专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110092414A1 COMPOSITION FOR TREATING VIRUS INFECTION DISEASE COMPRISING JAB1 有权
标题翻译：用于治疗包含JAB1的病毒感染疾病的组合物
公开(公告)号：US20110092414A1
公开(公告)日：2011-04-21
申请号：US12909443
申请日：2010-10-21
申请人： Jaewhan Song , Wonkyung Oh , Young Hoon Sung , Sung Ryul Lee , Han-Woong Lee , Suhk Neung Pyo , Joo-Sung Yang
发明人： Jaewhan Song , Wonkyung Oh , Young Hoon Sung , Sung Ryul Lee , Han-Woong Lee , Suhk Neung Pyo , Joo-Sung Yang
IPC分类号： A61K38/16 , A61K38/17 , A61P31/14
CPC分类号： A61K38/1709 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5023 , G01N33/5041 , G01N2333/18 , G01N2500/10 , Y02A50/393
摘要： Disclosed is a composition for treating or preventing a viral infection or associated disease comprising a Jab1 protein, a nucleic acid having a nucleotide sequence coding for a Jab1 protein or a recombinant virus expressing a Jab1 protein.
摘要翻译：公开了用于治疗或预防病毒感染或相关疾病的组合物，其包含Jab1蛋白，具有编码Jab1蛋白的核苷酸序列的核酸或表达Jab1蛋白的重组病毒。

2. 发明授权

US07790375B2 Primer for detection of human papillomavirus 失效
标题翻译：用于检测人乳头状瘤病毒的底物
公开(公告)号：US07790375B2
公开(公告)日：2010-09-07
申请号：US10581649
申请日：2006-03-14
申请人： Joo-Sung Yang , Hyeran Cha
发明人： Joo-Sung Yang , Hyeran Cha
IPC分类号： C12Q1/68
CPC分类号： C12Q1/708
摘要： Disclosed are primers specific to the genome of HPV genotypes 11, 16, 18 and 31. Also disclosed are a kit for detecting the HPV genome comprising the primers and a method of detecting the HPV genome using the primers.
摘要翻译：公开了对HPV基因型11,16,18和31的基因组特异的引物。还公开了用于检测包含引物的HPV基因组的试剂盒和使用引物检测HPV基因组的方法。

3. 发明申请

US20090104230A1 COMPOSITIONS AND METHODS OF USING CAPSID PROTEIN FROM FLAVIVIRUSES AND PESTIVIRUSES 审中-公开
标题翻译：使用蚜虫蛋白质和杀虫剂的组合物和方法
公开(公告)号：US20090104230A1
公开(公告)日：2009-04-23
申请号：US11972421
申请日：2008-01-10
申请人： David B. Weiner , Karuppiah Muthumani , Joo-Sung Yang
发明人： David B. Weiner , Karuppiah Muthumani , Joo-Sung Yang
IPC分类号： A61K39/00 , C12N5/06 , C12Q1/70 , A61K38/16 , A61K31/7088
CPC分类号： A61K38/162 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K2319/02 , C12N2740/16222 , C12N2770/24122 , C12N2770/24322 , G01N33/56983 , G01N2469/20 , Y02A50/39 , Y02A50/394
摘要： This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus including Flavivirus or Pestivirus capsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirus and/or anti-Pestivirus capsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.
摘要翻译：本发明提供了用黄病毒或瘟病毒衣壳蛋白（例如西尼罗河病毒（WNV）衣壳蛋白）及其功能片段诱导细胞死亡的方法。本发明还提供了通过施用包含WNV或其它病毒（包括黄病毒或瘟病毒衣壳或其他蛋白质）的药物组合物或其编码的核酸分子来治疗患有特征在于过度增殖细胞的疾病的患者的方法。公开了鉴定具有抗病毒和/或抗WNV和/或抗黄病毒和/或抗瘟病毒衣壳或其它蛋白质活性的化合物的方法。本发明还提供包含衣壳或其它蛋白质或其片段，或编码其的核酸的疫苗组合物，来自WNV或其它病毒，包括黄病毒或瘟病毒和药学上可接受的载体。本发明还提供用于鉴定暴露于WNV或其它病毒（包括黄病毒或瘟病毒）的个体的诊断方法和试剂盒。

4. 发明申请

US20080095742A1 Composition for Treating Virus Infection Disease Comprising Jab1 审中-公开
标题翻译：用于治疗包含Jab1的病毒感染疾病的组合物
公开(公告)号：US20080095742A1
公开(公告)日：2008-04-24
申请号：US10531543
申请日：2004-08-31
申请人： Jaewhan Hwan Song , Wonkyung Oh , Young Hoon Sung , Sung Ryul Lee , Han-Woong Lee , Suhk Neung Pyo , Joo-Sung Yang
发明人： Jaewhan Hwan Song , Wonkyung Oh , Young Hoon Sung , Sung Ryul Lee , Han-Woong Lee , Suhk Neung Pyo , Joo-Sung Yang
IPC分类号： A61K38/16 , A61K31/7088 , A61K48/00 , A61P31/12 , C12Q1/02 , C12Q1/68 , G01N33/53
CPC分类号： A61K38/1709 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5023 , G01N33/5041 , G01N2333/18 , G01N2500/10 , Y02A50/393
摘要： Disclosed is a composition for treating or preventing a viral infection or associated disease comprising a Jab1 protein, a nucleic acid having a nucleotide sequence coding for a Jab1 protein or a recombinant virus expressing a jab1 protein.
摘要翻译：公开了用于治疗或预防病毒感染或相关疾病的组合物，其包含Jab1蛋白，具有编码Jab1蛋白的核苷酸序列的核酸或表达jab1蛋白的重组病毒。

5. 发明授权

US06331616B1 Nucleic acids obtained from the envelope coding region of feline immunodeficiency virus molecular clone designated JSY3 失效
标题翻译：从猫免疫缺陷病毒分子克隆的包膜编码区获得的核酸为JSY3
公开(公告)号：US06331616B1
公开(公告)日：2001-12-18
申请号：US08811682
申请日：1997-03-05
申请人： Wayne Tompkins , Mary Tompkins , Joo-Sung Yang
发明人： Wayne Tompkins , Mary Tompkins , Joo-Sung Yang
IPC分类号： C07H2104
CPC分类号： C07K14/005 , A01K67/027 , A61K39/00 , C12N2740/15022
摘要： A full-length feline immunodeficiency virus NCSU1 (FIV-NCSU1) genome (JSY3) was cloned directly from FIV-NCSU1-infected feline CD4+ lymphocyte (FCD4E) genomic DNA and identified by PCR amplification with 5′ long terminal repeat (LTR), gag, env, and 3′ LTR primer sets. Cell-free JSY3 virus was cytopathogenic for FCD4E lymphocytes but did not infect CrFK cells in vitro. To determine in vivo infectivity and pathogenesis, six young adult specific-pathogen-free cats were inoculated with cell-free JSY3 virus. Provirus was detected at 2 weeks postinfection (p.i.) and was still detectable at 25 weeks p.i. as determined by gag region PCR-Southern blot analysis of peripheral blood mononuclear cell lysates. Infectious virus was recovered from peripheral blood mononuclear cells at 6 and 25 weeks p.i., and an antibody response to FIV was detected by 4 weeks. In the acute phase of infection, JSY3 provirus was found only in the CD4+ lymphocyte subset; however, by 14 weeks p.i., the greatest provirus burden was detected in B lymphocytes. All six cats were panlymphopenic at 2 weeks p.i., CD4+/CD8+ ratios were inverted by 6 weeks p.i., and five of the six cats developed lymphadenopathy by 10 weeks p.i. The claimed invention is directed toward isolated nucleic acids corresponding to the full-length JSY3 env coding region (nt. 6269-8824) and an env fragment comprising the transmembrane spanning domain (nt. 8339-8374). These nucleic acids will prove useful, inter alia, as molecular probes for FIV-specific sequences and in the generation of FIV-specific antigens and immunological reagents.
摘要翻译：从FIV-NCSU1感染的猫CD4 +淋巴细胞（FCD4E）基因组DNA中直接克隆全长猫免疫缺陷病毒NCSU1（FIV-NCSU1）基因组（JSY3），并通过5'长末端重复（LTR），gag ，env和3'LTR引物组。无细胞的JSY3病毒对于FCD4E淋巴细胞是细胞致病性的，但在体外未感染CrFK细胞。为了确定体内感染和发病机制，将6只年轻成年无特异病原体的猫用无细胞的JSY3病毒接种。在感染后2周检测到病毒（p.i.），并且在25周p.i仍然可检测到。通过gag区PCR确定外周血单核细胞裂解物的PCR- DNA印迹分析。在6周和25周时从外周血单核细胞中回收感染性病毒，4周后检测到对FIV的抗体反应。在感染的急性期，仅在CD4 +淋巴细胞亚群中发现JSY3原病毒; 然而，在14周的时间内，B淋巴细胞中检测到最大的病毒负担。所有六只猫在2周时均为泛淋巴细胞，CD4 + / CD8 +比例在6周时反转，六只猫中有五只发生10周p.i的淋巴结肿大。所要求保护的发明涉及对应于全长JSY3环编码区（nt.6269-8824）的分离的核酸和包含跨膜跨膜结构域（nt.8339-8374）的env片段。这些核酸尤其可用作FIV特异性序列的分子探针和FIV特异性抗原和免疫试剂的产生。

6. 发明申请

US20120276142A1 NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IGE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME 审中-公开
标题翻译：包含IGE信号肽和/或IL-15的核酸序列编码和组合物及其使用方法
公开(公告)号：US20120276142A1
公开(公告)日：2012-11-01
申请号：US13466015
申请日：2012-05-07
申请人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
发明人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
IPC分类号： A61K39/00 , C12N15/86 , A61K31/7088 , C07H21/04 , A61K39/285 , C12N15/85
CPC分类号： C07K14/5443 , A61K2039/53 , A61K2039/55527 , C07K14/70578 , C07K2319/02 , Y02A50/394
摘要： Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.
摘要翻译：公开了融合蛋白和编码融合蛋白的核酸分子。公开了包含与IL-15蛋白质序列连接的非IL-15信号肽和包含与非IgE蛋白序列连接的IgE信号肽的融合蛋白的融合蛋白。包含这种核酸分子的载体; 公开了包含这种载体的宿主细胞以及编码融合蛋白的重组疫苗和活减毒病原体及其使用方法。公开了递送IL-15和CD40L（含有或不含免疫原）后的免疫调节作用，用于递送此类蛋白质的各种核酸分子及其组合物以及使用该组合物的方法。

7. 发明申请

US20110059129A1 AVIAN INFLUENZA VIRUS VACCINE AND A METHOD FOR PREPARING 有权
标题翻译： AVIAN流感病毒疫苗及其制备方法
公开(公告)号：US20110059129A1
公开(公告)日：2011-03-10
申请号：US12297205
申请日：2007-10-01
申请人： Joo-Sung Yang , Eun Hee Yang
发明人： Joo-Sung Yang , Eun Hee Yang
IPC分类号： A61K39/145 , C12N15/63 , A01H1/00 , A01H5/00 , C07K14/11 , A61P31/16
CPC分类号： C07K16/1018 , A61K39/12 , A61K39/145 , A61K2039/517 , A61K2039/542 , C07K14/005 , C12N15/8258 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to an avian influenza vaccine of plant origin, prepared by transforming a plant with a surface protein of avian influenza virus, hemagglutinin (HA) or neuraminidase (NA), and a method for preparing the same. Further, the present invention relates to an oral vaccine for preventing avian influenza virus, of which mass-production conditions are established, and thus the produced transgenic plant can be more easily, safely, and economically used as a fodder additive. Furthermore, the present invention relates to a reagent for diagnosing avian influenza virus infection, prepared by isolating and purifying a recombinant antigen protein from the transgenic plant.
摘要翻译：本发明涉及通过用禽流感病毒，血凝素（HA）或神经氨酸酶（NA）的表面蛋白质转化植物制备的植物来源的禽流感疫苗及其制备方法。此外，本发明涉及用于预防禽流感病毒的口服疫苗，其中建立了大量生产条件，因此所生产的转基因植物可以更容易，安全和经济地用作饲料添加剂。此外，本发明涉及通过从转基因植物中分离和纯化重组抗原蛋白而制备的用于诊断禽流感病毒感染的试剂。

8. 发明申请

US20100285058A1 DNA VACCINE FOR TREATING OR PREVENTING CERVICAL CANCER COMPRISING A GENE ENCODING HPV PROTEIN 失效
标题翻译：用于治疗或预防包含编码HPV蛋白的基因的癌细胞的DNA疫苗
公开(公告)号：US20100285058A1
公开(公告)日：2010-11-11
申请号：US11995624
申请日：2007-08-28
申请人： Joo Sung Yang , Sang Woo Kim , Jung Ah Choi
发明人： Joo Sung Yang , Sang Woo Kim , Jung Ah Choi
IPC分类号： A61K39/12 , C12N5/00 , C12Q1/70 , A61P35/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/55522 , A61K2039/55544 , A61K2039/585 , A61K2039/70 , C12N7/00 , C12N2710/20022 , C12N2710/20034
摘要： Disclosed herein is a DNA vaccine for treating cervical cancer including an E5 gene of human papillomavirus (HPV). Also, disclosed is a combination DNA vaccine for preventing and treating cervical cancer including a gene encoding HPV L1 and/or L2 along with the HPV E5 gene.
摘要翻译：本文公开了一种用于治疗宫颈癌的DNA疫苗，其包括人乳头状瘤病毒（HPV）的E5基因。此外，公开了用于预防和治疗宫颈癌的组合DNA疫苗，包括编码HPV L1和/或L2的基因以及HPV E5基因。

9. 发明授权

US07625751B2 WNV core protein/capsid interacting protein and uses of the same 有权
标题翻译： WNV核心蛋白/衣壳相互作用蛋白及其用途相同
公开(公告)号：US07625751B2
公开(公告)日：2009-12-01
申请号：US10478743
申请日：2002-05-28
申请人： David B. Weiner , Mathura P. Ramanathan , Joo-Sung Yang
发明人： David B. Weiner , Mathura P. Ramanathan , Joo-Sung Yang
IPC分类号： C12N15/12 , C12N5/10 , C12N1/21 , C07H21/00
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/393
摘要： Substantially pure WIP-1 and its use in assays to identify PAP-1/WIP-1 interaction inhibitors or WIP-I/WNV Cp interaction inhibitors are disclosed. Compositions comprising antisense sequences to prevent expression of WIP-1 and methods of treating cancer using the same are disclosed.
摘要翻译：公开了基本上纯的WIP-1及其在鉴定PAP-1 / WIP-1相互作用抑制剂或WIP-I / WNV Cp相互作用抑制剂的测定中的用途。公开了包含用于预防WIP-1表达的反义序列的组合物和使用其的治疗癌症的方法。

10. 发明申请

US20060088824A1 Wnv core protein/capsid interacting protein and uses of the same 有权
标题翻译： Wnv核心蛋白/衣壳相互作用蛋白及其用途相同
公开(公告)号：US20060088824A1
公开(公告)日：2006-04-27
申请号：US10478743
申请日：2002-05-28
申请人： David Weiner , Mathura Ramanathan , Joo-Sung Yang
发明人： David Weiner , Mathura Ramanathan , Joo-Sung Yang
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/393
摘要： Substantially pure WIP-1 and its use in assays to identify PAP-1/WIP-1 interaction inhibitors or WIP-1/WNV Cp interaction inhibitors are disclosed. Compositions comprising antisense sequences to prevent expression of WIP-1 and methods of treating cancer using the same are disclosed.
摘要翻译：公开了基本上纯的WIP-1及其在鉴定PAP-1 / WIP-1相互作用抑制剂或WIP-1 / WNV Cp相互作用抑制剂的测定中的用途。公开了包含用于预防WIP-1表达的反义序列的组合物和使用其的治疗癌症的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式