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1. 发明授权

US07974671B2 Living body information signal processing system combining living body optical measurement apparatus and brain wave measurement apparatus and probe device used for the same 有权
标题翻译：生物体信息处理系统结合生物体光学测量装置和脑波测量装置以及用于其的探针装置
公开(公告)号：US07974671B2
公开(公告)日：2011-07-05
申请号：US10572357
申请日：2004-09-03
申请人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
发明人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B5/0261 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0488 , A61B5/11 , A61B5/6822 , A61B5/742 , A61B2562/0209 , A61B2562/0233 , A61B2562/046
摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.
摘要翻译：一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光，通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

2. 发明授权

US5678556A Imaging method for spatial distributions of absorber concentrations 失效
标题翻译：吸收剂浓度空间分布成像方法
公开(公告)号：US5678556A
公开(公告)日：1997-10-21
申请号：US502844
申请日：1995-07-14
申请人： Atsushi Maki , Adi Bonen , Yoshitoshi Ito , Yuichi Yamashita , Yukiko Hirabayashi , Hideaki Koizumi , Fumio Kawaguchi , Hideji Fujii
发明人： Atsushi Maki , Adi Bonen , Yoshitoshi Ito , Yuichi Yamashita , Yukiko Hirabayashi , Hideaki Koizumi , Fumio Kawaguchi , Hideji Fujii
IPC分类号： G01N21/27 , A61B5/145 , A61B10/00 , G01N21/17 , G01N21/47 , A61B6/00
CPC分类号： G01N21/4795 , G01N2021/4797
摘要： An imaging method for spatial distributions of concentrations of absorbers distributed in an object including a radiation step of applying pulsating or continuous light radiated from predetermined incident positions with predetermined wavelengths to the object in the form of a scattering medium containing the absorbers, and a detection step of detecting intensities of light passing through the object at predetermined detection positions. The imaging method also includes a step of finding a plurality photon paths for a plurality of pairs of the incident and detected positions of a model with similar dimensions to the object but without absorbers starting at the incident positions and ending at the detected positions, a step of finding averaged photon-path lengths of the photon paths starting at the incident positions and ending at the detection positions in the model by simulation, a step of finding spatial distributions of absorber concentrations from the averaged photon-path lengths, radiated intensities of the radiated light applied to the object, detected intensities of light detected at the detection positions and optical constants of the absorbers for the radiated light applied to the object, and a step of displaying the spatial distributions of the absorber concentrations.
摘要翻译：一种用于分散在物体中的吸收体的浓度的空间分布的成像方法，包括：将包含预定波长的预定入射位置的脉冲或连续光以包含吸收体的散射介质的形式施加到物体的辐射步骤;以及检测步骤检测在预定检测位置通过物体的光的强度。该成像方法还包括以下步骤：为具有与物体相似尺寸的模型的多个成对的入射和检测位置找到多个光子路径，但没有从入射位置开始并在检测位置结束的吸收体的步骤;步骤通过模拟发现在入射位置开始并结束于模型中的检测位置的光子路径的平均光子路径长度，从平均光子路径长度，辐射强度的辐射强度中找到吸收剂浓度的空间分布的步骤施加到物体的光，检测到的检测到的光的检测强度和被施加到物体的辐射光的吸收体的光学常数，以及显示吸收体浓度的空间分布的步骤。

3. 发明授权

US06904302B2 Optical system for measuring metabolism in a body 失效
标题翻译：用于测量身体新陈代谢的光学系统
公开(公告)号：US06904302B2
公开(公告)日：2005-06-07
申请号：US10639439
申请日：2003-08-13
申请人： Yukiko Hirabayashi , Tsuyoshi Yamamoto
发明人： Yukiko Hirabayashi , Tsuyoshi Yamamoto
IPC分类号： G01N21/17 , A61B5/00 , A61B5/026 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/0261 , A61B2562/0233 , A61B2562/046
摘要： Irradiated points and light receiving points are arranged such that sampling points are arranged over an entire spherical head with no vacant space. The sampling points are arranged to cover the entire spherical head by combining a plurality of rhombic shells and inverting the respective positions of irradiated points and light receiving points in the adjacent shells. As a result, a whole brain probe capable of covering the entire head is provided to allow an image of the whole brain to be viewed as a single image.
摘要翻译：照射点和受光点被布置成使得采样点布置在没有空位的整个球形头部上。采样点被布置成通过组合多个菱形壳并使相邻壳体中的照射点和光接收点的相应位置反转来覆盖整个球形头部。结果，提供能够覆盖整个头部的整个脑探针，以使整个大脑的图像被视为单个图像。

4. 发明授权

US06180941B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06180941B2
公开(公告)日：2001-01-30
申请号：US09447578
申请日：1999-11-23
申请人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
发明人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
IPC分类号： H01J4942
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and an ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译：一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分析分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置，意味着通过设置在电极中的孔进入真空区域，以及离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置的电极之间其中所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，并且注入离子阱质谱分析装置的离子降低。即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。

5. 发明授权

US5969351A Mass spectrometer 失效
标题翻译：质谱仪
公开(公告)号：US5969351A
公开(公告)日：1999-10-19
申请号：US796548
申请日：1997-02-06
申请人： Takayuki Nabeshima , Minoru Sakairi , Yasuaki Takada , Yukiko Hirabayashi , Hideaki Koizumi
发明人： Takayuki Nabeshima , Minoru Sakairi , Yasuaki Takada , Yukiko Hirabayashi , Hideaki Koizumi
IPC分类号： H01J49/04 , H01J49/28
CPC分类号： H01J49/168 , H01J49/0404 , H01J49/049 , G01N30/726
摘要： A semi-micro liquid chromatograph/mass spectrometer apparatus has an ion source. The space from the end portion of a flow passage of a liquid chromatograph shell to a vaporization portion is closed so as to prevent the inflow of a gas from outside the ion source into the space. Further, the nebulization and vaporization portions are joined together and heated by a common heater. Dilution of a sample to be analyzed is prevented, and high sensitivity detection becomes possible in a low velocity liquid chromatograph/mass spectrometer.
摘要翻译：半微量液相色谱仪/质谱仪装置具有离子源。从液相色谱仪壳体的流路端部到气化部分的空间被封闭，以防止从离子源外部的气体流入空间。此外，将雾化和蒸发部分接合在一起并通过公共加热器加热。防止要分析的样品的稀释，并且可以在低速液相色谱仪/质谱仪中进行高灵敏度检测。

6. 发明授权

US5898175A Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution 失效
标题翻译：用于分析溶液中所含化合物的质谱仪和质谱法
公开(公告)号：US5898175A
公开(公告)日：1999-04-27
申请号：US708415
申请日：1996-09-05
申请人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： G01N27/62 , G01N27/447 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： G01N30/7266 , H01J49/0468 , H01J49/167
摘要： A mass spectrometer employing an ion source includes a capillary for spraying therethrough liquid into the atmospheres and an orifice through which a portion in the vicinity of a tip of the capillary is inserted, the orifice being designed in such a way that gases are caused to flow up to the tip of the capillary along a peripheral wall face of the capillary. The flow rate of gas in the vicinity of the tip of the capillary is about the sonic velocity, and a voltage is applied across the liquid flowing through the capillary and the orifice or an electrode arranged in the vicinity of the tip of the capillary.
摘要翻译：使用离子源的质谱仪包括用于将液体喷射到气氛中的毛细管和插入毛细管的尖端附近的部分的孔，孔被设计成使气体流动直到毛细管的尖端沿着毛细管的周壁面。毛细管尖端附近的气体的流速大约是声速，并且在流过毛细管的液体和布置在毛细管尖端附近的孔或电极之间施加电压。

7. 发明申请

US20060122477A1 Probe for optical measurement instrument for living body and optical measurement instrument for living body using the same 失效
标题翻译：探头用于生物体光学测量仪器和使用其的活体光学测量仪器
公开(公告)号：US20060122477A1
公开(公告)日：2006-06-08
申请号：US11070816
申请日：2005-03-03
申请人： Yukiko Hirabayashi , Kenko Uchida
发明人： Yukiko Hirabayashi , Kenko Uchida
IPC分类号： A61B5/00
CPC分类号： A61B5/6814 , A61B5/0042 , A61B5/0261 , A61B5/14553 , A61B2562/0233 , A61B2562/046
摘要： Disclosed is a probe for biomeasurement by use of light capable of adjusting positions of incident points and detection points without changing the distance between the incident point and the detection point in accordance with the size of a subject's head, and an optical bioinstrumentation for living body using the probe. The distances between the incident points and the detection points are approximately the same. A gap is formed by removing part of connecting members, rotatable about the incident point and the detection point, around the subject head top portion. The size of the probe is changed by changing the distance between the incident points or the detection points around the gap.
摘要翻译：公开了一种用于通过使用能够调整入射点和检测点的位置的光而不改变入射点与检测点之间的距离的光的探针，该探针根据受检者的头部的尺寸和使用的生物体的光学生物仪器探针。入射点和检测点之间的距离大致相同。通过将围绕入射点和检测点旋转的连接构件的一部分围绕被检体顶部部分去除而形成间隙。通过改变入射点或间隙周围的检测点之间的距离来改变探头的尺寸。

8. 发明授权

US06190316B1 Method of mass-analyzing body fluid and apparatus therefor 有权
标题翻译：体液质量分析方法及其设备
公开(公告)号：US06190316B1
公开(公告)日：2001-02-20
申请号：US09273554
申请日：1999-03-22
申请人： Yukiko Hirabayashi , Atsumu Hirabayashi , Hideaki Koizumi
发明人： Yukiko Hirabayashi , Atsumu Hirabayashi , Hideaki Koizumi
IPC分类号： A61B500
CPC分类号： H01J49/0431 , A61B5/145 , A61B5/14528 , A61B5/14557 , A61B5/1459 , A61B5/4064 , A61B2010/0077
摘要： A living body fluid analyzing system includes a microdialysis for sending a first solution having an osmotic pressure which is substantially similar to a osmotic pressure of a body fluid into a living body and extracting a second solution from the living body. A first flow passage is provided in which the second solution from the microdialysis flows and a second flow passage is provided which mixes the second solution with an organic solution. Furthermore, there is provided a gas source and a gas flow controller which controls a flow quantity of the gas from the gas source and a third flow passage in which a gas introduced from the gas source flows. An ion source is provided having an orifice for spraying and ionizing the second solution from the second flow passage at an end of the third flow passage, and a mass spectrometer is provided for mass-analyzing the ions sprayed from the orifice.
摘要翻译：活体液分析系统包括微透析，用于将具有基本上类似于体液渗透压的渗透压的第一溶液送入生物体并从生物体提取第二溶液。提供第一流动通道，其中来自微量透析的第二溶液流动，并且提供将第二溶液与有机溶液混合的第二流动通道。此外，提供了气体源和气体流量控制器，其控制来自气体源的气体的流量和从气体源引入的气体流过的第三流路。提供离子源，其具有用于在第三流动通道的端部处从第二流动通道喷射和离子化第二溶液的孔，并且提供质量分析器以对从孔喷射的离子进行质量分析。

9. 发明授权

US5825027A Mass spectrometer 失效
公开(公告)号：US5825027A
公开(公告)日：1998-10-20
申请号：US831486
申请日：1997-03-31
申请人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
发明人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
IPC分类号： G01N27/62 , H01J49/04 , H01J49/06 , H01J49/34 , H01J49/42
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region and a ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.

10. 发明授权

US06787017B1 Capillary electrophoretis system, sample analyzer and liquid sample cassette for electrophoretic separation 失效
标题翻译：毛细管电泳系统，样品分析仪和电泳分离液体样品盒
公开(公告)号：US06787017B1
公开(公告)日：2004-09-07
申请号：US09806913
申请日：2001-04-06
申请人： Atsumu Hirabayashi , Yukiko Hirabayashi , Akihiko Okumura , Hideaki Koizumi
发明人： Atsumu Hirabayashi , Yukiko Hirabayashi , Akihiko Okumura , Hideaki Koizumi
IPC分类号： G01N27447
CPC分类号： G01N27/44791 , G01N27/44704
摘要： The capillary electrophoresis system includes a wafer-shaped part having passages filled with a buffer solution for introducing sample solutions; a body having a configuration suitable to removably hold and to move the wafer-shaped part. The body includes first and second electrodes for applying a voltage across both ends of passages of the wafer-shaped part to separate and remove the sample solution. The body also includes first and second buffer reservoirs conductive to passages of the wafer-shaped part at specific positions for filling buffer solution around the first and second electrodes. The system according to the present invention facilitates washing of electrophoresis passages and reduces the time and labor costs required for replacement of the fused-silica wafers and simplifies operation by allowing a plurality of sample solutions to be analyzed more quickly.
摘要翻译：毛细管电泳系统包括具有填充有用于引入样品溶液的缓冲溶液的通道的晶片状部件; 具有适于可移除地保持和移动晶片形部分的构造的本体。本体包括第一和第二电极，用于跨晶片形部分的通道的两端施加电压以分离和去除样品溶液。身体还包括第一和第二缓冲储存器，其导电到晶片状部分在特定位置处的通道，用于在第一和第二电极周围填充缓冲溶液。根据本发明的系统有助于电泳通道的洗涤，并且减少了更换熔凝石英晶片所需的时间和人力成本，并且通过允许更快速地分析多个样品溶液来简化操作。

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