Williams , Vincent S. Rossitto , Jaroslaw Wlodarczyk , Matthew Schrauder
发明人： Kevin P. Cowan , Raymond C. Hoffman , Charles A. Lang , Mark Trocki , Arthur E. Uber, III , Joseph C. Mator , Edward P. Liscio , Bernard J. Hobi , L. Robert Crouthamel , Glen P. Williams , Vincent S. Rossitto , Jaroslaw Wlodarczyk , Matthew Schrauder
IPC分类号： A61M5/00
CPC分类号： A61M5/007 , A61M5/1452 , A61M5/148 , A61M5/2425 , A61M5/31511
摘要： A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.
摘要翻译：用于流体输送系统的膀胱注射器包括圆柱体，囊 - 囊组件，设置在圆柱体中的柱塞元件和用于将囊 - 囊组件固定到圆柱体上的安装组件。圆柱体具有远端和近端并限定通孔。盖囊组件适于连接到圆柱体的远端，并且包括帽体和囊。盖体限定内腔和远端排出导管，并适于接合圆柱体的远端。盘状囊体设置在内腔内，通常包括中央膜部分。柱塞元件设置在圆柱形主体的通孔中并且被排气以便能够排出柱塞元件和圆柱体中的囊 - 囊组件之间的空间。

2. 发明申请

US20130126559A1 Displacement Syringe 审中-公开
标题翻译：置换注射器
公开(公告)号：US20130126559A1
公开(公告)日：2013-05-23
申请号：US13695189
申请日：2011-05-02
申请人： Kevin P. Cowan , Mark Trocki , Barry L. Tucker , Edward J. Rhinehart , Raymond C. Hoffman , David H. Berry , Arthur E. Uber, III
发明人： Kevin P. Cowan , Mark Trocki , Barry L. Tucker , Edward J. Rhinehart , Raymond C. Hoffman , David H. Berry , Arthur E. Uber, III
IPC分类号： B65D88/54 , G01F11/00
CPC分类号： B65D83/0005 , A61M5/204 , A61M5/315 , A61M5/31505 , A61M5/31513 , A61M5/31525 , A61M5/31573 , A61M5/3158 , A61M5/31591 , A61M5/31595 , A61M2005/3101 , A61M2005/3121 , A61M2005/3128 , A61M2005/31598
摘要： A displacement syringe having a housing with a distal tip and a proximal end; a moveable outer plunger within the housing having an elongated passageway; at least one moveable inner plunger within the passageway of the outer plunger; at least one first seal between the outer plunger and the housing; and at least one second seal between the inner plunger and the outer plunger is disclosed herein. The syringe may have a lock at the proximal end of the housing and/or a valve at the distal tip of the housing. The syringe may also have a plurality of inner plungers of various diameters. A transfer system and delivery system are also disclosed herein. Methods to accurately and efficiently deliver small volumes using the displacement syringe are also disclosed.
摘要翻译：一种置换式注射器，其具有具有远侧末端和近端的壳体; 壳体内的可移动外柱塞具有细长通道; 在所述外柱塞的通道内的至少一个可动内柱塞; 所述外柱塞和所述壳体之间的至少一个第一密封; 并且本文公开了内柱塞和外柱塞之间的至少一个第二密封。注射器可以在壳体的近端处具有锁定和/或在壳体的远侧末端处的阀。注射器还可以具有多个各种直径的内部柱塞。本文还公开了传送系统和传送系统。还公开了使用位移注射器精确和有效地递送小体积的方法。

3. 发明申请

US20120209111A1 BLADDER SYRINGE FLUID DELIVERY SYSTEM 有权
标题翻译： BLADDER SYRINGE流体输送系统
公开(公告)号：US20120209111A1
公开(公告)日：2012-08-16
申请号：US13453335
申请日：2012-04-23
申请人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III
发明人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III
IPC分类号： A61M5/315
CPC分类号： A61M5/31 , A61M5/002 , A61M5/007 , A61M5/1452 , A61M5/14546 , A61M5/148 , A61M5/16827 , A61M5/2425 , A61M5/31511 , A61M5/31515 , A61M2005/14553 , A61M2005/3123 , A61M2005/31516 , A61M2207/10 , B29C45/1418 , B29C45/14336 , B29K2023/12 , B29L2031/7544
摘要： A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.
摘要翻译：用于流体输送系统的膀胱注射器包括圆柱体，囊 - 囊组件，设置在圆柱体中的柱塞元件和用于将囊 - 囊组件固定到圆柱体上的安装组件。圆柱体具有远端和近端并限定通孔。盖囊组件适于连接到圆柱体的远端，并且包括帽体和囊。盖体限定内腔和远端排出导管，并适于接合圆柱体的远端。盘状囊体设置在内腔内，通常包括中央膜部分。柱塞元件设置在圆柱形主体的通孔中并且被排气以便能够排出柱塞元件和圆柱体中的囊 - 囊组件之间的空间。

4. 发明授权

US10046106B2 Bladder syringe fluid delivery system 有权
公开(公告)号：US10046106B2
公开(公告)日：2018-08-14
申请号：US13881072
申请日：2011-10-25
申请人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III , Bernard J. Hobi , Vincent S. Rossitto , Jaroslaw Wlodarczyk , Matthew Schrauder
发明人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III , Bernard J. Hobi , Vincent S. Rossitto , Jaroslaw Wlodarczyk , Matthew Schrauder
IPC分类号： A61M37/00 , A61M5/00 , A61M5/145 , A61M5/148 , A61M5/24 , A61M5/315
CPC分类号： A61M5/007 , A61M5/1452 , A61M5/148 , A61M5/2425 , A61M5/31511
摘要： A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.

5. 发明授权

US09498570B2 Bladder syringe fluid delivery system 有权
标题翻译：膀胱注射器液体输送系统
公开(公告)号：US09498570B2
公开(公告)日：2016-11-22
申请号：US13453335
申请日：2012-04-23
申请人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III , Barry L. Tucker , Jaroslaw Wlodarczyk
发明人： Kevin P. Cowan , Raymond C. Hoffman , Arthur E. Uber, III , Barry L. Tucker , Jaroslaw Wlodarczyk
IPC分类号： A61M5/00 , A61M5/145 , A61M5/148 , A61M5/24 , A61M5/315 , A61M5/168 , A61M5/31
CPC分类号： A61M5/31 , A61M5/002 , A61M5/007 , A61M5/1452 , A61M5/14546 , A61M5/148 , A61M5/16827 , A61M5/2425 , A61M5/31511 , A61M5/31515 , A61M2005/14553 , A61M2005/3123 , A61M2005/31516 , A61M2207/10 , B29C45/1418 , B29C45/14336 , B29K2023/12 , B29L2031/7544
摘要： A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.
摘要翻译：用于流体输送系统的膀胱注射器包括圆柱体，囊 - 囊组件，设置在圆柱体中的柱塞元件和用于将囊 - 囊组件固定到圆柱体上的安装组件。圆柱体具有远端和近端并限定通孔。盖囊组件适于连接到圆柱体的远端，并且包括帽体和囊。盖体限定内腔和远端排出导管，并适于接合圆柱体的远端。盘状囊体设置在内腔内，通常包括中央膜部分。柱塞元件设置在圆柱形主体的通孔中并且被排气以便能够排出柱塞元件和圆柱体中的囊 - 囊组件之间的空间。

6. 发明授权

US09056200B2 Apparatus and methods for delivery of fluid injection boluses to patients and handling harmful fluids 有权
标题翻译：用于向患者输送流体注射剂并处理有害流体的装置和方法
公开(公告)号：US09056200B2
公开(公告)日：2015-06-16
申请号：US12996520
申请日：2009-06-05
申请人： Arthur E. Uber, III , Mark Trocki , Marc A. Mabie , Larry McCutchan , L. George Siddoway , Kevin P. Cowan , Lisa M. Coates , John F. Kalafut , Aaron Hughes , David M. Griffiths , Peter Twichell , Julie Gulick , Frederick W. Trombley, III
发明人： Arthur E. Uber, III , Mark Trocki , Marc A. Mabie , Larry McCutchan , L. George Siddoway , Kevin P. Cowan , Lisa M. Coates , John F. Kalafut , Aaron Hughes , David M. Griffiths , Peter Twichell , Julie Gulick , Frederick W. Trombley, III
IPC分类号： A61N5/00 , A61N5/10 , A61M5/00 , A61M5/168 , A61M5/178 , A61M5/14
CPC分类号： A61N5/1007 , A61M5/007 , A61M5/16827 , A61M5/1785 , A61M2005/1402 , A61M2202/0225 , A61M2202/049 , A61M2206/11 , A61M2206/18 , Y10T137/0318
摘要： A hazardous fluid transport container and a hazardous fluid delivery system are disclosed. The hazardous fluid transport container includes a housing enclosing an at least partially shielded enclosure. First and second fluid path elements are disposed within the housing, with the first fluid path element and second fluid path element fluidly coupled together. A pump unit may be provided for dispensing fluid from the first and second fluid path elements optionally into a third fluid path element. Also, methods for priming the hazardous fluid transport container and for mitigating laminar flow injection bolus spreading are disclosed. Additionally, disclosed is a radioactive fluid transport container for a syringe or other container. The radioactive fluid transport container allows the syringe or container to be used in an injection procedure without removal from the container.
摘要翻译：公开了一种危险流体输送容器和危险流体输送系统。危险流体输送容器包括封闭至少部分屏蔽的外壳的壳体。第一和第二流体通道元件设置在壳体内，第一流体路径元件和第二流体路径元件流体耦合在一起。可以提供泵单元，用于将流体从第一和第二流体路径元件任选地分配到第三流体路径元件中。此外，公开了用于引燃危险流体输送容器和减轻层流注射团块扩散的方法。此外，公开了一种用于注射器或其他容器的放射性流体输送容器。放射性流体输送容器允许注射器或容器在注射过程中使用而不从容器中取出。

7. 发明申请

US20080294096A1 Delivery of Agents Such as Cells to Tissue 有权
标题翻译：将细胞递送给组织
公开(公告)号：US20080294096A1
公开(公告)日：2008-11-27
申请号：US12092448
申请日：2006-11-06
申请人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
发明人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
IPC分类号： A61M5/168
CPC分类号： A61M5/142 , A61M5/1452 , A61M5/1723 , A61M5/3291 , A61M25/007 , A61M25/04 , A61M31/005 , A61M2025/0089 , A61M2025/009 , A61M2025/0092
摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be pregenitor cells or stem cells.
摘要翻译：一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。通信系统适于向控制系统提供信息。控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。细胞可以例如是前体细胞或干细胞。

8. 发明授权

US5145163A Film sheet load magazine 失效
标题翻译：电影片载入杂志
公开(公告)号：US5145163A
公开(公告)日：1992-09-08
申请号：US441004
申请日：1989-11-24
申请人： Kevin P. Cowan , Stanley R. Lewandowski , David M. Reilly , Arthur E. Uber, III
发明人： Kevin P. Cowan , Stanley R. Lewandowski , David M. Reilly , Arthur E. Uber, III
IPC分类号： G03B42/04 , B65H1/00 , B65H3/06 , B65H7/04
CPC分类号： B65H3/0684 , B65H1/00 , B65H7/04 , B65H2301/531 , B65H2511/30 , B65H2515/71 , B65H2553/22
摘要： A film sheet load magazine is adapted to hold a stack of superimposed films with at least central portions of the films in a curved configuration and leading ends of the films adjacent a film separator mechanism. The curvature of the films is such that they retain themselves in desired positions in the magazine independent of the orientation of the films with respect to gravity. When a top cover of the magazine is opened, floating primary feed rollers are raised by spring-biasing assemblies to facilitate loading of the films under the rollers, and when the top cover is subsequently closed, the rollers are moved into feeding engagement with an innermost film, and the films are held in position by leaf biasing springs. A cleaning mechanism removes contaminants from the primary feed rollers, which feed each film to secondary feed rollers driven at a faster speed than the primary feed rollers. A number-of-films-remaining mechanism, which may be of a mechanical or electrical type which is adjustable for films of different thicknesses, and which is automatically preset to the number of films in the magazine upon closing of the cover, is responsive to downward movement of the primary feed rollers as each innermost film is fed from the stack. A system also is provided for indicating if enough films remain in the magazine for a particular film processing operation and to inhibit operation of an associated device if insufficient films remain. The magazine may be self-driven or driven from an associated device.
摘要翻译：薄膜片装载盒适于将至少中心部分的膜的叠加的薄膜的一叠叠放在弯曲构型中，并且薄膜的前端邻近薄膜分离器机构。膜的曲率使得它们保持它们独立于胶片相对于重力的取向而在胶带中的期望位置。当打开杂志的顶盖时，浮动的主馈送辊由弹簧偏置组件升高以便于将膜下载到辊下方，并且当顶盖随后关闭时，辊被移动到与最内侧的进料接合薄膜，并且薄膜通过叶偏压弹簧保持就位。清洁机构从主进料辊中除去污染物，这些污染物将每个胶片送到以比主进料辊更快的速度驱动的二次进料辊。可以是可以为不同厚度的膜调节的机械或电气类型的数字电影剩余机构，并且其在盖封闭时自动预设为盒中胶片的数量，其响应于当每个最内层的薄膜从堆叠进料时，主进料辊的向下运动。还提供了一种系统，用于指示在特定胶片处理操作中是否有足够的胶片残留在胶卷盒中，如果剩余的胶片不足，则禁止相关装置的操作。杂志可以是自驱动的或者是从相关联的设备驱动的。

9. 发明申请

US20110178359A1 Systems For Integrated Radiopharmaceutical Generation, Preparation, Transportation and Administration 有权
标题翻译：综合放射性药物生成，制备，运输和管理系统
公开(公告)号：US20110178359A1
公开(公告)日：2011-07-21
申请号：US12595165
申请日：2007-12-28
申请人： Alan D. Hirschman , Arthur E. Uber, III , Kevin P. Cowan , David M. Reilly , Edward J. Rhinehart , John Kalafut , Bronwyn Uber , Frederick W. Trombley, III , Steven J. Remis , Paul D. Levin , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths
发明人： Alan D. Hirschman , Arthur E. Uber, III , Kevin P. Cowan , David M. Reilly , Edward J. Rhinehart , John Kalafut , Bronwyn Uber , Frederick W. Trombley, III , Steven J. Remis , Paul D. Levin , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths
IPC分类号： A61M36/06
CPC分类号： A61N5/1001 , A61B5/0205 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/0478 , A61B6/107 , A61B6/4057 , A61B6/4258 , A61B6/4423 , A61B6/507 , A61B6/508 , A61B6/5288 , A61B6/548 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/16827 , A61M5/16881 , A61M5/1723 , A61M5/1785 , A61M2205/3576 , A61N5/1071 , A61N2005/1021 , A61N2005/1094 , G06F19/00 , G06F19/3468 , G16H20/17 , G21F5/015 , G21G4/08
摘要： An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.
摘要翻译：公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

10. 发明申请

US20110028908A1 SYSTEM FOR PROCESSING CELLS AND CONTAINER FOR USE THEREWITH 有权
标题翻译：用于处理细胞和容器的系统用于其中
公开(公告)号：US20110028908A1
公开(公告)日：2011-02-03
申请号：US12732250
申请日：2010-03-26
申请人： Arthur E. Uber, III , Mark Trocki , Frederick W. Trombley, III , Kevin P. Cowan
发明人： Arthur E. Uber, III , Mark Trocki , Frederick W. Trombley, III , Kevin P. Cowan
IPC分类号： A61M5/31 , A61J1/00
CPC分类号： A61J1/1443 , A61J1/1456 , A61J1/1475 , A61M5/142 , A61M5/1723 , A61M5/3145 , A61M31/005 , B01L3/502 , B01L2300/044 , B01L2300/0681 , G06F19/3468
摘要： A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.
摘要翻译：用于处理细胞（和/或其它注射组分）的系统包括适于可滑动地定位在容器内的容器和柱塞。该系统包括至少一个入口，流体可以通过该入口进入系统和至少一个流出物端口，流出物可通过该至少一个出口端口离开系统。柱塞部分形成与容器的内壁的密封接合，使得柱塞的向后运动适于经由入口将流体引入系统，并且柱塞的向前运动适于通过流出物强制流出系统的流出物港口。

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