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1. 发明申请

WO2008111013A2 BEAD ASSISTED ANALYTE DETECTION 审中-公开
标题翻译： BEAD辅助分析检测
公开(公告)号：WO2008111013A2
公开(公告)日：2008-09-18
申请号：PCT/IB2008/050967
申请日：2008-03-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE THEIJE, Femke, K. , BOHMER, Marcel, R. , SCHROEDERS, Richard, J., M. , IMMINK, Albert, H., J.
发明人： DE THEIJE, Femke, K. , BOHMER, Marcel, R. , SCHROEDERS, Richard, J., M. , IMMINK, Albert, H., J.
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , B82Y25/00 , G01N27/745 , H01F1/0054 , H01F13/00
摘要： The present invention relates to beads (7) for use in biotechnical applications such as biosensing. The beads (7) comprise at least one magnetic or magnetisable particle (34) and an organic moiety and are freeze-dried. The latter has the advantage that the reactivity of such particles is low, resulting in a longer shelf life. Furthermore, as the beads comprise a magnetic or magnetisable component, this allows accurately providing and positioning of the beads in a biosensor, e.g. by magnetic actuation. The magnetic or magnetisable component furthermore can be used as labels during biosensing. A method of manufacturing the beads, a method for analyzing sample fluid using the beads and a sensor system and method of manufacturing thereof also is disclosed.
摘要翻译：本发明涉及用于生物技术应用例如生物传感的珠粒（7）。珠粒（7）包含至少一种磁性或可磁化颗粒（34）和有机部分，并被冷冻干燥。后者的优点在于这种颗粒的反应性低，从而延长了保存期限。此外，由于珠粒包含磁性或可磁化的组分，这允许珠子准确地提供和定位在生物传感器中，例如，通过磁力驱动。此外，磁性或可磁化组分可以在生物传感期间用作标签。公开了一种制造珠的方法，使用该珠分析样品流体的方法和传感器系统及其制造方法。

2. 发明申请

WO2007085990A1 METHOD FOR PRODUCING A PARTICLE COMPRISING A GAS CORE AND A SHELL AND PARTICLES THUS OBTAINED 审中-公开
标题翻译：生产包含气体核的颗粒和获得的壳和颗粒的方法
公开(公告)号：WO2007085990A1
公开(公告)日：2007-08-02
申请号：PCT/IB2007/050186
申请日：2007-01-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOHMER, Marcel, R. , DE WINTER, Suzanna, H., P., M. , SHI, William, T. , HALL, Christopher , DE JONG, Nico , VAN WAMEL, Johanna, E., T. , EMMER, Marcia
发明人： BOHMER, Marcel, R. , DE WINTER, Suzanna, H., P., M. , SHI, William, T. , HALL, Christopher , DE JONG, Nico , VAN WAMEL, Johanna, E., T. , EMMER, Marcia
IPC分类号： A61K9/50
CPC分类号： A61K49/223 , A61K9/5031 , A61K9/5089 , A61K41/0028
摘要： The invention relates to a method for the preparation of particles comprising a gas core and shell which particles are suitable for use as contrast agent and as part of a therapeutic composition, especially for drug delivery. These particles show a surprisingly high activation level on provision of ultrasound energy.
摘要翻译：本发明涉及一种制备包含气芯和壳的颗粒的方法，所述颗粒适合用作造影剂和作为治疗组合物的一部分，特别是用于药物递送。这些颗粒在提供超声能量时表现出惊人的高活化水平。

3. 发明申请

WO2009053900A1 METHODS FOR PREPARING POLYMER MICROPARTICLES 审中-公开
标题翻译：制备聚合物微球的方法
公开(公告)号：WO2009053900A1
公开(公告)日：2009-04-30
申请号：PCT/IB2008/054324
申请日：2008-10-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , OCTOPLUS SCIENCES B.V. , BOHMER, Marcel, R. , STEENBAKKERS, Johannes, A., M. , DE WINTER, Suzanna, H., P., M. , BECHET, Anne , VERRIJK, Rudolf
发明人： BOHMER, Marcel, R. , STEENBAKKERS, Johannes, A., M. , DE WINTER, Suzanna, H., P., M. , BECHET, Anne , VERRIJK, Rudolf
IPC分类号： A61K9/16 , B01J2/06 , B01J2/08 , B01J2/18
CPC分类号： A61K9/1647 , A61K9/1635 , A61K9/1641 , B01J2/06 , B01J2/08 , B01J2/18
摘要： The present invention describes methods and tools for preparing a population ofmonodisperse polymer microparticles, which are of particular interestin the field of drug delivery.
摘要翻译：本发明描述了用于制备在药物递送领域中特别有兴趣的单分散聚合物微粒群的方法和工具。

4. 发明申请

WO2006006123A1 LIGHT MODULATOR 审中-公开
标题翻译：光调制器
公开(公告)号：WO2006006123A1
公开(公告)日：2006-01-19
申请号：PCT/IB2005/052223
申请日：2005-07-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAESJOU, Patrick , JOHNSON, Mark, T. , SCHLANGEN, Lucas, J., M. , RIETJENS, Gerardus, H. , BOHMER, Marcel, R. , DUINEVELD, Paulus, C.
发明人： BAESJOU, Patrick , JOHNSON, Mark, T. , SCHLANGEN, Lucas, J., M. , RIETJENS, Gerardus, H. , BOHMER, Marcel, R. , DUINEVELD, Paulus, C.
IPC分类号： G02F1/167
CPC分类号： G02F1/167
摘要： The light modulator for modulating light has a light modulating element, having a medium with a particle (6) and an optical state depending on the position of the particle (6), and a particle controller (10,11,100) being arranged to enable a movement of the particle (6) to one of the positions for modulating the light. For the light modulator to have a particle (6) which can relatively easily be moved, the particle (6) has a carrier particle (81) which contributes in operation to the ability of the particle (6) to be moved and is substantially non-contributing to the optical state, and an optical particle (86) which has an optical property for contributing to the optical state, is associated with the carrier particle (81), and has a position depending on the position of the carrier particle (81).
摘要翻译：用于调制光的光调制器具有光调制元件，具有具有颗粒（6）的介质和取决于颗粒（6）的位置的光学状态，并且颗粒控制器（10,11,100）被布置成使得能够颗粒（6）移动到用于调制光的位置之一。对于光调制器具有可以相对容易地移动的颗粒（6），颗粒（6）具有载体颗粒（81），其有助于使颗粒（6）移动的能力运行，并且基本上不是 - 具有光学状态的光学粒子（86）和具有促进光学状态的光学特性的光学粒子（86）与载体颗粒（81）相关联，并且具有取决于载体颗粒（81）的位置的位置）。

5. 发明申请

WO2009115967A2 METHOD FOR THE SYNTHESIS OF HOLLOW SPHERES 审中-公开
标题翻译：合成空心球的方法
公开(公告)号：WO2009115967A2
公开(公告)日：2009-09-24
申请号：PCT/IB2009/051052
申请日：2009-03-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOHMER, Marcel, R. , CHLON, Caecilia, H., T. , SHI, William, T. , HALL, Christopher, S.
发明人： BOHMER, Marcel, R. , CHLON, Caecilia, H., T. , SHI, William, T. , HALL, Christopher, S.
IPC分类号： A61K49/22 , A61K41/00 , A61K9/51 , B01J13/12
CPC分类号： A61K49/223 , A61K9/5153 , A61K9/5192 , A61K41/0028 , A61K49/0002 , B01J13/125
摘要： The present invention relates to a method of synthesizing acoustically active biodegradable hollow spheres with a size below 1 micron. By using water soluble organic solvents and pegylated polymers, direct precipitation of these spheres is facilitated leading to a fast and convenient preparation route.
摘要翻译：本发明涉及一种合成尺寸小于1微米的声学活性生物可降解空心球的方法。通过使用水溶性有机溶剂和聚乙二醇化聚合物，这些球体的直接沉淀便于进行，从而导致快速和方便的制备途径。

6. 发明申请

WO2009053885A2 METHODS FOR PREPARING POLYMER MICROPARTICLES 审中-公开
标题翻译：制备聚合物微球的方法
公开(公告)号：WO2009053885A2
公开(公告)日：2009-04-30
申请号：PCT/IB2008/054300
申请日：2008-10-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOHMER, Marcel, R. , STEENBAKKERS, Johannes, A., M. , DE WINTER, Suzanna, H., P., M.
发明人： BOHMER, Marcel, R. , STEENBAKKERS, Johannes, A., M. , DE WINTER, Suzanna, H., P., M.
IPC分类号： A61K9/16 , B01J2/02
CPC分类号： A61K9/1694 , A61K9/1647 , B01J2/06 , B01J2/08 , B01J2/18 , B01J13/04
摘要： The present invention describes methods and tools for preparing a population of monodisperse polymer microparticles, which are of particular interest in the field of drug delivery.
摘要翻译：本发明描述了用于制备单分散聚合物微粒群体的方法和工具，其在药物递送领域是特别有意义的。

7. 发明申请

WO2006046202A1 APPARATUS AND METHODS FOR THE PRODUCTION OF ULTRASOUND CONTRAST AGENTS 审中-公开
标题翻译：用于生产超声对比剂的装置和方法
公开(公告)号：WO2006046202A1
公开(公告)日：2006-05-04
申请号：PCT/IB2005/053488
申请日：2005-10-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOHMER, Marcel, R. , WIMBERGER-FRIEDL, Reinhold
发明人： BOHMER, Marcel, R. , WIMBERGER-FRIEDL, Reinhold
IPC分类号： B01F3/04
CPC分类号： B01F3/04439 , A61K49/223 , B01F5/0475 , B01F5/0476
摘要： Disclosed is a method of making gas bubbles in a liquid, the bubbles having substantially uniform size suitable for responding to ultrasound or other diagnostic tools. Gas (P2) is forced through one or more pores or nozzles, into the liquid (P1), the nozzles or pores being of substantially uniform diameter, the flow of the gas being controlled to thereby cause the formation of substantially monodisperse gas bubbles in the liquid. Moreover, an apparatus is disclosed for making a suspension of gas bubbles in a liquid of a size suitable for responding to ultrasound or other diagnostic tools. Said apparatus comprises means for forcing a gas through an array of nozzles or pores into the liquid, the nozzles or pores being of substantially uniform diameter, and first means for controlling; a flow parameter of the gas so that gas is suspended as substantially monodisperse gas bubbles in the liquid. Furthermore a kit for preparing a dispersion of gas bubbles of substantially uniform size suitable for ultrasound purposes, is disclosed.
摘要翻译：公开了一种在液体中制造气泡的方法，气泡具有适合于响应超声波或其它诊断工具的基本均匀的尺寸。气体（P2）被迫通过一个或多个孔或喷嘴进入液体（P1），喷嘴或孔具有基本上均匀的直径，气体的流动受到控制，从而在该气体中产生基本上单分散的气泡液体。此外，公开了一种用于使气泡悬浮在适于响应于超声波或其它诊断工具的尺寸的液体中的装置。所述设备包括用于迫使气体通过喷嘴或孔阵列进入液体的装置，所述喷嘴或孔具有基本均匀的直径，以及用于控制的第一装置; 气体的流动参数使得气体作为基本上单分散的气泡悬浮在液体中。此外，公开了一种用于制备适合于超声波目的基本均匀尺寸的气泡分散体的试剂盒。

8. 发明申请

WO2006046200A1 PREPARATION OF DISPERSIONS OF PARTICLES FOR USE AS CONTRAST AGENTS IN ULTRASOUND IMAGING 审中-公开
标题翻译：在超声成像中作为对比剂使用颗粒分散液的制备
公开(公告)号：WO2006046200A1
公开(公告)日：2006-05-04
申请号：PCT/IB2005/053486
申请日：2005-10-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOHMER, Marcel, R. , GRUELL, Holger , ROOZEBOOM, Freddy , KEMMEREN, Antonius, L., A., M.
发明人： BOHMER, Marcel, R. , GRUELL, Holger , ROOZEBOOM, Freddy , KEMMEREN, Antonius, L., A., M.
IPC分类号： B01F13/00 , B01F3/08 , B01F5/04 , A61K49/22
CPC分类号： B01F3/0865 , A61K49/223 , A61K49/225 , B01F3/0807 , B01F3/0811 , B01F3/0819 , B01F5/0453 , B01F5/0475 , B01F13/0059 , B01F15/0255
摘要： A method of making a suspension of particles in a first fluid of a size suitable for responding to ultrasound, by forcing a second fluid (2) through an array of pores (30) into the first fluid (1), the pores being of substantially uniform diameter, and the pressure of the second fluid and a flow rate of the first fluid across the pores being arranged so that shear forces at the pores cause the second fluid to be suspended as substantially monodisperse particles in the first fluid. This can enable a more monodisperse suspension. The array of pores can be an etched silicon array. The suspension can be used as a contrast agent, or can be an emulsion to make droplets of a precursor material, which can be formed into capsules with a core and a shell. A liquid core can be converted to a gas to provide hollow shells.
摘要翻译：一种通过迫使第二流体（2）穿过孔（30）阵列进入第一流体（1），使颗粒悬浮在适于响应于超声波的尺寸的第一流体中的悬浮液的方法，所述孔基本上均匀的直径，并且第二流体的压力和穿过孔的第一流体的流量被布置成使得孔处的剪切力使得第二流体作为基本上单分散的颗粒悬浮在第一流体中。这可以使更多的单分散悬浮液。孔阵列可以是蚀刻硅阵列。悬浮液可以用作造影剂，或者可以是乳液，以制备可以形成具有核和壳的胶囊的前体材料的液滴。液芯可以转化为气体以提供中空的外壳。

9. 发明申请

WO2008117192A1 A CHEMOTAXIS ASSAY BASED ON CHEMOTACTIC AGENTS RELEASING CARRIER STRUCTURES 审中-公开
标题翻译：基于化学药剂的化学试剂释放载体结构
公开(公告)号：WO2008117192A1
公开(公告)日：2008-10-02
申请号：PCT/IB2008/050950
申请日：2008-03-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , MERKLE, Dennis , BOHMER, Marcel, R. , DE HOOG, Thomas, J. , GILLIES, Murray, F. , VULTO, Simone, I., E.
发明人： MERKLE, Dennis , BOHMER, Marcel, R. , DE HOOG, Thomas, J. , GILLIES, Murray, F. , VULTO, Simone, I., E.
IPC分类号： G01N33/50
CPC分类号： G01N33/5029 , B01L3/502761 , B01L2200/0668 , B01L2400/0424 , B03C5/005 , B03C5/026 , G01N33/54313 , G01N33/5438
摘要： The present invention is concerned inter alia with a method of detecting movement of cells by dielectrophoresis. The present invention is further concerned with providing a dielectrophoresis device for detecting movement of cells.
摘要翻译：本发明特别涉及通过介电电泳检测细胞运动的方法。本发明还涉及提供一种用于检测细胞运动的介电电泳装置。

10. 发明公开

EP2265292A2 METHOD FOR THE SYNTHESIS OF HOLLOW SPHERES 审中-公开
标题翻译： VERFAHREN ZUR SYNTHESE VON HOHLKUGELN
公开(公告)号：EP2265292A2
公开(公告)日：2010-12-29
申请号：EP09723081.7
申请日：2009-03-13
申请人： Koninklijke Philips Electronics N.V.
发明人： BOHMER, Marcel, R. , CHLON, Caecilia, H., T. , SHI, William, T. , HALL, Christopher, S.
IPC分类号： A61K49/22 , A61K41/00 , A61K47/48 , B01J13/12 , A61K9/51
CPC分类号： A61K49/223 , A61K9/5153 , A61K9/5192 , A61K41/0028 , A61K49/0002 , B01J13/125
摘要： The present invention relates to a method of synthesizing acoustically active biodegradable hollow spheres. By using water soluble organic solvents and pegylated polymers, direct precipitation of these spheres is facilitated leading to a fast and convenient preparation route.
摘要翻译：本发明涉及一种合成声学活性的可生物降解的中空球的方法。通过使用水溶性有机溶剂和聚乙二醇化聚合物，促进这些球体的直接沉淀，从而导致快速和方便的制备途径。

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