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1. 发明授权

US06989401B2 Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products 失效
公开(公告)号：US06989401B2
公开(公告)日：2006-01-24
申请号：US10333266
申请日：2001-07-19
申请人： Kazuhiro Maeda , Shuji Sonda , Tadahiro Takemoto , Tomokazu Goto , Fujio Kobayashi , Masahiko Kajii , Naruyasu Komorita , Fumihiro Hirayama
发明人： Kazuhiro Maeda , Shuji Sonda , Tadahiro Takemoto , Tomokazu Goto , Fujio Kobayashi , Masahiko Kajii , Naruyasu Komorita , Fumihiro Hirayama
IPC分类号： A61K31/403 , C07D207/408
CPC分类号： C07D209/48 , A61K31/185 , C07C309/11 , C07C309/15 , C07C309/51
摘要： The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.

2. 发明授权

US06528514B1 IgE antibody production inhibitors and autoimmune diseases inhibitors 失效
标题翻译： IgE抗体产生抑制剂和自身免疫疾病抑制剂
公开(公告)号：US06528514B1
公开(公告)日：2003-03-04
申请号：US09646388
申请日：2000-12-20
申请人： Fujio Kobayashi , Shigeki Kuwahara , Naruyasu Komorita , Koji Naito , Teruaki Imada , Tsutomu Yoshikawa
发明人： Fujio Kobayashi , Shigeki Kuwahara , Naruyasu Komorita , Koji Naito , Teruaki Imada , Tsutomu Yoshikawa
IPC分类号： A61K31505
CPC分类号： C07D239/47 , A61K31/506 , A61K31/513 , A61K38/00 , C07K5/06139
摘要： The present invention relates to an IgE antibody production inhibitor and an autoimmune disease suppressant containing a heterocyclic amide compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient wherein R represents a hydrogen atom, alkyl, —CHO, —COOH, etc.; R5, R6 and R7 represent each hydrogen, alkyl, aryl, etc.; M represents a carbon atom or a nitrogen atom; Y represents aryl, etc.; and Z represents hydrogen, alkyl, aryl, etc.
摘要翻译：本发明涉及含有由以下通式（1）表示的杂环酰胺化合物或其药学上可接受的盐作为活性成分的IgE抗体产生抑制剂和自身免疫性疾病抑制剂，其中R表示氢原子，烷基，-CHO， -COOH等; R5，R6和R7表示氢，烷基，芳基等; M表示碳原子或氮原子; Y代表芳基等; Z表示氢，烷基，芳基等。

3. 发明授权

US07935700B2 Morpholine compound 有权
标题翻译：吗啉化合物
公开(公告)号：US07935700B2
公开(公告)日：2011-05-03
申请号：US11662228
申请日：2005-09-08
申请人： Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
发明人： Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
IPC分类号： A61K31/535 , C07D417/12
CPC分类号： C07D265/30 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： A compound represented by the formula (1) wherein ring A is aryl optionally having substituent(s) and the like; ring B is arylene optionally having substituent(s) and the like; m=0-2; n=1-5; X is a bond and the like; Y is a bond and the like; and Z is hydrogen atom and the like or a pharmaceutically acceptable salt thereof, and a hydrate or solvate thereof have affinity for CCR3, and can be pharmaceutical products for the treatment and/or prophylaxis of immune or inflammatory diseases.
摘要翻译：由式（1）表示的化合物，其中环A为任选具有取代基的芳基等; 环B是任选具有取代基的亚芳基等; m = 0-2; n = 1-5; X是一个键等; Y是一个债券等; Z是氢原子等或其药学上可接受的盐，其水合物或溶剂化物对CCR3具有亲和性，可以是用于治疗和/或预防免疫或炎性疾病的药物。

4. 发明授权

US06648940B2 Process for production compost 失效
标题翻译：生产堆肥过程
公开(公告)号：US06648940B2
公开(公告)日：2003-11-18
申请号：US10315098
申请日：2002-12-10
申请人： Shinji Yagihashi , Toshio Kurihara , Shinji Yamashita , Fujio Kobayashi , Yasukazu Nakakita
发明人： Shinji Yagihashi , Toshio Kurihara , Shinji Yamashita , Fujio Kobayashi , Yasukazu Nakakita
IPC分类号： C05F1102
CPC分类号： C05F17/00 , C05F17/0036 , C05F17/0072 , C05F17/02 , Y02P20/145 , Y02W30/43
摘要： The present invention relates to a process for producing compost, characterized in that when the compost is produced by inoculating aerobic composting seed bacteria to an organic waste material, the process comprises: supplying oxygen while the waste material is stirred, and supplying water so that the water content of the waste material is 60±5%, and to a process for producing compost, characterized in that when the compost is produced by inoculating aerobic composting seed bacteria to an organic waste material, the process comprises, after begining of the fermentation, adding sugars to the waste material in a divisional manner before a main fermentation is transferred to the amine/ammonium metabolic system. Further, according to the present invention, an apparatus for producing compost is provided. The apparatus comprises: a fermentation vessel having an oxygen supplying means, a water distributing means, and a stirring means; and a control means for detecting or determining the moisture content of an organic waste material contained in the fermentation vessel to control, on the basis of the detected or determined result, the amount of water to be distributed by the water distributing means. According to the present invention, when organic waste materials disposed from food processing factories and the like is processed to produce compost of high quality, formation of ammonium and amines mainly causing unpleasant odors or generation of lower fatty acid which is a factor for a growth inhibition of plants can be suppressed, and the compost can be produced in stable, and within a short period of time.
摘要翻译：本发明涉及一种生产堆肥的方法，其特征在于，当通过将有氧堆肥种子细菌接种到有机废料来生产堆肥时，该方法包括：在废料搅拌的同时供氧，并供水废弃物的含水量为60±5％，生产堆肥的方法，其特征在于，当通过将有氧堆肥种子细菌接种到有机废料中生产堆肥时，该方法包括在发酵开始后，在主发酵转移到胺/铵代谢系统之前，以分开方式向废料中加入糖。此外，根据本发明，提供了一种生产堆肥的设备。该装置包括：发酵容器，其具有供氧装置，水分配装置和搅拌装置; 以及控制装置，用于检测或确定包含在发酵容器中的有机废物的水分含量，以根据检测到的或确定的结果来控制由水分配装置分配的水量。根据本发明当处理从食品加工厂等处理的有机废弃材料生产高品质的堆肥时，主要产生令人不快的气味或产生作为植物生长抑制因素的低级脂肪酸的铵和胺的形成被抑制，堆肥可以稳定生产，并在短时间内生产。

5. 发明授权

US6135071A Two-stroke internal combustion engine 失效
标题翻译：二冲程内燃机
公开(公告)号：US6135071A
公开(公告)日：2000-10-24
申请号：US18739
申请日：1998-02-04
申请人： Fujio Kobayashi , Katsuya Tajima
发明人： Fujio Kobayashi , Katsuya Tajima
IPC分类号： F02B25/16 , F02B33/04 , F02B33/28 , F02B63/02 , F02B75/02 , F02F1/00 , F02F1/22 , F02M29/14 , F02M35/10
CPC分类号： F02F1/22 , F02B33/04 , F02B33/28 , F02B63/02 , F02F1/002 , F02M29/14 , F02B2075/025
摘要： A two-stroke internal combustion engine having a crankcase provided with a crank chamber, a suction port which opens to the crank chamber, a scavenging passage opening into the crank chamber, and a crankshaft is provided with a flow control surface formed on an inner peripheral wall portion of the crank chamber which is capable of retarding the flow rate of unatomized raw fuel and which extends from the vicinity of the suction port to the vicinity of the scavenging passage. The flow control surface is comprised of a large number of intersecting unit ribs.
摘要翻译：一种二冲程内燃机，其具有设置有曲柄室的曲轴箱，通向曲轴室的吸入口，通向曲轴室的扫气通路和曲轴，具有形成在内周侧的流量控制面曲柄室的壁部，其能够延迟未溶解的原料燃料的流量，并且从吸入口附近延伸到清扫通道的附近。流量控制表面由大量相交的单位肋构成。

6. 发明授权

US5934240A Internal combustion engine 失效
标题翻译：内燃机
公开(公告)号：US5934240A
公开(公告)日：1999-08-10
申请号：US844252
申请日：1997-04-18
申请人： Yoetsu Yokocho , Fujio Kobayashi
发明人： Yoetsu Yokocho , Fujio Kobayashi
IPC分类号： F01N13/14 , F02B63/00 , F02B63/02 , F02B75/02 , F02B77/11 , F02F7/00
CPC分类号： F02F7/00 , F02B63/02 , F01N2260/20 , F01N2590/06 , F02B2075/025
摘要： An internal combustion engine which comprises an engine body, and an air-intake side protective cover disposed at an air-intake side of the engine body, wherein the air-intake side protective cover is provided on the outer surface thereof with recessed grooves. The internal combustion engine may further comprise an exhaust side protective cover which is disposed in opposite to the air-intake side protective cover with the engine body being interposed therebetween and the recessed grooves are made to have substantially the same width and interval as those of a suitable number of heat radiating slit-like through-holes formed parallel with each other in the exhaust side protective cover.
摘要翻译：一种内燃机，其包括发动机主体和设置在发动机主体的进气侧的进气侧保护盖，其中，进气侧保护盖在其外表面上设置有凹槽。内燃机还可以包括排气侧保护盖，该排气侧保护盖设置在与进气侧保护罩相对的位置，发动机主体被插入其间，并且凹槽被制成具有基本相同的宽度和间隔合适数量的散热狭缝状通孔在排气侧保护罩中彼此平行地形成。

7. 发明授权

US5921364A Centrifugal clutch 失效
标题翻译：离心离合器
公开(公告)号：US5921364A
公开(公告)日：1999-07-13
申请号：US935261
申请日：1997-09-22
申请人： Fujio Kobayashi
发明人： Fujio Kobayashi
IPC分类号： F16D43/18 , F16D23/10
CPC分类号： F16D43/18
摘要： A centrifugal clutch has a clutch boss including a hub fixed to a drive shaft, several guides that extend radially from the hub, and clutch shoe retaining flanges that extend radially outward from each of the guides. The centrifugal clutch also has a clutch drum disposed coaxially with the clutch boss and is rotatable about the driving shaft independently from the clutch boss. Clutch shoes are slidably fitted to the guides in a radial direction of the clutch boss, and a spring biases each clutch shoe radially inward. Resilient snaps hold each of the clutch shoes with respect to the clutch boss so that each of the clutch shoes is biased toward each of the flanges in an axial direction of the drive shaft.
摘要翻译：离心式离合器具有离合器凸台，该离合器凸台包括固定到驱动轴的轮毂，从轮毂径向延伸的多个导向件以及从每个导向件径向向外延伸的离合器止动凸缘。离心式离合器还具有与离合器凸轮同轴设置的离合器鼓，并且能够独立于离合器凸台绕驱动轴旋转。离合器鞋在离合器凸台的径向方向上可滑动地安装到导向件上，并且弹簧径向向内偏压每个离合器靴。弹性卡扣相对于离合器凸台保持每个离合器靴，使得每个离合器靴沿着驱动轴的轴向方向朝向每个凸缘偏置。

8. 发明授权

US4873946A Two-cycle internal combustion engine 失效
标题翻译：双循环内燃机
公开(公告)号：US4873946A
公开(公告)日：1989-10-17
申请号：US230141
申请日：1988-08-09
申请人： Isao Masuda , Takashi Fukuoka , Fujio Kobayashi
发明人： Isao Masuda , Takashi Fukuoka , Fujio Kobayashi
IPC分类号： F01M3/00 , F02B25/00 , F02B75/02 , F02F1/22 , F02F1/30
CPC分类号： F02B25/00 , F01M3/00 , F02F1/22 , F02F1/30 , F02B2075/025
摘要： Disclosed is a two-cycle internal combustion engine including a protruding edge portion formed in a section of a lower side surface of an intake port which is adjacent to a pre-compression chamber of a cylinder. This protruding edge portion serves to deflect air-fuel mixture introduced into the pre-compression chamber through the intake port so as to direct it to a bearing portion provided between a piston and a connecting rod. Further, a cut-in groove is formed in the protruding edge section and is adapted to allow any liquid remaining in the intake port to flow into the pre-comparison chamber.
摘要翻译：公开了一种双循环内燃机，其包括形成在与气缸的预压缩室相邻的进气口的下侧表面的一部分中的突出边缘部分。该突出边缘部分用于使通过进气口引入预压缩室的空气燃料混合物偏转，以将其引导到设置在活塞和连接杆之间的轴承部分。此外，在突出边缘部分中形成切入槽，并且适于允许残留在进气口中的任何液体流入预比较室。

9. 发明授权

US4779835A Mold for transfer molding 失效
标题翻译：模具用于传递成型
公开(公告)号：US4779835A
公开(公告)日：1988-10-25
申请号：US903562
申请日：1986-09-04
申请人： Yuichi Fukushima , Fujio Kobayashi , Shinichiro Takahashi
发明人： Yuichi Fukushima , Fujio Kobayashi , Shinichiro Takahashi
IPC分类号： H01L21/56 , B29C45/02 , B29C45/14 , B29C45/17 , B29C45/26 , B29K101/10 , B29L31/34 , B29C45/04 , B29C45/03
CPC分类号： B29C45/1744 , B29C2045/14098 , B29C45/14655 , B29C45/2673
摘要： A mold for transfer molding having a cavity block in which a mold injected with resin is formed and a templet for holding the cavity block, in which a liquid layer is provided between the templet and a support member for supporting the templet, whereby the templet can be moved up and down on the liquid layer at its respective portions.
摘要翻译：一种用于传递模制的模具，其具有形成注射有树脂的模具的腔体块和用于保持腔模块的镜腿，其中在所述镜腿之间设置有液体层和用于支撑所述镜腿的支撑构件，由此所述镜腿可以在其各自的部分在液体层上上下移动。

10. 发明申请

US20070265257A1 Morpholine Compound 有权
标题翻译：吗啉化合物
公开(公告)号：US20070265257A1
公开(公告)日：2007-11-15
申请号：US11662228
申请日：2005-09-08
申请人： Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
发明人： Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
IPC分类号： A61K31/5375 , A61K31/5377 , A61P37/08 , C07D265/30 , C07D413/02
CPC分类号： C07D265/30 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： A compound represented by the formula (1) wherein ring A is aryl optionally having substituent(s) and the like; ring B is arylene optionally having substituent(s) and the like; m=0-2; n=1-5; X is a bond and the like; Y is a bond and the like; and Z is hydrogen atom and the like or a pharmaceutically acceptable salt thereof, and a hydrate or solvate thereof have affinity for CCR3, and can be pharmaceutical products for the treatment and/or prophylaxis of immune or inflammatory diseases.
摘要翻译：由式（1）表示的化合物，其中环A为任选具有取代基的芳基等; 环B是任选具有取代基的亚芳基等; m = 0-2; n = 1-5; X是一个键等; Y是一个债券等; Z是氢原子等或其药学上可接受的盐，其水合物或溶剂化物对CCR3具有亲和性，可以是用于治疗和/或预防免疫或炎性疾病的药物。

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