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1. 发明授权

US5756458A Stabilized potent GRF analogs 失效
标题翻译：稳定的有效GRF类似物
公开(公告)号：US5756458A
公开(公告)日：1998-05-26
申请号：US442029
申请日：1995-05-16
申请人： Teresa M. Kubiak , Alan R. Friedman
发明人： Teresa M. Kubiak , Alan R. Friedman
IPC分类号： A61K38/00 , C07K14/60 , A61K38/25
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： Novel GRF PEPTIDES having Thr, Val or Ile at position 2, having an amino acid selected from the group consisting of Ala, Val, Leu, Ile or Gly at position 15, and optionally substituted with Val or Ile at position 19 are described. Compositions and the method of stimulating the release of growth hormone utilizing GRF PEPTIDES having Thr, Val or Ile at position 2 and having an amino acid selected from the group consisting of Ala, Val, Leu, Ile or Gly at position 15 are also described. The GRF PEPTIDES of the present invention have enhanced stability in plasma.
摘要翻译：描述了在位置2具有Thr，Val或Ile的新型GRF肽，其具有选自第15位的Ala，Val，Leu，Ile或Gly的氨基酸，并且任选地被位置19上的Val或Ile取代。还描述了利用在位置2具有Thr，Val或Ile并且在15位具有选自Ala，Val，Leu，Ile或Gly的氨基酸的GRF PEPTIDES刺激生长激素释放的组合物和方法。本发明的GRF肽具有提高血浆中的稳定性。

2. 发明授权

US3947591A Pesticidal N,N"-thio and dithio bis(substituted phenyl formamidines) 失效
标题翻译：杀虫剂N，N {41-硫代和二硫代双（取代苯基甲酰胺）
公开(公告)号：US3947591A
公开(公告)日：1976-03-30
申请号：US575248
申请日：1975-05-07
申请人： Victor L. Rizzo , Alan R. Friedman
发明人： Victor L. Rizzo , Alan R. Friedman
IPC分类号： A01N37/52 , A01N20060101 , C07C20060101 , C07C67/00 , C07C325/00 , C07C381/06 , C07D20060101 , C07C123/00 , C07C145/02
CPC分类号： C07D215/42
摘要： Novel pesticidal compounds of the formula: ##SPC1##Wherein R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of lower alkyl of from 1 to 4 carbon atoms; R.sub.3 and R.sub.4 are the same or different and are selected from the group consisting of hydrogen, halogen, and lower alkyl of from 1 to 4 carbon atoms, n = 1 or 2 provided that when n is 2 then R.sub.1 and R.sub.2 are the same as R.sub.3 and R.sub.4 are the same.The compounds are combined with carriers to prepare compositions and are useful in controlling insect pests either as an insecticide or behavioral modifier and are particularly effective as miticides.
摘要翻译：新型杀虫化合物的配方：

3. 发明授权

US5859188A Method for discovering novel anthelmintic compounds 失效
标题翻译：发现新型驱肠虫化合物的方法
公开(公告)号：US5859188A
公开(公告)日：1999-01-12
申请号：US866845
申请日：1997-05-30
申请人： Timothy G. Geary , Jerry W. Bowman , Alan R. Friedman
发明人： Timothy G. Geary , Jerry W. Bowman , Alan R. Friedman
IPC分类号： G01N33/50 , A61P33/10 , C07K1/13 , C07K7/06 , C07K14/435 , G01N33/15 , A61K38/08
CPC分类号： C07K7/06 , C07K14/4354
摘要： The present invention provides a novel radioactive neuropeptide represented by the formula Lys-His-Glu-Tyr.sup.--I -Leu-Arg-Phe-amide. The invention also provides a method for detecting anthelmintic activity of a compound using the novel neuropeptide of the present invention in a receptor binding assay. The novel radioactive neuropeptide has potent bioactivity in Ascaris suum neuromuscular strips, and therefore is particularly useful for high volume screening for potential anthelmintic compounds.
摘要翻译：本发明提供了一种由式Lys-His-Glu-Tyr-I-Leu-Arg-Phe-酰胺表示的新型放射性神经肽。本发明还提供了在受体结合测定中使用本发明的新型神经肽检测化合物的驱肠虫活性的方法。新型放射性神经肽在蛔虫肌瘤神经肌肉条中具有很强的生物活性，因此特别适用于大量筛选潜在的驱虫剂。

4. 发明授权

US4794768A Push button combination lock type gas cap and actuator employed therein 失效
标题翻译：按钮组合锁式气帽和执行机构
公开(公告)号：US4794768A
公开(公告)日：1989-01-03
申请号：US98658
申请日：1987-09-21
申请人： Douglas J. Moser , Damian Synclair , Alan R. Friedman
发明人： Douglas J. Moser , Damian Synclair , Alan R. Friedman
IPC分类号： B60K15/04 , B65D55/14 , E05B37/16
CPC分类号： E05B37/163 , B60K15/0409 , B65D55/145 , Y10T70/5571 , Y10T70/5814 , Y10T70/7164 , Y10T70/7271
摘要： A push button combination lock type gas cap and an actuator forming a part thereof, takes the form of a casing which may be mounted to an open end of a fuel tank filling neck with a stopper mounted within the casing for movement between a first position in which the cap is removable from the filler neck, and a second position where the cap is locked thereto. A first center push button mounted on the casing for movement in the direction of its axis between projected and depressed position, shifts the stopper to the first position for locking the cap to the filler tube upon depression thereof. The first push button is maintained in depressed position with a laterally shiftable slide plate operatively engaging the first push button for normally preventing retraction of the first push button absent a selective depression of one or more of a plurality of second push buttons mounted circumferentially about the center push button. The second push buttons are also normally held in depressed position, unless further depressed and released. Spline engagement between the push buttons and casing bores alternatively lock the depressible push buttons in initial depressed position and subsequent projected position. Rotatable pods beneath the depressible push button, engage lock pins having side recesses which when aligned with holes within the slide plate receiving the lock pins permit lateral shifting of the slide plate to release the first push button.
摘要翻译：按钮组合锁式气帽和形成其一部分的致动器采取壳体的形式，壳体可以安装到燃料箱填充颈部的开口端，安装在壳体内的止动件用于在第一位置帽可以从加注颈部移除，以及第二位置，其中盖被锁定在其上。安装在壳体上的第一中心按钮，用于在其突出和凹陷位置之间沿其轴线的方向移动，将止动器移动到第一位置，以在压下时将盖锁定到加注管。第一按钮保持在按压位置，其中横向可移动的滑动板可操作地接合第一按钮，用于正常地防止第一按钮的缩回，而不选择性地按压围绕中心周向安装的多个第二按钮中的一个或多个按钮。第二按钮通常也保持在按压位置，除非进一步按压并释放。按钮和套管孔之间的花键接合将可压下的按钮交替地锁定在初始按压位置和随后的突出位置。在可按压的按钮下面的可旋转荚接合具有侧凹槽的锁定销，当与接收锁定销的滑动板内的孔对准时，该凹槽允许滑动板的横向移位以释放第一按钮。

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