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1. 发明授权

US07935700B2 Morpholine compound 有权
标题翻译：吗啉化合物
公开(公告)号：US07935700B2
公开(公告)日：2011-05-03
申请号：US11662228
申请日：2005-09-08
申请人： Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
发明人： Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
IPC分类号： A61K31/535 , C07D417/12
CPC分类号： C07D265/30 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： A compound represented by the formula (1) wherein ring A is aryl optionally having substituent(s) and the like; ring B is arylene optionally having substituent(s) and the like; m=0-2; n=1-5; X is a bond and the like; Y is a bond and the like; and Z is hydrogen atom and the like or a pharmaceutically acceptable salt thereof, and a hydrate or solvate thereof have affinity for CCR3, and can be pharmaceutical products for the treatment and/or prophylaxis of immune or inflammatory diseases.
摘要翻译：由式（1）表示的化合物，其中环A为任选具有取代基的芳基等; 环B是任选具有取代基的亚芳基等; m = 0-2; n = 1-5; X是一个键等; Y是一个债券等; Z是氢原子等或其药学上可接受的盐，其水合物或溶剂化物对CCR3具有亲和性，可以是用于治疗和/或预防免疫或炎性疾病的药物。

2. 发明申请

US20070265257A1 Morpholine Compound 有权
标题翻译：吗啉化合物
公开(公告)号：US20070265257A1
公开(公告)日：2007-11-15
申请号：US11662228
申请日：2005-09-08
申请人： Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
发明人： Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
IPC分类号： A61K31/5375 , A61K31/5377 , A61P37/08 , C07D265/30 , C07D413/02
CPC分类号： C07D265/30 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： A compound represented by the formula (1) wherein ring A is aryl optionally having substituent(s) and the like; ring B is arylene optionally having substituent(s) and the like; m=0-2; n=1-5; X is a bond and the like; Y is a bond and the like; and Z is hydrogen atom and the like or a pharmaceutically acceptable salt thereof, and a hydrate or solvate thereof have affinity for CCR3, and can be pharmaceutical products for the treatment and/or prophylaxis of immune or inflammatory diseases.
摘要翻译：由式（1）表示的化合物，其中环A为任选具有取代基的芳基等; 环B是任选具有取代基的亚芳基等; m = 0-2; n = 1-5; X是一个键等; Y是一个债券等; Z是氢原子等或其药学上可接受的盐，其水合物或溶剂化物对CCR3具有亲和性，可以是用于治疗和/或预防免疫或炎性疾病的药物。

3. 发明申请

US20100041643A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF 有权
标题翻译：苯并噻唑啉酮化合物及其药物用途
公开(公告)号：US20100041643A1
公开(公告)日：2010-02-18
申请号：US11916015
申请日：2006-05-30
申请人： Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
发明人： Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
IPC分类号： A61K31/551 , C07D495/14
CPC分类号： C07D495/14
摘要： [Solving means] A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound. [Effect]Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.
摘要翻译： [解决方案]下述式（I）的噻吩并三唑并氮杂化合物是含有该化合物作为有效成分的药剂，以及噻吩并三唑并氮杂化合物的制造中间体和制造方法。 [效果]由于该化合物对T细胞上的CD28的共刺激信号具有抑制作用，因此可用于预防或抑制移植器官或骨髓等中的排斥反应，以及预防或治疗自身免疫性疾病或过敏性疾病

4. 发明授权

US08044042B2 Thienotriazolodiazepine compound and medicinal use thereof 有权
标题翻译：噻吩并三唑并氮杂化合物及其药用
公开(公告)号：US08044042B2
公开(公告)日：2011-10-25
申请号：US11916015
申请日：2006-05-30
申请人： Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
发明人： Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
IPC分类号： A61P1/04 , A61P3/10 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/00 , A61P27/14 , A61P29/00 , A61P37/00 , A61P43/00 , A61K31/551 , C07D495/14
CPC分类号： C07D495/14
摘要： A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound. Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.
摘要翻译：下式（I）的噻吩并三唑并噻嗪类化合物是含有该化合物作为活性成分的药剂，以及噻吩并三唑并噻吩类化合物的制造中间体和制造方法。由于该化合物对T细胞上的CD28的共刺激信号具有抑制作用，因此可用于预防或抑制移植器官或骨髓等中的排斥反应，以及预防或治疗自身免疫疾病或过敏性疾病。

5. 发明申请

US20090082311A1 2-Aminobutanol Compound and Use Thereof for Medical Purposes 有权
标题翻译： 2-氨基丁醇化合物及其用途
公开(公告)号：US20090082311A1
公开(公告)日：2009-03-26
申请号：US12226745
申请日：2007-04-27
申请人： Masatoshi Kiuchi , Mitsuharu Nakamura , Maiko Hamada , Kunio Sugahara
发明人： Masatoshi Kiuchi , Mitsuharu Nakamura , Maiko Hamada , Kunio Sugahara
IPC分类号： A61K31/137 , C07C215/20 , C07C69/34 , C07D317/30 , A61P37/00 , A61K31/675 , A61K31/662 , A61K31/216 , C07F9/653 , A61K31/357
CPC分类号： C07F9/653 , C07C217/64 , C07C225/16 , C07C309/65 , C07C323/32 , C07C323/38 , C07C323/41 , C07D333/22 , C07D333/34 , C07F9/091
摘要： The present invention provides a novel compound having few side effects such as bradycardia and the like and having superior peripheral blood lymphocyte-decreasing effect.The present invention provides a 2-aminobutanol compound represented by the following formula (I) wherein R1 is a hydrogen atom or P(═O) (OH)2, R2 is an alkyl having 1 to 4 carbon atoms optionally substituted by hydroxyl group(s) or optionally substituted by halogen atom(s), R3 is a hydrogen atom; a halogen atom; cyano; an alkyl having 1 to 4 carbon atoms optionally substituted by halogen atom(s); or an acyl having 2 to 5 carbon atoms optionally substituted by halogen atom(s), X is an oxygen atom, a sulfur atom, carbonyl or NR4 wherein R4 is a hydrogen atom or an alkyl having 1 to 4 carbon atoms, Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene, and Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl, provided that when X is an oxygen atom, Ar1 is phenylene and Ar2 is phenyl, then the phenyl for Ar2 should be substituted, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof, as well as a production method of the above-mentioned 2-aminobutanol compound.
摘要翻译：本发明提供一种副作用少的新型化合物，如心动过缓等，具有优异的外周血淋巴细胞减少作用。本发明提供由下式（I）表示的2-氨基丁醇化合物，其中R 1为氢原子或P（-O）（OH）2，R 2为任选被羟基取代的具有1至4个碳原子的烷基或任选被卤素原子取代，R 3是氢原子; 卤素原子; 氰基; 任选被卤素原子取代的碳原子数1〜4的烷基; 或任选被卤素原子取代的具有2至5个碳原子的酰基，X是氧原子，硫原子，羰基或NR 4，其中R 4是氢原子或具有1至4个碳原子的烷基，Ar 1是任选取代的亚芳基或任选取代的亚杂芳基，Ar 2是任选取代的芳基或任选取代的杂芳基，条件是当X是氧原子时，Ar 1是亚苯基，Ar 2是苯基，则Ar 2的苯基应该被取代，或其药学上可接受的酸加成盐或其水合物或其溶剂合物，以及上述2-氨基丁醇化合物的制备方法。

6. 发明授权

US09150555B2 Amide derivative and use thereof 有权
标题翻译：酰胺衍生物及其用途
公开(公告)号：US09150555B2
公开(公告)日：2015-10-06
申请号：US13879475
申请日：2011-10-13
申请人： Hiroyuki Ushio , Maiko Hamada , Masayuki Watanabe , Atsushi Numata , Naoto Fujie , Tooru Takashima , Hiroyuki Furukawa , Junki Ando
发明人： Hiroyuki Ushio , Maiko Hamada , Masayuki Watanabe , Atsushi Numata , Naoto Fujie , Tooru Takashima , Hiroyuki Furukawa , Junki Ando
IPC分类号： A61K31/47 , C07D211/14 , C07D405/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12 , C07D495/04
CPC分类号： C07D405/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12 , C07D495/04
摘要： The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.
摘要翻译：本发明涉及新型酰胺衍生物。更具体地说，本发明提供可用作疾病的预防或治疗剂的药剂，其依赖于来自T细胞的细胞因子的产生，并且其包含酰胺衍生物或其药理学上可接受的盐或衍生物的溶剂合物或药理学上可接受的盐作为活性成分。本发明提供通式（I）表示的酰胺衍生物或其药理学上可接受的盐，或其衍生物或药理学上可接受的盐的溶剂合物。

7. 发明授权

US08114902B2 2-aminobutanol compound and use thereof for medical purposes 有权
标题翻译： 2-氨基丁醇化合物及其用于医疗用途
公开(公告)号：US08114902B2
公开(公告)日：2012-02-14
申请号：US12226745
申请日：2007-04-27
申请人： Masatoshi Kiuchi , Mitsuharu Nakamura , Maiko Hamada , Kunio Sugahara
发明人： Masatoshi Kiuchi , Mitsuharu Nakamura , Maiko Hamada , Kunio Sugahara
IPC分类号： A61K31/335 , C07D319/06
CPC分类号： C07F9/653 , C07C217/64 , C07C225/16 , C07C309/65 , C07C323/32 , C07C323/38 , C07C323/41 , C07D333/22 , C07D333/34 , C07F9/091
摘要： Disclosed is a 2-aminobutanol compound represented by the following formula (I) or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof, as well as a production method of the 2-aminobutanol compound of formula (I). The 2-aminobutanol compounds of formula (I) have few side effects including bradycardia and have superior peripheral blood lymphocyte-decreasing effects.
摘要翻译：公开了由下式（I）表示的2-氨基丁醇化合物或其药学上可接受的酸加成盐或其水合物或其溶剂合物，以及式（I）的2-氨基丁醇化合物的制备方法）。式（I）的2-氨基丁醇化合物具有很少的副作用，包括心动过缓，并且具有优异的外周血淋巴细胞减少作用。

8. 发明申请

US20130211075A1 AMIDE DERIVATIVE AND USE THEREOF 有权
标题翻译：酰胺衍生物及其用途
公开(公告)号：US20130211075A1
公开(公告)日：2013-08-15
申请号：US13879475
申请日：2011-10-13
申请人： Hiroyuki Ushio , Maiko Hamada , Masayuki Watanabe , Atsushi Numata , Naoto Fujie , Tooru Takashima , Hiroyuki Furukawa , Junki Ando
发明人： Hiroyuki Ushio , Maiko Hamada , Masayuki Watanabe , Atsushi Numata , Naoto Fujie , Tooru Takashima , Hiroyuki Furukawa , Junki Ando
IPC分类号： C07D405/14 , C07D401/12 , C07D401/14
CPC分类号： C07D405/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12 , C07D495/04
摘要： The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.
摘要翻译：本发明涉及新型酰胺衍生物。更具体地说，本发明提供可用作疾病的预防或治疗剂的药剂，其依赖于来自T细胞的细胞因子的产生，并且其包含酰胺衍生物或其药理学上可接受的盐或衍生物的溶剂合物或药理学上可接受的盐作为活性成分。本发明提供通式（I）表示的酰胺衍生物或其药理学上可接受的盐，或其衍生物或药理学上可接受的盐的溶剂合物。

9. 发明授权

US08129361B2 Amine compound and pharmaceutical use thereof 有权
标题翻译：胺化合物及其药物用途
公开(公告)号：US08129361B2
公开(公告)日：2012-03-06
申请号：US12664366
申请日：2008-06-13
申请人： Masatoshi Kiuchi , Kaoru Tashiro , Maiko Hamada , Kunio Sugahara
发明人： Masatoshi Kiuchi , Kaoru Tashiro , Maiko Hamada , Kunio Sugahara
IPC分类号： A61K31/045 , A61K31/137 , C07C215/20 , C07C215/28
CPC分类号： C07C255/54 , C07C217/70 , C07C255/59 , C07C317/32 , C07C323/19 , C07C323/32 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D211/14 , C07D295/08 , C07D307/79 , C07D317/22 , C07D317/62 , C07D333/16 , C07D333/28 , C07D333/56 , C07F9/091 , C07F9/5456 , C07F9/653 , C07F9/65517 , C07F9/655345 , C07F9/655354 , C07F9/65586
摘要： Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.
摘要翻译：提供了具有优异的外周血淋巴细胞减少作用和优异的免疫抑制作用，排斥抑制作用等的下述式（I）表示的新型胺化合物，其表现出例如心动过缓等的副作用降低，或其药学上可接受的酸加成盐或其水合物或其溶剂合物。其中每个符号如说明书中所定义。

10. 发明申请

US20100179216A1 AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF 有权
标题翻译：胺化合物及其药物用途
公开(公告)号：US20100179216A1
公开(公告)日：2010-07-15
申请号：US12664366
申请日：2008-06-13
申请人： Masatoshi Kiuchi , Kaoru Tashiro , Maiko Hamada , Kunio Sugahara
发明人： Masatoshi Kiuchi , Kaoru Tashiro , Maiko Hamada , Kunio Sugahara
IPC分类号： A61K31/135 , C07D319/06 , C07C255/58 , C07C229/36 , C07C217/62 , C07C271/16 , A61K31/357 , A61K31/277 , A61K31/225 , A61K31/27 , A61P37/00 , A61P37/06 , A61P37/08
CPC分类号： C07C255/54 , C07C217/70 , C07C255/59 , C07C317/32 , C07C323/19 , C07C323/32 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D211/14 , C07D295/08 , C07D307/79 , C07D317/22 , C07D317/62 , C07D333/16 , C07D333/28 , C07D333/56 , C07F9/091 , C07F9/5456 , C07F9/653 , C07F9/65517 , C07F9/655345 , C07F9/655354 , C07F9/65586
摘要： Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.
摘要翻译：提供了具有优异的外周血淋巴细胞减少作用和优异的免疫抑制作用，排斥抑制作用等的下述式（I）表示的新型胺化合物，其表现出例如心动过缓等的副作用降低，或其药学上可接受的酸加成盐或其水合物或其溶剂合物。其中每个符号如说明书中所定义。

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