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1. 发明申请

WO2011001337A1 MAGNETIC SENSOR DEVICE, METHOD OF OPERATING SUCH A DEVICE AND SAMPLE 审中-公开
标题翻译：磁传感器装置，操作这种装置和样品的方法
公开(公告)号：WO2011001337A1
公开(公告)日：2011-01-06
申请号：PCT/IB2010/052880
申请日：2010-06-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , DITTMER, Wendy, U. , DE THEIJE, Femke, K. , IMMINK, Albert, H., J. , NIEWENHUIS, Jeroen, H. , VAN LANKVELT, Petrus, J., W.
发明人： DITTMER, Wendy, U. , DE THEIJE, Femke, K. , IMMINK, Albert, H., J. , NIEWENHUIS, Jeroen, H.
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N21/552 , G01N27/745 , G01N33/54366 , G01N33/54386
摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40'). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14') from the detection of the further detectable label (40') in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14') falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.
摘要翻译：公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生第二检测信号在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。

2. 发明公开

EP2449382A1 MAGNETIC SENSOR DEVICE, METHOD OF OPERATING SUCH A DEVICE AND SAMPLE 有权转让
标题翻译：磁性传感器装置，用于操作这样的装置和探头
公开(公告)号：EP2449382A1
公开(公告)日：2012-05-09
申请号：EP10734820.3
申请日：2010-06-24
申请人： Koninklijke Philips Electronics N.V. , Van Lankvelt, Petrus J. W.
发明人： DITTMER, Wendy, U. , DE THEIJE, Femke, K. , IMMINK, Albert, H., J. , NIEWENHUIS, Jeroen, H. , VAN LANKVELT, Petrus J. W.
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N21/552 , G01N27/745 , G01N33/54366 , G01N33/54386
摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40′). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14′) from the detection of the further detectable label (40′) in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14′) falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.

3. 发明授权

EP2449382B1 MAGNETIC SENSOR DEVICE, METHOD OF OPERATING SUCH A DEVICE AND SAMPLE 有权转让
标题翻译：磁传感器装置，操作这种装置和样品的方法
公开(公告)号：EP2449382B1
公开(公告)日：2018-03-28
申请号：EP10734820.3
申请日：2010-06-24
申请人： Koninklijke Philips N.V. , Van Lankvelt, Petrus J. W.
发明人： DITTMER, Wendy, U. , DE THEIJE, Femke, K. , IMMINK, Albert, H., J. , NIEWENHUIS, Jeroen, H. , VAN LANKVELT, Petrus J. W.
IPC分类号： G01N27/74 , G01N21/552 , G01N33/543
CPC分类号： G01N33/54326 , G01N21/552 , G01N27/745 , G01N33/54366 , G01N33/54386
摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40′). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14′) from the detection of the further detectable label (40′) in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14′) falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.

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