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1. 发明申请

US20110092948A1 Remotely Activated Piezoelectric Pump for Delivery of Biological Agents to the Intervertebral Disc and Spine 有权
标题翻译：用于将椎间盘和脊柱递送生物剂的远程活化压电泵
公开(公告)号：US20110092948A1
公开(公告)日：2011-04-21
申请号：US12581785
申请日：2009-10-19
申请人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Brett Jordan , Kyle Zimmerman , Herwin Chan , Winston Wu
发明人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Brett Jordan , Kyle Zimmerman , Herwin Chan , Winston Wu
IPC分类号： A61M1/00 , A61M37/00
CPC分类号： A61M37/00 , A61F2/4465 , A61F2002/2817 , A61F2002/3067 , A61F2002/30677 , A61F2002/30785 , A61F2002/30787 , A61F2002/30841 , A61F2002/3092 , A61F2002/4475 , A61F2310/00023 , A61M5/14276 , A61M5/1452 , A61M2205/0294 , A61M2205/8243 , A61M2210/1003
摘要： The present disclosure describes a remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.
摘要翻译：本公开描述了用于将生物制剂递送到椎间盘和脊柱的远程激活的压电泵，以便实现脊柱融合。将脊柱泵植入患者的椎骨上，并且在移除椎骨盘后将脊柱插入两个相邻的椎骨之间。压电电动机驱动泵并将成骨细胞剂通过脊柱笼并推入置于笼内的海绵中。泵由患者佩戴的外部可移除感应带进行充电。根据患者的具体需要，可以在植入脊柱泵之前改变输送持续时间和输送频率。目前的装置采用数学模型，通过扩展和推广模型来增强骨骼融合过程的调节和衰减，从而以稳定的方式增强和优化成骨细胞的传递。

2. 发明申请

US20100160737A1 BRAIN RETRACTOR APPARATUS FOR MEASURING AND PREDICTING ELECTROPHYSIOLOGICAL PARAMETERS 有权
标题翻译：用于测量和预测电生理参数的脑回缩装置
公开(公告)号：US20100160737A1
公开(公告)日：2010-06-24
申请号：US12343436
申请日：2008-12-23
申请人： Josh Shachar , Thomas Chen , Leslie Farkas , Winston Wu , Kyle Zimmerman , Moran Cerf , Bruce Marx , David Johnson , Laszlo Farkas
发明人： Josh Shachar , Thomas Chen , Leslie Farkas , Winston Wu , Kyle Zimmerman , Moran Cerf , Bruce Marx , David Johnson , Laszlo Farkas
IPC分类号： A61B1/32 , A61B5/00
CPC分类号： A61B5/0478 , A61B17/02 , A61B2562/0209 , A61B2562/043
摘要： Described is a surgical system for monitoring a patient's condition during surgery. One aspect is a non-contact EEG sensor. The non-contact EEG sensor can be used to predict the onset of physiological disorders. Another aspect includes the use of a plurality of pressure sensors to determine the pressure applied by retractors on the patient, including the brain and other organs.
摘要翻译：描述了一种用于在手术期间监测患者状况的手术系统。一个方面是非接触式EEG传感器。非接触式EEG传感器可用于预测生理障碍的发病。另一方面包括使用多个压力传感器来确定牵引器对患者施加的压力，包括脑部和其他器官。

3. 发明申请

US20090194921A1 HIGH FORCE CIVIL ENGINEERING DAMPER 审中-公开
标题翻译：高强度民用工程阻尼器
公开(公告)号：US20090194921A1
公开(公告)日：2009-08-06
申请号：US12026353
申请日：2008-02-05
申请人： Tyn Smith , Kyle Zimmerman , Donald Russell
发明人： Tyn Smith , Kyle Zimmerman , Donald Russell
IPC分类号： F16F7/00 , G05D19/00
CPC分类号： F16F9/20 , E04H2009/026
摘要： A civil engineering damper for damping civil engineered structures comprising a damper housing including two dynamic fluid chambers within a piston cylinder and two static fluid chambers straddling the dynamic fluid chambers along an axis of the housing a piston mounted for reciprocation along the axis of the damper housing. A piston web portion divides the piston cylinder into the two dynamic fluid chamber. A restricted passageway through the piston web portion includes an orifice that provides a resistance to fluid flow between the dynamic fluid chambers. The damper also includes regulated passageways between adjacent dynamic and static fluid chambers valved to allow a flow of fluid from the static fluid chambers to the dynamic fluid chambers and check flows of fluid from the dynamic fluid chambers to the static fluid chambers.
摘要翻译：一种用于阻尼土木工程结构的土木工程阻尼器，其包括阻尼器壳体，该阻尼器壳体包括位于活塞气缸内的两个动态流体室和沿壳体的轴线跨过动态流体室的两个静态流体室，该活塞安装成沿阻尼器壳体的轴线往复运动。活塞腹板部分将活塞缸分成两个动态流体室。通过活塞腹板部分的限制通道包括提供对动态流体室之间的流体流动的阻力的孔口。阻尼器还包括在相邻的动态和静态流体室之间限定的通道，其被限制为允许流体从静态流体室流动到动态流体室并且检查流体从动态流体室到静态流体室的流动。

4. 发明授权

US08571805B2 Method and apparatus for detecting and regulating vascular endothelial growth factor (VEGF) by forming a homeostatic loop employing a half-antibody biosensor 有权
标题翻译：通过使用半抗体生物传感器形成稳态环来检测和调节血管内皮生长因子（VEGF）的方法和装置
公开(公告)号：US08571805B2
公开(公告)日：2013-10-29
申请号：US12820830
申请日：2010-06-22
申请人： Yehoshua Shachar , Winston Wu , Thomas Chen , Brett Jordan , Kyle Zimmerman , Herwin Chan , Paladin Luboff
发明人： Yehoshua Shachar , Winston Wu , Thomas Chen , Brett Jordan , Kyle Zimmerman , Herwin Chan , Paladin Luboff
IPC分类号： G01N33/48
CPC分类号： G01N33/48 , G01N33/5438 , G01N33/74 , G01N2333/475
摘要： A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a homeostatic loop for chemotherapy.
摘要翻译：用于检测血管内皮生长因子（VEGF）杂交的生物传感器使用并联电容器阵列来检测循环VEGF与固定的抗VEGF单克隆半抗体（a-VEGF mhAb）的电化学结合。 a-VEGF mhAb的结合调节电路的阈值电压，改变电路的阻抗。涂覆有p-Si底物的电极增强了VEGF分子之间的亲和力。流体细胞将VEGF样品递送到芯片的有效表面上。排列成交错图案的并联电容器阵列检测流体中的VEGF。检测器在体内提供精确测量和量化的VEGF分子的变化率，提供实时反馈，其用于测量肿瘤对递送的化学治疗剂和生物反应调节剂（BRM）的响应，以确定肿瘤负荷和化疗作为化疗的稳态环路的一部分的功效。

5. 发明申请

US20120245565A1 METHOD FOR DELIVERING GENE AND CELL THERAPY TO A TUMOR OR TARGETED SITE USING AN IMPLANTED METRONOMIC BIOFEEDBACK PUMP 审中-公开
标题翻译：使用植入式生物反应器将基因和细胞治疗方法递送至肿瘤或靶向位点
公开(公告)号：US20120245565A1
公开(公告)日：2012-09-27
申请号：US13052811
申请日：2011-03-21
申请人： Yehoshua Shachar , Thomas C. Chen , Winston Wu , Brett Jordan , Herwin Chan , Kyle Zimmerman , Paladin Luboff
发明人： Yehoshua Shachar , Thomas C. Chen , Winston Wu , Brett Jordan , Herwin Chan , Kyle Zimmerman , Paladin Luboff
IPC分类号： A61M37/00
CPC分类号： A61M5/14276 , A61M5/1407 , A61M5/14224 , A61M5/1723 , A61M2005/14292 , A61M2202/0464 , A61M2205/0294 , A61M2205/3523 , A61M2205/3561 , A61M2205/8243 , A61M2209/045 , A61M2209/10 , A61M2210/0693 , A61M2230/005
摘要： A method for utilizing a controlled pump implanted into a patient connected to a multilumen catheter allowing delivery to and sampling from the brain or other organ for treatment of a cancer. The pump delivers a plurality of medicating agents, including viral and non-viral vectors for gene therapy and cell therapy at a controlled rate, corresponding to the specific needs of the patient. A catheter is implanted in or adjacent to the tumoral region. Fluid drawn from the tumor region to the pump via the multilumen catheter is analyzed within the pump by various biofeedback sensors. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller. The method allows localized delivery of gene and cell therapy to a solid tumor or tumoral region, or to any other treatment area of interest within the patient.
摘要翻译：一种利用植入连接到多腔导管的患者中的受控泵的方法，其允许从脑或其它器官进行递送和取样以治疗癌症。该泵以对应于患者的具体需要的受控速率递送多种药剂，包括用于基因治疗和细胞治疗的病毒和非病毒载体。将导管植入或邻近肿瘤区域。通过各种生物反馈传感器在泵内分析通过多腔导管从肿瘤区域抽吸到泵的流体。基于这些测量，该装置的操作以及因此的处理被远程控制并通过外部控制器显示。该方法允许将基因和细胞治疗局部递送至实体肿瘤或肿瘤区域，或患者内任何感兴趣的其它治疗区域。

6. 发明授权

US08133172B2 Brain retractor apparatus for measuring and predicting electrophysiological parameters 有权
标题翻译：用于测量和预测电生理参数的脑牵开装置
公开(公告)号：US08133172B2
公开(公告)日：2012-03-13
申请号：US12343436
申请日：2008-12-23
申请人： Josh Shachar , Thomas Chen , Leslie Farkas , Winston Wu , Kyle Zimmerman , Moran Cerf , Bruce Marx , David Johnson , Laszlo Farkas
发明人： Josh Shachar , Thomas Chen , Leslie Farkas , Winston Wu , Kyle Zimmerman , Moran Cerf , Bruce Marx , David Johnson , Laszlo Farkas
IPC分类号： A61B1/32
CPC分类号： A61B5/0478 , A61B17/02 , A61B2562/0209 , A61B2562/043
摘要： Described is a surgical system for monitoring a patient's condition during surgery. One aspect is a non-contact EEG sensor. The non-contact EEG sensor can be used to predict the onset of physiological disorders. Another aspect includes the use of a plurality of pressure sensors to determine the pressure applied by retractors on the patient, including the brain and other organs.
摘要翻译：描述了用于在手术期间监测患者状况的手术系统。一个方面是非接触式EEG传感器。非接触式EEG传感器可用于预测生理障碍的发病。另一方面包括使用多个压力传感器来确定牵引器对患者施加的压力，包括脑部和其他器官。

7. 发明申请

US20120041562A1 Remotely Activated Piezoelectric Pump for Delivery of Biological Agents to the Intervertebral Disc and Spine 审中-公开
标题翻译：用于将椎间盘和脊柱递送生物剂的远程活化压电泵
公开(公告)号：US20120041562A1
公开(公告)日：2012-02-16
申请号：US13283368
申请日：2011-10-27
申请人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Brett Jordan , Kyle Zimmerman , Herwin Chan , Winston Wu
发明人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Brett Jordan , Kyle Zimmerman , Herwin Chan , Winston Wu
IPC分类号： A61F2/44 , A61M37/00
CPC分类号： A61M37/00 , A61F2/4465 , A61F2002/2817 , A61F2002/3067 , A61F2002/30677 , A61F2002/30785 , A61F2002/30787 , A61F2002/30841 , A61F2002/3092 , A61F2002/4475 , A61F2310/00023 , A61M5/14276 , A61M5/1452 , A61M2205/0294 , A61M2205/8243 , A61M2210/1003
摘要： A remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.
摘要翻译：一种远程激活的压电泵，用于将生物制剂递送到椎间盘和脊柱，以实现脊柱融合。将脊柱泵植入患者的椎骨上，并且在移除椎骨盘后将脊柱插入两个相邻的椎骨之间。压电电动机驱动泵并将成骨细胞剂通过脊柱笼并推入置于笼内的海绵中。泵由患者佩戴的外部可移除感应带进行充电。根据患者的具体需要，可以在植入脊柱泵之前改变输送持续时间和输送频率。目前的装置采用数学模型，通过扩展和推广模型来增强骨骼融合过程的调节和衰减，从而以稳定的方式增强和优化成骨细胞的传递。

8. 发明公开

US20240067397A1 Stackable Storage Container 审中-公开
公开(公告)号：US20240067397A1
公开(公告)日：2024-02-29
申请号：US18455383
申请日：2023-08-24
申请人： Kyle Zimmerman
发明人： Kyle Zimmerman
IPC分类号： B65D21/02 , B65D1/22 , B65D25/02 , B65D25/20 , B65D43/02 , B65D51/24 , B65D53/02 , B65D65/38 , B65D81/20
CPC分类号： B65D21/0219 , B65D1/22 , B65D25/02 , B65D25/20 , B65D43/0204 , B65D43/0214 , B65D51/24 , B65D53/02 , B65D65/38 , B65D81/2038 , B65D2543/00194 , B65D2543/00972 , G01L19/08
摘要： A stackable storage container that includes multiple quick connect fittings for flushing the container atmosphere and maintaining a vacuum within the closed stackable storage container, as well as pressure, temperature, and relative humidity sensors and displays for monitoring the interior volume of the container. The base includes a honeycomb structure that includes vertical perimeter edges intersecting at perpendicular angles to form a grid of squares. The base also includes vertically oriented support posts and bracing contact points positioned above each of the support posts.

9. 发明授权

US09329173B2 Method and apparatus for forming of an automated sampling device for the detection of Salmonella enterica utilizing an electrochemical aptamer biosensor 有权
标题翻译：用于形成用于利用电化学适体生物传感器检测沙门氏菌的自动取样装置的方法和装置
公开(公告)号：US09329173B2
公开(公告)日：2016-05-03
申请号：US12684025
申请日：2010-01-07
申请人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Zimmerman
发明人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Zimmerman
IPC分类号： C40B30/04 , G01N33/53 , G01N33/543 , G01N33/569
CPC分类号： G01N33/5308 , G01N33/5438 , G01N33/56916 , G01N2333/255
摘要： An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.
摘要翻译：一种基于适体的固态电化学生物传感器，用于利用固定化适体进行无标记检测肠炎沙门氏菌血清型。该器件通过形成并联电容器的矩阵阵列实现，从而允许实现低成本，便携式，完全集成的器件。蛋白质 - 适体结合调节电路的阈值电压，改变电路的阻抗（电容）。该电路的特征还在于用p-Si衬底编码的电极，增强了沙门氏菌外膜蛋白（OMP）和适体之间的亲和力。适配器嵌入式检测板配置在测试盖装置内，该测试盖装置适合标准的市售聚合物样品瓶。将样品与肉汤混合以孵育和培养任何目前的沙门氏菌，以获得用于测试的病原体的可接受浓度。获得的信息可以通过无线网络传输。

10. 发明授权

US08827986B2 Remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine 有权
标题翻译：远程激活的压电泵用于将生物制剂输送到椎间盘和脊柱
公开(公告)号：US08827986B2
公开(公告)日：2014-09-09
申请号：US12581785
申请日：2009-10-19
申请人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Brett Jordan , Kyle Zimmerman , Herwin Chan , Winston Wu
发明人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Brett Jordan , Kyle Zimmerman , Herwin Chan , Winston Wu
IPC分类号： A61K9/22 , A61F2/44 , A61M5/142 , A61M5/145 , A61M37/00 , A61F2/30 , A61F2/28
CPC分类号： A61M37/00 , A61F2/4465 , A61F2002/2817 , A61F2002/3067 , A61F2002/30677 , A61F2002/30785 , A61F2002/30787 , A61F2002/30841 , A61F2002/3092 , A61F2002/4475 , A61F2310/00023 , A61M5/14276 , A61M5/1452 , A61M2205/0294 , A61M2205/8243 , A61M2210/1003
摘要： A remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.
摘要翻译：一种远程激活的压电泵，用于将生物制剂递送到椎间盘和脊柱，以实现脊柱融合。将脊柱泵植入患者的椎骨上，并且在移除椎骨盘后将脊柱插入两个相邻的椎骨之间。压电电动机驱动泵并将成骨细胞剂通过脊柱笼并推入置于笼内的海绵中。泵由患者佩戴的外部可移除感应带进行充电。根据患者的具体需要，可以在植入脊柱泵之前改变输送持续时间和输送频率。目前的装置采用数学模型，通过扩展和推广模型来增强骨骼融合过程的调节和衰减，从而以稳定的方式增强和优化成骨细胞的传递。

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