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1. 发明授权

US07285790B2 Optical measurement system for living bodies and method thereof 失效
标题翻译：生物体光学测量系统及其方法
公开(公告)号：US07285790B2
公开(公告)日：2007-10-23
申请号：US11044040
申请日：2005-01-28
申请人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
发明人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
IPC分类号： A61B5/00
CPC分类号： A61B5/16 , A61B5/14553 , A61B5/6814
摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.
摘要翻译：响应时间是任意确定的。由于信号中包含的伪影等，不能提供令人满意的检测能力。因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。测量信号的相位与参考信号的相位的同步性被数字表示。对这样得到的数值进行统计处理，以便数值地表达可靠度。因此，大脑活动或功能连接可视化。

2. 发明授权

US07150717B2 Optical measurement apparatus for a living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US07150717B2
公开(公告)日：2006-12-19
申请号：US10764561
申请日：2004-01-27
申请人： Takusige Katura , Atsushi Maki , Masashi Kiguchi
发明人： Takusige Katura , Atsushi Maki , Masashi Kiguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/4884 , A61B5/02055 , A61B5/021 , A61B5/0261 , A61B5/0816 , A61B5/14553
摘要： Disclosed is an optical measurement apparatus for a living body to provide a means for measuring blood flow activity within a short time inside the body, even if the test subject cannot distinguish between the active task period and the rest period. An optical measurement apparatus for a living body comprises a light irradiating section, and a light detecting section for detecting light transmitting through or reflected from the interior of the body. The concentration of carbon dioxide gas taken into the body is controlled by the respiration of the test subject and the resulting change in output from the light detecting section is then evaluated.
摘要翻译：公开了一种生物体的光学测量装置，即使被检体不能区分活动任务期间和休止期间，也能够在体内短时间内测定血液流动活动的手段。用于生物体的光学测量装置包括光照射部分和用于检测透射到身体内部或从身体内部反射的光的光检测部分。进入身体的二氧化碳气体的浓度由受检对象的呼吸控制，然后评估所得到的光检测部分的输出变化。

3. 发明申请

US20060006343A1 Optical measurement system for living bodies and method thereof 失效
标题翻译：生物体光学测量系统及其方法
公开(公告)号：US20060006343A1
公开(公告)日：2006-01-12
申请号：US11044040
申请日：2005-01-28
申请人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
发明人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
IPC分类号： A61B8/06
CPC分类号： A61B5/16 , A61B5/14553 , A61B5/6814
摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.
摘要翻译：响应时间是任意确定的。由于信号中包含的伪影等，不能提供令人满意的检测能力。因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。测量信号的相位与参考信号的相位的同步性被数字表示。对这样得到的数值进行统计处理，以便数值地表达可靠度。因此，大脑活动或功能连接可视化。

4. 发明授权

US09198624B2 Biological photometric device and biological photometry method using same 有权
标题翻译：生物光度测定装置及其生物测光方法
公开(公告)号：US09198624B2
公开(公告)日：2015-12-01
申请号：US13806790
申请日：2011-07-06
申请人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
发明人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
IPC分类号： A61B6/00 , A61B5/00 , G01N21/359 , G01N21/49
CPC分类号： A61B6/00 , A61B5/0042 , A61B5/0075 , A61B5/6814 , G01N21/359 , G01N21/49
摘要： The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.
摘要翻译：本发明能够分离/去除包含在近红外光谱（NIRS）信号中的皮肤血流的影响并提取脑或脑皮层起始信号。此外，鉴于个体之间的差异，本发明能够多功能地分离脑起源和皮肤起始信号。一种生物测光装置，其中光发射器和光接收器以这样的方式定位，使得可以在多个源 - 检测器（SD）距离处进行测量，并且由各个光接收器接收的光可以通过灰质，从而分离脑起始信号和皮肤起始信号。对各个测量点获得的数据进行单独分量分析（ICA）。然后，使用每个分离的组分的加权值的SD距离相关性来确定每个单独组分是否来自大脑或皮肤。

5. 发明申请

US20130102907A1 BIOLOGICAL PHOTOMETRIC DEVICE AND BIOLOGICAL PHOTOMETRY METHOD USING SAME 有权
标题翻译：生物光学设备和使用相同的生物光度测定方法
公开(公告)号：US20130102907A1
公开(公告)日：2013-04-25
申请号：US13806790
申请日：2011-07-06
申请人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
发明人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
IPC分类号： A61B6/00
CPC分类号： A61B6/00 , A61B5/0042 , A61B5/0075 , A61B5/6814 , G01N21/359 , G01N21/49
摘要： The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.
摘要翻译：本发明能够分离/去除包含在近红外光谱（NIRS）信号中的皮肤血流的影响并提取脑或脑皮层起始信号。此外，鉴于个体之间的差异，本发明能够多功能地分离脑起源和皮肤起始信号。一种生物测光装置，其中光发射器和光接收器以这样的方式定位，使得可以在多个源 - 检测器（SD）距离处进行测量，并且由各个光接收器接收的光可以通过灰质，从而分离脑起始信号和皮肤起始信号。对各个测量点获得的数据进行单独分量分析（ICA）。然后，使用每个分离的组分的加权值的SD距离相关性来确定每个单独组分是否来自大脑或皮肤。

6. 发明授权

US07022083B2 Measurement system for living bodies 失效
标题翻译：活体测量系统
公开(公告)号：US07022083B2
公开(公告)日：2006-04-04
申请号：US10457478
申请日：2003-06-10
申请人： Naoki Tanaka , Atsushi Maki , Masashi Kiguchi
发明人： Naoki Tanaka , Atsushi Maki , Masashi Kiguchi
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/486 , A61B5/0086 , A61B5/1455
摘要： A satisfactory averaged signal can be obtained with only a small number of repetitions of measurement in the measurement of responses to a stimulus given to a living body. A low-frequency biological fluctuation is extracted and a stimulus is presented to the living body in synchronism with the phase of the extracted fluctuation.
摘要翻译：在对给予生物体的刺激的响应的测量的测量中，可以仅获得少量的测量重复来获得满意的平均信号。提取低频生物波动，并且与提取的波动的相位同步地向生物体提供刺激。

7. 发明授权

US07974671B2 Living body information signal processing system combining living body optical measurement apparatus and brain wave measurement apparatus and probe device used for the same 有权
标题翻译：生物体信息处理系统结合生物体光学测量装置和脑波测量装置以及用于其的探针装置
公开(公告)号：US07974671B2
公开(公告)日：2011-07-05
申请号：US10572357
申请日：2004-09-03
申请人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
发明人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B5/0261 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0488 , A61B5/11 , A61B5/6822 , A61B5/742 , A61B2562/0209 , A61B2562/0233 , A61B2562/046
摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.
摘要翻译：一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光，通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

8. 发明授权

US07516021B2 Optical system for measuring metabolism in a body, method and program 有权
标题翻译：用于测量身体代谢的光学系统，方法和程序
公开(公告)号：US07516021B2
公开(公告)日：2009-04-07
申请号：US11570558
申请日：2005-06-08
申请人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
IPC分类号： G01N31/00
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/7425 , A61B5/743 , G06F19/00 , G16H40/63
摘要： Apparatus and method for hemoglobin measurement including irradiating light to a living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; irradiating light to the living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; classifying the data measured at the first step and the data measured at the second step according to each of an increase or a decrease in the concentration of oxidized hemoglobin and an increase or a decrease in the concentration of deoxidized hemoglobin; and displaying the classifications determined at the third step.
摘要翻译：用于血红蛋白测量的装置和方法，包括向生物体照射光，检测通过活体传播的光，并获取表示生物体中氧化血红蛋白浓度变化的测量数据和脱氧浓度变化血红蛋白对生物体照射光，检测通过生物体传播的光，获取表示生物体中氧化血红蛋白浓度变化的测定数据和脱氧血红蛋白浓度的变化; 根据氧化血红蛋白浓度的增加或减少以及脱氧血红蛋白浓度的增加或减少，分别在第一步骤测量的数据和在第二步骤测量的数据; 并显示在第三步确定的分类。

9. 发明授权

US08229531B2 Optical bioinstrumentation devices 有权
标题翻译：光学生物仪器
公开(公告)号：US08229531B2
公开(公告)日：2012-07-24
申请号：US11914701
申请日：2006-02-13
申请人： Hirokazu Atsumori , Masashi Kiguchi , Atsushi Maki , Michiyuki Fujiwara
发明人： Hirokazu Atsumori , Masashi Kiguchi , Atsushi Maki , Michiyuki Fujiwara
IPC分类号： A61B5/1455
CPC分类号： A61B5/0059 , A61B5/6814 , A61B2562/0233 , A61B2562/046
摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.
摘要翻译：提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上，固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。

10. 发明申请

US20080040049A1 Optical System for Measuring Metabolism in a Body, Method and Program 有权
标题翻译：用于测量身体代谢的光学系统，方法和程序
公开(公告)号：US20080040049A1
公开(公告)日：2008-02-14
申请号：US11570558
申请日：2005-06-08
申请人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
IPC分类号： G06F19/00
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/7425 , A61B5/743 , G06F19/00 , G16H40/63
摘要： In the past, comparison of mean values or variances measured from multiple subjects with one another has been a mainstream of diagnostic support to be achieved using cerebral activity signals. However, in this case, it is hard to absorb individual differences, and the precision in a diagnostic support technology is low. In order to improve the precision in the diagnostic support technology, the property of data acquired by an optical organism measurement system is utilized in order to create and display information representing a change in the condition of each person. Thus, diagnosis of each person is effectively supported. Measured light signals are used to calculate and record changes in the concentrations of oxidized hemoglobin (Hb), deoxidized Hb, and total Hb respectively. Based on each data (representing the Hb concentration changes), two or more Hb concentration changes (for example, the oxidized Hb concentration change and deoxidized Hb concentration change) are classified according to whether the changes are increases or decreases, and indicated in the form of symbols, an image, or a graph. Thus, an examining person is provided with compressed and simplified information and supported in diagnosis.
摘要翻译：在过去，从多个受试者相互测量的平均值或差异的比较已经成为使用脑活动信号来实现的诊断支持的主流。然而，在这种情况下，难以吸收个体差异，诊断支持技术的精度低。为了提高诊断支持技术的精度，利用光学生物测量系统获取的数据的属性来创建和显示表示每个人的状况变化的信息。因此，有效地支持每个人的诊断。测量光信号用于计算和记录氧化血红蛋白（Hb），脱氧Hb和总Hb的浓度变化。基于每个数据（表示Hb浓度变化），根据变化是增加还是减少来分类两种或更多种Hb浓度变化（例如，氧化的Hb浓度变化和脱氧的Hb浓度变化），并以表格的符号，图像或图形。因此，检查人员被提供压缩和简化的信息并且在诊断中被支持。

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