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1. 发明授权

US08173786B2 Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same 有权
标题翻译：编码核酸序列和包含IgE信号肽和/或IL-15的组合物及其使用方法
公开(公告)号：US08173786B2
公开(公告)日：2012-05-08
申请号：US10560650
申请日：2004-06-14
申请人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
发明人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00
CPC分类号： C07K14/5443 , A61K2039/53 , A61K2039/55527 , C07K14/70578 , C07K2319/02 , Y02A50/394
摘要： Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.
摘要翻译：公开了融合蛋白和编码融合蛋白的核酸分子。公开了包含与IL-15蛋白质序列连接的非IL-15信号肽和包含与非IgE蛋白序列连接的IgE信号肽的融合蛋白的融合蛋白。包含这种核酸分子的载体; 公开了包含这种载体的宿主细胞以及编码融合蛋白的重组疫苗和活减毒病原体及其使用方法。公开了递送IL-15和CD40L（含有或不含免疫原）后的免疫调节作用，用于递送此类蛋白质的各种核酸分子及其组合物以及使用该组合物的方法。

2. 发明申请

US20090104230A1 COMPOSITIONS AND METHODS OF USING CAPSID PROTEIN FROM FLAVIVIRUSES AND PESTIVIRUSES 审中-公开
标题翻译：使用蚜虫蛋白质和杀虫剂的组合物和方法
公开(公告)号：US20090104230A1
公开(公告)日：2009-04-23
申请号：US11972421
申请日：2008-01-10
申请人： David B. Weiner , Karuppiah Muthumani , Joo-Sung Yang
发明人： David B. Weiner , Karuppiah Muthumani , Joo-Sung Yang
IPC分类号： A61K39/00 , C12N5/06 , C12Q1/70 , A61K38/16 , A61K31/7088
CPC分类号： A61K38/162 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K2319/02 , C12N2740/16222 , C12N2770/24122 , C12N2770/24322 , G01N33/56983 , G01N2469/20 , Y02A50/39 , Y02A50/394
摘要： This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus including Flavivirus or Pestivirus capsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirus and/or anti-Pestivirus capsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.
摘要翻译：本发明提供了用黄病毒或瘟病毒衣壳蛋白（例如西尼罗河病毒（WNV）衣壳蛋白）及其功能片段诱导细胞死亡的方法。本发明还提供了通过施用包含WNV或其它病毒（包括黄病毒或瘟病毒衣壳或其他蛋白质）的药物组合物或其编码的核酸分子来治疗患有特征在于过度增殖细胞的疾病的患者的方法。公开了鉴定具有抗病毒和/或抗WNV和/或抗黄病毒和/或抗瘟病毒衣壳或其它蛋白质活性的化合物的方法。本发明还提供包含衣壳或其它蛋白质或其片段，或编码其的核酸的疫苗组合物，来自WNV或其它病毒，包括黄病毒或瘟病毒和药学上可接受的载体。本发明还提供用于鉴定暴露于WNV或其它病毒（包括黄病毒或瘟病毒）的个体的诊断方法和试剂盒。

3. 发明申请

US20120276142A1 NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IGE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME 审中-公开
标题翻译：包含IGE信号肽和/或IL-15的核酸序列编码和组合物及其使用方法
公开(公告)号：US20120276142A1
公开(公告)日：2012-11-01
申请号：US13466015
申请日：2012-05-07
申请人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
发明人： David B. Weiner , Michele Kutzler , Andrew Y. Choo , Joo-Sung Yang , Jean D. Boyer
IPC分类号： A61K39/00 , C12N15/86 , A61K31/7088 , C07H21/04 , A61K39/285 , C12N15/85
CPC分类号： C07K14/5443 , A61K2039/53 , A61K2039/55527 , C07K14/70578 , C07K2319/02 , Y02A50/394
摘要： Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.
摘要翻译：公开了融合蛋白和编码融合蛋白的核酸分子。公开了包含与IL-15蛋白质序列连接的非IL-15信号肽和包含与非IgE蛋白序列连接的IgE信号肽的融合蛋白的融合蛋白。包含这种核酸分子的载体; 公开了包含这种载体的宿主细胞以及编码融合蛋白的重组疫苗和活减毒病原体及其使用方法。公开了递送IL-15和CD40L（含有或不含免疫原）后的免疫调节作用，用于递送此类蛋白质的各种核酸分子及其组合物以及使用该组合物的方法。

4. 发明授权

US07625751B2 WNV core protein/capsid interacting protein and uses of the same 有权
标题翻译： WNV核心蛋白/衣壳相互作用蛋白及其用途相同
公开(公告)号：US07625751B2
公开(公告)日：2009-12-01
申请号：US10478743
申请日：2002-05-28
申请人： David B. Weiner , Mathura P. Ramanathan , Joo-Sung Yang
发明人： David B. Weiner , Mathura P. Ramanathan , Joo-Sung Yang
IPC分类号： C12N15/12 , C12N5/10 , C12N1/21 , C07H21/00
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/393
摘要： Substantially pure WIP-1 and its use in assays to identify PAP-1/WIP-1 interaction inhibitors or WIP-I/WNV Cp interaction inhibitors are disclosed. Compositions comprising antisense sequences to prevent expression of WIP-1 and methods of treating cancer using the same are disclosed.
摘要翻译：公开了基本上纯的WIP-1及其在鉴定PAP-1 / WIP-1相互作用抑制剂或WIP-I / WNV Cp相互作用抑制剂的测定中的用途。公开了包含用于预防WIP-1表达的反义序列的组合物和使用其的治疗癌症的方法。

5. 发明授权

US07348138B2 Method of inducing cell death using West Nile virus capsid protein 失效
标题翻译：使用西尼罗病毒衣壳蛋白诱导细胞死亡的方法
公开(公告)号：US07348138B2
公开(公告)日：2008-03-25
申请号：US10966576
申请日：2004-10-14
申请人： David B. Weiner , Joo-Sung Yang , Karuppiah Muthumani
发明人： David B. Weiner , Joo-Sung Yang , Karuppiah Muthumani
IPC分类号： C12Q1/70 , A61K39/12
CPC分类号： A61K38/162 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K2319/02 , C12N2740/16222 , C12N2770/24122 , C12N2770/24322 , G01N33/56983 , G01N2469/20 , Y02A50/394
摘要： This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus including Flavivirus or Pestivirus capsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirus and/or anti-Pestivirus capsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.
摘要翻译：本发明提供了用黄病毒或瘟病毒衣壳蛋白（例如西尼罗河病毒（WNV）衣壳蛋白）及其功能片段诱导细胞死亡的方法。本发明还提供了通过施用包含WNV或其它病毒（包括黄病毒或瘟病毒衣壳或其他蛋白质）的药物组合物或其编码的核酸分子来治疗患有特征在于过度增殖细胞的疾病的患者的方法。公开了鉴定具有抗病毒和/或抗WNV和/或抗黄病毒和/或抗瘟病毒衣壳或其它蛋白质活性的化合物的方法。本发明还提供包含衣壳或其它蛋白质或其片段，或编码其的核酸的疫苗组合物，来自WNV或其它病毒，包括黄病毒或瘟病毒和药学上可接受的载体。本发明还提供用于鉴定暴露于WNV或其它病毒（包括黄病毒或瘟病毒）的个体的诊断方法和试剂盒。

6. 发明授权

US06733994B2 Highly expressible genes 有权
标题翻译：高度可表达的基因
公开(公告)号：US06733994B2
公开(公告)日：2004-05-11
申请号：US09971806
申请日：2001-10-04
申请人： David B. Weiner , Joo-Sung Yang
发明人： David B. Weiner , Joo-Sung Yang
IPC分类号： C12P2102
CPC分类号： A61K38/162 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K2319/02 , C12N2740/16222 , C12N2770/24122 , C12N2770/24322 , G01N33/56983 , G01N2469/20 , Y02A50/394
摘要： The present invention provides methods of producing protein in a recombinant expression system that comprises translation of mRNA transcribed from a heterologous DNA sequence in the expression system, said method comprising the steps of predicting the secondary structure of mRNA transcribed from a native heterologous DNA sequence; modifying the native heterologous DNA sequence to produce a modified heterologous DNA sequence wherein mRNA transcribed from the modified heterologous DNA sequence has a secondary structure having increased free energy compared to that of the secondary structure of the mRNA transcribed from the native heterologous DNA sequence; and using the modified heterologous DNA sequence in the recombinant expression system for protein production. The invention also provides injectable pharmaceutical compositions comprising a nucleic acid molecule that includes a modified coding sequence. The invention also provides recombinant viral vectors comprising a nucleic acid molecule that includes a modified coding sequence.
摘要翻译：本发明提供了在重组表达系统中产生蛋白质的方法，该重组表达系统包括从表达系统中异源DNA序列转录的mRNA的翻译，所述方法包括预测从天然异源DNA序列转录的mRNA的二级结构的步骤; 修饰天然异源DNA序列以产生修饰的异源DNA序列，其中从修饰的异源DNA序列转录的mRNA具有与从天然异源DNA序列转录的mRNA的二级结构相比具有增加的自由能的二级结构; 并在重组表达系统中使用修饰的异源DNA序列进行蛋白质生产。本发明还提供了包含核酸分子的可注射药物组合物，其包含修饰的编码序列。本发明还提供包含核酸分子的重组病毒载体，其包含修饰的编码序列。

7. 发明授权

US11851477B2 DNA monoclonal antibodies targeting influenza virus 有权
公开(公告)号：US11851477B2
公开(公告)日：2023-12-26
申请号：US16098921
申请日：2017-05-05
申请人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
发明人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
IPC分类号： C07K16/28 , C07K16/10 , A61P31/16 , C12Q1/68 , A61K39/00 , C07K16/24
CPC分类号： C07K16/1018 , A61P31/16 , A61K2039/505 , A61K2039/545 , C07K16/248 , C07K16/2866 , C07K2317/76
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemagglutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said composition and method of generation.

8. 发明申请

US20190135899A1 DNA Monoclonal Antibodies Targeting Influenza Virus 审中-公开
公开(公告)号：US20190135899A1
公开(公告)日：2019-05-09
申请号：US16098921
申请日：2017-05-05
申请人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
发明人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
IPC分类号： C07K16/10 , A61P31/16
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemagglutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said composition and method of generation.

9. 发明授权

US09669091B2 Vaccines having an antigen and interleukin-23 as an adjuvant 有权
公开(公告)号：US09669091B2
公开(公告)日：2017-06-06
申请号：US14775087
申请日：2014-03-13
申请人： David B. Weiner , Jian Yan , Matthew Morrow , Bernadette Ferraro , David Hokey
发明人： David B. Weiner , Jian Yan , Matthew Morrow , Bernadette Ferraro , David Hokey
IPC分类号： C12P21/02 , C12N15/03 , A61K39/39 , C07K14/54 , A61K9/00 , A61K39/015 , A61K39/12 , C12N7/00 , C12P21/00 , C12N15/09 , C12N15/10 , A61K39/00
CPC分类号： A61K39/39 , A61K9/0009 , A61K39/015 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/55527 , C07K14/54 , C12N7/00 , C12N15/03 , C12N2710/20033 , C12N2710/20034 , C12P21/02 , Y02A50/412
摘要： Disclosed herein is a vaccine comprising an antigen and IL-23. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.

10. 发明授权

US09403879B2 Nucleic acid molecule encoding hepatitis B virus core protein and vaccine comprising the same 有权
标题翻译：编码乙型肝炎病毒核心蛋白的核酸分子和包含其的疫苗
公开(公告)号：US09403879B2
公开(公告)日：2016-08-02
申请号：US13984771
申请日：2012-02-13
申请人： David B. Weiner , Jian Yan , Nyamekye Obeng-Adjei
发明人： David B. Weiner , Jian Yan , Nyamekye Obeng-Adjei
IPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , A61K39/29 , C07K14/02 , A61K39/00
CPC分类号： A61K39/292 , A61K39/12 , A61K39/39 , A61K2039/53 , A61K2039/57 , A61K2039/572 , C07K14/005 , C07K14/02 , C12N7/00 , C12N2730/10134 , C12N2730/10171
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequence of HBV core protein, as well as genetic constructs/vectors and vaccines that express said protein sequences. Also provided herein are methods for generating an immune response against HBV using the nucleic acid sequences that are provided.
摘要翻译：本文提供了编码HBV核心蛋白的新的共有氨基酸序列的核酸序列，以及表达所述蛋白质序列的遗传构建体/载体和疫苗。本文还提供了使用提供的核酸序列产生针对HBV的免疫应答的方法。

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