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1. 发明申请

WO2008102994A1 COMPOSITION COMPRISING DECURSIN DERIVATIVE FOR TREATING AND PREVENTING ATOPIC DERMATITIS 审中-公开
标题翻译：组合物包含用于治疗和预防原发性损伤的降钙素衍生物
公开(公告)号：WO2008102994A1
公开(公告)日：2008-08-28
申请号：PCT/KR2008/001017
申请日：2008-02-21
申请人： PARK, Yong Jin , KIM, Joo Hwan , SONG, Gyu Yong , WOO, Jin Suk , KIM, Jin Sook , KIM, Dong Hee , LEE, Jee Hyun , YUN, Chi-Young , KIM, In Sik , LEE, Ji Sook , KIM, Young Kook , RHO, Mun Chual , CHOI, Yong Seok
发明人： PARK, Yong Jin , KIM, Joo Hwan , SONG, Gyu Yong , WOO, Jin Suk , KIM, Jin Sook , KIM, Dong Hee , LEE, Jee Hyun , YUN, Chi-Young , KIM, In Sik , LEE, Ji Sook , KIM, Young Kook , RHO, Mun Chual , CHOI, Yong Seok
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： The present invention relates to the novel decursin derivatives, the preparation thereof and the composition comprising the same. The novel decursin derivatives of the present invention showedpotent inhibiting activity of the release of MCP-1, IL-6 and IL-8 induced by dermite in THP-1 or EoL-1 cell, therefore the compounds can be useful in treating or preventing atopic dermatitis.
摘要翻译：本发明涉及新颖的衍生物衍生物及其制备方法及包含其的组合物。本发明的新颖衍生物衍生物显示了在THP-1或EoL-1细胞中由白细胞诱导的MCP-1，IL-6和IL-8释放的强力抑制活性，因此该化合物可用于治疗或预防特应性皮炎。

2. 发明申请

WO2007083908A1 A METHOD FOR PREPARING DECURSINOL FROM ANGELICA GIGAS WITH HIGH YIELD 审中-公开
标题翻译：用于制备具有高YIELD的ANGELICA GIGAS的十二烷基磺酸的方法
公开(公告)号：WO2007083908A1
公开(公告)日：2007-07-26
申请号：PCT/KR2007/000251
申请日：2007-01-16
申请人： PARK, Yong Jin , KIM, Joo Hwan , KIM, Jin Sook , SONG, Gyu Yong , LEE, Jee Hyun , JEONG, Hye Gwang , KIM, Dong Hee , YUN, Mi Young , JIN, Wen Yi , SHIM, In Sop , CHOI, Yong Seok
发明人： PARK, Yong Jin , KIM, Joo Hwan , KIM, Jin Sook , SONG, Gyu Yong , LEE, Jee Hyun , JEONG, Hye Gwang , KIM, Dong Hee , YUN, Mi Young , JIN, Wen Yi , SHIM, In Sop , CHOI, Yong Seok
IPC分类号： C07D493/04 , A61K31/35
CPC分类号： C07D493/04
摘要： The present invention relates to a novel process for preparing decursinol (7-hydroxy-8,8-dimethyl-7,8-dihydro-6H-pyrano(3,2-)chromen-2-one) comprising the steps consisting of: extracting dried root of Angelica decursiva Fr. St, with water, lower alcohol or the mixture thereof, filtering and concentrating the filtrate to obtain the extract of root of Angelica decursiva Fr. St at 1st step; suspending and fractionating the extract with non-polar organic solvent selected from ether, chloroform, ethylacetate or acetone solvent to obtain the non-polar soluble extract at 2nd step; subjecting the non-polar soluble extract to basic hydrolysis with base selected from sodium hydroxide, potassium hydroxide, potassium carbonate or sodium carbonate to obtain hydrolyzed product at 3r step; neutralizing the solution with acid and recovering the hydrolyzed decursinol fraction from the solution with non-polar organic solvent selected from ether, chloroform, methylene chloride, ethylacetate or acetone at 4 step; purifying the fraction to obtain purposed decursinol with high-yield.
摘要翻译：本发明涉及一种制备前胡桃醇（7-羟基-8,8-二甲基-7,8-二氢-6H-吡喃并（3,2-）色烯-2-酮）的新方法，包括以下步骤：提取当归干根 St，用水，低级醇或其混合物，过滤并浓缩滤液，得到当归提取物。圣第一步; 用乙醚，氯仿，乙酸乙酯或丙酮溶剂中的非极性有机溶剂悬浮和分馏提取物，在第二步获得非极性可溶性提取物; 将非极性可溶性提取物用选自氢氧化钠，氢氧化钾，碳酸钾或碳酸钠的碱进行碱性水解，得到3r步骤的水解产物; 用酸中和溶液，并用4步的非极性有机溶剂从乙醚，氯仿，二氯甲烷，乙酸乙酯或丙酮中回收水解的前胡烯醇馏分; 纯化该级分以获得高产量的前胡椒醇。

3. 发明申请

WO2008018645A1 PESTICIDES 审中-公开
标题翻译：农药
公开(公告)号：WO2008018645A1
公开(公告)日：2008-02-14
申请号：PCT/KR2006/003139
申请日：2006-08-10
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , KIM, Young Kook , LEE, Hyun Sun , RHO, Mun Chual , CHOI, Yong Seok , SONG, Gyu Yong
发明人： KIM, Young Kook , LEE, Hyun Sun , RHO, Mun Chual , CHOI, Yong Seok , SONG, Gyu Yong
IPC分类号： A01N31/08 , A01N31/00 , A01P15/00
CPC分类号： A01N41/10
摘要： Disclosed herein are novel compounds and salts thereof having inhibitory activity against the biosynthesis of triglycerides, pesticidal compositions comprising the same as active ingredients, and a method for killing insects using the same. Functioning to inhibit the activity of diacyl CoA: glycerol acyltransferase, the novel compounds deny insects triglycerides, which are essential for their growth, thereby having a potent pesticidal effect. The compounds are safe for humans and may be used as environment- friendly pesticides.
摘要翻译：本文公开了具有抑制甘油三酯生物合成的抑制活性的新化合物及其盐，包含与活性成分相同的杀虫组合物，以及使用其杀死昆虫的方法。通过抑制二酰基CoA：甘油酰基转移酶的活性，新型化合物可以抵抗昆虫甘油三酸酯，这些甘油三酯对其生长至关重要，从而具有很强的杀虫作用。这些化合物对人类是安全的，可以用作环保农药。

4. 发明申请

WO2008004817A1 NOVEL DECURSIN DERIVATIVES AND THE USE THEREOF 审中-公开
标题翻译：新的德固辛衍生物及其用途
公开(公告)号：WO2008004817A1
公开(公告)日：2008-01-10
申请号：PCT/KR2007/003257
申请日：2007-07-04
申请人： PARK, Yong Jin , SONG, Gyu Yong , LEE, Jee Hyun , CHOI, Yong Seok , YUN, Mi Young , SHEN, Gui Nam , KIM, Eui Keom , KIM, Sung Hoon
发明人： PARK, Yong Jin , SONG, Gyu Yong , LEE, Jee Hyun , CHOI, Yong Seok , YUN, Mi Young , SHEN, Gui Nam , KIM, Eui Keom , KIM, Sung Hoon
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： The present invention relates to novel (+)-decursin derivatives having anti-cancer activity, the preparation thereof and a composition containing the same for treating cancer disease. The (+)-decursin derivatives of the present invention showed potent inhibiting effect on the cancer cell being confirmed by various experiments such as cytotoxicity test in A549 lung cancer cell line, HCT15 colon cancer cell line and ACHN rectal cancer cell line, therefore the compounds can be useful in treating or preventing cancer diseases as an anti-cancer agent, health care food, or functional health food.
摘要翻译：本发明涉及具有抗癌活性的新型（+） - 去甲衍生物，其制备方法和含有该抗癌活性的组合物。本发明的（+） - 去甲衍生物通过A549肺癌细胞系，HCT15结肠癌细胞系和ACHN直肠癌细胞系的细胞毒性试验等各种实验证实，对癌细胞具有有效的抑制作用，因此化合物可用于治疗或预防作为抗癌剂，保健食品或功能保健食品的癌症疾病。

5. 发明申请

WO2008133387A1 NEW ACYCLIC TRITERPENOIDS COMPOUND, AND PHARMACEUTICAL COMPOSITION COMPRISING ALPINIA KATSUMADAI EXTRACT OR ACYCLIC TRITERPENOIDS COMPOUNDS ISOLATED FROM THE SAME 审中-公开
标题翻译：新型ACYCLIC TRITERPENOIDS化合物和包含ALPINIA KATSUMADAI萃取物的药物组合物或从其分离的ACYCLIC TRITERPENOIDS化合物
公开(公告)号：WO2008133387A1
公开(公告)日：2008-11-06
申请号：PCT/KR2007/005787
申请日：2007-11-16
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , RHO, Mun-Chual , KIM, Young-Kook , LEE, Hyun-Sun , JUN, Chang-Duk , KIM, Koanhoi , LEE, Seung-Woong , CHOI, Jung Ho , SONG, Gyu Yong
发明人： RHO, Mun-Chual , KIM, Young-Kook , LEE, Hyun-Sun , JUN, Chang-Duk , KIM, Koanhoi , LEE, Seung-Woong , CHOI, Jung Ho , SONG, Gyu Yong
IPC分类号： C07J3/00
CPC分类号： C07J3/00
摘要： The present invention relates to a novel acyclic triterpenoid compound and a pharmaceutical composition comprising an Alpinia katsumadai extract or acyclic triterpenoid compound isolated therefrom. The Alpinia katsumadai extract or acyclic triterpenoid compound isolated therefrom of the present invention inhibits ICAM-1/LFA-1 mediated cell adhesion to effectively inhibit the adhesion and infiltration of blood cells such as monocytes, neutrophils and lymphocytes to vascular endothelial cells, thereby being used for preventing or treating diseases caused by ICAM-1/LFA-1 mediated cell adhesion.
摘要翻译：本发明涉及一种新型无环三萜化合物和一种药物组合物，其包含从其分离的卡介丝提取物或无环三萜化合物。由本发明分离的高山ai ai提取物或无环三萜化合物抑制ICAM-1 / LFA-1介导的细胞粘附以有效抑制血管细胞如单核细胞，嗜中性粒细胞和淋巴细胞对血管内皮细胞的粘附和浸润，由此被使用用于预防或治疗由ICAM-1 / LFA-1介导的细胞粘附引起的疾病。

6. 发明申请

WO2009014287A1 THE COMPOSITION FOR KILLING INSECTS COMPRISING AZOLE COMPOUNDS AS AN EFFECTIVE INGREDIENT 审中-公开
标题翻译：杀死化学成分的组合物作为有效成分包含AZOLE化合物
公开(公告)号：WO2009014287A1
公开(公告)日：2009-01-29
申请号：PCT/KR2007/006501
申请日：2007-12-13
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , KIM, Young-Kook , LEE, Kyeong , LEE, Jung Joon , LEE, Hyun-Sun , RHO, Mun-Chual , CHOI, Yongseok , SONG, Gyu Yong
发明人： KIM, Young-Kook , LEE, Kyeong , LEE, Jung Joon , LEE, Hyun-Sun , RHO, Mun-Chual , CHOI, Yongseok , SONG, Gyu Yong
IPC分类号： A01N43/90
CPC分类号： A01N43/52 , A01N43/76
摘要： The present invention relates to an insecticide composition containing the azole compound synthesized organic chemically as an active ingredient and a method for killing insects using the same. The azole compound of the present invention has the effect of spoiling appetite in larvae and excellent insecticidal activity, so that it can be used as a pro-environmental insecticide.
摘要翻译：本发明涉及含有化学有机化合物的唑类化合物作为活性成分的杀虫剂组合物和使用其杀死昆虫的方法。本发明的唑类化合物具有破坏幼虫食欲和极好的杀虫活性的作用，因此可用作亲环境杀虫剂。

7. 发明申请

WO2007133054A1 A NOVEL PROCESS FOR PREPARING BLACK GINSENG AND THE COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：制备黑金刚的新方法和包含其的组合物
公开(公告)号：WO2007133054A1
公开(公告)日：2007-11-22
申请号：PCT/KR2007/002418
申请日：2007-05-17
申请人： THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) , SONG, Gyu Yong , LEE, Jee Hyun , PARK, Yong Jin , MYUNG, Chang Seon , OH, Han Jin , SHIN, Hyun Joong , SEO, Young Bae
发明人： SONG, Gyu Yong , LEE, Jee Hyun , PARK, Yong Jin , MYUNG, Chang Seon , OH, Han Jin , SHIN, Hyun Joong , SEO, Young Bae
IPC分类号： A23L1/212
CPC分类号： A61K36/258 , A23L33/105 , A23V2002/00 , A23V2250/2124 , A23V2200/308
摘要： The present invention relates to a novel process for preparing black ginseng showing shorter time, easier to mass production than other conventional methods for preparing black ginseng and the inventive extract contains more abundant amount of ginseng saponin and showed potent anti-cancer effect.
摘要翻译：本发明涉及一种制备黑参的新方法，其比制备黑参的其它常规方法更短时间，更容易批量生产，本发明提取物含有更多的人参皂苷并显示出有效的抗癌作用。

8. 发明申请

WO2008060112A1 COMPOSITION COMPRISING ARALIAE CORDATAE RADIX EXTRACT OR COMPOUNDS ISOLATED FROM THE SAME FOR PREVENTING OR TREATING PERIODONTITIS 审中-公开
标题翻译：包含ARALIAE CORDATAE RADIX提取物或其化合物的组合物从其分离用于预防或治疗周期性
公开(公告)号：WO2008060112A1
公开(公告)日：2008-05-22
申请号：PCT/KR2007/005741
申请日：2007-11-15
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Dae-sil , KOH, Sukhoon , KIM, Joong Su , BAE, Jungdon , KIM, Dooil , PARK, Jung Eun , PARK, Miri , CHOI, Yongseok , PARK, Bo Hyun , KIM, Jin Sook , JANG, Dae Sik , KOOK, Joong-ki , SONG, Gyu Yong
发明人： LEE, Dae-sil , KOH, Sukhoon , KIM, Joong Su , BAE, Jungdon , KIM, Dooil , PARK, Jung Eun , PARK, Miri , CHOI, Yongseok , PARK, Bo Hyun , KIM, Jin Sook , JANG, Dae Sik , KOOK, Joong-ki , SONG, Gyu Yong
IPC分类号： A61K36/25 , A61K31/19 , A23L1/29 , A61P1/02
CPC分类号： A61K31/19 , A23L33/105 , A61K36/25
摘要： The present invention relates to a composition comprising an Araliae Cordatae Radix extract or compounds isolated from the same for preventing or treating periodontitis. The Araliae Cordatae Radix extract or compounds isolated from the extract according to the present invention has/have excellent antimicrobial and bactericidal activities against Porphyromonas endodontalis, Porphyromonas gingivalis and Prevotella intermedia, which are periodontal pathogens, thereby being used to prevent or treat periodontitis.
摘要翻译：本发明涉及包含Araliae Cordatae Radix提取物或从其分离的用于预防或治疗牙周炎的化合物的组合物。根据本发明的提取物中分离出的Araliae Cordatae Radix提取物或化合物对牙龈卟啉单胞菌属牙龈卟啉单胞菌和牙周膜间质瘤具有优异的抗菌和杀菌活性，它们是牙周病原体，因此用于预防或治疗牙周炎。

9. 发明申请

WO2008147141A1 A METHOD FOR PREPARING NOVEL BLACK-RED GINSENG AND THE EXTRACT THEREFROM AND THE COMPOSITION COMPRISING THE EXTRACT ISOLATED THEREFROM 审中-公开
标题翻译：一种制备新型黑红葡萄酒及其提取物的方法及包含其中分离的提取物的组合物
公开(公告)号：WO2008147141A1
公开(公告)日：2008-12-04
申请号：PCT/KR2008/003057
申请日：2008-05-30
申请人： PARK, Yong Jin , SONG, Gyu Yong , KIM, Sang Kyum , KIM, Eui Keom , SONG, Woo Yong , LEE, Chung Yeol
发明人： PARK, Yong Jin , SONG, Gyu Yong , KIM, Sang Kyum , KIM, Eui Keom , SONG, Woo Yong , LEE, Chung Yeol
IPC分类号： A23L1/212
CPC分类号： A23L33/105
摘要： The present invention relates the present invention relates to a novel process for preparing black-red ginseng and the extract isolated therefrom. The inventive extracts of the present invention showed more favorable advantages than the conventionally known red ginseng and black ginseng, for example, (1) the extract of black-red ginseng contains Rg2, Rg3, RhI, Rh2 and Rkl+Rg5, a trace component of red ginseng, as well as RbI, Rb2, Rc, Rd, Re and RgI, a trace component of black ginseng; (2) the inventive black red ginseng showed better final product having finely textured structure comparing with black ginseng with porous structure; (3) the extract of black-red ginseng contains no carcinogens such as benzopyrene, pyrane etc comparing with that of black ginseng; (4) the inventive black red ginseng showed more potent anti-cancer activity than that of red ginseng; (5) the inventive black-red ginseng showed more potent anti-oxidative activity than that of red ginseng, therefore, it can be used as a pharmaceutical composition and health functional food for treating and preventing cancer and hyper- oxidation-involved disease.
摘要翻译：本发明涉及一种制备黑参人参的新方法和从其中分离的提取物。本发明的本发明提取物比常规已知的红参和黑参具有更好的优点，例如（1）黑红参提取物含有Rg2，Rg3，RhI，Rh2和Rk1 + Rg5，痕量成分红参的RbI，Rb2，Rc，Rd，Re和RgI是黑参的微量成分; （2）与具有多孔结构的黑参相比，本发明的黑红参显示出具有细纹理结构的更好的最终产品; （3）与黑参相比，黑红参提取物不含苯并芘，吡喃等致癌物质; （4）本发明黑参人参比红参显示出更强的抗癌活性; （5）本发明的黑参人参比红参表现出更强的抗氧化活性，因此可用作治疗和预防癌症和超氧化相关疾病的药物组合物和保健功能食品。

10. 发明申请

WO2006006751A1 A COMPOSITION COMPRISING PURIFIED EXTRACT OF WILD GINSENG HAVING NEURONAL CELL PROTECTING ACTIVITY 审中-公开
标题翻译：包含具有神经细胞保护活性的金山纯化提取物的组合物
公开(公告)号：WO2006006751A1
公开(公告)日：2006-01-19
申请号：PCT/KR2004/001942
申请日：2004-08-02
申请人： SEOCKSANTEO MEDICAL CO., LTD. , PARK, Yong Jin , SHIM, In Sop , SONG, Gyu Yong
发明人： PARK, Yong Jin , SHIM, In Sop , SONG, Gyu Yong
IPC分类号： A61K35/78
CPC分类号： A61K36/258
摘要： The present invention relates to a use of a purified extract prepared by the method comprising the steps consisting of; subjecting the wild ginseng material to distillation extracting method with extracting solvent repeatedly; freezing the distilled extract to obtain frozen purified extract; thawing the extract and filtrating to obtain purified extract for the preparation of a pharmaceutical composition for the treatment and prevention of degenerative brain disease by protecting neuronal cell in human or mammal, and a composition comprising the same prepared by inventive method. The composition have potent neuronal cell protective activity, therefore, it can be used as the therapeutics for treating and preventing neuro-degenerative brain diseases caused by neuronal cell such as death stroke, apoplexy, dementia, Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease, Pick's disease and Creutzfeld-Jakob's disease and the like.
摘要翻译：本发明涉及通过包括以下步骤的方法制备的纯化提取物的用途：将野参人参材料进行蒸馏提取，反复萃取溶剂; 冷冻蒸馏提取物，得到冷冻纯化提取物; 解冻提取物并过滤以获得纯化的提取物，用于制备用于通过保护人或哺乳动物中的神经元细胞来治疗和预防退行性脑病的药物组合物，以及包含通过本发明方法制备的组合物的组合物。该组合物具有有效的神经元细胞保护活性，因此可用作治疗和预防神经元细胞如死亡中风，中风，痴呆，阿尔茨海默病（AD），帕金森病（PD）），亨廷顿疾病，皮克病和克雅氏病等。

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