基本信息:
- 专利标题： METHOD FOR DETERMINATION OF PROGRESSION RISK OF GLAUCOMA
- 专利标题（中）：用于确定GLAUCOMA进程风险的方法
- 申请号：US12596462 申请日：2008-04-17
- 公开(公告)号：US20110207122A1 公开(公告)日：2011-08-25
- 发明人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
- 申请人： Shigeru Kinoshita , Kei Tashiro , Masakazu Nakano , Tomohito Yagi , Kazuhiko Mori , Yoko Ikeda , Takazumi Taniguchi , Masaaki Kageyama
- 申请人地址： JP Osaka-shi, Osaka JP Kyoto-shi, Kyoto JP Osaka-shi, Osaka
- 专利权人： Shigeru KINOSHITA,Kei TASHIRO,SANTEN PHARMACEUTICAL CO., LTD.
- 当前专利权人： Shigeru KINOSHITA,Kei TASHIRO,SANTEN PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： JP Osaka-shi, Osaka JP Kyoto-shi, Kyoto JP Osaka-shi, Osaka
- 优先权： JP2007-108688 20070417
- 国际申请： PCT/JP2008/057533 WO 20080417
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H21/04
摘要：
A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.
摘要（中）：
一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。
公开/授权文献:
- US08431345B2 Method for determination of progression risk of glaucoma 公开/授权日：2013-04-30