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1. 发明授权

US09329173B2 Method and apparatus for forming of an automated sampling device for the detection of Salmonella enterica utilizing an electrochemical aptamer biosensor 有权
标题翻译：用于形成用于利用电化学适体生物传感器检测沙门氏菌的自动取样装置的方法和装置
公开(公告)号：US09329173B2
公开(公告)日：2016-05-03
申请号：US12684025
申请日：2010-01-07
申请人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Zimmerman
发明人： Yehoshua Shachar , Winston Wu , Thomas Chen , Leslie Farkas , Brett Jordan , Paladin Luboff , Herwin Chan , Kyle Zimmerman
IPC分类号： C40B30/04 , G01N33/53 , G01N33/543 , G01N33/569
CPC分类号： G01N33/5308 , G01N33/5438 , G01N33/56916 , G01N2333/255
摘要： An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.
摘要翻译：一种基于适体的固态电化学生物传感器，用于利用固定化适体进行无标记检测肠炎沙门氏菌血清型。该器件通过形成并联电容器的矩阵阵列实现，从而允许实现低成本，便携式，完全集成的器件。蛋白质 - 适体结合调节电路的阈值电压，改变电路的阻抗（电容）。该电路的特征还在于用p-Si衬底编码的电极，增强了沙门氏菌外膜蛋白（OMP）和适体之间的亲和力。适配器嵌入式检测板配置在测试盖装置内，该测试盖装置适合标准的市售聚合物样品瓶。将样品与肉汤混合以孵育和培养任何目前的沙门氏菌，以获得用于测试的病原体的可接受浓度。获得的信息可以通过无线网络传输。

2. 发明授权

US08827986B2 Remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine 有权
标题翻译：远程激活的压电泵用于将生物制剂输送到椎间盘和脊柱
公开(公告)号：US08827986B2
公开(公告)日：2014-09-09
申请号：US12581785
申请日：2009-10-19
申请人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Brett Jordan , Kyle Zimmerman , Herwin Chan , Winston Wu
发明人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Brett Jordan , Kyle Zimmerman , Herwin Chan , Winston Wu
IPC分类号： A61K9/22 , A61F2/44 , A61M5/142 , A61M5/145 , A61M37/00 , A61F2/30 , A61F2/28
CPC分类号： A61M37/00 , A61F2/4465 , A61F2002/2817 , A61F2002/3067 , A61F2002/30677 , A61F2002/30785 , A61F2002/30787 , A61F2002/30841 , A61F2002/3092 , A61F2002/4475 , A61F2310/00023 , A61M5/14276 , A61M5/1452 , A61M2205/0294 , A61M2205/8243 , A61M2210/1003
摘要： A remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.
摘要翻译：一种远程激活的压电泵，用于将生物制剂递送到椎间盘和脊柱，以实现脊柱融合。将脊柱泵植入患者的椎骨上，并且在移除椎骨盘后将脊柱插入两个相邻的椎骨之间。压电电动机驱动泵并将成骨细胞剂通过脊柱笼并推入置于笼内的海绵中。泵由患者佩戴的外部可移除感应带进行充电。根据患者的具体需要，可以在植入脊柱泵之前改变输送持续时间和输送频率。目前的装置采用数学模型，通过扩展和推广模型来增强骨骼融合过程的调节和衰减，从而以稳定的方式增强和优化成骨细胞的传递。

3. 发明申请

US20130006100A1 METHOD AND APPARATUS FOR CONTROLLING CATHETER POSITIONING AND ORIENTATION 审中-公开
标题翻译：用于控制导管定位和定向的方法和装置
公开(公告)号：US20130006100A1
公开(公告)日：2013-01-03
申请号：US13440188
申请日：2012-04-05
申请人： Yehoshua Shachar , Bruce Marx , Leslie Farkas
发明人： Yehoshua Shachar , Bruce Marx , Leslie Farkas
IPC分类号： A61M25/095
CPC分类号： A61B5/06 , A61B5/062 , A61B5/7285 , A61B34/20 , A61B34/25 , A61B34/76 , A61B90/36 , A61B2017/00703 , A61B2034/102 , A61B2034/105 , A61B2034/107 , A61B2034/2051
摘要： A method and apparatus for detecting position and orientation of catheter distal magnetic element end while moving in a patient's heart is described. The apparatus comprising of four sensors, detecting the magnetic field of a generated by the catheter tip. Each sensor transmits the field magnitude and direction to a detection unit, which filters the signals and removes other field sources, such, as generated by CGCI coils and external medical hardware. The method allows the measurements of magnitude corresponding to the catheter tip distance from the sensor and the orientation of the field showing the magnetic tip orientation. Since the tip's magnetic field is not symmetric, the position and orientation computation technique are not independent of each other. Hence, an iterative calculation is used to converge to a solution.
摘要翻译：描述了一种用于在患者心脏中移动时检测导管远侧磁性元件端部的位置和方向的方法和装置。该装置包括四个传感器，用于检测由导管尖端产生的磁场。每个传感器将场强和方向传输到检测单元，该检测单元对信号进行滤波并去除其它场源，如由CGCI线圈和外部医疗硬件产生的。该方法允许测量对应于来自传感器的导管尖端距离的大小以及示出磁性尖端取向的场的取向。由于尖端的磁场不对称，位置和方向计算技术不是彼此独立的。因此，迭代计算用于收敛到解。

4. 发明申请

US20120289780A1 INTRALUMEN MEDICAL DELIVERY VESSEL PROPELLED BY SUPERCONDUCTIVE REPULSION-LEVITATION MAGNETIC FIELDS 审中-公开
标题翻译：超声波补偿磁场的INTRALUMEN医疗运输船
公开(公告)号：US20120289780A1
公开(公告)日：2012-11-15
申请号：US13505724
申请日：2010-11-17
申请人： Laszlo Farkas , Leslie Farkas
发明人： Laszlo Farkas , Leslie Farkas
IPC分类号： A61M5/00 , A61B1/04
CPC分类号： A61B1/041 , A61B1/00158 , A61B5/6861 , A61B34/73
摘要： A magnetically guided device driven by the repulsive forces generated by superconductive materials, housed in a thermally insulated vessel, due to phenomenon known as the Meissner-effect in response to the externally generated magnetic fields. The vessels will be installed in or on medical diagnostic, delivery or other procedural devices or capsules, and will enable wireless maneuvering and navigation of the host device through the lumens and cavities of the human body without any physical contact. Medical application fields include, but are not limited to, visual mapping, diagnostics, biopsy and other therapeutic and drug delivery procedures in the human body. The vessel is equipped with superconductive material, such as superconductive rings and/or disks, possessing supermagnetic properties. Shaped externally generated magnetic fields exert sufficient magnetic forces and rotational torques on the superconductive material causing the host device to move, tilt and rotate in the body lumens and cavities following the operator's closed-loop regulated directional and orientation commands.
摘要翻译：由超导材料产生的排斥力驱动的磁导引装置，由于外部产生的磁场而被称为Meissner效应的现象，该超导材料容纳在绝热容器中。船只将安装在医疗诊断，运送或其他程序设备或胶囊中，也可以通过人体内腔和腔体进行主机设备的无线操作和导航，无需任何物理接触。医学应用领域包括但不限于人体视觉测绘，诊断，活检和其他治疗和药物递送程序。该容器配备有超导材料，例如具有超磁性质的超导环和/或盘。形状的外部产生的磁场在超导材料上施加足够的磁力和旋转扭矩，导致主机装置在操作者的闭环调节的定向和定向命令之后在体腔和空腔中移动，倾斜和旋转。

5. 发明申请

US20110092950A1 Metronomic Convection Enhanced Delivery of Intrathecal Chemotherapy Using an Implanted Magnetic Breather Pump (MBP) for Leptomeningeal Carcinomatosis 有权
标题翻译：使用植入式磁通呼吸泵（MBP）进行脑膜瘤化疗的Metronomic对流增强交付
公开(公告)号：US20110092950A1
公开(公告)日：2011-04-21
申请号：US12581756
申请日：2009-10-19
申请人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Bruce Marx , David Johnson , Laszlo Farkas
发明人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Bruce Marx , David Johnson , Laszlo Farkas
IPC分类号： A61M5/145 , A61M37/00
CPC分类号： A61M5/14276 , A61M5/1408 , A61M5/14224 , A61M5/148 , A61M5/1723 , A61M2005/14292 , A61M2005/14296 , A61M2005/1726 , A61M2202/0464 , A61M2202/049 , A61M2205/3523 , A61M2205/3569 , A61M2205/8243 , A61M2209/01 , A61M2210/0693 , A61M2230/005
摘要： A magnetically controlled pump is implanted into the cerebrospinal fluid of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled lumen, intratumoral catheter which will be implanted. Spinal fluid drawn from the patient is analyzed. Medication is delivered on a continuous metronomic basis into the CSF via an internalized pump. CSF is removed and analyzed for VEGF and other cytokines via spectrophotometer analysis or a lab on a chip. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
摘要翻译：将磁力控制的泵植入患者的脑脊液中并以对应于患者的特定需要的受控速率输送多个治疗剂。本发明包括将被植入的柔性双壁管腔，瘤内导管。分析从患者抽取的脊髓液。通过内部泵将药物以连续的节律基础递送至CSF。通过分光光度计分析或芯片实验室去除CSF并分析VEGF和其他细胞因子。基于这些测量，该装置的操作以及因此的处理被远程控制并通过外部控制器显示。

6. 发明申请

US20110091853A1 METHOD FOR SIMULATING A CATHETER GUIDANCE SYSTEM FOR CONTROL, DEVELOPMENT AND TRAINING APPLICATIONS 审中-公开
标题翻译：用于模拟控制，开发和培训应用的导管指导系统的方法
公开(公告)号：US20110091853A1
公开(公告)日：2011-04-21
申请号：US12582621
申请日：2009-10-20
申请人： Yehoshua Shachar , Bruce Mark , David Johnson , Leslie Farkas , Steven Kim
发明人： Yehoshua Shachar , Bruce Mark , David Johnson , Leslie Farkas , Steven Kim
IPC分类号： G09B23/28 , A61B5/00 , G09B9/00 , G05B13/04
CPC分类号： G09B23/285 , A61B5/061 , A61B34/20 , A61B34/35 , A61B2034/2051 , G05B13/048
摘要： A system is disclosed for incorporating a realistic simulated catheter or catheters within a catheter guidance and control system that operate from the same closed-loop position control feedback and geometric mapping data as the real position control system and are able to make contact with real and simulated datasets. These catheters may be operated in a pure simulation mode without interacting with real catheters and position control hardware, or may be used as control cursors to enhance the placement of catheter positioning targets. The catheter tip, which is focus of magnetic control, is realistically guided by the control system parameters, while the remainder of the catheter line is realistically constrained by the mapped chamber geometry and introducer sheath.
摘要翻译：公开了一种用于将真实的模拟导管或导管结合在导管引导和控制系统内的系统，其从与实际位置控制系统相同的闭环位置控制反馈和几何映射数据操作并且能够与实际和模拟的数据集。这些导管可以以纯仿真模式操作，而不与实际导管和位置控制硬件相互作用，或者可以用作控制光标以增强导管定位目标的放置。作为磁控制焦点的导管尖端由控制系统参数实际引导，而导管线的其余部分实际上受到映射室几何形状和引导器护套的约束。

7. 发明申请

US20100305402A1 METHOD AND APPARATUS FOR MAGNETIC WAVEGUIDE FORMING A SHAPED FIELD EMPLOYING A MAGNETIC APERTURE FOR GUIDING AND CONTROLLING A MEDICAL DEVICE 审中-公开
标题翻译：用于形成用于引导和控制医疗装置的磁性孔的形成磁场的方法和装置
公开(公告)号：US20100305402A1
公开(公告)日：2010-12-02
申请号：US12475370
申请日：2009-05-29
申请人： Yehoshua Shachar , Laszlo Farkas , Leslie Farkas
发明人： Yehoshua Shachar , Laszlo Farkas , Leslie Farkas
IPC分类号： A61B1/00 , H01F3/00
CPC分类号： A61B1/00158 , A61B5/05 , A61B5/062 , A61B34/73 , A61B2034/731 , A61M25/0127
摘要： A system that uses a magnetic aperture and electromagnets to configure a magnetic shaped field is described. In one embodiment, the system can be used for guiding a catheter or other devices through a patient's body. In further modification of the system, the waveguide field and field gradient is achieved by the use of varying the electromagnetic wave and its respective flux density axis. In one embodiment, one or more magnetic pole pieces (electromagnet cores) are configured with anisotropic permeability to control the shape of the resulting magnetic field. In one embodiment, the shape and permeability distribution in an electromagnet poleface is configured to produce the desired field distribution. In one embodiment, a number of electromagnets are arranged in a spherical pattern to produce a desired magnetic field in an enclosed spherical region. In one embodiment, a distal end of a catheter is provided with a plurality of magnets having different coercivity to allow improved control of the position and orientation of the distal end
摘要翻译：描述了使用磁性孔和电磁体来构造磁场的系统。在一个实施例中，系统可用于通过患者身体引导导管或其他装置。在系统的进一步修改中，通过使用改变电磁波及其各自的磁通密度轴来实现波导场和场梯度。在一个实施例中，一个或多个磁极片（电磁铁芯）被构造为具有各向异性磁导率以控制所得到的磁场的形状。在一个实施例中，电磁铁极面中的形状和磁导率分布被配置为产生所需的场分布。在一个实施例中，多个电磁体被布置成球形图案以在封闭的球形区域中产生期望的磁场。在一个实施例中，导管的远端设置有具有不同矫顽力的多个磁体，以允许改善对远端的位置和取向的控制

8. 发明申请

US20100262375A1 METHOD AND APPARATUS FOR FORMING A HOMEOSTATIC LOOP EMPLOYING AN APTAMER BIOSENSOR 有权
标题翻译：用于形成使用APTAMER生物传感器的家庭环境的方法和装置
公开(公告)号：US20100262375A1
公开(公告)日：2010-10-14
申请号：US12422125
申请日：2009-04-10
申请人： Josh Yehoshua Shachar , Winston H. Wu , Leslie Farkas , Thomas Chen
发明人： Josh Yehoshua Shachar , Winston H. Wu , Leslie Farkas , Thomas Chen
IPC分类号： G01N33/48 , G01R27/26
CPC分类号： G01N33/54373 , G01N33/542
摘要： A novel architecture solid-state biosensor for label-free detection of vascular endothelial growth factor (VEGF) hybridization is presented. The new device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. The detection mechanism is based on an electrochemical binding of circulating VEGF to an immobilized VEGF aptamer; whereby binding of these two compounds modulates the threshold voltage of a novel circuit, changing the impedance (capacitance) of the circuit. This novel circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the VEGF molecules and the aptamer. An apparatus forming a fluid cell is configured so as to enable the flow for delivering VEGF samples onto the active surface of the chip. The device has an array of parallel capacitors which act as an integrated, individual counter-electrode, computational apparatus which employs the sensory output over the time domain so as to enable detection, reporting and formation of a homeostatic loop for VEGF measurements. Moreover, this detector is able to provide an accurately measured and quantifiable rate of change of the VEGF molecules in-vivo, providing real time feedback of this important biomarker which may be used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden.
摘要翻译：提出了一种用于无标记检测血管内皮生长因子（VEGF）杂交的新型结构固态生物传感器。新器件通过形成并联电容器的矩阵阵列实现，从而允许实现低成本，便携式，完全集成的器件。检测机制是基于循环VEGF与固定的VEGF适体的电化学结合; 由此这两种化合物的结合调节新电路的阈值电压，改变电路的阻抗（电容）。该新型电路的特征还在于用p-Si衬底编码的电极，增强了VEGF分子与适体之间的亲和力。形成流体池的装置被配置为使得能够将VEGF样品输送到芯片的有源表面上的流动。该装置具有并联电容器阵列，其作为集成的单独的对电极计算装置，其在时域上采用感觉输出，以便能够检测，报告和形成用于VEGF测量的稳态环路。此外，该检测器能够在体内提供精确测量和定量的VEGF分子变化率，从而提供该重要生物标志物的实时反馈，其可用于测量肿瘤对递送的化学治疗剂和生物反应调节剂的反应（BRM），以确定肿瘤负担。

9. 发明授权

US07799016B2 Magnetic breather pump and a method for treating a brain tumor using the same 有权
标题翻译：磁性呼吸泵和使用其治疗脑肿瘤的方法
公开(公告)号：US07799016B2
公开(公告)日：2010-09-21
申请号：US12143720
申请日：2008-06-20
申请人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Bruce Marx , David Johnson , Laszlo Farkas
发明人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Bruce Marx , David Johnson , Laszlo Farkas
IPC分类号： A61K9/22
CPC分类号： A61M5/16827 , A61M5/14276 , A61M2210/0693
摘要： A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
摘要翻译：将磁力控制的泵植入患者的脑中，并以对应于患者的特定需要的受控速率递送多个治疗剂。本发明包括由两层聚合物形成的柔性双壁袋。该小袋由磁性螺线管交替地膨胀和收缩。当收缩时，通过多根针将药剂从袋中推出。当袋膨胀时，将周围的脑液吸入小袋的双壁之间的空间，通过导管将其从拉伸到分析器。分析从患者抽取的脑液。基于这些测量，该装置的操作以及因此的处理被远程控制并通过外部控制器显示。

10. 发明申请

US20090275828A1 METHOD AND APPARATUS FOR CREATING A HIGH RESOLUTION MAP OF THE ELECTRICAL AND MECHANICAL PROPERTIES OF THE HEART 审中-公开
标题翻译：用于创建心脏电气和机械特性的高分辨率图的方法和装置
公开(公告)号：US20090275828A1
公开(公告)日：2009-11-05
申请号：US12113804
申请日：2008-05-01
申请人： Yehoshua Shachar , Bruce Marx , Laszlo Farkas , David Johnson , Leslie Farkas
发明人： Yehoshua Shachar , Bruce Marx , Laszlo Farkas , David Johnson , Leslie Farkas
IPC分类号： A61B5/00 , A61B5/053
CPC分类号： A61B5/0422 , A61B5/0452 , A61B5/053 , A61B5/0538 , A61B5/062 , A61B5/1107 , A61B5/6885 , A61B2034/2051
摘要： A system method that tracks one or more points on the surface of a cardiac tissue throughout a cardiac cycle and collect various types of data points which are then subsequently used to generate a corresponding model of the tissue and display the model as a 3D color coded image is described. In one embodiment, the system determines the position and orientation of a distal tip of a catheter, manipulates the catheter tip so as to maintain constant contact between the tip and a region of cardiac tissue using the impedance method, acquires positional and electrical data of the tip-tissue configuration through an entire heartbeat cycle, repeats the measurements as many times as needed in different tissue regions, and forms a 3D color coded map displaying various mechanical and electrical properties of the heart using the acquired data.
摘要翻译：一种跟踪心脏周围心脏组织表面上的一个或多个点的系统方法，并收集各种类型的数据点，然后随后使用这些数据点来生成组织的相应模型并将该模型显示为3D彩色编码图像被描述。在一个实施例中，系统确定导管的远侧末端的位置和取向，操纵导管尖端，以便使用阻抗方法保持尖端与心脏组织区域之间的恒定接触，获取位置和电气数据通过整个心跳周期的尖端组织配置，在不同组织区域中根据需要重复测量多次，并且使用获取的数据形成显示心脏的各种机械和电学性质的3D颜色编码图。

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