专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100160737A1 BRAIN RETRACTOR APPARATUS FOR MEASURING AND PREDICTING ELECTROPHYSIOLOGICAL PARAMETERS 有权
标题翻译：用于测量和预测电生理参数的脑回缩装置
公开(公告)号：US20100160737A1
公开(公告)日：2010-06-24
申请号：US12343436
申请日：2008-12-23
申请人： Josh Shachar , Thomas Chen , Leslie Farkas , Winston Wu , Kyle Zimmerman , Moran Cerf , Bruce Marx , David Johnson , Laszlo Farkas
发明人： Josh Shachar , Thomas Chen , Leslie Farkas , Winston Wu , Kyle Zimmerman , Moran Cerf , Bruce Marx , David Johnson , Laszlo Farkas
IPC分类号： A61B1/32 , A61B5/00
CPC分类号： A61B5/0478 , A61B17/02 , A61B2562/0209 , A61B2562/043
摘要： Described is a surgical system for monitoring a patient's condition during surgery. One aspect is a non-contact EEG sensor. The non-contact EEG sensor can be used to predict the onset of physiological disorders. Another aspect includes the use of a plurality of pressure sensors to determine the pressure applied by retractors on the patient, including the brain and other organs.
摘要翻译：描述了一种用于在手术期间监测患者状况的手术系统。一个方面是非接触式EEG传感器。非接触式EEG传感器可用于预测生理障碍的发病。另一方面包括使用多个压力传感器来确定牵引器对患者施加的压力，包括脑部和其他器官。

2. 发明授权

US08133172B2 Brain retractor apparatus for measuring and predicting electrophysiological parameters 有权
标题翻译：用于测量和预测电生理参数的脑牵开装置
公开(公告)号：US08133172B2
公开(公告)日：2012-03-13
申请号：US12343436
申请日：2008-12-23
申请人： Josh Shachar , Thomas Chen , Leslie Farkas , Winston Wu , Kyle Zimmerman , Moran Cerf , Bruce Marx , David Johnson , Laszlo Farkas
发明人： Josh Shachar , Thomas Chen , Leslie Farkas , Winston Wu , Kyle Zimmerman , Moran Cerf , Bruce Marx , David Johnson , Laszlo Farkas
IPC分类号： A61B1/32
CPC分类号： A61B5/0478 , A61B17/02 , A61B2562/0209 , A61B2562/043
摘要： Described is a surgical system for monitoring a patient's condition during surgery. One aspect is a non-contact EEG sensor. The non-contact EEG sensor can be used to predict the onset of physiological disorders. Another aspect includes the use of a plurality of pressure sensors to determine the pressure applied by retractors on the patient, including the brain and other organs.
摘要翻译：描述了用于在手术期间监测患者状况的手术系统。一个方面是非接触式EEG传感器。非接触式EEG传感器可用于预测生理障碍的发病。另一方面包括使用多个压力传感器来确定牵引器对患者施加的压力，包括脑部和其他器官。

3. 发明授权

US09329173B2 Method and apparatus for forming of an automated sampling device for the detection of Salmonella enterica utilizing an electrochemical aptamer biosensor 有权
标题翻译：用于形成用于利用电化学适体生物传感器检测沙门氏菌的自动取样装置的方法和装置
公开(公告)号：US09329173B2
公开(公告)日：2016-05-03
申请号：US12684025
申请日：2010-01-07
申请人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Zimmerman
发明人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Zimmerman
IPC分类号： C40B30/04 , G01N33/53 , G01N33/543 , G01N33/569
CPC分类号： G01N33/5308 , G01N33/5438 , G01N33/56916 , G01N2333/255
摘要： An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.
摘要翻译：一种基于适体的固态电化学生物传感器，用于利用固定化适体进行无标记检测肠炎沙门氏菌血清型。该器件通过形成并联电容器的矩阵阵列实现，从而允许实现低成本，便携式，完全集成的器件。蛋白质 - 适体结合调节电路的阈值电压，改变电路的阻抗（电容）。该电路的特征还在于用p-Si衬底编码的电极，增强了沙门氏菌外膜蛋白（OMP）和适体之间的亲和力。适配器嵌入式检测板配置在测试盖装置内，该测试盖装置适合标准的市售聚合物样品瓶。将样品与肉汤混合以孵育和培养任何目前的沙门氏菌，以获得用于测试的病原体的可接受浓度。获得的信息可以通过无线网络传输。

4. 发明授权

US09310363B2 Method and apparatus for forming of an automated sampling device for the detection of salmonella enterica utilizing an electrochemical aptamer biosensor 有权
标题翻译：用于形成用于利用电化学适体生物传感器检测沙门氏菌的自动取样装置的方法和装置
公开(公告)号：US09310363B2
公开(公告)日：2016-04-12
申请号：US12764828
申请日：2010-04-21
申请人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Zimmerman
发明人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Zimmerman
IPC分类号： C12Q1/04 , G01N33/543 , G01N33/569
CPC分类号： G01N33/5438 , G01N33/56916 , G01N2333/255
摘要： An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.
摘要翻译：一种基于适体的固态电化学生物传感器，用于利用固定化适体进行无标记检测肠炎沙门氏菌血清型。该器件通过形成并联电容器的矩阵阵列实现，从而允许实现低成本，便携式，完全集成的器件。蛋白质 - 适体结合调节电路的阈值电压，改变电路的阻抗（电容）。该电路的特征还在于用p-Si衬底编码的电极，增强了沙门氏菌外膜蛋白（OMP）和适体之间的亲和力。适配器嵌入式检测板配置在测试盖装置内，该测试盖装置适合标准的市售聚合物样品瓶。将样品与肉汤混合以孵育和培养任何目前的沙门氏菌，以获得用于测试的病原体的可接受浓度。获得的信息可以通过无线网络传输。

5. 发明申请

US20110166033A1 Method and Apparatus for Forming of an Automated Sampling Device for the Detection of Salmonella Enterica Utilizing an Electrochemical Aptamer Biosensor 有权
公开(公告)号：US20110166033A1
公开(公告)日：2011-07-07
申请号：US12684025
申请日：2010-01-07
申请人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Zimmerman
发明人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Zimmerman
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： G01N33/5308 , G01N33/5438 , G01N33/56916 , G01N2333/255
摘要： An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.

6. 发明申请

US20110162979A1 Method and Apparatus for Forming of an Automated Sampling Device for the Detection of Salmonella Enterica Utilizing an Electrochemical Aptamer Biosensor 有权
标题翻译：用于形成利用电化学适体生物传感器检测沙门氏菌的自动取样装置的方法和装置
公开(公告)号：US20110162979A1
公开(公告)日：2011-07-07
申请号：US12764828
申请日：2010-04-21
申请人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Nichdas Zimmerman
发明人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Nichdas Zimmerman
IPC分类号： G01N27/26 , G01N33/50
CPC分类号： G01N33/5438 , G01N33/56916 , G01N2333/255
摘要： An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.
摘要翻译：一种基于适体的固态电化学生物传感器，用于利用固定化适体进行无标记检测肠炎沙门氏菌血清型。该器件通过形成并联电容器的矩阵阵列实现，从而允许实现低成本，便携式，完全集成的器件。蛋白质 - 适体结合调节电路的阈值电压，改变电路的阻抗（电容）。该电路的特征还在于用p-Si衬底编码的电极，增强了沙门氏菌外膜蛋白（OMP）和适体之间的亲和力。适配器嵌入式检测板配置在测试盖装置内，该测试盖装置适合标准的市售聚合物样品瓶。将样品与肉汤混合以孵育和培养任何目前的沙门氏菌，以获得用于测试的病原体的可接受浓度。获得的信息可以通过无线网络传输。

7. 发明授权

US08571805B2 Method and apparatus for detecting and regulating vascular endothelial growth factor (VEGF) by forming a homeostatic loop employing a half-antibody biosensor 有权
标题翻译：通过使用半抗体生物传感器形成稳态环来检测和调节血管内皮生长因子（VEGF）的方法和装置
公开(公告)号：US08571805B2
公开(公告)日：2013-10-29
申请号：US12820830
申请日：2010-06-22
申请人： Yehoshua Shachar , Winston Wu , Thomas Chen , Brett Jordan , Kyle Zimmerman , Herwin Chan , Paladin Luboff
发明人： Yehoshua Shachar , Winston Wu , Thomas Chen , Brett Jordan , Kyle Zimmerman , Herwin Chan , Paladin Luboff
IPC分类号： G01N33/48
CPC分类号： G01N33/48 , G01N33/5438 , G01N33/74 , G01N2333/475
摘要： A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a homeostatic loop for chemotherapy.
摘要翻译：用于检测血管内皮生长因子（VEGF）杂交的生物传感器使用并联电容器阵列来检测循环VEGF与固定的抗VEGF单克隆半抗体（a-VEGF mhAb）的电化学结合。 a-VEGF mhAb的结合调节电路的阈值电压，改变电路的阻抗。涂覆有p-Si底物的电极增强了VEGF分子之间的亲和力。流体细胞将VEGF样品递送到芯片的有效表面上。排列成交错图案的并联电容器阵列检测流体中的VEGF。检测器在体内提供精确测量和量化的VEGF分子的变化率，提供实时反馈，其用于测量肿瘤对递送的化学治疗剂和生物反应调节剂（BRM）的响应，以确定肿瘤负荷和化疗作为化疗的稳态环路的一部分的功效。

8. 发明申请

US20110295159A1 Method and Apparatus for an Implantable Inertial-Based Sensing System for Real-Time, In Vivo Detection of Spinal Pseudarthrosis and Adjacent Segment Motion 审中-公开
标题翻译：基于植入式惯性传感系统的方法和装置，用于实时，体内检测脊柱假关节和相邻段运动
公开(公告)号：US20110295159A1
公开(公告)日：2011-12-01
申请号：US12787286
申请日：2010-05-25
申请人： Yehoshua Shachar , Thomas Chen , Winston Wu , Brett Jordan , Herwin Chan , Paladin Luboff , Kyle Zimmerman
发明人： Yehoshua Shachar , Thomas Chen , Winston Wu , Brett Jordan , Herwin Chan , Paladin Luboff , Kyle Zimmerman
IPC分类号： A61B5/103 , A61F2/44
CPC分类号： A61B5/1114 , A61B5/413 , A61B5/45 , A61B5/6878 , A61B17/7074 , A61B2505/05 , A61B2560/0219 , A61B2562/043 , A61F2/442 , A61F2/4455 , A61F2/4657
摘要： A vertebral processor designed to collect and interpret data from multiple surgically implanted accelerometers. Each accelerometer is surgically implanted into a vertebra of a patient utilizing a bone screw. Additional accelerometers are implanted in adjacent vertebrae. The data from the accelerometers is compared by an algorithm to determine the relative movement of the accelerometers implanted in adjacent vertebrae. Data is generated via the algorithm and compared against the expected behavior of the surgically implanted accelerometers as if they were connected to a rigid body, thus determining the level of success of a spinal fusion procedure for those adjacent segments. The apparatus may be utilized with or without spinal stabilization hardware, and with or without fusion cages or artificial discs. The vertebral processor is supplemented by an external system worn by the patient, which provides for an inductive charging power source and for data transfer.
摘要翻译：设计用于收集和解读来自多个手术植入加速度计的数据的椎体处理器。使用骨螺钉将每个加速度计手术植入患者的椎骨。附加的加速度计植入相邻的椎骨。来自加速度计的数据通过算法进行比较，以确定相邻椎骨中植入的加速度计的相对运动。通过算法生成数据，并将其与手术植入的加速度计的预期行为进行比较，就好像它们连接到刚体一样，从而确定了相邻段的脊柱融合程序的成功程度。该装置可以与或不与脊椎稳定硬件一起使用，以及有或没有融合笼或人造盘。脊椎处理器由患者佩戴的外部系统补充，其提供感应充电电源和用于数据传输。

9. 发明申请

US20100260679A1 METHOD AND APPARATUS FOR DETECTING AND REGULATING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) BY FORMING A HOMEOSTATIC LOOP EMPLOYING A HALF-ANTIBODY BIOSENSOR 有权
标题翻译：通过形成使用半抗体生物传感器的家庭环境来检测和调节血管内皮生长因子（VEGF）的方法和装置
公开(公告)号：US20100260679A1
公开(公告)日：2010-10-14
申请号：US12820830
申请日：2010-06-22
申请人： Yehoshua Shachar , Winston Wu , Thomas Chen , Brett Jordan , Kyle Zimmerman , Herwin Chan , Paladin Luboff
发明人： Yehoshua Shachar , Winston Wu , Thomas Chen , Brett Jordan , Kyle Zimmerman , Herwin Chan , Paladin Luboff
IPC分类号： G01N33/53 , C40B40/10 , A61K49/00 , G01N27/22
CPC分类号： G01N33/48 , G01N33/5438 , G01N33/74 , G01N2333/475
摘要： A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a homeostatic loop for chemotherapy.
摘要翻译：用于检测血管内皮生长因子（VEGF）杂交的生物传感器使用并联电容器阵列来检测循环VEGF与固定的抗VEGF单克隆半抗体（a-VEGF mhAb）的电化学结合。 a-VEGF mhAb的结合调节电路的阈值电压，改变电路的阻抗。涂覆有p-Si底物的电极增强了VEGF分子之间的亲和力。流体细胞将VEGF样品递送到芯片的有效表面上。排列成交错图案的并联电容器阵列检测流体中的VEGF。检测器在体内提供精确测量和量化的VEGF分子的变化率，提供实时反馈，其用于测量肿瘤对递送的化学治疗剂和生物反应调节剂（BRM）的响应，以确定肿瘤负荷和化疗作为化疗的稳态环路的一部分的功效。

10. 发明申请

US20100262375A1 METHOD AND APPARATUS FOR FORMING A HOMEOSTATIC LOOP EMPLOYING AN APTAMER BIOSENSOR 有权
标题翻译：用于形成使用APTAMER生物传感器的家庭环境的方法和装置
公开(公告)号：US20100262375A1
公开(公告)日：2010-10-14
申请号：US12422125
申请日：2009-04-10
申请人： Josh Yehoshua Shachar , Winston H. Wu , Leslie Farkas , Thomas Chen
发明人： Josh Yehoshua Shachar , Winston H. Wu , Leslie Farkas , Thomas Chen
IPC分类号： G01N33/48 , G01R27/26
CPC分类号： G01N33/54373 , G01N33/542
摘要： A novel architecture solid-state biosensor for label-free detection of vascular endothelial growth factor (VEGF) hybridization is presented. The new device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. The detection mechanism is based on an electrochemical binding of circulating VEGF to an immobilized VEGF aptamer; whereby binding of these two compounds modulates the threshold voltage of a novel circuit, changing the impedance (capacitance) of the circuit. This novel circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the VEGF molecules and the aptamer. An apparatus forming a fluid cell is configured so as to enable the flow for delivering VEGF samples onto the active surface of the chip. The device has an array of parallel capacitors which act as an integrated, individual counter-electrode, computational apparatus which employs the sensory output over the time domain so as to enable detection, reporting and formation of a homeostatic loop for VEGF measurements. Moreover, this detector is able to provide an accurately measured and quantifiable rate of change of the VEGF molecules in-vivo, providing real time feedback of this important biomarker which may be used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden.
摘要翻译：提出了一种用于无标记检测血管内皮生长因子（VEGF）杂交的新型结构固态生物传感器。新器件通过形成并联电容器的矩阵阵列实现，从而允许实现低成本，便携式，完全集成的器件。检测机制是基于循环VEGF与固定的VEGF适体的电化学结合; 由此这两种化合物的结合调节新电路的阈值电压，改变电路的阻抗（电容）。该新型电路的特征还在于用p-Si衬底编码的电极，增强了VEGF分子与适体之间的亲和力。形成流体池的装置被配置为使得能够将VEGF样品输送到芯片的有源表面上的流动。该装置具有并联电容器阵列，其作为集成的单独的对电极计算装置，其在时域上采用感觉输出，以便能够检测，报告和形成用于VEGF测量的稳态环路。此外，该检测器能够在体内提供精确测量和定量的VEGF分子变化率，从而提供该重要生物标志物的实时反馈，其可用于测量肿瘤对递送的化学治疗剂和生物反应调节剂的反应（BRM），以确定肿瘤负担。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式