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    • 5. 发明授权
    • Apparatus and method for shaped magnetic field control for catheter, guidance, control, and imaging
    • 用于导管,引导,控制和成像的成形磁场控制的装置和方法
    • US08027714B2
    • 2011-09-27
    • US11140475
    • 2005-05-27
    • Yehoshua Shachar
    • Yehoshua Shachar
    • A61B5/05A61B5/06
    • A61B5/06A61B1/00158A61B5/0507A61B5/062A61B34/25A61B34/70A61B34/73A61B34/77A61B2017/00703A61B2034/2051A61B2034/2063A61B2034/732A61B2090/376A61M25/0127A61M2025/0166
    • A variable magnet system for manipulating a magnetic catheter is described. In one embodiment, a cluster of electromagnets is configured to generate a desired magnetic field. In one embodiment, one or more poles of the cluster are moveable with respect to other poles in the cluster to allow shaping of the magnetic field. In one embodiment, one or more magnetic poles can be extended or retracted to shape the magnetic field. In one embodiment, the electromagnets can be positioned to generate magnetic fields that exert a desired torque and/or movement force on the catheter. In one embodiment, the catheter guidance system includes a closed-loop servo feedback system. In one embodiment, a radar system is used to determine the location of the distal end of the catheter inside the body, thus, minimizing or eliminating the use of ionizing radiation such as X-rays. The catheter guidance system can also be used in combination with an X-ray system (or other imaging systems) to provide additional imagery to the operator. The magnetic system used in the magnetic catheter guidance system can also be used to locate the catheter tip to provide location feedback to the operator and the control system. In one embodiment, a magnetic field source is used to create a magnetic field of sufficient strength and orientation to move a magnetically-responsive catheter tip in a desired direction by a desired amount.
    • 描述了用于操纵磁导管的可变磁体系统。 在一个实施例中,一组电磁体被配置为产生期望的磁场。 在一个实施例中,簇的一个或多个极可相对于簇中的其它极点移动,以允许磁场成形。 在一个实施例中,可以延伸或缩回一个或多个磁极以使磁场成形。 在一个实施例中,电磁体可以被定位成产生在导管上施加期望的扭矩和/或移动力的磁场。 在一个实施例中,导管引导系统包括闭环伺服反馈系统。 在一个实施例中,使用雷达系统来确定导管在体内的远端的位置,从而最小化或消除诸如X射线的电离辐射的使用。 导管引导系统还可以与X射线系统(或其他成像系统)组合使用,以向操作者提供额外的图像。 用于磁导管引导系统的磁系统也可用于定位导管尖端以向操作者和控制系统提供位置反馈。 在一个实施例中,使用磁场源来产生具有足够强度和取向的磁场,以将磁响应导管尖端沿所需方向移动所需量。
    • 9. 发明申请
    • APPARATUS FOR PIEZOELECTRIC LAYER-WISE PUMP AND VALVE FOR USE IN LOCAL ADMINISTRATION OF BIOLOGICAL RESPONSE MODIFIERS AND THERAPEUTIC AGENTS
    • 用于生物反应改性剂和治疗剂的当地管理的压电层 - 泵和阀的装置
    • US20080089921A1
    • 2008-04-17
    • US11959419
    • 2007-12-18
    • Yehoshua Shachar
    • Yehoshua Shachar
    • A61K9/00
    • A61M5/16827A61M5/14276A61M5/1723A61M2202/049A61M2205/0294A61M2205/3331A61M2205/3368A61M2205/3523A61M2205/50
    • A method and apparatus for local infusion of a variety of biological response modifiers (BRMs) and chemotherapeutic agents including tumor necrosis factors (TNF) is described. In one embodiment, the device contains a synthetic pouch compartmentalized into three or more chambers, and an electronic apparatus controlling and modulating the delivery of the agents to the site of the tumor, so as to achieve a desired regimen in support of the elimination of a tumor burden. In one embodiment, an electronic system provides tailored and controlled regulation of the administration of such agents, using sensors to monitor the progress of the treatment. Desired dosing and scheduling of anti-tumor agents in a local setting is provided In one embodiment, active control and regulation of the administration of medicating agents is attached to a synthetic pouch and with the aid of a piezoelectric valve and pump actuating mechanism. The apparatus provides the desired dose, duration and timing of dose delivery. In one embodiment, reporting the events in the tumor site via an RF link to the external control box is provided.
    • 描述了用于局部输注各种生物反应调节剂(BRM)和化学治疗剂(包括肿瘤坏死因子(TNF))的方法和装置。 在一个实施方案中,该装置包含分隔成三个或更多个室的合成袋,以及控制和调节药剂递送至肿瘤部位的电子装置,以实现支持消除肿瘤的期望方案 肿瘤负担。 在一个实施例中,电子系统使用传感器监测治疗的进展情况来提供对这些药剂的管理的定制和受控制的调节。 提供了在局部设置中所需的抗肿瘤剂的给药和调度。在一个实施方案中,主动控制和调节治疗剂的施用被附接到合成袋并借助于压电阀和泵致动机构。 该装置提供剂量递送所需的剂量,持续时间和时间。 在一个实施例中,提供了通过RF链路向外部控制箱报告肿瘤部位中的事件。