会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明授权
    • Process for the preparation of .beta.-hydroxyethyl-(1,2,4-triazole)
derivatives
    • 制备β-羟乙基 - (1,2,4-三唑)衍生物的方法
    • US4719307A
    • 1988-01-12
    • US916077
    • 1986-10-06
    • Reinhard LantzschKarl-Julius Reubke
    • Reinhard LantzschKarl-Julius Reubke
    • B01J31/00C07B61/00C07D249/08C07D521/00
    • C07D231/12C07D233/56C07D249/08
    • The known .beta.-hydroxyethyl-(1,2,4-triazole) derivatives of the formula ##STR1## in which R.sup.1 represents alkyl, halogenoalkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl or an optionally substituted heterocyclic radical andR.sup.2 represents hydrogen, alkyl, halogenoalkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl or an optionally substituted heterocyclic radical,are prepared by a new process, which comprises stirring a .beta.-hydroxyethyl-(1,3,4-triazole) derivative of the formula ##STR2## in which R.sup.1 and R.sup.2 have the abovementional meanings, in the presence of a base and in the presence of an aprotic, dipolar diluent.
    • 已知的式(I)的β-羟基乙基 - (1,2,4-三唑)衍生物,其中R 1表示烷基,卤代烷基,烯基,炔基,任选取代的环烷基,任选取代的环烯基,任选取代的芳基,任选地 取代的芳烷基,任选取代的芳烯基或任选取代的杂环基,R 2表示氢,烷基,卤代烷基,烯基,炔基,任选取代的环烷基,任选取代的环烯基,任选取代的芳基,任选取代的芳烷基,任选取代的芳烯基或任选取代的杂环基 通过新方法制备,其包括在存在下述步骤的情况下搅拌式(II)的β-羟乙基 - (1,3,4-三唑)衍生物,其中R 1和R 2具有上述含义 在非质子偶极稀释剂的存在下。
    • 4. 发明授权
    • Process for the preparation of beta-hydroxyethyl-(1,2,4-triazole)
derivatives
    • β-羟乙基 - (1,2,4-三唑)衍生物的制备方法
    • US4626594A
    • 1986-12-02
    • US672767
    • 1984-11-19
    • Reinhard LantzschKarl-Julius Reubke
    • Reinhard LantzschKarl-Julius Reubke
    • B01J31/00C07B61/00C07D249/08C07D521/00
    • C07D231/12C07D233/56C07D249/08
    • Known .beta.-hydroxyethyl-(1,2,4-triazole) derivatives of the formula ##STR1## in which R represents alkyl, halogenoalkyl, optionally substituted cycloalkyl or optionally substituted phenyl,Z represents halogen, alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy andm represents the number 0, 1, 2 or 3,are prepared by a new process, which comprises reacting oxiranes of the formula ##STR2## in which R, Z and m have the abovementioned meaning, with 1,2,4-triazole of the formula ##STR3## in the presence of a cylcic amid of the formula ##STR4## in which R.sup.1 represents alkyl with 1 to 4 carbon atoms andn represents the number 3, 4 or 5,as diluent, and in the presence of a base.
    • 已知的式(I)的β-羟乙基 - (1,2,4-三唑)衍生物,其中R表示烷基,卤代烷基,任选取代的环烷基或任选取代的苯基,Z表示卤素,烷基,环烷基,烷氧基, 烷基硫代,卤代烷基,卤代烷氧基,卤代烷硫基,任选取代的苯基,任选取代的苯氧基,任选取代的苯基烷基或任选取代的苯基烷氧基,m代表数字0,1,2或3,通过新方法制备,其包括使式 在其中R,Z和m具有上述含义的式(II)中,与式(III)的1,2,4-三唑在式(IV)的酰胺存在下反应 ),其中R 1表示具有1至4个碳原子的烷基,n表示3,4或5个作为稀释剂,并且在碱的存在下。
    • 5. 发明授权
    • Process for the preparation of .beta.-hydroxyethyl-(1,2,4-triazole)
derivatives
    • 制备β-羟乙基 - (1,2,4-三唑)衍生物的方法
    • US4639527A
    • 1987-01-27
    • US672553
    • 1984-11-19
    • Reinhard LantzschKarl-Julius Reubke
    • Reinhard LantzschKarl-Julius Reubke
    • B01J31/00C07B61/00C07D249/08C07D521/00
    • C07D231/12C07D233/56C07D249/08
    • The known .beta.-hydroxyethyl-(1,2,4-triazole) derivatives of the formula ##STR1## in which R.sup.1 represents alkyl, halogenoalkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl or an optionally substituted heterocyclic radical andR.sup.2 represents hydrogen, alkyl, halogenoalkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl or an optionally substituted heterocyclic radical,are prepared by a new process, which comprises stirring a .beta.-hydroxyethyl-(1,3,4-triazole) derivative of the formula ##STR2## in which R.sup.1 and R.sup.2 have the abovementioned meanings, in the presence of a base and in the presence of an aprotic, dipolar diluent.
    • 已知的式(I)的β-羟基乙基 - (1,2,4-三唑)衍生物,其中R 1表示烷基,卤代烷基,烯基,炔基,任选取代的环烷基,任选取代的环烯基,任选取代的芳基,任选地 取代的芳烷基,任选取代的芳烯基或任选取代的杂环基,R 2表示氢,烷基,卤代烷基,烯基,炔基,任选取代的环烷基,任选取代的环烯基,任选取代的芳基,任选取代的芳烷基,任选取代的芳烯基或任选取代的杂环基 通过新方法制备,其包括在存在下述步骤的同时搅拌式(II)的β-羟乙基 - (1,3,4-三唑)衍生物,其中R 1和R 2具有上述含义 在非质子偶极稀释剂的存在下。
    • 8. 发明授权
    • Process for preparing substituted N-carbamoyl-Tetrazolinones
    • 取代的N-氨基甲酰基 - 四唑啉酮的制备方法
    • US5686392A
    • 1997-11-11
    • US595088
    • 1996-02-01
    • Uwe StelzerWolfgang GauKarl-Julius Reubke
    • Uwe StelzerWolfgang GauKarl-Julius Reubke
    • A01N47/38B01J31/02C07D257/04
    • C07D257/04
    • The herbicidally active substituted N-carbamoyl-tetrazolinones of the formula (I) ##STR1## in which R.sup.1 represents, inter alia, an (optionally substituted) phenyl radical, R.sup.2 represents, inter alia, an alkyl radical, and R.sup.3 represents, inter alia, a cycloalkyl radical, are obtained in very good yields and at high purity--i.e. free from the isomeric O-carbamoyloxytetrazoles (Ia)--by reacting tetrazolinones of the formula (II) with carbamoyl halides of the formula (III) (X=halogen) ##STR2## in the presence of an acid acceptor and in the presence of a diluent, at temperatures of between 0.degree. C. and 200.degree. C., and either isomerizing the O-carbamoylation product of the formula (Ia), which is formed under these circumstances as a byproduct, into the desired product of the formula (I) by heating, or else converting it by hydrolysis or alcoholysis into water-soluble, and thus readily separable, components (variable (a)). Three variants (b), (c) and (d) which are closely related to this process (a) are also described: Process variant (b) proceeds in analogy with (a) but via the (novel, isolated) metal salts (IIa) of the tetrazolinones (II). In variant (c), the isomer (Ia) is isomerized thermally, either in pure isolated form or mixed with (I), while, in variant (d), the (Ia) isomer is removed from (I)/(Ia) mixtures by means of hydrolysis or alcoholysis. The novel intermediates (Ia) and (IIa) also belong, as such, to the subject-matter of the invention.
    • 式(I)的除草活性的取代的N-氨基甲酰基 - 四唑啉酮,其中R 1特别是(任选取代的)苯基,R 2特别包括, 烷基,和R3代表环烷基,以非常好的产率和高纯度获得,即 通过使式(II)的四唑啉酮与式(III)的氨基甲酰基卤化物(X =卤素)在酸受体的存在下反应而不存在异构O-氨基甲酰氧基四唑(Ia) 稀释剂,在0℃至200℃的温度下,将在这些情况下作为副产物形成的式(Ia)的O-氨基甲酰基化产物异构化为所需的式(I ),或者通过水解或醇解将其转化为水溶性的,因此易于分离的组分(可变(a))。 还描述了与该方法(a)密切相关的三个变体(b),(c)和(d):方法变体(b)类似于(a)进行,但通过(新颖的,分离的)金属盐 IIa)四唑啉酮(II)。 在变体(c)中,异构体(Ia)以纯分离形式或与(I)混合而异构化,而在变体(d)中,(Ia)异构体从(I)/(Ia) 混合物通过水解或醇解。 新颖的中间体(Ia)和(IIa)也属于本发明的主题。