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    • 1. 发明授权
    • Process for the preparation of .beta.-hydroxyethyl-(1,2,4-triazole)
derivatives
    • 制备β-羟乙基 - (1,2,4-三唑)衍生物的方法
    • US4639527A
    • 1987-01-27
    • US672553
    • 1984-11-19
    • Reinhard LantzschKarl-Julius Reubke
    • Reinhard LantzschKarl-Julius Reubke
    • B01J31/00C07B61/00C07D249/08C07D521/00
    • C07D231/12C07D233/56C07D249/08
    • The known .beta.-hydroxyethyl-(1,2,4-triazole) derivatives of the formula ##STR1## in which R.sup.1 represents alkyl, halogenoalkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl or an optionally substituted heterocyclic radical andR.sup.2 represents hydrogen, alkyl, halogenoalkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl or an optionally substituted heterocyclic radical,are prepared by a new process, which comprises stirring a .beta.-hydroxyethyl-(1,3,4-triazole) derivative of the formula ##STR2## in which R.sup.1 and R.sup.2 have the abovementioned meanings, in the presence of a base and in the presence of an aprotic, dipolar diluent.
    • 已知的式(I)的β-羟基乙基 - (1,2,4-三唑)衍生物,其中R 1表示烷基,卤代烷基,烯基,炔基,任选取代的环烷基,任选取代的环烯基,任选取代的芳基,任选地 取代的芳烷基,任选取代的芳烯基或任选取代的杂环基,R 2表示氢,烷基,卤代烷基,烯基,炔基,任选取代的环烷基,任选取代的环烯基,任选取代的芳基,任选取代的芳烷基,任选取代的芳烯基或任选取代的杂环基 通过新方法制备,其包括在存在下述步骤的同时搅拌式(II)的β-羟乙基 - (1,3,4-三唑)衍生物,其中R 1和R 2具有上述含义 在非质子偶极稀释剂的存在下。
    • 2. 发明授权
    • Process for the preparation of .beta.-hydroxyethyl-(1,2,4-triazole)
derivatives
    • 制备β-羟乙基 - (1,2,4-三唑)衍生物的方法
    • US4719307A
    • 1988-01-12
    • US916077
    • 1986-10-06
    • Reinhard LantzschKarl-Julius Reubke
    • Reinhard LantzschKarl-Julius Reubke
    • B01J31/00C07B61/00C07D249/08C07D521/00
    • C07D231/12C07D233/56C07D249/08
    • The known .beta.-hydroxyethyl-(1,2,4-triazole) derivatives of the formula ##STR1## in which R.sup.1 represents alkyl, halogenoalkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl or an optionally substituted heterocyclic radical andR.sup.2 represents hydrogen, alkyl, halogenoalkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl or an optionally substituted heterocyclic radical,are prepared by a new process, which comprises stirring a .beta.-hydroxyethyl-(1,3,4-triazole) derivative of the formula ##STR2## in which R.sup.1 and R.sup.2 have the abovementional meanings, in the presence of a base and in the presence of an aprotic, dipolar diluent.
    • 已知的式(I)的β-羟基乙基 - (1,2,4-三唑)衍生物,其中R 1表示烷基,卤代烷基,烯基,炔基,任选取代的环烷基,任选取代的环烯基,任选取代的芳基,任选地 取代的芳烷基,任选取代的芳烯基或任选取代的杂环基,R 2表示氢,烷基,卤代烷基,烯基,炔基,任选取代的环烷基,任选取代的环烯基,任选取代的芳基,任选取代的芳烷基,任选取代的芳烯基或任选取代的杂环基 通过新方法制备,其包括在存在下述步骤的情况下搅拌式(II)的β-羟乙基 - (1,3,4-三唑)衍生物,其中R 1和R 2具有上述含义 在非质子偶极稀释剂的存在下。
    • 3. 发明授权
    • Process for the preparation of beta-hydroxyethyl-(1,2,4-triazole)
derivatives
    • β-羟乙基 - (1,2,4-三唑)衍生物的制备方法
    • US4626594A
    • 1986-12-02
    • US672767
    • 1984-11-19
    • Reinhard LantzschKarl-Julius Reubke
    • Reinhard LantzschKarl-Julius Reubke
    • B01J31/00C07B61/00C07D249/08C07D521/00
    • C07D231/12C07D233/56C07D249/08
    • Known .beta.-hydroxyethyl-(1,2,4-triazole) derivatives of the formula ##STR1## in which R represents alkyl, halogenoalkyl, optionally substituted cycloalkyl or optionally substituted phenyl,Z represents halogen, alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy andm represents the number 0, 1, 2 or 3,are prepared by a new process, which comprises reacting oxiranes of the formula ##STR2## in which R, Z and m have the abovementioned meaning, with 1,2,4-triazole of the formula ##STR3## in the presence of a cylcic amid of the formula ##STR4## in which R.sup.1 represents alkyl with 1 to 4 carbon atoms andn represents the number 3, 4 or 5,as diluent, and in the presence of a base.
    • 已知的式(I)的β-羟乙基 - (1,2,4-三唑)衍生物,其中R表示烷基,卤代烷基,任选取代的环烷基或任选取代的苯基,Z表示卤素,烷基,环烷基,烷氧基, 烷基硫代,卤代烷基,卤代烷氧基,卤代烷硫基,任选取代的苯基,任选取代的苯氧基,任选取代的苯基烷基或任选取代的苯基烷氧基,m代表数字0,1,2或3,通过新方法制备,其包括使式 在其中R,Z和m具有上述含义的式(II)中,与式(III)的1,2,4-三唑在式(IV)的酰胺存在下反应 ),其中R 1表示具有1至4个碳原子的烷基,n表示3,4或5个作为稀释剂,并且在碱的存在下。
    • 9. 发明授权
    • Process for preparing pyridylmethyl isothiocyanates
    • 制备吡啶基甲基异硫氰酸酯的方法
    • US6166214A
    • 2000-12-26
    • US298593
    • 1999-04-23
    • Klaus WagnerReinhard Lantzsch
    • Klaus WagnerReinhard Lantzsch
    • C07D213/36C07D213/40C07D213/61C07D249/53
    • C07D213/40C07D213/61
    • The present invention relates to a novel process for preparing pyridylmethyl isothiocyanates of the formula (I) ##STR1## in which R.sup.1 represents halogen or C.sub.1 -C.sub.4 -alkyl, characterized in that in a first step, amines of the formula (II) ##STR2## in which R.sup.1 is as defined above, are reacted with xanthogenates of the formula (III)R.sup.2 O--CS--S.sup..crclbar. M.sup..sym. (III)in whichR.sup.2 represents C.sub.1 -C.sub.4 -alkyl, preferably methyl or ethyl andM represents an alkali metal, preferably sodium and potassium or represents ammonium,if appropriate in the presence of a diluent, and in a second step, the resulting novel dithiocarbamates of the formula (IV) ##STR3## in which R.sup.1 and M are each as defined above, are oxidized, if appropriate in the presence of a diluent, to give the isothiocyanates of the formula (I).
    • 本发明涉及一种制备式(I)的吡啶基甲基异硫氰酸酯的新方法,其中R 1表示卤素或C 1 -C 4 - 烷基,其特征在于在第一步中,式(II)的胺其中R1为 与式(III)R2O-CS-S( - )M(+)(III)的黄原酸酯反应,其中R 2表示C 1 -C 4烷基,优选甲基或乙基,M表示碱金属,优选 钠和钾,或代表铵,如果合适,在稀释剂存在下,并且在第二步中,得到的式(Ⅳ)的新型二硫代氨基甲酸酯,其中R 1和M如上所定义,如果适用,则在 存在稀释剂,得到式(I)的异硫氰酸酯。