专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4374828A Biologically active thymones from the thymus 失效
标题翻译：来自胸腺的生物活性胸腺
公开(公告)号：US4374828A
公开(公告)日：1983-02-22
申请号：US199997
申请日：1980-11-17
申请人： Karl Folkers , Teresa M. Kubiak , Henryk M. Stepien , Naoki Sakura
发明人： Karl Folkers , Teresa M. Kubiak , Henryk M. Stepien , Naoki Sakura
IPC分类号： A61K35/26 , A61K37/00
CPC分类号： A61K35/26 , Y10S530/837 , Y10S930/18
摘要： A class of three substances has been isolated in highly purified form and in substantially pure form by utilizing thymus tissue as a source material. These three substances are designated thymone A, thymone B and thymone C. Thymones A and B are new peptides which yield approximately 13 and 14 individual amino acid moieties, respectively, on acid hydrolysis. Thymones A and B are chemically characterized by electrophoretic and chromatographic values which are appropriate for substances which are substantially pure. Thymone C was highly purified and its biological activity was reproducibly detected and measured. Thymones A, B and C stimulate the proliferation of lymphocytes. Thymone A stimulates the formation of cyclic adenosine monophosphate. Thymone B stimulates the formation of cyclic guanosine monophosphate.The biological activities of these thymones to stimulate the proliferation of lymphocytes and the formations of cyclic nucleotides are basic hormonal functions for the therapeutic enhancement of the immune system in patients who have immune deficiencies from diverse causes.
摘要翻译：通过利用胸腺组织作为源材料，已经以高度纯化的形式和基本上纯的形式分离了一类三种物质。这三种物质被称为胸腺嘧啶A，胸腺嘧啶B和胸腺素C.胸腺嘧啶A和B是分别在酸水解上产生大约13和14个单个氨基酸部分的新肽。百里香酮A和B的化学特征在于电泳和色谱值，其适用于基本上纯的物质。胸腺C高度纯化，其生物学活性被重复检测和测定。胸腺素A，B和C刺激淋巴细胞的增殖。 Thymone A刺激环磷酸腺苷的形成。胸腺B刺激环磷酸鸟苷的形成。刺激淋巴细胞增殖和循环核苷酸形成的这些胸腺嘧啶的生物活性是用于治疗增强免疫系统的基础激素功能，其具有不同原因的免疫缺陷。

IPRDB

热门服务

关于我们

友情链接

联系方式