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1. 发明授权

US07171250B2 Living body light measurement system and signal processing method 失效
标题翻译：生活体光测量系统及信号处理方法
公开(公告)号：US07171250B2
公开(公告)日：2007-01-30
申请号：US11010668
申请日：2004-12-14
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B2562/0233 , A61B2562/046
摘要： An image generating methodology for displaying brain activation areas with improved accuracy in a living body light measurement system for generating an image of the changes in blood volume of the brain. A spatial intensity distribution of changes in blood volume can be generated by detecting brain activation in many sampling points, and a spatial interpolation process is executed on this data. A threshold process is executed on the distribution to extract the distribution of coordinates having a signal intensity of at least the predetermined threshold. The displacement between the brain activation area and the maximal location of the distribution is stored in a recording unit of the system in order to compensate for the distribution extracted by the threshold process. Accordingly, brain activation areas can be estimated with greater location accuracy, and the diagnosis and medial treatment for brain diseases can likewise be executed with greater accuracy.
摘要翻译：一种用于在生物体光测量系统中显示脑激活区域以提高准确度的图像产生方法，用于产生脑的血容量变化的图像。通过检测许多采样点的大脑激活可以产生血容量变化的空间强度分布，并对该数据执行空间插值处理。对分布执行阈值处理以提取具有至少预定阈值的信号强度的坐标分布。大脑激活区域和分布的最大位置之间的位移被存储在系统的记录单元中，以便补偿由阈值处理提取的分布。因此，可以以更高的定位精度估计脑激活区域，并且同样可以更准确地执行脑疾病的诊断和内侧治疗。

2. 发明申请

US20050192490A1 Living body light measurement system and signal processing method 失效
标题翻译：生活体光测量系统及信号处理方法
公开(公告)号：US20050192490A1
公开(公告)日：2005-09-01
申请号：US11010668
申请日：2004-12-14
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
IPC分类号： G01N21/17 , A61B5/00 , A61B10/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B2562/0233 , A61B2562/046
摘要： An image generating methodology for displaying brain activation areas with improved accuracy in a living body light measurement system for generating an image of the changes in blood volume of the brain. A spatial intensity distribution of changes in blood volume can be generated by detecting brain activation in many sampling points, and a spatial interpolation process is executed on this data. A threshold process is executed on the distribution to extract the distribution of coordinates having a signal intensity of at least the predetermined threshold. The displacement between the brain activation area and the maximal location of the distribution is stored in a recording unit of the system in order to compensate for the distribution extracted by the threshold process. Accordingly, brain activation areas can be estimated with greater location accuracy, and the diagnosis and medial treatment for brain diseases can likewise be executed with greater accuracy.
摘要翻译：一种用于在生物体光测量系统中显示脑激活区域以提高准确度的图像产生方法，用于产生脑的血容量变化的图像。通过检测许多采样点的大脑激活，可以产生血容量变化的空间强度分布，并对该数据执行空间插值处理。对分布执行阈值处理以提取具有至少预定阈值的信号强度的坐标的分布。大脑激活区域和分布的最大位置之间的位移被存储在系统的记录单元中，以便补偿由阈值处理提取的分布。因此，可以以更高的定位精度估计脑激活区域，并且同样可以更准确地执行脑疾病的诊断和内侧治疗。

3. 发明授权

US07974671B2 Living body information signal processing system combining living body optical measurement apparatus and brain wave measurement apparatus and probe device used for the same 有权
标题翻译：生物体信息处理系统结合生物体光学测量装置和脑波测量装置以及用于其的探针装置
公开(公告)号：US07974671B2
公开(公告)日：2011-07-05
申请号：US10572357
申请日：2004-09-03
申请人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
发明人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B5/0261 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0488 , A61B5/11 , A61B5/6822 , A61B5/742 , A61B2562/0209 , A61B2562/0233 , A61B2562/046
摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.
摘要翻译：一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光，通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

4. 发明授权

US07991447B2 Biological photometric equipment 有权
标题翻译：生物测光设备
公开(公告)号：US07991447B2
公开(公告)日：2011-08-02
申请号：US10577944
申请日：2004-07-01
申请人： Hiroki Sato , Masashi Kiguchi , Atsushi Maki , Tsuyoshi Yamamoto
发明人： Hiroki Sato , Masashi Kiguchi , Atsushi Maki , Tsuyoshi Yamamoto
IPC分类号： A61B5/1455
CPC分类号： A61B5/14553
摘要： To control information obtained from inside of a living body with higher precision as compared to that in the conventional technology by controlling a ratio of intensities of light, directed to a trial body, in a plurality of wavelength ranges different in peak wavelength from each other, a measurement error included in information obtained from the living body can be controlled by changing a ratio of intensity of the light in the first wavelength range against that of the light in the second wavelength range. When intensity of irradiated light is limited from the viewpoint of safety to the trial subject, keeping a ratio of the light irradiated to the trial body in the first wavelength range against that of the light in the second wavelength range under a prespecified value and also changing the ratio of irradiated light intensities under the prespecified value.
摘要翻译：通过在峰值波长不同的多个波长范围内控制指向试验体的光的强度比，通过控制比现有技术更高的精度从内部获得的生物体的信息，可以通过改变第一波长范围内的光的强度与第二波长范围内的光的强度的比例来控制从生物体获得的信息中包括的测量误差。当照射光的强度从安全性的角度受限于试验对象时，将照射在试验体上的光的第1波长范围内的光与第2波长范围内的光的比例保持在规定值以下，照射光强度的比例在预先指定的值之下。

5. 发明授权

US07613502B2 Optical bioinstrumentation for living body 有权
标题翻译：活体光生物仪器
公开(公告)号：US07613502B2
公开(公告)日：2009-11-03
申请号：US11205184
申请日：2005-08-17
申请人： Yukari Yamamoto , Atsushi Maki , Masashi Kiguchi , Tsuyoshi Yamamoto
发明人： Yukari Yamamoto , Atsushi Maki , Masashi Kiguchi , Tsuyoshi Yamamoto
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/064 , A61B5/6814 , A61B5/7425 , A61B5/743 , A61B34/20 , A61B2034/2051 , A61B2034/2055 , A61B2034/2063
摘要： In a probe positioning technology, an optical bioinstrumentation includes a region selecting unit that is used to delineate a region of interest in an anatomical image of a subject, a computing unit that determines a recommended probe position according to the region of interest, a probe position sensor that detects a current probe position, a computing unit that calculates the distance between the recommended probe position and the current probe position, and an alarm device that generates an alarm sound or the like when the distance falls within a predetermined range. Moreover, the optical bioinstrumentation for living body further includes a memory unit in which the probe position is saved together with measurement data.
摘要翻译：在探针定位技术中，光学生物仪器包括区域选择单元，其用于描绘对象的解剖图像中的感兴趣区域，计算单元，其根据感兴趣的区域确定推荐的探针位置，探针位置检测当前探头位置的传感器，计算推荐探测位置与当前探测位置之间的距离的计算单元，以及当距离在预定范围内时产生报警声等的报警装置。此外，生物体的光学生物仪器还包括存储单元，其中探测位置与测量数据一起被保存。

6. 发明授权

US07139597B2 Living body light measuring device 有权
标题翻译：活体光测量装置
公开(公告)号：US07139597B2
公开(公告)日：2006-11-21
申请号：US10762498
申请日：2004-01-23
申请人： Atsushi Maki , Tsuyoshi Yamamoto
发明人： Atsushi Maki , Tsuyoshi Yamamoto
IPC分类号： A61B5/00
CPC分类号： A61B5/7207 , A61B5/0261 , A61B5/14553 , A61B5/16 , A61B2562/0233 , A61B2562/046
摘要： There has been no device for measuring changes in Hb concentrations associated with activities of the cerebral function of an infant or subject prone to movement during measurement. Removing and reducing any influences of body movement is needed. In the present invention, light is irradiated on the subject's head, and changes in Hb concentrations associated with activities of the cerebral function are measured from scattered light which has passed through the head. From this blood circulation movement, a parameter is inputted arbitrarily to judge the body movement component, and feed-back is applied to a stimulus device for giving a stimulus to the subject.
摘要翻译：没有用于测量与测量期间容易运动的婴儿或受试者的脑功能活动相关的Hb浓度变化的装置。需要去除和减少身体运动的任何影响。在本发明中，将光照射到受检者的头部，并且通过头部的散射光测量与脑功能的活动有关的Hb浓度的变化。从该血液循环运动中，任意地输入参数以判断身体运动成分，并且将反馈应用于刺激装置以对受试者施加刺激。

7. 发明授权

US06895269B2 Device for controlling equipment by using signals from a living body 失效
标题翻译：通过使用生物体信号控制设备的装置
公开(公告)号：US06895269B2
公开(公告)日：2005-05-17
申请号：US09987334
申请日：2001-11-14
申请人： Yoshitoshi Ito , Hideaki Koizumi , Atsushi Maki , Yuichi Yamashita , Tsuyoshi Yamamoto
发明人： Yoshitoshi Ito , Hideaki Koizumi , Atsushi Maki , Yuichi Yamashita , Tsuyoshi Yamamoto
IPC分类号： G06F3/00 , G06F3/01 , A61B6/00
CPC分类号： G06F3/015
摘要： A device for controlling equipment includes at least one light projector adapted to project light onto a head of a living body. A light collecting section for collecting the light having passed through the head, a light measuring section for measuring an intensity of the light collected by the light collecting section, a memory section for storing a previous history of changes of the intensity of the light measured, a signal judging section for judging if both the intensity of the light measured by said light measuring section and the previous history of changes of the intensity of the light satisfy a predetermined condition, a displaying section for displaying the intensity of the light measured and a result obtained by the signal judging section, and a control signal generating section for generating a control signal for external equipment.
摘要翻译：一种用于控制设备的设备包括至少一个适于将光投射到生物体的头部上的投影仪。用于收集通过头部的光的聚光部分，用于测量由聚光部分收集的光的强度的光测量部分，用于存储测量的光的强度变化的先前历史的存储部分，信号判断部分，用于判断由所述光测量部分测量的光的强度和光的强度变化的先前历史是否都满足预定条件;显示部分，用于显示所测量的光的强度和结果由信号判定部获得的控制信号生成部，生成外部设备的控制信号。

8. 发明授权

US07890270B2 Optical system for measuring metabolism in a body, method and program 有权
标题翻译：用于测量身体代谢的光学系统，方法和程序
公开(公告)号：US07890270B2
公开(公告)日：2011-02-15
申请号：US12392207
申请日：2009-02-25
申请人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
IPC分类号： G01N31/00
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/7425 , A61B5/743 , G06F19/00 , G16H40/63
摘要： A living body light measuring device including plural light-radiating devices for radiating light to a head of a subject, plural light-receiving devices for detecting light which is transmitted through the head of the subject after radiation from the light-radiating devices, a calculator for calculating a change of concentration of oxidized and deoxidized hemoglobin in the head of the subject at a measurement point using a pair of each of the plural light-radiating devices and corresponding ones of the light-receiving devices. The calculator decides whether the oxidized hemoglobin concentration change and the deoxidized hemoglobin concentration change are statistically significant at each of the measurement points, and the display displays the decisions regarding the individual measurement points.
摘要翻译：一种生物体光测量装置，包括：多个用于将光照射到被检体的头部的光辐射装置;多个光检测装置，用于检测从所述光辐射装置辐射后透过所述被检体的头部的光;计算器用于使用多个光辐射装置和对应的光接收装置中的每一个来计算测量点处的受试者头部中的氧化和脱氧血红蛋白的浓度的变化。计算器确定每个测量点氧化血红蛋白浓度变化和脱氧血红蛋白浓度变化是否具有统计学意义，显示显示各个测量点的决定。

9. 发明授权

US07359825B2 Optical measurement instrument and optical measurement method 有权
标题翻译：光学测量仪器和光学测量方法
公开(公告)号：US07359825B2
公开(公告)日：2008-04-15
申请号：US11378448
申请日：2006-03-20
申请人： Atsushi Maki , Yuuichi Yamashita , Tsuyoshi Yamamoto , Hideaki Koizumi
发明人： Atsushi Maki , Yuuichi Yamashita , Tsuyoshi Yamamoto , Hideaki Koizumi
IPC分类号： G01C17/00
CPC分类号： G01N21/49 , A61B5/0042 , A61B5/14553 , A61B5/7435
摘要： In order to provide an optical measurement system and an optical measurement method which is suitable for optically measuring a body to be inspected and easily obtaining an image of a desired item based on information obtained by the measurement, an optical measurement method including an initial display process for selectively instructing any one of selection of optical measurement, analysis of said optical measurement result and completion of a program; a process for inputting items of condition including a measurement mode; a process for displaying a light irradiation position and a light detection position and a state expressing measurement position relationship together with said mode; a process for instructing to form a file for storing said optical measurement result; a process for instructing a measurement condition to detect light signals from the inside of a body to be inspected which is irradiated by a multi-wavelength multi-channel; and a process for displaying said signals for each channel detected according to said instructed result.
摘要翻译：为了提供一种光学测量系统和光学测量方法，该光学测量系统和光学测量方法适合于光学测量待检查的物体，并且基于通过测量获得的信息容易地获得期望项目的图像，包括初始显示处理用于选择性地指示光学测量的选择，所述光学测量结果的分析和程序的完成中的任何一个; 用于输入包括测量模式的条件项目的处理; 用于显示光照射位置和光检测位置以及表示测量位置关系的状态与所述模式的过程; 用于指示形成用于存储所述光学测量结果的文件的处理; 用于指示测量条件从多波长多通道照射的被检体的内部检测光信号的处理; 以及用于显示根据所述指示结果检测的每个通道的所述信号的处理。

10. 发明申请

US20070135694A1 Biological photometric equipment 有权
标题翻译：生物测光设备
公开(公告)号：US20070135694A1
公开(公告)日：2007-06-14
申请号：US10577944
申请日：2004-07-01
申请人： Hiroki Sato , Massashi Kiguchi , Atsushi Maki , Tsuyoshi Yamamoto
发明人： Hiroki Sato , Massashi Kiguchi , Atsushi Maki , Tsuyoshi Yamamoto
IPC分类号： A61B5/00
CPC分类号： A61B5/14553
摘要： To control information obtained from inside of a living body with higher precision as compared to that in the conventional technology by controlling a ratio of intensities of light, directed to a trial body, in a plurality of wavelength ranges different in peak wavelength from each other, a measurement error included in information obtained from the living body can be controlled by changing a ratio of intensity of the light in the first wavelength range against that of the light in the second wavelength range. When intensity of irradiated light is limited from the viewpoint of safety to the trial subject, by keeping a ratio of the light irradiated to the trial body in the first wavelength range against that of the light in the second wavelength range under a prespecified value and also by changing the ratio of irradiated light intensities under the prespecified value, a measurement error included in information obtained from the living body can be controlled.
摘要翻译：通过在峰值波长不同的多个波长范围内控制指向试验体的光的强度比，通过控制比现有技术更高的精度从内部获得的生物体的信息，可以通过改变第一波长范围内的光的强度与第二波长范围内的光的强度的比例来控制从生物体获得的信息中包括的测量误差。当照射光的强度从安全性的角度受限于试验对象时，通过将照射到试验体的光在第一波长范围内的光与第二波长范围内的光的比例保持在规定值，并且还通过改变预定值下的照射光强度的比率，可以控制从活体获得的信息中包括的测量误差。

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