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    • 2. 发明申请
    • METHOD FOR DETERMINATION OF PROGRESSION RISK OF GLAUCOMA
    • 用于确定GLAUCOMA进程风险的方法
    • US20110207122A1
    • 2011-08-25
    • US12596462
    • 2008-04-17
    • Shigeru KinoshitaKei TashiroMasakazu NakanoTomohito YagiKazuhiko MoriYoko IkedaTakazumi TaniguchiMasaaki Kageyama
    • Shigeru KinoshitaKei TashiroMasakazu NakanoTomohito YagiKazuhiko MoriYoko IkedaTakazumi TaniguchiMasaaki Kageyama
    • C12Q1/68C07H21/04
    • C12Q1/6886C12Q1/6883C12Q2600/156
    • A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
    • 一种确定青光眼风险的存在或不存在的方法,包括以下步骤:在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型, 其中所述碱基序列是选自SEQ ID NO:203至752所示的碱基序列或其互补序列的至少一种碱基序列(步骤A),并比较检测到的等位基因和/或基因型 在SEQ ID NO:203〜752(步骤B)所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法,可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平,使得样品供体可以 采取预防措施的青光眼,或者可以根据这种风险接受适当的治疗。
    • 3. 发明申请
    • METHOD FOR DETERMINATION OF PROGRESSION RISK OF GLAUCOMA
    • 用于确定GLAUCOMA进程风险的方法
    • US20130210668A1
    • 2013-08-15
    • US13850453
    • 2013-03-26
    • Shigeru KINOSHITAKei TashiroMasakazu NakanoTomohito YagiKazuhiko MoriYoko IkedaTakazumi TaniguchiMasaaki Kageyama
    • Shigeru KINOSHITAKei TashiroMasakazu NakanoTomohito YagiKazuhiko MoriYoko IkedaTakazumi TaniguchiMasaaki Kageyama
    • C12Q1/68
    • C12Q1/6886C12Q1/6883C12Q2600/156
    • A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
    • 一种确定青光眼风险的存在或不存在的方法,包括以下步骤:在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型, 其中所述碱基序列是选自SEQ ID NO:203至752所示的碱基序列或其互补序列的至少一种碱基序列(步骤A),并比较检测到的等位基因和/或基因型 在SEQ ID NO:203〜752(步骤B)所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法,可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平,使得样品供体可以 采取预防措施的青光眼,或者可以根据这种风险接受适当的治疗。
    • 4. 发明授权
    • Method for determination of progression risk of glaucoma
    • 确定青光眼进展风险的方法
    • US08431345B2
    • 2013-04-30
    • US12596462
    • 2008-04-17
    • Shigeru KinoshitaKei TashiroMasakazu NakanoTomohito YagiKazuhiko MoriYoko IkedaTakazumi TaniguchiMasaaki Kageyama
    • Shigeru KinoshitaKei TashiroMasakazu NakanoTomohito YagiKazuhiko MoriYoko IkedaTakazumi TaniguchiMasaaki Kageyama
    • C12Q1/68C07H21/02C07H21/04
    • C12Q1/6886C12Q1/6883C12Q2600/156
    • A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
    • 一种确定青光眼风险的存在或不存在的方法,包括以下步骤:在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型, 其中所述碱基序列是选自SEQ ID NO:203至752所示的碱基序列或其互补序列的至少一种碱基序列(步骤A),并比较检测到的等位基因和/或基因型 在SEQ ID NO:203〜752(步骤B)所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法,可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平,使得样品供体可以 采取预防措施的青光眼,或者可以根据这种风险接受适当的治疗。
    • 6. 发明申请
    • METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA
    • 确定葡萄球菌风险的方法
    • US20100196895A1
    • 2010-08-05
    • US12596258
    • 2008-04-17
    • Shigeru KinoshitaKei TashiroMasakazu NakanoTomohito YagiKazuhiko MoriYoko IkedaTakazumi TaniguchiMasaaki Kageyama
    • Shigeru KinoshitaKei TashiroMasakazu NakanoTomohito YagiKazuhiko MoriYoko IkedaTakazumi TaniguchiMasaaki Kageyama
    • C12Q1/68C07H21/04
    • C12Q1/6886C12Q1/6883C12Q2600/156
    • A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 514 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 514 (step B). According to the method of the present invention, the level of an onset risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention on the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
    • 一种确定青光眼风险的存在或不存在的方法,包括以下步骤:在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型, 其中所述碱基序列是选自SEQ ID NO:203至514所示的碱基序列或其互补序列的至少一种碱基序列(步骤A),并比较检测到的等位基因和/或基因型 具有SEQ ID NO:203〜514(步骤B)所示的碱基序列中的含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法,可以通过对样品中的本发明中的单核苷酸多态性的等位基因或基因型进行分析来确定样品供体中的青光眼的发病风险水平,从而样品供体可以 采取预防措施的青光眼,或者可以根据这种风险接受适当的治疗。