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1. 发明授权

US07364847B2 Nucleic acid participating in the formation of presenilin-2-gene exon 5-defective splicing variant 失效
标题翻译：核酸参与早老素-2基因外显子5缺陷剪接变体的形成
公开(公告)号：US07364847B2
公开(公告)日：2008-04-29
申请号：US10482115
申请日：2002-06-27
申请人： Masaya Tohyama , Taiichi Katayama , Takayuki Manabe , Kazunori Imaizumi , Yoko Ikeda
发明人： Masaya Tohyama , Taiichi Katayama , Takayuki Manabe , Kazunori Imaizumi , Yoko Ikeda
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/00
CPC分类号： C07K14/4711 , C12Q1/6883 , C12Q2600/156 , G01N33/6896 , G01N2500/00
摘要： The present invention provides a means for treatment and/or prevention of a disease caused by aberrant splicing, a neurodegenerative disease represented by Alzheimer's disease, or the like. The present invention relates to a nucleic acid which can be associated with generation of a splice variant that lacks exon 5 of presenilin-2 gene, an inhibitor for inhibiting a binding between protein-nucleic acid caused by aberrant splicing, and a method for screening the inhibitor.
摘要翻译：本发明提供了治疗和/或预防由异常剪接引起的疾病，由阿尔茨海默病代表的神经变性疾病等的方法。本发明涉及可以与缺少早老素-2基因的外显子5的剪接变体的产生相关联的核酸，抑制由异常剪接引起的蛋白质 - 核酸之间的结合的抑制剂，以及用于筛选抑制剂。

2. 发明申请

US20050065102A1 Medicinal compositions 审中-公开
标题翻译：药用成分
公开(公告)号：US20050065102A1
公开(公告)日：2005-03-24
申请号：US10482103
申请日：2002-06-27
申请人： Masaya Tohyama , Taiichi Katayama , Takayuki Manabe , Kazunori Imaizumi , Yoko Ikeda
发明人： Masaya Tohyama , Taiichi Katayama , Takayuki Manabe , Kazunori Imaizumi , Yoko Ikeda
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/10 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07K14/47 , C07H21/02
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/4711
摘要： To provide a means useful for treating or preventing a disease such as a brain disorder or a neurodegenerative disease even more efficiently and even more sustainedly. The present invention relates to an inhibitor capable of inhibiting a binding between HMG-I protein and exon 5 of presenilin-2 mRNA, an agent for suppressing neuronal death, capable of suppressing neuronal death, a pharmaceutical composition which is useful for treatment or prevention of a disease caused by the generation of a splice variant that lacks exon 5 of presenilin-2 mRNA, a method for treating or preventing the disease and a use of the inhibitor.
摘要翻译：提供用于更有效地甚至更持久地治疗或预防诸如脑部疾病或神经变性疾病的疾病的方法。本发明涉及能够抑制HMG-1蛋白与早老蛋白-2 mRNA的外显子5之间的结合的抑制剂，抑制神经元死亡的能力，能够抑制神经元死亡的药剂组合物，其可用于治疗或预防由缺乏早老素-2 mRNA的外显子5的剪接变体的产生引起的疾病，治疗或预防疾病的方法和抑制剂的使用。

3. 发明申请

US20080107600A1 Gene Marker And Composition For Diagnosis And Treatment Of Neurological Disorders And Diseases And Use Of The Same 审中-公开
标题翻译：基因标记和组成用于诊断和治疗神经系统疾病和疾病及其使用
公开(公告)号：US20080107600A1
公开(公告)日：2008-05-08
申请号：US10545564
申请日：2004-02-12
申请人： Taiichi Katayama , Takeshi Miyoshi , Masaya Tohyama , Kousuke Baba , Akiko Honda
发明人： Taiichi Katayama , Takeshi Miyoshi , Masaya Tohyama , Kousuke Baba , Akiko Honda
IPC分类号： A61K45/00 , C07K2/00 , C07H21/00 , C07K14/00 , A61P25/18 , A61P25/00 , G01N33/566 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/6896 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2500/20 , G01N2800/28
摘要： The present invention provides a marker, kit and method for determining the level of axon outgrowth and/or fasciculation, or conditions, disorders or diseases associated with the level of axon outgrowth and/or fasciculation. The present invention was achieved by unexpectedly finding the relationship between DISC1 and FEZ1 and KIAA0844 and unexpectedly finding that axon outgrowth and/or fasciculation are not normally conducted if the normal binding therebetween was inhibited. Therefore, the present invention relates to an agent specifically interacting with DISC1 and a gene product thereof, an agent specifically binding FEZ1 and a gene product thereof, an agent specifically binding FEZ1 and a gene product thereof, and an agent specifically binding KIAA0844 and a gene product thereof.
摘要翻译：本发明提供了一种用于确定与轴突生长和/或束缚水平相关的轴突生长和/或引导或条件，紊乱或疾病的水平的标记物，试剂盒和方法。本发明通过意外地发现DISC1与FEZ1和KIAA0844的关系而意外地发现，如果其间的正常结合被抑制，则通常不会进行轴突向外生长和/或成像。因此，本发明涉及与DISC1及其基因产物特异性结合的试剂，特异性结合FEZ1及其基因产物，特异性结合FEZ1及其基因产物的试剂，以及特异性结合KIAA0844和基因的试剂其产品。

4. 发明申请

US20060024699A1 Method for evaluating a substance capable of effecting on endoplasmic reticulum stress-and/or amyloid beta-induced apoptosis 审中-公开
标题翻译：用于评估能够影响内质网应激和/或淀粉样蛋白β诱导凋亡的物质的方法
公开(公告)号：US20060024699A1
公开(公告)日：2006-02-02
申请号：US11124103
申请日：2005-05-09
申请人： Junichi Hitomi , Taiichi Katayama , Yutaka Eguchi , Yoshihide Tsujimoto , Masaya Tohyama
发明人： Junichi Hitomi , Taiichi Katayama , Yutaka Eguchi , Yoshihide Tsujimoto , Masaya Tohyama
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/5041 , G01N2333/96466 , G01N2510/00
摘要： The present invention relates to a method for evaluating a substance capable of affecting endoplasmic reticulum stress-induced apoptosis and/or amyloid-β-induced apoptosis, a kit for evaluating the substance and a pharmaceutical composition.
摘要翻译：本发明涉及一种评估能够影响内质网应激诱导的凋亡和/或淀粉样蛋白-β诱导的细胞凋亡的物质的方法，用于评价该物质和药物组合物的试剂盒。

5. 发明授权

US5112606A Method of producing antibodies using colloidal metal as carrier 失效
标题翻译：使用胶体金属作为载体生产抗体的方法
公开(公告)号：US5112606A
公开(公告)日：1992-05-12
申请号：US414608
申请日：1989-09-29
申请人： Sadao Shiosaka , Johji Kohno , Hiroshi Kiyama , Masaya Tohyama , Yahe Shiotani
发明人： Sadao Shiosaka , Johji Kohno , Hiroshi Kiyama , Masaya Tohyama , Yahe Shiotani
IPC分类号： A61K39/385 , A61K39/395 , C07K1/00 , C07K14/00 , C07K14/575 , C07K16/00 , C12N5/00 , C12N5/06 , C12P21/00 , C12P21/08 , G01N33/531 , G01N33/553 , G01N33/68
CPC分类号： G01N33/6812 , G01N33/531 , G01N33/553 , Y10S435/96
摘要： The present invention relates to methods of producing an antibody highly specific to a low-molecular weight substance such as amino acids, peptides, amines, steroids, etc. The invention also relates to a process for producing the same by forming a complex of the substance with colloidal metal particles and sensitizing a mammal with the complex. The antibody can be in the form of an antiserum containing the antibody. Since the antibody has a high specificity to the intended low-molecular weight substance, it is useful as a reagent for various immunohistochemical methods and immunoassays.
摘要翻译：本发明涉及制备对低分子量物质如氨基酸，肽，胺，类固醇等具有高度特异性的抗体的方法。本发明还涉及通过形成物质的复合物来生产该抗体的方法与胶体金属颗粒并使哺乳动物与复合物致敏。抗体可以是含抗体的抗血清形式。由于抗体对于目标的低分子量物质具有高度的特异性，因此可用作各种免疫组织化学方法和免疫测定的试剂。

6. 发明申请

US20070054848A1 Composition and method for nerve regeneration 审中-公开
标题翻译：神经再生的组成和方法
公开(公告)号：US20070054848A1
公开(公告)日：2007-03-08
申请号：US10551157
申请日：2004-03-26
申请人： Masaya Tohyama , Toshihide Yamashita , Hiroyuki Tanaka , Haruhisa Higuchi
发明人： Masaya Tohyama , Toshihide Yamashita , Hiroyuki Tanaka , Haruhisa Higuchi
IPC分类号： A61K48/00 , A61K38/17 , A61K39/395
CPC分类号： G01N33/6896 , A61K38/10 , A61K38/1709 , C07K16/2878
摘要： The present invention provides a pharmaceutical composition and method for regenerating nerves and treating neurological diseases based on nerve regeneration. The present invention employs a substance, such as Pep5, PKC, IP3, Rho, Rho GDI, Rho kinase, or the like, which are involved in a p75 signal transduction pathway, or an agent capable of specifically interacting with any of these substances to block or suppress the p75 signal transduction pathway, thereby stopping inhibition of nerve regeneration. As a result, nerve regeneration is resumed. The present invention is also the first to disclose that the PTD domain is useful as an agent for nerve regeneration.
摘要翻译：本发明提供一种神经再生神经再生治疗神经系统疾病的药物组合物和方法。本发明使用参与p75信号转导途径的物质，例如Pep5，PKC，IP3，Rho，Rho GDI，Rho激酶等物质，或能够与这些物质中的任何物质特异性相互作用的物质阻断或抑制p75信号转导途径，从而阻止神经再生的抑制。结果，恢复神经再生。本发明也首先公开了PTD结构域可用作神经再生剂。

7. 发明授权

US06579679B1 Method for examining central nervous system diseases and method for screening remedies 有权
标题翻译：检查中枢神经系统疾病的方法和筛查治疗方法
公开(公告)号：US06579679B1
公开(公告)日：2003-06-17
申请号：US09700847
申请日：2000-11-21
申请人： Tsutomu Takagi , Naoya Sato , Masaya Tohyama
发明人： Tsutomu Takagi , Naoya Sato , Masaya Tohyama
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C07K14/4711 , C12Q2600/158
摘要： The present invention relates to a method for screening and identifying therapeutic agents or preventive agents for central nervous system diseases which comprises assaying a suppressing effect of a test substance on an expression of a splicing variant transcribed from presenilin-2 gene and to a method for examining central nervous system diseases which comprises detecting an expression of a splicing variant transcribed from presenilin-2 gene in a test sample originated from an animal individual.
摘要翻译：本发明涉及筛选和鉴定中枢神经系统疾病的治疗剂或预防剂的方法，其包括测定受试物质对从早老蛋白-2基因转录的剪接变体的表达的抑制作用以及检查方法包括检测源自动物个体的测试样品中从早老蛋白-2基因转录的剪接变体的表达的中枢神经系统疾病。

8. 发明授权

US07358063B2 Method of detecting PS2V 有权
标题翻译：检测PS2V的方法
公开(公告)号：US07358063B2
公开(公告)日：2008-04-15
申请号：US10484152
申请日：2002-07-17
申请人： Masaya Tohyama , Yuichi Yasuda , Yasushi Hasui , Hideki Ishihara , Koichi Yamagata
发明人： Masaya Tohyama , Yuichi Yasuda , Yasushi Hasui , Hideki Ishihara , Koichi Yamagata
IPC分类号： G01N33/53 , G01N33/537 , G01N33/542 , G01N1/30 , G01N33/566 , G01N33/567 , G01N33/48
CPC分类号： G01N33/6896
摘要： A method of detecting PS2V characterized by comprising reacting PS2V in a sample with a primary antibody which is bonded to a solid phase and specifically recognizes PA2V, then reacting with a secondary antibody recognizing PS2 or PS2V by any of the following procedures: (a) reacting with a secondary antibody having been enzyme-labeled and recognizing PS2 or PS2V; (b) reacting with a secondary antibody having been biotinylated and recognizing PS2 or PS2V and then reacting with an avidinylated or streptoavidinylated enzyme; (c) reacting with a secondary antibody having been biotinylated and recognizing PS2 or PS2V and then reacting with a biotinylated enzyme and avidin or streptoavidin; and (d) reacting with a secondary antibody recognizing PS2 or PS2V and then reacting with an antibody having been enzyme-labeled and recognizing the secondary antibody; then adding the substrate of the above enzyme and detecting the product formed by the enzyme reaction.
摘要翻译：一种检测PS2V的方法，其特征在于包括使样品中的PS2V与与固相结合的一抗并特异性识别PA2V，然后通过以下任一方法与识别PS2或PS2V的二抗反应：（a）使二抗被酶标记并识别PS2或PS2V; （b）与已经生物素化并识别PS2或PS2V的第二抗体反应，然后与二脱水或链脲霉素化酶反应; （c）与已经生物素化并识别PS2或PS2V的二级抗体反应，然后与生物素化的酶和抗生物素蛋白或链霉亲和素反应; 和（d）与识别PS2或PS2V的二抗反应，然后与经酶标记的抗体和识别第二抗体反应; 然后加入上述酶的底物并检测通过酶反应形成的产物。

9. 发明申请

US20050003339A1 Method of detecting ps2v 有权
标题翻译：检测ps2v的方法
公开(公告)号：US20050003339A1
公开(公告)日：2005-01-06
申请号：US10484152
申请日：2002-07-17
申请人： Masaya Tohyama , Yuichi Yasuda , Yasushi Hasui , Hideki Ishihara , Koichi Yamagata
发明人： Masaya Tohyama , Yuichi Yasuda , Yasushi Hasui , Hideki Ishihara , Koichi Yamagata
IPC分类号： G01N33/68 , C12Q1/70
CPC分类号： G01N33/6896
摘要： A method of detecting PS2V characterized by comprising reacting PS2V in a sample with a primary antibody which is bonded to a solid phase and specifically recognizes PA2V, then reacting with a secondary antibody recognizing PS2 or PS2V by any of the following procedures: (a) reacting with a secondary antibody having been enzyme-labeled and recognizing PS2 or PS2V; (b) reacting with a secondary antibody having been biotinylated and recognizing PS2 or PS2V and then reacting with an avidinylated or streptoavidinylated enzyme; (c) reacting with a secondary antibody having been biotinylated and recognizing PS2 or PS2V and then reacting with a biotinylated enzyme and avidin or streptoavidin; and (d) reacting with a secondary antibody recognizing PS2 or PS2V and then reacting with an antibody having been enzyme-labeled and recognizing the secondary antibody; then adding the substrate of the above enzyme and detecting the product formed by the enzyme reaction.
摘要翻译：一种检测PS2V的方法，其特征在于包括使样品中的PS2V与与固相结合的一抗并特异性识别PA2V，然后通过以下任一方法与识别PS2或PS2V的二抗反应：（a）使二抗被酶标记并识别PS2或PS2V; （b）与已经生物素化并识别PS2或PS2V的第二抗体反应，然后与二脱水或链脲霉素化酶反应; （c）与已经生物素化并识别PS2或PS2V的二级抗体反应，然后与生物素化的酶和抗生物素蛋白或链霉亲和素反应; 和（d）与识别PS2或PS2V的二抗反应，然后与经酶标记的抗体和识别第二抗体反应; 然后加入上述酶的底物并检测通过酶反应形成的产物。

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