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1. 发明授权

US08431345B2 Method for determination of progression risk of glaucoma 有权
标题翻译：确定青光眼进展风险的方法
公开(公告)号：US08431345B2
公开(公告)日：2013-04-30
申请号：US12596462
申请日：2008-04-17
申请人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译：一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型，其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

2. 发明申请

US20110207122A1 METHOD FOR DETERMINATION OF PROGRESSION RISK OF GLAUCOMA 有权
标题翻译：用于确定GLAUCOMA进程风险的方法
公开(公告)号：US20110207122A1
公开(公告)日：2011-08-25
申请号：US12596462
申请日：2008-04-17
申请人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译：一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型，其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

3. 发明申请

US20130012408A1 METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA 审中-公开
标题翻译：确定葡萄球菌风险的方法
公开(公告)号：US20130012408A1
公开(公告)日：2013-01-10
申请号：US13546674
申请日：2012-07-11
申请人： Shigeru KINOSHITA , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru KINOSHITA , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk by detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism, comparing the allele and/or the genotype detected with at least one of an allele and/or a genotype with a high-risk allele, wherein the presence of a glaucoma risk is determined in a case where the allele detected is the high-risk allele, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele or a heterozygote when the high-risk allele complies with a dominant genetic model, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele when the high-risk allele complies with a recessive genetic model.
摘要翻译：通过体外检测单核苷酸多态性的等位基因和/或基因型来确定青光眼存在或不存在青光眼风险的方法，比较检测到的等位基因和/或基因型与等位基因和/或具有高风险等位基因的基因型，其中在检测到的等位基因是高风险等位基因的情况下确定青光眼风险的存在，或者在检测到的基因型是纯合子的情况下确定青光眼风险的存在在高风险等位基因符合显性遗传模型的情况下，包括高风险等位基因或杂合子的基因型的基因型，或者在检测到的基因型是包含高表达的基因型的纯合子的情况下，确定青光眼风险的存在当高风险等位基因符合隐性遗传模型时，这种等位基因是错误的。

4. 发明申请

US20100196895A1 METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA 审中-公开
标题翻译：确定葡萄球菌风险的方法
公开(公告)号：US20100196895A1
公开(公告)日：2010-08-05
申请号：US12596258
申请日：2008-04-17
申请人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 514 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 514 (step B). According to the method of the present invention, the level of an onset risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention on the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译：一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型，其中所述碱基序列是选自SEQ ID NO：203至514所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型具有SEQ ID NO：203〜514（步骤B）所示的碱基序列中的含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。根据本发明的方法，可以通过对样品中的本发明中的单核苷酸多态性的等位基因或基因型进行分析来确定样品供体中的青光眼的发病风险水平，从而样品供体可以采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

5. 发明申请

US20130210668A1 METHOD FOR DETERMINATION OF PROGRESSION RISK OF GLAUCOMA 审中-公开
标题翻译：用于确定GLAUCOMA进程风险的方法
公开(公告)号：US20130210668A1
公开(公告)日：2013-08-15
申请号：US13850453
申请日：2013-03-26
申请人： Shigeru KINOSHITA , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
发明人： Shigeru KINOSHITA , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/156
摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要翻译：一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型，其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

6. 发明申请

US20130275349A1 Comprehensive Glaucoma Determination Method Utilizing Glaucoma Diagnosis Chip And Deformed Proteomics Cluster Analysis 审中-公开
标题翻译：综合青光眼测定方法利用青光眼诊断芯片和变形蛋白质组学分析
公开(公告)号：US20130275349A1
公开(公告)日：2013-10-17
申请号：US13976967
申请日：2011-12-28
申请人： Kei Tashiro , Shigeru Kinoshita , Tomohito Yagi , Masakazu Nakano , Kazuhiko Mori , Yoko Ikeda , Morio Ueno , Yuichi Tokuda , Katsumi Yagi , Kengo Yoshii , Masahiro Fuwa
发明人： Kei Tashiro , Shigeru Kinoshita , Tomohito Yagi , Masakazu Nakano , Kazuhiko Mori , Yoko Ikeda , Morio Ueno , Yuichi Tokuda , Katsumi Yagi , Kengo Yoshii , Masahiro Fuwa
IPC分类号： G06N99/00
CPC分类号： G06N20/00 , C12Q1/6886 , G16B20/00 , G16B25/00 , G16B40/00
摘要： Provided is a technique for determining a physiological attribute in a mammal, including the onset or progression of human glaucoma, with high accuracy. The results of the determination of genotype date and the results of the determination of cytokine date are consolidated by a consolidated determination unit (114); comparison is made for determining as to which is larger, the number of Case determination procedures or the number of control determination procedures (S330); and it is determined as Case (glaucoma) when the number of Case determination procedures is larger and it is determined as Control (normal person) when the number of Control determination procedures is larger.
摘要翻译：提供了一种用于以高精度确定哺乳动物的生理属性，包括人类青光眼的发病或进展的技术。确定基因型日期的结果和细胞因子日期的确定结果由综合确定单位（114）合并; 比较确定哪个更大，判定程序的数量或控制确定程序的数量（S330）; 当判定判定过程的数量较多并且当控制确定过程的数量较大时被确定为控制（普通人）时被确定为病例（青光眼）。

7. 发明申请

US20130064520A1 Fiber Optic Connector/Dust Cover Organizer 有权
标题翻译：光纤连接器/防尘罩主办单位
公开(公告)号：US20130064520A1
公开(公告)日：2013-03-14
申请号：US13231768
申请日：2011-09-13
申请人： Masakazu Nakano , Jason Miller
发明人： Masakazu Nakano , Jason Miller
IPC分类号： G02B6/36
CPC分类号： G02B6/3849 , G02B6/3898
摘要： A device 10 for organizing an array of optical fiber cables (14) terminated with fiber optic connectors (20). The device includes a base plate (22) having a plurality of mounting sites (24) configured to receive a like plurality of dust covers (20) for the respective fiber optic connectors (18). Two or more base plates (22) may be stacked through use of stacking spacers (42) to increase the number of mounting sites (24). The device 10 maintains the array of optical fiber cables during manufacture, shipping and handling, eliminating snarling of the individual optical fiber cables (14).
摘要翻译：用于组织由光纤连接器（20）端接的光纤电缆阵列（14）的装置10。该装置包括具有多个安装位置（24）的基板（22），所述多个安装位置（24）被配置为接收相应的光纤连接器（18）的类似的多个防尘罩（20）。可以通过使用堆叠间隔物（42）堆叠两个或更多个基板（22），以增加安装位置（24）的数量。设备10在制造，运输和处理期间维持光纤电缆阵列，消除单个光纤电缆（14）的咆哮。

8. 发明授权

US08877779B2 Benzimidazole compound and pharmaceutical use thereof 有权
标题翻译：苯并咪唑化合物及其药物用途
公开(公告)号：US08877779B2
公开(公告)日：2014-11-04
申请号：US12449874
申请日：2008-02-28
申请人： Masakazu Nakano , Masanori Minoguchi , Tokushi Hanano , Shin-ichiro Ono , Hideki Horiuchi , Koji Teshima
发明人： Masakazu Nakano , Masanori Minoguchi , Tokushi Hanano , Shin-ichiro Ono , Hideki Horiuchi , Koji Teshima
IPC分类号： A61K31/445 , C07D401/04 , C07D417/14 , C07D405/14 , C07D471/04
CPC分类号： C07D401/04 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Provided is an ORL-1 receptor agonist having improved bioavailability based on superior metabolic stability and strong and high selectivity, as compared to conventional compounds. A compound represented by the formula (I) wherein each symbol is as defined in the claims.
摘要翻译：本发明提供的ORL-1受体激动剂与常规化合物相比，具有基于优异的代谢稳定性和强和高选择性的改善的生物利用度。由式（I）表示的化合物，其中每个符号如权利要求中所定义。

9. 发明授权

US07228049B2 Optical fixed attenuator and process and apparatus for producing the same 有权
标题翻译：光固定衰减器及其制造方法及装置
公开(公告)号：US07228049B2
公开(公告)日：2007-06-05
申请号：US10608211
申请日：2003-06-30
申请人： Masakazu Nakano , Makiko Miura
发明人： Masakazu Nakano , Makiko Miura
IPC分类号： G02B6/00
CPC分类号： G02B6/266 , G02B6/2551
摘要： A technique for manufacturing optical fixed attenuators in which two fibers are axially cojoined using fusion splicing. The spliced fibers are then captured in either a splice protection splint or cylindrical ferrule that can be housed in an optical adapter. In this process for producing the attenuator, the fusion splicing is preceded by a deformation of the mode field diameters of the ends of the fibers with the cleaning arc function of the splicing unit. The resulting attenuation of the splice is dependent on the amount of deformation of the fiber core and mode field diameter. Such a technique enables precision attenuation with very low wavelength dependent loss to be fabricated. The performance of Dense Wavelength Division Multiplexing systems, as well as test facilities and individual optical components can be improved by the use of such attenuators.
摘要翻译：一种用于制造光学固定衰减器的技术，其中使用熔接将两根纤维轴向共同连接。接合的纤维然后被捕获在可以容纳在光学适配器中的接头保护夹板或圆柱形套圈中。在该衰减器的制造方法中，熔融接合之前是用拼接单元的清洁电弧功能使纤维端部的模场直径发生变形。所得到的接头衰减取决于纤芯的变形量和模场直径。这种技术能够制造具有非常低的波长相关损耗的精度衰减。通过使用这种衰减器可以改善密集波分复用系统的性能，以及测试设备和各个光学部件。

10. 发明授权

US4470669A Liquid crystal display device 失效
标题翻译：液晶显示装置
公开(公告)号：US4470669A
公开(公告)日：1984-09-11
申请号：US333504
申请日：1981-12-22
申请人： Keiichi Kubota , Masakazu Nakano
发明人： Keiichi Kubota , Masakazu Nakano
IPC分类号： G02F1/135 , G02F1/133 , G09F9/30 , G02F1/13
CPC分类号： G02F1/132
摘要： A thermally addressable liquid crystal display device is disclosed herein. The device comprises twin transparent plates with a liquid crystal element disposed between them. A transparent electrode film is provided onto the inside surface of the first transparent plate (the inside surface being that surface which is in contact with the liquid crystal element). Both a light-reflecting film and a light-absorbing single layer are provided onto the inside surface of the second transparent plate. This light-absorbing layer is formed of an inorganic semiconductor compound selected from the group of II-V group semiconductor compounds containing magnesium or calcium, II-V group semiconductor compounds containing zinc or cadmium, or II-VI group and V-VI group semiconductor compounds containing tellurium. Preferably, the light-absorbing layer has a thickness which satisfies the relationshipt=.lambda./4n.+-..lambda./20nsuch that the resulting image display is high in image resolution. Further, by providing to the display device a light absorption layer with a thickness as determined by the above-mentioned relationship, the overall reliability of the display device is improved.
摘要翻译：本文公开了一种热寻址液晶显示装置。该装置包括在其间设置有液晶元件的双透明板。在第一透明板（与液晶元件接触的表面的内表面）的内表面上设置透明电极膜。光反射膜和光吸收单层都设置在第二透明板的内表面上。该光吸收层由选自含有镁或钙的II-V族半导体化合物，含有锌或镉的II-V族半导体化合物或II-VI族和V-VI族半导体的无机半导体化合物形成含碲化合物优选地，光吸收层具有满足关系t =λ/ 4n +/-λ/ 20n的厚度，使得所得到的图像显示图像分辨率高。此外，通过向显示装置提供由上述关系确定的厚度的光吸收层，改善了显示装置的整体可靠性。

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