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1. 发明申请

US20090017450A1 Primer for detection of human papillomavirus 失效
标题翻译：用于检测人乳头状瘤病毒的底物
公开(公告)号：US20090017450A1
公开(公告)日：2009-01-15
申请号：US10581649
申请日：2006-03-14
申请人： Joo-Sung Yang , Hyeran Cha
发明人： Joo-Sung Yang , Hyeran Cha
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/708
摘要： Disclosed are primers specific to the genome of HPV genotypes 11, 16, 18 and 31. Also disclosed are a kit for detecting the HPV genome comprising the primers and a method of detecting the HPV genome using the primers.
摘要翻译：公开了对HPV基因型11,16,18和31的基因组特异的引物。还公开了用于检测包含引物的HPV基因组的试剂盒和使用引物检测HPV基因组的方法。

2. 发明授权

US07790375B2 Primer for detection of human papillomavirus 失效
标题翻译：用于检测人乳头状瘤病毒的底物
公开(公告)号：US07790375B2
公开(公告)日：2010-09-07
申请号：US10581649
申请日：2006-03-14
申请人： Joo-Sung Yang , Hyeran Cha
发明人： Joo-Sung Yang , Hyeran Cha
IPC分类号： C12Q1/68
CPC分类号： C12Q1/708
摘要： Disclosed are primers specific to the genome of HPV genotypes 11, 16, 18 and 31. Also disclosed are a kit for detecting the HPV genome comprising the primers and a method of detecting the HPV genome using the primers.
摘要翻译：公开了对HPV基因型11,16,18和31的基因组特异的引物。还公开了用于检测包含引物的HPV基因组的试剂盒和使用引物检测HPV基因组的方法。

3. 发明申请

US20070041941A1 Nucleic acid sequences encoding and compositions comrpising ige signal peptide and/or il-15 and methods for using the same 有权
标题翻译：编码和组合的核酸序列信号肽和/或il-15及其使用方法
公开(公告)号：US20070041941A1
公开(公告)日：2007-02-22
申请号：US10560650
申请日：2004-06-14
申请人： David Weiner , Michele Kutzler , Andrew Choo , Joo-Sung Yang , Jean Boyer
发明人： David Weiner , Michele Kutzler , Andrew Choo , Joo-Sung Yang , Jean Boyer
IPC分类号： A61K48/00 , A61K39/21 , C07H21/04 , C07K14/16 , C07K16/10 , C12N15/867
CPC分类号： C07K14/5443 , A61K2039/53 , A61K2039/55527 , C07K14/70578 , C07K2319/02 , Y02A50/394
摘要： Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.
摘要翻译：公开了融合蛋白和编码融合蛋白的核酸分子。公开了包含与IL-15蛋白质序列连接的非IL-15信号肽和包含与非IgE蛋白序列连接的IgE信号肽的融合蛋白的融合蛋白。包含这种核酸分子的载体; 公开了包含这种载体的宿主细胞以及编码融合蛋白的重组疫苗和活减毒病原体及其使用方法。公开了递送IL-15和CD40L（含有或不含免疫原）后的免疫调节作用，用于递送此类蛋白质的各种核酸分子及其组合物以及使用该组合物的方法。

4. 发明授权

US07348138B2 Method of inducing cell death using West Nile virus capsid protein 失效
标题翻译：使用西尼罗病毒衣壳蛋白诱导细胞死亡的方法
公开(公告)号：US07348138B2
公开(公告)日：2008-03-25
申请号：US10966576
申请日：2004-10-14
申请人： David B. Weiner , Joo-Sung Yang , Karuppiah Muthumani
发明人： David B. Weiner , Joo-Sung Yang , Karuppiah Muthumani
IPC分类号： C12Q1/70 , A61K39/12
CPC分类号： A61K38/162 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K2319/02 , C12N2740/16222 , C12N2770/24122 , C12N2770/24322 , G01N33/56983 , G01N2469/20 , Y02A50/394
摘要： This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus including Flavivirus or Pestivirus capsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirus and/or anti-Pestivirus capsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.
摘要翻译：本发明提供了用黄病毒或瘟病毒衣壳蛋白（例如西尼罗河病毒（WNV）衣壳蛋白）及其功能片段诱导细胞死亡的方法。本发明还提供了通过施用包含WNV或其它病毒（包括黄病毒或瘟病毒衣壳或其他蛋白质）的药物组合物或其编码的核酸分子来治疗患有特征在于过度增殖细胞的疾病的患者的方法。公开了鉴定具有抗病毒和/或抗WNV和/或抗黄病毒和/或抗瘟病毒衣壳或其它蛋白质活性的化合物的方法。本发明还提供包含衣壳或其它蛋白质或其片段，或编码其的核酸的疫苗组合物，来自WNV或其它病毒，包括黄病毒或瘟病毒和药学上可接受的载体。本发明还提供用于鉴定暴露于WNV或其它病毒（包括黄病毒或瘟病毒）的个体的诊断方法和试剂盒。

5. 发明申请

US20050226849A1 Compositions and methods of using capsid protein from Flaviviruses and Pestiviruses 失效
标题翻译：使用来自黄病毒和瘟病毒的衣壳蛋白的组合物和方法
公开(公告)号：US20050226849A1
公开(公告)日：2005-10-13
申请号：US10966576
申请日：2004-10-14
申请人： David Weiner , Joo-Sung Yang , Karuppiah Muthumani
发明人： David Weiner , Joo-Sung Yang , Karuppiah Muthumani
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K38/16 , A61K38/22 , A61K38/43 , A61K39/00 , A61K39/12 , A61K48/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/16 , C07K14/18 , C12N15/67 , C12P21/02 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569 , C12N15/86
CPC分类号： A61K38/162 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K2319/02 , C12N2740/16222 , C12N2770/24122 , C12N2770/24322 , G01N33/56983 , G01N2469/20 , Y02A50/394
摘要： This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus including Flavivirus or Pestivirus capsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirus and/or anti-Pestivirus capsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.
摘要翻译：本发明提供了用黄病毒或瘟病毒衣壳蛋白（例如西尼罗河病毒（WNV）衣壳蛋白）及其功能片段诱导细胞死亡的方法。本发明还提供了通过施用包含WNV或其它病毒（包括黄病毒或瘟病毒衣壳或其他蛋白质）的药物组合物或其编码的核酸分子来治疗患有特征在于过度增殖细胞的疾病的患者的方法。公开了鉴定具有抗病毒和/或抗WNV和/或抗黄病毒和/或抗瘟病毒衣壳或其它蛋白质活性的化合物的方法。本发明还提供包含衣壳或其它蛋白质或其片段，或编码其的核酸的疫苗组合物，来自WNV或其它病毒，包括黄病毒或瘟病毒和药学上可接受的载体。本发明还提供用于鉴定暴露于WNV或其它病毒（包括黄病毒或瘟病毒）的个体的诊断方法和试剂盒。

6. 发明授权

US06733994B2 Highly expressible genes 有权
标题翻译：高度可表达的基因
公开(公告)号：US06733994B2
公开(公告)日：2004-05-11
申请号：US09971806
申请日：2001-10-04
申请人： David B. Weiner , Joo-Sung Yang
发明人： David B. Weiner , Joo-Sung Yang
IPC分类号： C12P2102
CPC分类号： A61K38/162 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K2319/02 , C12N2740/16222 , C12N2770/24122 , C12N2770/24322 , G01N33/56983 , G01N2469/20 , Y02A50/394
摘要： The present invention provides methods of producing protein in a recombinant expression system that comprises translation of mRNA transcribed from a heterologous DNA sequence in the expression system, said method comprising the steps of predicting the secondary structure of mRNA transcribed from a native heterologous DNA sequence; modifying the native heterologous DNA sequence to produce a modified heterologous DNA sequence wherein mRNA transcribed from the modified heterologous DNA sequence has a secondary structure having increased free energy compared to that of the secondary structure of the mRNA transcribed from the native heterologous DNA sequence; and using the modified heterologous DNA sequence in the recombinant expression system for protein production. The invention also provides injectable pharmaceutical compositions comprising a nucleic acid molecule that includes a modified coding sequence. The invention also provides recombinant viral vectors comprising a nucleic acid molecule that includes a modified coding sequence.
摘要翻译：本发明提供了在重组表达系统中产生蛋白质的方法，该重组表达系统包括从表达系统中异源DNA序列转录的mRNA的翻译，所述方法包括预测从天然异源DNA序列转录的mRNA的二级结构的步骤; 修饰天然异源DNA序列以产生修饰的异源DNA序列，其中从修饰的异源DNA序列转录的mRNA具有与从天然异源DNA序列转录的mRNA的二级结构相比具有增加的自由能的二级结构; 并在重组表达系统中使用修饰的异源DNA序列进行蛋白质生产。本发明还提供了包含核酸分子的可注射药物组合物，其包含修饰的编码序列。本发明还提供包含核酸分子的重组病毒载体，其包含修饰的编码序列。

7. 发明授权

US08226944B2 Composition for treating virus infection disease comprising Jab1 有权
标题翻译：用于治疗包含Jab1的病毒感染疾病的组合物
公开(公告)号：US08226944B2
公开(公告)日：2012-07-24
申请号：US12909443
申请日：2010-10-21
申请人： Jaewhan Song , Wonkyung Oh , Young Hoon Sung , Sung Ryul Lee , Han-Woong Lee , Suhk Neung Pyo , Joo-Sung Yang
发明人： Jaewhan Song , Wonkyung Oh , Young Hoon Sung , Sung Ryul Lee , Han-Woong Lee , Suhk Neung Pyo , Joo-Sung Yang
IPC分类号： A61K39/395 , A61K39/42
CPC分类号： A61K38/1709 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5023 , G01N33/5041 , G01N2333/18 , G01N2500/10 , Y02A50/393
摘要： Disclosed is a composition for treating or preventing a viral infection or associated disease comprising a Jab1 protein, a nucleic acid having a nucleotide sequence coding for a Jab1 protein or a recombinant virus expressing a Jab1 protein.
摘要翻译：公开了用于治疗或预防病毒感染或相关疾病的组合物，其包含Jab1蛋白，具有编码Jab1蛋白的核苷酸序列的核酸或表达Jab1蛋白的重组病毒。

8. 发明授权

US08173786B2 Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same 有权
标题翻译：编码核酸序列和包含IgE信号肽和/或IL-15的组合物及其使用方法
公开(公告)号：US08173786B2
公开(公告)日：2012-05-08
申请号：US10560650
申请日：2004-06-14
申请人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
发明人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00
CPC分类号： C07K14/5443 , A61K2039/53 , A61K2039/55527 , C07K14/70578 , C07K2319/02 , Y02A50/394
摘要： Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.
摘要翻译：公开了融合蛋白和编码融合蛋白的核酸分子。公开了包含与IL-15蛋白质序列连接的非IL-15信号肽和包含与非IgE蛋白序列连接的IgE信号肽的融合蛋白的融合蛋白。包含这种核酸分子的载体; 公开了包含这种载体的宿主细胞以及编码融合蛋白的重组疫苗和活减毒病原体及其使用方法。公开了递送IL-15和CD40L（含有或不含免疫原）后的免疫调节作用，用于递送此类蛋白质的各种核酸分子及其组合物以及使用该组合物的方法。

9. 发明授权

US07960609B2 Plant vector pBSNB-TEV, vectors derived therefrom, and methods of use 有权
标题翻译：植物载体pBSNB-TEV，由其衍生的载体和使用方法
公开(公告)号：US07960609B2
公开(公告)日：2011-06-14
申请号：US12297205
申请日：2007-10-01
申请人： Joo-Sung Yang , Eun Hee Yang
发明人： Joo-Sung Yang , Eun Hee Yang
IPC分类号： C12N15/82 , C12N5/04 , C12N5/10 , A01H5/00 , C07H21/04
CPC分类号： C07K16/1018 , A61K39/12 , A61K39/145 , A61K2039/517 , A61K2039/542 , C07K14/005 , C12N15/8258 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to an avian influenza vaccine of plant origin, prepared by transforming a plant with a surface protein of avian influenza virus, hemagglutinin (HA) or neuraminidase (NA), and a method for preparing the same. Further, the present invention relates to an oral vaccine for preventing avian influenza virus, of which mass-production conditions are established, and thus the produced transgenic plant can be more easily, safely, and economically used as a fodder additive. Furthermore, the present invention relates to a reagent for diagnosing avian influenza virus infection, prepared by isolating and purifying a recombinant antigen protein from the transgenic plant.
摘要翻译：本发明涉及通过用禽流感病毒，血凝素（HA）或神经氨酸酶（NA）的表面蛋白质转化植物制备的植物来源的禽流感疫苗及其制备方法。此外，本发明涉及用于预防禽流感病毒的口服疫苗，其中建立了大量生产条件，因此所生产的转基因植物可以更容易，安全和经济地用作饲料添加剂。此外，本发明涉及通过从转基因植物中分离和纯化重组抗原蛋白而制备的用于诊断禽流感病毒感染的试剂。

10. 发明申请

US20120276142A1 NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IGE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME 审中-公开
标题翻译：包含IGE信号肽和/或IL-15的核酸序列编码和组合物及其使用方法
公开(公告)号：US20120276142A1
公开(公告)日：2012-11-01
申请号：US13466015
申请日：2012-05-07
申请人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
发明人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
IPC分类号： A61K39/00 , C12N15/86 , A61K31/7088 , C07H21/04 , A61K39/285 , C12N15/85
CPC分类号： C07K14/5443 , A61K2039/53 , A61K2039/55527 , C07K14/70578 , C07K2319/02 , Y02A50/394
摘要： Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.
摘要翻译：公开了融合蛋白和编码融合蛋白的核酸分子。公开了包含与IL-15蛋白质序列连接的非IL-15信号肽和包含与非IgE蛋白序列连接的IgE信号肽的融合蛋白的融合蛋白。包含这种核酸分子的载体; 公开了包含这种载体的宿主细胞以及编码融合蛋白的重组疫苗和活减毒病原体及其使用方法。公开了递送IL-15和CD40L（含有或不含免疫原）后的免疫调节作用，用于递送此类蛋白质的各种核酸分子及其组合物以及使用该组合物的方法。

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