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1. 发明申请

US20090036781A1 EXTERNAL CONDITION CONTROL DEVICE BASED ON MEASUREMENT OF BRAIN FUNCTIONS 有权
标题翻译：基于脑功能测量的外部条件控制装置
公开(公告)号：US20090036781A1
公开(公告)日：2009-02-05
申请号：US12039864
申请日：2008-02-29
申请人： Kei Utsugi , Atsushi Maki
发明人： Kei Utsugi , Atsushi Maki
IPC分类号： A61B5/00
CPC分类号： G06F3/011 , A61B5/04842 , A61B5/14553
摘要： The present invention is helpful in improving stability of repeated measurement and can be applied with high reliability for operations of devices for measurement based on brain functions. A module 801 (a sampler) receives measurement data at each of the measuring points based on information of cerebral blood amount sent from an input unit. The information data accumulated in this sampler are processed by filtering at a secondary agent 803 and a tertiary agent 804 and are analyzed. The synthesizer 802 integrates output information of each agent by weighted linear sum and transmits the data as an output data 602 to the device and operates the device.
摘要翻译：本发明有助于提高重复测量的稳定性，并且可以高度可靠地应用于基于脑功能的测量装置的操作。模块801（采样器）基于从输入单元发送的脑血量的信息，在每个测量点处接收测量数据。在该采样器中累积的信息数据通过在二次代理803和第三代理804进行过滤来进行处理，并进行分析。合成器802通过加权线性和积分每个代理的输出信息，并将数据作为输出数据602发送到设备并操作该设备。

2. 发明授权

US08175686B2 External condition control device based on measurement of brain functions 有权
标题翻译：基于大脑功能测量的外部条件控制装置
公开(公告)号：US08175686B2
公开(公告)日：2012-05-08
申请号：US12039864
申请日：2008-02-29
申请人： Kei Utsugi , Atsushi Maki
发明人： Kei Utsugi , Atsushi Maki
IPC分类号： A61B6/00
CPC分类号： G06F3/011 , A61B5/04842 , A61B5/14553
摘要： The present invention is helpful in improving stability of repeated measurement and can be applied with high reliability for operations of devices for measurement based on brain functions. A module 801 (a sampler) receives measurement data at each of the measuring points based on information of cerebral blood amount sent from an input unit. The information data accumulated in this sampler are processed by filtering at a secondary agent 803 and a tertiary agent 804 and are analyzed. The synthesizer 802 integrates output information of each agent by weighted linear sum and transmits the data as an output data 602 to the device and operates the device.
摘要翻译：本发明有助于提高重复测量的稳定性，并且可以高度可靠地应用于基于脑功能的测量装置的操作。模块801（采样器）基于从输入单元发送的脑血量的信息，在每个测量点处接收测量数据。在该采样器中累积的信息数据通过在二次代理803和第三代理804进行过滤来进行处理，并进行分析。合成器802通过加权线性和积分每个代理的输出信息，并将数据作为输出数据602发送到设备并操作该设备。

3. 发明授权

US08050744B2 Optical system for measuring metabolism in a body and imaging method 有权
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US08050744B2
公开(公告)日：2011-11-01
申请号：US11037338
申请日：2005-01-19
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译：在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在信号一次。

4. 发明授权

US07974671B2 Living body information signal processing system combining living body optical measurement apparatus and brain wave measurement apparatus and probe device used for the same 有权
标题翻译：生物体信息处理系统结合生物体光学测量装置和脑波测量装置以及用于其的探针装置
公开(公告)号：US07974671B2
公开(公告)日：2011-07-05
申请号：US10572357
申请日：2004-09-03
申请人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
发明人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B5/0261 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0488 , A61B5/11 , A61B5/6822 , A61B5/742 , A61B2562/0209 , A61B2562/0233 , A61B2562/046
摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.
摘要翻译：一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光，通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

5. 发明授权

US07516021B2 Optical system for measuring metabolism in a body, method and program 有权
标题翻译：用于测量身体代谢的光学系统，方法和程序
公开(公告)号：US07516021B2
公开(公告)日：2009-04-07
申请号：US11570558
申请日：2005-06-08
申请人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
IPC分类号： G01N31/00
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/7425 , A61B5/743 , G06F19/00 , G16H40/63
摘要： Apparatus and method for hemoglobin measurement including irradiating light to a living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; irradiating light to the living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; classifying the data measured at the first step and the data measured at the second step according to each of an increase or a decrease in the concentration of oxidized hemoglobin and an increase or a decrease in the concentration of deoxidized hemoglobin; and displaying the classifications determined at the third step.
摘要翻译：用于血红蛋白测量的装置和方法，包括向生物体照射光，检测通过活体传播的光，并获取表示生物体中氧化血红蛋白浓度变化的测量数据和脱氧浓度变化血红蛋白对生物体照射光，检测通过生物体传播的光，获取表示生物体中氧化血红蛋白浓度变化的测定数据和脱氧血红蛋白浓度的变化; 根据氧化血红蛋白浓度的增加或减少以及脱氧血红蛋白浓度的增加或减少，分别在第一步骤测量的数据和在第二步骤测量的数据; 并显示在第三步确定的分类。

6. 发明申请

US20070287922A1 Measurement System and Method for Measuring Living Bodies 审中-公开
标题翻译：生活体测量系统和方法
公开(公告)号：US20070287922A1
公开(公告)日：2007-12-13
申请号：US11696295
申请日：2007-04-04
申请人： Naoki Tanaka , Atsushi Maki , Takushige Katsura
发明人： Naoki Tanaka , Atsushi Maki , Takushige Katsura
IPC分类号： A61B5/02
CPC分类号： A61B5/0261 , A61B5/021 , A61B5/02416 , A61B5/6814
摘要： A living body measurement system including a cerebral blood volume measurement unit for measuring a regional cerebral blood volume of a subject, an arterial pressure/heart rate measurement unit for measuring an arterial pressure and/or a heart rate of the subject, an analysis unit for analyzing signals measured by the cerebral blood volume measurement unit and the arterial pressure/heart rate measurement unit, an extraction unit for extracting information concerning a regional cerebral vascular state of the subject on the basis of an output of the analysis unit, and a display unit for displaying a measurement result measured by the cerebral blood volume measurement unit and/or the arterial pressure/heart rate measurement unit, an analysis result analyzed by the analysis unit, or an extraction result extracted by the extraction unit.
摘要翻译：一种生物体测量系统，包括用于测量对象的局部脑血容量的脑血容量测量单元，用于测量受试者的动脉压和/或心率的动脉压/心率测量单元，用于分析由脑血容量测量单元和动脉压/心率测量单元测量的信号，提取单元，用于根据分析单元的输出提取关于对象的区域性脑血管状态的信息;以及显示单元用于显示由脑血容量测量单元和/或动脉压/心率测量单元测量的测量结果，由分析单元分析的分析结果或由提取单元提取的提取结果。

7. 发明授权

US07171250B2 Living body light measurement system and signal processing method 失效
标题翻译：生活体光测量系统及信号处理方法
公开(公告)号：US07171250B2
公开(公告)日：2007-01-30
申请号：US11010668
申请日：2004-12-14
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B2562/0233 , A61B2562/046
摘要： An image generating methodology for displaying brain activation areas with improved accuracy in a living body light measurement system for generating an image of the changes in blood volume of the brain. A spatial intensity distribution of changes in blood volume can be generated by detecting brain activation in many sampling points, and a spatial interpolation process is executed on this data. A threshold process is executed on the distribution to extract the distribution of coordinates having a signal intensity of at least the predetermined threshold. The displacement between the brain activation area and the maximal location of the distribution is stored in a recording unit of the system in order to compensate for the distribution extracted by the threshold process. Accordingly, brain activation areas can be estimated with greater location accuracy, and the diagnosis and medial treatment for brain diseases can likewise be executed with greater accuracy.
摘要翻译：一种用于在生物体光测量系统中显示脑激活区域以提高准确度的图像产生方法，用于产生脑的血容量变化的图像。通过检测许多采样点的大脑激活可以产生血容量变化的空间强度分布，并对该数据执行空间插值处理。对分布执行阈值处理以提取具有至少预定阈值的信号强度的坐标分布。大脑激活区域和分布的最大位置之间的位移被存储在系统的记录单元中，以便补偿由阈值处理提取的分布。因此，可以以更高的定位精度估计脑激活区域，并且同样可以更准确地执行脑疾病的诊断和内侧治疗。

8. 发明授权

US07150717B2 Optical measurement apparatus for a living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US07150717B2
公开(公告)日：2006-12-19
申请号：US10764561
申请日：2004-01-27
申请人： Takusige Katura , Atsushi Maki , Masashi Kiguchi
发明人： Takusige Katura , Atsushi Maki , Masashi Kiguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/4884 , A61B5/02055 , A61B5/021 , A61B5/0261 , A61B5/0816 , A61B5/14553
摘要： Disclosed is an optical measurement apparatus for a living body to provide a means for measuring blood flow activity within a short time inside the body, even if the test subject cannot distinguish between the active task period and the rest period. An optical measurement apparatus for a living body comprises a light irradiating section, and a light detecting section for detecting light transmitting through or reflected from the interior of the body. The concentration of carbon dioxide gas taken into the body is controlled by the respiration of the test subject and the resulting change in output from the light detecting section is then evaluated.
摘要翻译：公开了一种生物体的光学测量装置，即使被检体不能区分活动任务期间和休止期间，也能够在体内短时间内测定血液流动活动的手段。用于生物体的光学测量装置包括光照射部分和用于检测透射到身体内部或从身体内部反射的光的光检测部分。进入身体的二氧化碳气体的浓度由受检对象的呼吸控制，然后评估所得到的光检测部分的输出变化。

9. 发明授权

US07139600B2 Biophotometer 失效
标题翻译：生物光度计
公开(公告)号：US07139600B2
公开(公告)日：2006-11-21
申请号：US10450895
申请日：2002-01-18
申请人： Atsushi Maki , Michiyuki Fujiwara , Jacques Mehler , Ghislaine Dehaene-Lambertz , Marcela Pena
发明人： Atsushi Maki , Michiyuki Fujiwara , Jacques Mehler , Ghislaine Dehaene-Lambertz , Marcela Pena
IPC分类号： A61B5/00
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/14552 , A61B5/14553 , A61B2562/0233 , A61B2562/046
摘要： The present invention provides an optical measurement device of biological tissue having a probe attachable to a moving part of a living body with a high curvature in biophotometry. A member having a high flexibility and a high friction coefficient is disposed on a surface for contact with the living body. In addition, a device for light irradiation and a device for collection of light are fixed with an elastic material for uniform pressure application. The resulting double structure or double layer has solved a problem.
摘要翻译：本发明提供一种生物组织的光学测量装置，其具有可附接到生物光度测量中高曲率的活体的运动部分的探针。具有高柔性和高摩擦系数的构件设置在与生物体接触的表面上。此外，用于光照射的装置和用于收集光的装置用弹性材料固定以均匀地施加压力。所得到的双层结构或双层解决了一个问题。

10. 发明申请

US20060184047A1 Optical measurement instrument for living body 审中-公开
标题翻译：生物体光学测量仪器
公开(公告)号：US20060184047A1
公开(公告)日：2006-08-17
申请号：US11371919
申请日：2006-03-10
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B6/03
摘要： An input instrument for a living body, using an optical measurement system for the living body, includes first and second light incident units arranged on a head of a living body, and first and second light detectors which are paired with the first and the second light incident units respectively, and which are provided to collect light which passes through the living body based on the light irradiated onto the head of the living body by the light incident means. Measurement signals are obtained by measuring a plurality of regions of the living body by the first and the second light incident units, the first and the second light detectors, and characteristic parameters of the signals of an arbitrary time interval of the measured signals are calculated.
摘要翻译：使用生物体的光学测量系统的生物体的输入仪器具有设置在生物体的头部的第一和第二光入射单元，以及与第一和第二光线配对的第一和第二光检测器入射单元，其被设置成基于通过光入射装置照射到生物体的头部上的光来收集穿过生物体的光。通过第一和第二光入射单元，第一和第二光检测器测量生物体的多个区域以及测量信号的任意时间间隔的信号的特性参数来计算测量信号。

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