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1. 发明专利

CA2676797C NOVEL MACROMOLECULE TRANSDUCTION DOMAINS AND METHODS FOR IDENTIFICATION AND USES THEREOF 未知
公开(公告)号：CA2676797C
公开(公告)日：2014-04-22
申请号：CA2676797
申请日：2008-01-29
申请人： JO DAE WOONG , KO JAE SUN , KIM JIN SOOK , PARK KYUNG MI , SONG JIN KYUNG , LIM JUNG HEE , DO THI THUY NGA , DO THI LAN PHUONG , DUONG MINH TAM
发明人： JO DAE WOONG , KO JAE SUN , KIM JIN SOOK , PARK KYUNG MI , SONG JIN KYUNG , LIM JUNG HEE , DO THI THUY NGA , DO THI LAN PHUONG , DUONG MINH TAM
IPC分类号： C07K7/04 , C07K7/06 , C07K7/08
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.

2. 发明申请

WO2009145489A2 CELL-PERMEABLE ENDOSTATIN RECOMBINANT PROTEIN, A POLYNUCLEOTIDE COATED WITH THE SAME, AND AN ANTI-CANCER PREPARATION CONTAINING THE SAME AS AN ACTIVE COMPONENT 审中-公开
标题翻译：细胞渗透性内切素重组蛋白，与其包被的多核苷酸，以及包含其作为活性成分的抗癌制剂
公开(公告)号：WO2009145489A2
公开(公告)日：2009-12-03
申请号：PCT/KR2009001726
申请日：2009-04-03
申请人： PROCELL THERAPEUTICS INC , JO DAEWOONG , LEE JONG MIN , PARK KYOUNGHO , DUONG MINH TAM
发明人： JO DAEWOONG , LEE JONG MIN , PARK KYOUNGHO , DUONG MINH TAM
IPC分类号： C07K19/00 , A61K38/17 , A61P35/00 , C07K14/47 , C12N15/62
CPC分类号： C07K14/78 , A61K38/17 , C07K2319/01
摘要： The present invention relates to: a cell-permeable endostatin recombinant protein in which a macromolecule transduction domain (MTD) is fused to an angiogenesis inhibitor (angiogenic inhibitor) endostatin; a polynucleotide coated with the cell-permeable endostatin recombinant protein; an expression vector for the cell-permeable endostatin recombinant protein; and a pharmacological composition for an anti-cancer preparation with improved cancer angiogenesis inhibiting activity, which contains the cell-permeable endostatin recombinant protein as an active component. The cell-permeable endostatin recombinant protein according to the present invention can block the formation of microvessels and inhibit migration, proliferation, penetration, tube formation and the like of vascular endothelial cells present in tumor tissue by introducing angiogenesis inhibiting factor endostatin into the cell in a highly efficient fashion, and it exhibits outstanding anti-cancer activity and so can be used to good effect as an anti-cancer preparation used against various cancers.
摘要翻译：本发明涉及一种细胞可渗透的内皮抑素重组蛋白，其中大分子转导结构域（MTD）与血管发生抑制剂（血管生成抑制剂）内皮抑制素融合; 涂覆有细胞可渗透内皮抑素重组蛋白的多核苷酸; 用于细胞渗透性内皮抑素重组蛋白的表达载体; 以及具有改善的癌血管生成抑制活性的抗癌制剂的药理学组合物，其含有细胞可渗透的内皮抑素重组蛋白作为活性成分。根据本发明的细胞可渗透的内皮抑素重组蛋白可通过将血管生成抑制因子内皮抑制素引入细胞中来阻断微血管的形成并抑制存在于肿瘤组织中的血管内皮细胞的迁移，增殖，穿透，管形成等高效时尚，具有突出的抗癌活性，因此可用于作为抗癌制剂用于各种癌症的良好效果。

3. 发明申请

WO2008093982A1 NOVEL MACROMOLECULE TRANSDUCTION DOMAINS AND METHODS FOR IDENTIFICATION AND USES THEREOF 审中-公开
标题翻译：新型MACROMOLECULE传输域及其识别方法及其应用
公开(公告)号：WO2008093982A1
公开(公告)日：2008-08-07
申请号：PCT/KR2008/000525
申请日：2008-01-29
申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY , JO, Dae Woong , KO, Jae Sun , KIM, Jin Sook , PARK, Kyung Mi , SONG, Jin Kyung , LIM, Jung Hee , DO, Thi Thuy Nga , DO, Thi Lan Phuong , DUONG, Minh Tam
发明人： JO, Dae Woong , KO, Jae Sun , KIM, Jin Sook , PARK, Kyung Mi , SONG, Jin Kyung , LIM, Jung Hee , DO, Thi Thuy Nga , DO, Thi Lan Phuong , DUONG, Minh Tam
IPC分类号： C07K7/04 , C07K7/06 , C07K7/08
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译：本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。

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