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1. 发明授权

US4504414A Synthetic pyridyl-alanyl decapeptides having antiovulatory activity 失效
标题翻译：具有抗疟药活性的合成吡啶基 - 丙氨酰基十肽
公开(公告)号：US4504414A
公开(公告)日：1985-03-12
申请号：US479645
申请日：1983-03-28
申请人： Karl Folkers , Cyril Y. Bowers , Teresa M. Kubiak , Janusz Stepinski
发明人： Karl Folkers , Cyril Y. Bowers , Teresa M. Kubiak , Janusz Stepinski
IPC分类号： A61K38/00 , C07K7/23 , C07C103/52
CPC分类号： C07K7/23 , A61K38/00 , Y10S930/13
摘要： Pyridyl-alanyl decapeptides have been effectively synthesized and found to have antiovulatory activity. The exemplary [N-Ac-D-2-Nal.sup.1,pCl-D-Phe.sup.2, D-3-Pal.sup.3,D-Arg.sup.6,D-Ala.sup.10 ]-LHRH has very high potency to inhibit ovulation, both parenterally and orally. Also, this exemplary pyridyl-alanyl-decapeptide showed an unexpected prolonged duration of antiovulatory activity. Such pyridyl-alanyl-decapeptides are useful to control reproduction.
摘要翻译：已经有效地合成了吡啶基丙氨酸十肽，发现具有抗疟药活性。示例性的[N-Ac-D-2-Nal1，pCl-D-Phe2，D-3-Pal3，D-Arg6，D-Ala10] -LHRH具有非常高的效力以抑制排卵，肠胃外和口服。此外，该示例性吡啶基 - 丙氨酰 - 十肽显示出预期的持久的抗疟药活性。这种吡啶基 - 丙氨酰 - 十肽可用于控制繁殖。

2. 发明授权

US4374828A Biologically active thymones from the thymus 失效
标题翻译：来自胸腺的生物活性胸腺
公开(公告)号：US4374828A
公开(公告)日：1983-02-22
申请号：US199997
申请日：1980-11-17
申请人： Karl Folkers , Teresa M. Kubiak , Henryk M. Stepien , Naoki Sakura
发明人： Karl Folkers , Teresa M. Kubiak , Henryk M. Stepien , Naoki Sakura
IPC分类号： A61K35/26 , A61K37/00
CPC分类号： A61K35/26 , Y10S530/837 , Y10S930/18
摘要： A class of three substances has been isolated in highly purified form and in substantially pure form by utilizing thymus tissue as a source material. These three substances are designated thymone A, thymone B and thymone C. Thymones A and B are new peptides which yield approximately 13 and 14 individual amino acid moieties, respectively, on acid hydrolysis. Thymones A and B are chemically characterized by electrophoretic and chromatographic values which are appropriate for substances which are substantially pure. Thymone C was highly purified and its biological activity was reproducibly detected and measured. Thymones A, B and C stimulate the proliferation of lymphocytes. Thymone A stimulates the formation of cyclic adenosine monophosphate. Thymone B stimulates the formation of cyclic guanosine monophosphate.The biological activities of these thymones to stimulate the proliferation of lymphocytes and the formations of cyclic nucleotides are basic hormonal functions for the therapeutic enhancement of the immune system in patients who have immune deficiencies from diverse causes.
摘要翻译：通过利用胸腺组织作为源材料，已经以高度纯化的形式和基本上纯的形式分离了一类三种物质。这三种物质被称为胸腺嘧啶A，胸腺嘧啶B和胸腺素C.胸腺嘧啶A和B是分别在酸水解上产生大约13和14个单个氨基酸部分的新肽。百里香酮A和B的化学特征在于电泳和色谱值，其适用于基本上纯的物质。胸腺C高度纯化，其生物学活性被重复检测和测定。胸腺素A，B和C刺激淋巴细胞的增殖。 Thymone A刺激环磷酸腺苷的形成。胸腺B刺激环磷酸鸟苷的形成。刺激淋巴细胞增殖和循环核苷酸形成的这些胸腺嘧啶的生物活性是用于治疗增强免疫系统的基础激素功能，其具有不同原因的免疫缺陷。

3. 发明授权

US07208591B2 G protein-coupled receptor-like receptors and modulators thereof 失效
标题翻译： G蛋白偶联受体样受体及其调节剂
公开(公告)号：US07208591B2
公开(公告)日：2007-04-24
申请号：US10650467
申请日：2003-08-28
申请人： David E. Lowery , Timothy G. Geary , Teresa M. Kubiak , Martha J. Larsen
发明人： David E. Lowery , Timothy G. Geary , Teresa M. Kubiak , Martha J. Larsen
IPC分类号： C12N15/12
CPC分类号： C07K14/70571
摘要： The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.
摘要翻译：本发明提供神经肽配体，G蛋白偶联受体和筛选受体活性调节剂的方法。鉴定的调节剂，包括神经肽配体模拟物，可用作不同范围的生物杀灭剂和杀生物剂，从限制于特定无脊椎寄生虫的致死活性到广泛无脊椎动物（包括蠕虫和昆虫）的广谱无脊椎寄生虫寄生虫。

4. 发明授权

US06835546B1 Drosophila G protein coupled receptors, nucleic acids, and methods related to the same 失效
公开(公告)号：US06835546B1
公开(公告)日：2004-12-28
申请号：US09693746
申请日：2000-10-20
申请人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
发明人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
IPC分类号： G01N33566
CPC分类号： C07K14/705 , C12N2799/021
摘要： The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.

5. 发明申请

US20080241961A1 DROSOPHILA G PROTEIN COUPLED RECEPTORS, NUCLEIC ACIDS, AND MEHTODS RELATED TO THE SAME 审中-公开
标题翻译： DROSOPHILA G蛋白偶联受体，核酸和与其相关的酶
公开(公告)号：US20080241961A1
公开(公告)日：2008-10-02
申请号：US12032029
申请日：2008-02-15
申请人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
发明人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
IPC分类号： G01N33/566
CPC分类号： C07K14/705 , C12N2799/021
摘要： The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.
摘要翻译：本发明提供了一种果蝇黑腹果蝇GPCR（DmGPCR）多肽和鉴定和编码这种DmGPCR的多核苷酸。此外，本发明提供表达载体，宿主细胞及其生产方法。本发明还提供了用于鉴定其他动物和DmGPCR激动剂/拮抗剂的同系物的方法，其用于治疗动物疾病和控制对植物或动物有害或有害的昆虫。

6. 发明授权

US06632621B1 G protein-coupled receptor-like receptors and modulators thereof 失效
标题翻译： G蛋白偶联受体样受体及其调节剂
公开(公告)号：US06632621B1
公开(公告)日：2003-10-14
申请号：US09721870
申请日：2000-11-24
申请人： David E. Lowery , Timothy G. Geary , Teresa M. Kubiak , Martha J. Larsen
发明人： David E. Lowery , Timothy G. Geary , Teresa M. Kubiak , Martha J. Larsen
IPC分类号： G01N33569
CPC分类号： C07K14/70571
摘要： The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.
摘要翻译：本发明提供神经肽配体，G蛋白偶联受体和筛选受体活性调节剂的方法。鉴定的调节剂，包括神经肽配体模拟物，可用作不同范围的生物杀灭剂和杀生物剂，范围从限制于特定无脊椎寄生虫的致死活性到广泛无脊椎动物（包括蠕虫和昆虫）活性的广谱无脊椎寄生虫寄生虫。

7. 发明授权

US07364866B2 Drosophila G protein coupled receptors, nucleic acids, and methods related to the same 失效
标题翻译：果蝇G蛋白偶联受体，核酸和与之相关的方法
公开(公告)号：US07364866B2
公开(公告)日：2008-04-29
申请号：US10213821
申请日：2002-08-06
申请人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
发明人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
IPC分类号： G01N33/53 , C12N5/06 , C12N5/00 , C07K1/00 , C07K5/00
CPC分类号： C07K14/705 , C12N2799/021
摘要： The present invention provides Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells, and methods for its production. The invention also provides methods for the identification of homologs in other species and of DmGPCR agonists/antagonists useful as potential insecticides. The invention further provides methods for binding a DmGPCR, methods for identifying modulators of DmGPCR expression and activity, methods for controlling a population of insects with a DmGPCR antibody, a DmGPCR antisense polynucleotide, a DmGPCR binding partner or modulator, and methods of preventing or treating a disease or condition associated with an ectoparasite. Specifically, this invention discloses the matching of the orphan Drosophila drotachykinin, droleucokinin, and drostatin-C receptors with their cognate peptide ligands.
摘要翻译：本发明提供了果蝇黑腹果蝇GPCR（DmGPCR）多肽和鉴定和编码这种DmGPCR的多核苷酸。此外，本发明提供表达载体，宿主细胞及其生产方法。本发明还提供了用于鉴定其他物种中的同源物的方法和用作潜在杀虫剂的DmGPCR激动剂/拮抗剂。本发明还提供了用于结合DmGPCR的方法，用于鉴定DmGPCR表达和活性的调节剂的方法，用DmGPCR抗体，DmGPCR反义多核苷酸，DmGPCR结合配偶体或调节剂控制昆虫群体的方法，以及预防或治疗方法与外寄生物相关的疾病或病症。具体地说，本发明公开了孤儿果蝇的洛匹心碱，泪果状蛋白和抑制素-C受体与其同源肽配体的匹配。

8. 发明授权

US07354724B2 Drosophila G protein coupled receptors, nucleic acids, and methods related to the same 失效
标题翻译：果蝇G蛋白偶联受体，核酸和与之相关的方法
公开(公告)号：US07354724B2
公开(公告)日：2008-04-08
申请号：US10736048
申请日：2003-12-15
申请人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
发明人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： C07K14/705 , C12N2799/021
摘要： The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.
摘要翻译：本发明提供了一种果蝇黑腹果蝇GPCR（DmGPCR）多肽和鉴定和编码这种DmGPCR的多核苷酸。此外，本发明提供表达载体，宿主细胞及其生产方法。本发明还提供了用于鉴定其他动物和DmGPCR激动剂/拮抗剂的同系物的方法，其用于治疗动物疾病和控制对植物或动物有害或有害的昆虫。

9. 发明授权

US5756458A Stabilized potent GRF analogs 失效
标题翻译：稳定的有效GRF类似物
公开(公告)号：US5756458A
公开(公告)日：1998-05-26
申请号：US442029
申请日：1995-05-16
申请人： Teresa M. Kubiak , Alan R. Friedman
发明人： Teresa M. Kubiak , Alan R. Friedman
IPC分类号： A61K38/00 , C07K14/60 , A61K38/25
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： Novel GRF PEPTIDES having Thr, Val or Ile at position 2, having an amino acid selected from the group consisting of Ala, Val, Leu, Ile or Gly at position 15, and optionally substituted with Val or Ile at position 19 are described. Compositions and the method of stimulating the release of growth hormone utilizing GRF PEPTIDES having Thr, Val or Ile at position 2 and having an amino acid selected from the group consisting of Ala, Val, Leu, Ile or Gly at position 15 are also described. The GRF PEPTIDES of the present invention have enhanced stability in plasma.
摘要翻译：描述了在位置2具有Thr，Val或Ile的新型GRF肽，其具有选自第15位的Ala，Val，Leu，Ile或Gly的氨基酸，并且任选地被位置19上的Val或Ile取代。还描述了利用在位置2具有Thr，Val或Ile并且在15位具有选自Ala，Val，Leu，Ile或Gly的氨基酸的GRF PEPTIDES刺激生长激素释放的组合物和方法。本发明的GRF肽具有提高血浆中的稳定性。

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