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1. 发明申请

WO2008060112A1 COMPOSITION COMPRISING ARALIAE CORDATAE RADIX EXTRACT OR COMPOUNDS ISOLATED FROM THE SAME FOR PREVENTING OR TREATING PERIODONTITIS 审中-公开
标题翻译：包含ARALIAE CORDATAE RADIX提取物或其化合物的组合物从其分离用于预防或治疗周期性
公开(公告)号：WO2008060112A1
公开(公告)日：2008-05-22
申请号：PCT/KR2007/005741
申请日：2007-11-15
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Dae-sil , KOH, Sukhoon , KIM, Joong Su , BAE, Jungdon , KIM, Dooil , PARK, Jung Eun , PARK, Miri , CHOI, Yongseok , PARK, Bo Hyun , KIM, Jin Sook , JANG, Dae Sik , KOOK, Joong-ki , SONG, Gyu Yong
发明人： LEE, Dae-sil , KOH, Sukhoon , KIM, Joong Su , BAE, Jungdon , KIM, Dooil , PARK, Jung Eun , PARK, Miri , CHOI, Yongseok , PARK, Bo Hyun , KIM, Jin Sook , JANG, Dae Sik , KOOK, Joong-ki , SONG, Gyu Yong
IPC分类号： A61K36/25 , A61K31/19 , A23L1/29 , A61P1/02
CPC分类号： A61K31/19 , A23L33/105 , A61K36/25
摘要： The present invention relates to a composition comprising an Araliae Cordatae Radix extract or compounds isolated from the same for preventing or treating periodontitis. The Araliae Cordatae Radix extract or compounds isolated from the extract according to the present invention has/have excellent antimicrobial and bactericidal activities against Porphyromonas endodontalis, Porphyromonas gingivalis and Prevotella intermedia, which are periodontal pathogens, thereby being used to prevent or treat periodontitis.
摘要翻译：本发明涉及包含Araliae Cordatae Radix提取物或从其分离的用于预防或治疗牙周炎的化合物的组合物。根据本发明的提取物中分离出的Araliae Cordatae Radix提取物或化合物对牙龈卟啉单胞菌属牙龈卟啉单胞菌和牙周膜间质瘤具有优异的抗菌和杀菌活性，它们是牙周病原体，因此用于预防或治疗牙周炎。

2. 发明申请

WO2008111763A1 EXTRACTS OF ASTER KORAIENSIS, AND PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING THE SAME 审中-公开
标题翻译： ASTER KORAIENSIS的提取物，以及包括其的药物组合物和功能食品
公开(公告)号：WO2008111763A1
公开(公告)日：2008-09-18
申请号：PCT/KR2008/001292
申请日：2008-03-07
申请人： KOREA INSTITUTE OF ORIENTAL MEDICINE , KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook , SHON, Eun Jin , KIM, Chan Sik , KIM, Jung Hyun , KIM, Ohn Soon , JUNG, Dong Ho , YOO, Jeong Lim , KIM, Joo Hwan
发明人： KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook , SHON, Eun Jin , KIM, Chan Sik , KIM, Jung Hyun , KIM, Ohn Soon , JUNG, Dong Ho , YOO, Jeong Lim , KIM, Joo Hwan
IPC分类号： A61K36/28
CPC分类号： A61K36/28 , A23L33/105 , A23V2002/00 , A23V2200/328 , A23V2250/21
摘要： Disclosed herein are a leaf and stem extract of Aster koraiensis, a root extract of Aster koraiensis, a flower extract of Aster koraiensis, a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, in which each of the compositions and the foods contain, as an active ingredient, at least one of said Aster koraiensis extracts. Each of the extracts is obtained by drying and finely cutting each of the leaf and stem part, root and flower of Aster koraiensis, extracting the cut plant with alcohol or aqueous alcohol solution, filtering the extracted solution and concentrating the filtrate under reduced pressure. Also disclosed are a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, which contain, as an active ingredient, at least one of fractions obtained by fractionating each of said Aster koraiensis extracts in the order of hexane, ethyl acetate, n-butanol and water fractions. The leaf and stem extract of Aster koraiensis, the root extract of Aster koraiensis and the flower extract of Aster koraiensis have the effect of inhibiting the production of advanced glycation endproducts (AGEs), the causes of diabetic complications, and effectively inhibit aldose redductase (AR) activity. Thus, the disclosed extracts will be highly useful for the prevention or treatment of diabetic complications and the prevention of aging.
摘要翻译：本文公开了白菊的叶和茎提取物，菊科的根提取物，菊苣的花提取物，用于预防或治疗糖尿病并发症的药物组合物，用于改善糖尿病并发症的健康功能性食品，以及一种用于预防或延缓衰老的药物组合物和保健功能食品，其中每种组合物和食物含有至少一种所述菊科植物提取物作为活性成分。每个提取物通过干燥和精细切割菊科的叶子和茎部分，根部和花朵获得，用醇或醇水溶液萃取切割的植物，过滤提取的溶液并在减压下浓缩滤液。还公开了用于预防或治疗糖尿病并发症的药物组合物，用于改善糖尿病并发症的保健功能食品，以及用于预防或延缓衰老的药物组合物和保健功能食品，其含有作为活性成分的，通过以己烷，乙酸乙酯，正丁醇和水组分的顺序对每种所述的所述柯斯萃取物进行分馏得到的至少一种级分。菊科植物的叶和茎提取物，菊科植物的根提取物和白菊的花提取物具有抑制晚期糖基化终产物（AGEs）的产生，糖尿病并发症的原因，并有效抑制醛糖还原酶）活动。因此，所公开的提取物对于预防或治疗糖尿病并发症和预防老化将是非常有用的。

3. 发明申请

WO2007119959A1 COMPOSITION ISOLATED FROM PUERARIAE RADIX FOR PREVENTION OR TREATMENT OF DIABETIC COMPLICATIONS AND A SEPARATION METHOD THEREOF 审中-公开
标题翻译：用于预防或治疗糖尿病并发症的PUERARIAE RADIX分离的组合物及其分离方法
公开(公告)号：WO2007119959A1
公开(公告)日：2007-10-25
申请号：PCT/KR2007/001744
申请日：2007-04-11
申请人： KOREA INSTITUTE OF ORIENTAL MEDICINE , KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook
发明人： KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook
IPC分类号： A61K31/343
CPC分类号： A61K31/343 , A61K36/488
摘要： The present invention relates to compounds isolated from Puerariae Radix for treatment or prevention of diabetic complications and a method for isolating the same. More particularly, it relates to a method for isolating puerariafuran from Puerariae Radix which is effective in prevention or treatment of diabetic complications, prevention or delay of aging and prevention or treatment of cancers by inhibiting formation of advanced glycation end products (AGEs) which is a critical factor in the development of diabetic complications, and puerariafuran prepared therefrom. Puerariafuran, coumestrol, daidzein and genistein isolated from Puerariae Radix according to the present invention have inhibitive effect on production of AGEs which are factors inducing diabetic complications.
摘要翻译：本发明涉及从葛根分离的用于治疗或预防糖尿病并发症的化合物及其分离方法。更具体地说，本发明涉及从葛根葛根分离葛根呋喃的方法，其有效预防或治疗糖尿病并发症，预防或延缓衰老以及通过抑制晚期糖基化终产物（AGE）的形成来预防或治疗癌症糖尿病并发症发展的关键因素和由此制备的葛根呋喃。根据本发明从葛根分离的葛根呋喃，香豆素，黄豆苷原和染料木素对作为诱导糖尿病并发症的因素的AGEs的产生具有抑制作用。

4. 发明申请

WO2007083908A1 A METHOD FOR PREPARING DECURSINOL FROM ANGELICA GIGAS WITH HIGH YIELD 审中-公开
标题翻译：用于制备具有高YIELD的ANGELICA GIGAS的十二烷基磺酸的方法
公开(公告)号：WO2007083908A1
公开(公告)日：2007-07-26
申请号：PCT/KR2007/000251
申请日：2007-01-16
申请人： PARK, Yong Jin , KIM, Joo Hwan , KIM, Jin Sook , SONG, Gyu Yong , LEE, Jee Hyun , JEONG, Hye Gwang , KIM, Dong Hee , YUN, Mi Young , JIN, Wen Yi , SHIM, In Sop , CHOI, Yong Seok
发明人： PARK, Yong Jin , KIM, Joo Hwan , KIM, Jin Sook , SONG, Gyu Yong , LEE, Jee Hyun , JEONG, Hye Gwang , KIM, Dong Hee , YUN, Mi Young , JIN, Wen Yi , SHIM, In Sop , CHOI, Yong Seok
IPC分类号： C07D493/04 , A61K31/35
CPC分类号： C07D493/04
摘要： The present invention relates to a novel process for preparing decursinol (7-hydroxy-8,8-dimethyl-7,8-dihydro-6H-pyrano(3,2-)chromen-2-one) comprising the steps consisting of: extracting dried root of Angelica decursiva Fr. St, with water, lower alcohol or the mixture thereof, filtering and concentrating the filtrate to obtain the extract of root of Angelica decursiva Fr. St at 1st step; suspending and fractionating the extract with non-polar organic solvent selected from ether, chloroform, ethylacetate or acetone solvent to obtain the non-polar soluble extract at 2nd step; subjecting the non-polar soluble extract to basic hydrolysis with base selected from sodium hydroxide, potassium hydroxide, potassium carbonate or sodium carbonate to obtain hydrolyzed product at 3r step; neutralizing the solution with acid and recovering the hydrolyzed decursinol fraction from the solution with non-polar organic solvent selected from ether, chloroform, methylene chloride, ethylacetate or acetone at 4 step; purifying the fraction to obtain purposed decursinol with high-yield.
摘要翻译：本发明涉及一种制备前胡桃醇（7-羟基-8,8-二甲基-7,8-二氢-6H-吡喃并（3,2-）色烯-2-酮）的新方法，包括以下步骤：提取当归干根 St，用水，低级醇或其混合物，过滤并浓缩滤液，得到当归提取物。圣第一步; 用乙醚，氯仿，乙酸乙酯或丙酮溶剂中的非极性有机溶剂悬浮和分馏提取物，在第二步获得非极性可溶性提取物; 将非极性可溶性提取物用选自氢氧化钠，氢氧化钾，碳酸钾或碳酸钠的碱进行碱性水解，得到3r步骤的水解产物; 用酸中和溶液，并用4步的非极性有机溶剂从乙醚，氯仿，二氯甲烷，乙酸乙酯或丙酮中回收水解的前胡烯醇馏分; 纯化该级分以获得高产量的前胡椒醇。

5. 发明申请

WO2008102994A1 COMPOSITION COMPRISING DECURSIN DERIVATIVE FOR TREATING AND PREVENTING ATOPIC DERMATITIS 审中-公开
标题翻译：组合物包含用于治疗和预防原发性损伤的降钙素衍生物
公开(公告)号：WO2008102994A1
公开(公告)日：2008-08-28
申请号：PCT/KR2008/001017
申请日：2008-02-21
申请人： PARK, Yong Jin , KIM, Joo Hwan , SONG, Gyu Yong , WOO, Jin Suk , KIM, Jin Sook , KIM, Dong Hee , LEE, Jee Hyun , YUN, Chi-Young , KIM, In Sik , LEE, Ji Sook , KIM, Young Kook , RHO, Mun Chual , CHOI, Yong Seok
发明人： PARK, Yong Jin , KIM, Joo Hwan , SONG, Gyu Yong , WOO, Jin Suk , KIM, Jin Sook , KIM, Dong Hee , LEE, Jee Hyun , YUN, Chi-Young , KIM, In Sik , LEE, Ji Sook , KIM, Young Kook , RHO, Mun Chual , CHOI, Yong Seok
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： The present invention relates to the novel decursin derivatives, the preparation thereof and the composition comprising the same. The novel decursin derivatives of the present invention showedpotent inhibiting activity of the release of MCP-1, IL-6 and IL-8 induced by dermite in THP-1 or EoL-1 cell, therefore the compounds can be useful in treating or preventing atopic dermatitis.
摘要翻译：本发明涉及新颖的衍生物衍生物及其制备方法及包含其的组合物。本发明的新颖衍生物衍生物显示了在THP-1或EoL-1细胞中由白细胞诱导的MCP-1，IL-6和IL-8释放的强力抑制活性，因此该化合物可用于治疗或预防特应性皮炎。

6. 发明申请

WO2005074963A1 COMPOSITION FOR PREVENTION AND TREATMENT OF DIABETIC COMPLICATION 审中-公开
标题翻译：用于预防和治疗糖尿病合并的组合物
公开(公告)号：WO2005074963A1
公开(公告)日：2005-08-18
申请号：PCT/KR2004/003554
申请日：2004-12-31
申请人： KOREA INSTITUTE OF ORIENTAL MEDICINE , KIM, Jin Sook , LEE, Sang Won , LEE, Yin Mi
发明人： KIM, Jin Sook , LEE, Sang Won , LEE, Yin Mi
IPC分类号： A61K35/78
CPC分类号： A61K36/575 , A23L33/105 , A61K36/47 , A61K36/484 , A61K36/488 , A61K2300/00
摘要： The present invention relates to a composition for the prevention and treatment of diabetic complications, which contains an extract obtained by: crushing and drying any one selected from Euphorbiae radix, gingered Magnolia bark, parched Puerariae radix and Glycyrrhizae radix; extracting the dried herbal material with alcohol or aqueous alcohol solution; filtering the extract; and concentrating the filtrate under reduced pressure. Alternatively, the composition contains a mixture of extracts from Euphorbiae radix, gingered Magnolia bark, parched Puerariae radix and Glycyrrhizae radix, the amount of each of the herbal extracts being 5-85% by weight based on 100% by weight of the herbal extract mixture. Alternatively, the composition contains magnolol obtained by: extracting Magnolia bark with aqueous 80% ethanol solution at ambient temperature for 24 hours; systematically separating the extract in the order of normal-hexane, ethyl acetate and normal-butanol; selecting the normal-hexane layer and separating the selected layer into pre-fractions by normal silica gel chromatography; comparing the pre-fractions with the standard form magnolol on TLC to determine a magnolol-enriched fraction; and separating magnolol from the magnolol-enriched fraction by silica gel column chromatography.
摘要翻译：本发明涉及一种预防和治疗糖尿病并发症的组合物，其含有通过以下方法获得的提取物：将来自大戟，，ered的木兰树皮，茯苓和甘草的任何一种粉碎和干燥; 用酒精或醇水溶液提取干草本材料; 过滤提取物; 并在减压下浓缩滤液。或者，组合物含有来自大戟根，ered ered的木兰皮，灼热葛根和甘草的提取物的混合物，基于100重量％的草药提取物混合物，每个草药提取物的量为5-85重量％。或者，组合物含有通过以下方式获得的厚朴酚：用80％乙醇水溶液在室温下提取木兰树皮24小时; 以正己烷，乙酸乙酯和正丁醇的顺序系统分离提取物; 选择正己烷层，并通过常规硅胶色谱法将所选择的层分离成预成分; 在TLC上比较预分数与标准形式的厚朴酚，以测定富含木酚的部分; 并通过硅胶柱色谱从厚朴酚组分中分离厚朴酚。

7. 发明申请

WO2008105630A1 COMBINED USE OF CELL PERMEABLE NANOG AND OCT4 FOR INCREASING SELF-RENEWAL AND SUPPRESSING DIFFERENTIATION OF STEM CELLS 审中-公开
标题翻译：细胞渗透性纳米和OCT4的组合使用增加自我更新并抑制干细胞的分化
公开(公告)号：WO2008105630A1
公开(公告)日：2008-09-04
申请号：PCT/KR2008/001134
申请日：2008-02-27
申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY , PARK, Yun Kyung , KIM, Jin Sook , JO, Dae Woong
发明人： PARK, Yun Kyung , KIM, Jin Sook , JO, Dae Woong
IPC分类号： C07K14/71
CPC分类号： C07K14/4702
摘要： The present invention discloses cell permeable Nanog and Oct4 recombinant proteins that comprise a kaposi fibroblast growth factor 4 (kFGF4)-derived macromolecule transduction domain (MTD). Also disclosed are polynucleotides encoding the cell permeable Nanog and Oct4 recombinant proteins, a method of increasing self-renewal and suppressing differentiation of stem cells by treating the cells in combination with the cell permeable Nanog and Oct4 recombinant proteins, and the combined use of the cell permeable Nanog and Oct4 recombinant proteins for increasing self-renewal and suppressing differentiation of stem cells.
摘要翻译：本发明公开了包含kaposi成纤维细胞生长因子4（kFGF4）衍生的大分子转导结构域（MTD）的细胞渗透性Nanog和Oct4重组蛋白。还公开了编码细胞渗透性Nanog和Oct4重组蛋白的多核苷酸，通过与细胞渗透性Nanog和Oct4重组蛋白组合处理细胞来增加自我更新和抑制干细胞分化的方法，以及细胞的组合使用可渗透的Nanog和Oct4重组蛋白，用于增强自我更新和抑制干细胞的分化。

8. 发明申请

WO2008093982A1 NOVEL MACROMOLECULE TRANSDUCTION DOMAINS AND METHODS FOR IDENTIFICATION AND USES THEREOF 审中-公开
标题翻译：新型MACROMOLECULE传输域及其识别方法及其应用
公开(公告)号：WO2008093982A1
公开(公告)日：2008-08-07
申请号：PCT/KR2008/000525
申请日：2008-01-29
申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY , JO, Dae Woong , KO, Jae Sun , KIM, Jin Sook , PARK, Kyung Mi , SONG, Jin Kyung , LIM, Jung Hee , DO, Thi Thuy Nga , DO, Thi Lan Phuong , DUONG, Minh Tam
发明人： JO, Dae Woong , KO, Jae Sun , KIM, Jin Sook , PARK, Kyung Mi , SONG, Jin Kyung , LIM, Jung Hee , DO, Thi Thuy Nga , DO, Thi Lan Phuong , DUONG, Minh Tam
IPC分类号： C07K7/04 , C07K7/06 , C07K7/08
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译：本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。

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