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    • 2. 发明授权
    • Pegylated CD154 peptides and methods of inhibiting CD40 interacations with CD154
    • 聚乙二醇化CD154肽和用CD154抑制CD40相互作用的方法
    • US09562088B2
    • 2017-02-07
    • US13880387
    • 2011-10-19
    • David Wagner
    • David Wagner
    • A61K38/00C07K7/00C07K14/705A61K38/08A61K38/10A61K38/17
    • C07K14/70575A61K38/08A61K38/10A61K38/1774
    • The present invention provides methods and materials for treating and preventing autoimmune diseases. In particular, the present invention relates to the discovery that small peptides are capable of interacting with CD40, thereby interfering with the ability of CD40 to interact with CD 154, which is important in inflammation. The present invention also relate to the use of such peptides in reducing the inflammatory response, and in particular, the autoimmune inflammatory response. The present invention also relates to the use of such short peptides to prevent or reverse autoimmune disease, and particular, diabetes, in individuals suffering from such disease. It also relates to methods and materials for detecting T-cells that express CD40 (Th40 cells). Also provided are kits for reducing inflammation, treating autoimmune diseases, or detecting Th40 cells.
    • 本发明提供治疗和预防自身免疫疾病的方法和材料。 特别地,本发明涉及小肽能够与CD40相互作用的发现,从而干扰CD40与CD154相互作用的能力,这在炎症中是重要的。 本发明还涉及这些肽在减少炎症反应,特别是自身免疫性炎症反应中的用途。 本发明还涉及这种短肽在预防或逆转患有这种疾病的个体中的自身免疫性疾病,特别是糖尿病的用途。 它还涉及用于检测表达CD40(Th40细胞)的T细胞的方法和材料。 还提供用于减少炎症,治疗自身免疫疾病或检测Th40细胞的试剂盒。
    • 3. 发明授权
    • Commercial shelf product alignment device
    • 商品货架对位装置
    • US09510697B2
    • 2016-12-06
    • US14706769
    • 2015-05-07
    • David Wagner
    • David Wagner
    • F24B15/00A47F13/06B25J1/04
    • A47F13/06
    • A commercial shelf product alignment device for facilitating neat and straight alignment of commercial products on a shelf in a market includes a handle having a first end and a second end. An elongated shaft is coupled to and extends from the handle. A bend is positioned in the shaft defining a first section and a second section of the shaft. The first section defines a right angle with the second section wherein the shaft is configured for aligning products on a commercial shelf by abutting the products against the first section of the shaft.
    • 用于促进市场上的商品的商业产品的整齐和直线对准的商业货架产品对准装置包括具有第一端和第二端的手柄。 细长的轴联接到手柄并从手柄延伸。 弯曲部定位在轴中,限定轴的第一部分和第二部分。 第一部分与第二部分形成直角,其中轴构造成通过使产品抵靠轴的第一部分将产品对准在商业货架上。
    • 4. 发明授权
    • Copper plating method
    • 镀铜方法
    • US09103012B2
    • 2015-08-11
    • US12931854
    • 2011-02-11
    • Chao-Peng ChenJas ChudasamaChien-Li LinDavid Wagner
    • Chao-Peng ChenJas ChudasamaChien-Li LinDavid Wagner
    • C25D5/34C23C2/02C23C14/58C25D5/02G11B5/17C23F1/12
    • C23F1/12C23C2/02C23C14/5873C25D5/022C25D5/34G11B5/17
    • A method of activating a copper seed layer during a plating process is disclosed that comprises application of vapor generated by an ultrasonic wave nebulizer. The energized vapor droplets include water and a weak organic acid such as acetic acid, lactic acid, citric acid, uric acid, oxalic acid, or formic acid that have a vapor pressure proximate to that of water. The weak organic acid preferably has a pKa high enough to avoid Cu etching but is sufficiently acidic to remove copper oxide at a rate that is compatible with high throughput manufacturing. In one embodiment, weak acid/water vapor is applied to a substrate in a spin bowl and is followed by a deionized water rinse step in the same spin bowl. Improved wettability results in improved uniformity in subsequently plated copper films. Considerable cost savings is realized as a result of reduced chemical consumption and higher product yields.
    • 公开了一种在镀覆工艺期间激活铜籽晶层的方法,其包括施加由超声波雾化器产生的蒸气。 通电的蒸气滴包括水和弱的有机酸如乙酸,乳酸,柠檬酸,尿酸,草酸或甲酸,其蒸气压接近于水。 弱有机酸优选具有足够高的pKa以避免Cu蚀刻,但是足够的酸性以与高通量制造相容的速率除去氧化铜。 在一个实施方案中,将弱酸/水蒸汽施加到旋转碗中的基底上,然后在同一旋转碗中进行去离子水漂洗步骤。 改进的润湿性导致随后镀覆的铜膜的均匀性提高。 由于化学品消耗减少和产品产量提高,实现了大量的成本节约。
    • 9. 发明授权
    • Bumper cross-section with hinges
    • 带铰链的保险杠横截面
    • US07066508B1
    • 2006-06-27
    • US11095357
    • 2005-03-31
    • Ridha BaccoucheHikmat MahmoodChelliah MadasamyDavid Wagner
    • Ridha BaccoucheHikmat MahmoodChelliah MadasamyDavid Wagner
    • B60R19/18
    • B60R19/18B60R2019/1826
    • A bumper beam is formed from a tailor welded blank with thinner gage sheet metal laser welded to thicker gage sheet metal at opposing sides thereof. The tailor welded blank is then formed into a bumper beam having a uniform B-shaped cross-sectional configuration from one terminal end to the other. Each fore-and-aft extending wall of each cell of the B-shaped cross-sectional configuration is formed with first and second hinges at a bend line between substantially horizontal portions of the wall and an intermediate transitional portion such that the horizontal portions are at different vertically spaced positions. Upon receipt of an impact, the first hinges bend into the corresponding cell while the second hinges bend outwardly. The second hinges on the corresponding inner walls of the two cells contacting upon deep collapse to enhance energy absorption.
    • 保险杠梁由裁缝焊接的坯料形成,较薄的金属片金属激光焊接在较厚的金属片金属片的相对侧。 然后将裁缝焊接坯件形成为具有从一个终端到另一终端的均匀B形横截面构造的保险杠梁。 B形横截面构造的每个单元的每个前后延伸壁在第一和第二铰链处形成有在壁的基本水平部分和中间过渡部分之间的弯曲线处,使得水平部分处于 不同的垂直间隔位置。 当接收到冲击时,第一铰链弯曲成相应的电池,而第二铰链向外弯曲。 第二个铰链在两个细胞的相应内壁上,在深塌陷时接触以增强能量吸收。