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1. 发明授权

US08644913B2 Occlusion-crossing devices, imaging, and atherectomy devices 有权
标题翻译：闭塞装置，成像和粥样斑块切除装置
公开(公告)号：US08644913B2
公开(公告)日：2014-02-04
申请号：US13433049
申请日：2012-03-28
申请人： John B. Simpson , Himanshu N. Patel , Michael Zung , Charles W. McNall , Priyanshu Gupta , Maegan K. Spencer , Christopher B. White , Dennis W. Jackson , John F. Black
发明人： John B. Simpson , Himanshu N. Patel , Michael Zung , Charles W. McNall , Priyanshu Gupta , Maegan K. Spencer , Christopher B. White , Dennis W. Jackson , John F. Black
IPC分类号： A61B6/00 , A61B6/08
CPC分类号： A61B5/0084 , A61B5/0035 , A61B5/0062 , A61B5/0066 , A61B5/02007 , A61B5/4836 , A61B5/6852 , A61B6/12 , A61B6/485 , A61B6/487 , A61B8/0841 , A61B17/32002 , A61B17/320758 , A61B90/37 , A61B90/39 , A61B2017/00057 , A61B2017/003 , A61B2017/00778 , A61B2017/22068 , A61B2090/306 , A61B2090/3614 , A61B2090/3735 , A61B2090/376 , A61B2090/3966 , A61B2090/3983 , A61B2217/007 , A61B2562/0233 , F04C2270/0421
摘要： The present invention relates to: (1) guidewire support/placement catheters; (2) support/placement catheters with imaging; (3) atherectomy catheters, (4) atherectomy catheters with imaging, (5) occlusion crossing catheters, and (6) occlusion crossing catheters with imaging as well as methods for using them to treat disorders (and particularly peripheral artery disease) and systems including them.
摘要翻译：本发明涉及：（1）导丝支撑/放置导管; （2）成像辅助/放置导管; （3）粥样斑块切除术导管，（4）具有成像的粥样斑块切除导管，（5）闭塞导管，（6）具有成像的闭塞导管以及使用它们治疗疾病（特别是外周动脉疾病）和系统的方法，包括他们。

2. 发明授权

US09125562B2 Catheter-based off-axis optical coherence tomography imaging system 有权
标题翻译：基于导管的离轴光学相干断层成像系统
公开(公告)号：US09125562B2
公开(公告)日：2015-09-08
申请号：US12829267
申请日：2010-07-01
申请人： Maegan K. Spencer , Christopher B. White , Charles W. McNall , Dennis W. Jackson , Michael Zung , Nicholas J. Spinelli , Benjamin Ngo , Evangeline Lumabas , Kin F. Chan , John F. Black , Michael H. Rosenthal , John B. Simpson
发明人： Maegan K. Spencer , Christopher B. White , Charles W. McNall , Dennis W. Jackson , Michael Zung , Nicholas J. Spinelli , Benjamin Ngo , Evangeline Lumabas , Kin F. Chan , John F. Black , Michael H. Rosenthal , John B. Simpson
IPC分类号： A61B5/00 , A61B5/02
CPC分类号： A61B5/0066 , A61B5/0062 , A61B5/0073 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B5/7257
摘要： Catheter-based Optical Coherence Tomography (OCT) systems utilizing an optical fiber that is positioned off-axis of the central longitudinal axis of the catheter have many advantage over catheter-based OCT systems, particularly those having centrally-positioned optical fibers or fibers that rotate independently of the elongate body of the catheter. An OCT system having an off-axis optical fiber for visualizing the inside of a body lumen may be rotated with the body of the elongate catheter, relative to a handle portion. The handle may include a fiber management pathway for the optical fiber that permits the off-axis optical fiber to rotate with the catheter body relative to the handle. The system may also include optical processing elements adapted to prepare and process the OCT image collected by the off-axis catheter systems described herein.
摘要翻译：使用位于导管的中心纵向轴线离轴的光纤的基于导管的光学相干断层扫描（OCT）系统具有优于基于导管的OCT系统的许多优点，特别是具有中心定位的光纤或旋转的光纤独立于导管的细长主体。具有用于可视化体腔内部的离轴光纤的OCT系统可以相对于手柄部分与细长导管的主体一起旋转。手柄可以包括用于光纤的光纤管理路径，其允许离轴光纤相对于手柄与导管主体一起旋转。该系统还可以包括适于制备和处理由本文所述的离轴导管系统收集的OCT图像的光学处理元件。

3. 发明申请

US20110021926A1 CATHETER-BASED OFF-AXIS OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM 有权
标题翻译：基于导管的离轴光学相干成像系统
公开(公告)号：US20110021926A1
公开(公告)日：2011-01-27
申请号：US12829267
申请日：2010-07-01
申请人： Maegan K. SPENCER , Christopher B. White , Charles W. McNall , Dennis W. Jackson , Michael Zung , Nicholas J. Spinelli , Benjamin Ngo , Evangeline Lumabas , Kin F. Chan , John F. Black , Michael H. Rosenthal , John B. Simpson
发明人： Maegan K. SPENCER , Christopher B. White , Charles W. McNall , Dennis W. Jackson , Michael Zung , Nicholas J. Spinelli , Benjamin Ngo , Evangeline Lumabas , Kin F. Chan , John F. Black , Michael H. Rosenthal , John B. Simpson
IPC分类号： A61B6/00
CPC分类号： A61B5/0066 , A61B5/0062 , A61B5/0073 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B5/7257
摘要： Catheter-based Optical Coherence Tomography (OCT) systems utilizing an optical fiber that is positioned off-axis of the central longitudinal axis of the catheter have many advantage over catheter-based OCT systems, particularly those having centrally-positioned optical fibers or fibers that rotate independently of the elongate body of the catheter. An OCT system having an off-axis optical fiber for visualizing the inside of a body lumen may be rotated with the body of the elongate catheter, relative to a handle portion. The handle may include a fiber management pathway for the optical fiber that permits the off-axis optical fiber to rotate with the catheter body relative to the handle. The system may also include optical processing elements adapted to prepare and process the OCT image collected by the off-axis catheter systems described herein.
摘要翻译：使用位于导管的中心纵向轴线离轴的光纤的基于导管的光学相干断层扫描（OCT）系统具有优于基于导管的OCT系统的许多优点，特别是具有中心定位的光纤或旋转的光纤独立于导管的细长主体。具有用于可视化体腔内部的离轴光纤的OCT系统可以相对于手柄部分与细长导管的主体一起旋转。手柄可以包括用于光纤的光纤管理路径，其允许离轴光纤相对于手柄与导管主体一起旋转。该系统还可以包括适于制备和处理由本文所述的离轴导管系统收集的OCT图像的光学处理元件。

4. 发明授权

US09788790B2 Optical coherence tomography for biological imaging 有权
公开(公告)号：US09788790B2
公开(公告)日：2017-10-17
申请号：US12790703
申请日：2010-05-28
申请人： John F. Black , Maegan K. Spencer , Michael Zung , Charles W. McNall , Evangeline Lumabas , Michael H. Rosenthal , John B. Simpson
发明人： John F. Black , Maegan K. Spencer , Michael Zung , Charles W. McNall , Evangeline Lumabas , Michael H. Rosenthal , John B. Simpson
IPC分类号： A61B8/00 , A61B5/00
CPC分类号： A61B5/6852 , A61B5/0066
摘要： Described herein are catheters for use with Optical Coherence Tomography (OCT) that include an optical fiber core having a first refractive index and an interface medium having a second refractive index, where the first and second refractive indexes are mismatched such that receiving electronics configured to receive optical radiation reflected from the reference interface and the target operate in a total noise range that is within 5dB of the shot noise limit. These OCT catheters may include a silicon die mirror having a reflective coating that is embedded in the interface medium. The optical fiber can be fixed at just the distal end of the catheter, and may be managed within a handle that is attached to the proximal end of the catheter body, and is configured to allow rotation of both the catheter body and the optical fiber relative to the handle.

5. 发明申请

US20100305452A1 OPTICAL COHERENCE TOMOGRAPHY FOR BIOLOGICAL IMAGING 有权
标题翻译：光学相关图像生物成像
公开(公告)号：US20100305452A1
公开(公告)日：2010-12-02
申请号：US12790703
申请日：2010-05-28
申请人： John F. Black , Maegan K. Spencer , Michael Zung , Charles W. McNall , Evangeline Lumabas , Michael H. Rosenthal , John B. Simpson
发明人： John F. Black , Maegan K. Spencer , Michael Zung , Charles W. McNall , Evangeline Lumabas , Michael H. Rosenthal , John B. Simpson
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B5/0066
摘要： Described herein are catheters for use with Optical Coherence Tomography (OCT) that include an optical fiber core having a first refractive index and an interface medium having a second refractive index, where the first and second refractive indexes are mismatched such that receiving electronics configured to receive optical radiation reflected from the reference interface and the target operate in a total noise range that is within 5 dB of the shot noise limit. These OCT catheters may include a silicon die mirror having a reflective coating that is embedded in the interface medium. The optical fiber can be fixed at just the distal end of the catheter, and may be managed within a handle that is attached to the proximal end of the catheter body, and is configured to allow rotation of the both catheter body and the optical fiber relative to the handle.
摘要翻译：这里描述的是用于光学相干断层扫描（OCT）的导管，其包括具有第一折射率的光纤芯和具有第二折射率的界面介质，其中第一和第二折射率不匹配，使得接收电子器件被配置为接收从参考接口和目标反射的光辐射在总噪声范围内工作，该噪声范围在散粒噪声极限的5 dB以内。这些OCT导管可以包括具有嵌入在界面介质中的反射涂层的硅模镜。光纤可以固定在导管的远端处，并且可以在附接到导管主体的近端的手柄内管理，并且被配置为允许导管主体和光纤相对的两个旋转到处理。

6. 发明授权

US09498600B2 Atherectomy catheter with laterally-displaceable tip 有权
标题翻译：动脉粥样硬化切除导管具有横向位移尖端
公开(公告)号：US09498600B2
公开(公告)日：2016-11-22
申请号：US12829277
申请日：2010-07-01
申请人： Michael H. Rosenthal , Michael Zung , Nicholas J. Spinelli , Charles W. McNall , John B. Simpson , John F. Black
发明人： Michael H. Rosenthal , Michael Zung , Nicholas J. Spinelli , Charles W. McNall , John B. Simpson , John F. Black
IPC分类号： A61M25/01 , A61M25/00 , A61B17/3207 , A61B17/29
CPC分类号： A61B17/320758 , A61B17/32075 , A61B90/361 , A61B2017/2927 , A61B2017/320064 , A61B2017/320766 , A61B2017/320791 , A61B2090/3614 , A61M25/0074 , A61M25/0133
摘要： Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.
摘要翻译：这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

7. 发明申请

US20110004107A1 ATHERECTOMY CATHETER WITH LATERALLY-DISPLACEABLE TIP 有权
标题翻译： ATHERECTOMY导管与侧向放置提示
公开(公告)号：US20110004107A1
公开(公告)日：2011-01-06
申请号：US12829277
申请日：2010-07-01
申请人： Michael H. Rosenthal , Michael Zung , Nicholas J. Spinelli , Charles W. McNall , John B. Simpson , John F. Black
发明人： Michael H. Rosenthal , Michael Zung , Nicholas J. Spinelli , Charles W. McNall , John B. Simpson , John F. Black
IPC分类号： A61B17/22 , A61B6/00
CPC分类号： A61B17/320758 , A61B17/32075 , A61B90/361 , A61B2017/2927 , A61B2017/320064 , A61B2017/320766 , A61B2017/320791 , A61B2090/3614 , A61M25/0074 , A61M25/0133
摘要： Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.
摘要翻译：这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

8. 发明授权

US08548571B2 Devices and methods for predicting and preventing restenosis 有权
标题翻译：用于预测和预防再狭窄的装置和方法
公开(公告)号：US08548571B2
公开(公告)日：2013-10-01
申请号：US12963536
申请日：2010-12-08
申请人： Xuanmin He , John B. Simpson , Michael H. Rosenthal , John F. Black
发明人： Xuanmin He , John B. Simpson , Michael H. Rosenthal , John F. Black
IPC分类号： A61B1/07 , A61B6/00
CPC分类号： A61B5/02007 , A61B5/0066 , A61B5/0084 , A61B5/4836 , A61B17/22 , A61F2/06 , A61M31/005 , G06T7/0012 , G06T2207/10068 , G06T2207/30101
摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.
摘要翻译：本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

9. 发明申请

US20110263936A1 DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS 有权
标题翻译：用于预测和预防保留的装置和方法
公开(公告)号：US20110263936A1
公开(公告)日：2011-10-27
申请号：US12963536
申请日：2010-12-08
申请人： Xuanmin He , John B. Simpson , Michael H. Rosenthal , John F. Black
发明人： Xuanmin He , John B. Simpson , Michael H. Rosenthal , John F. Black
IPC分类号： A61B1/04
CPC分类号： A61B5/02007 , A61B5/0066 , A61B5/0084 , A61B5/4836 , A61B17/22 , A61F2/06 , A61M31/005 , G06T7/0012 , G06T2207/10068 , G06T2207/30101
摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.
摘要翻译：本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

10. 发明授权

US08920668B2 Fire suppressing materials and systems and methods of use 有权
标题翻译：消防材料及系统及使用方法
公开(公告)号：US08920668B2
公开(公告)日：2014-12-30
申请号：US13594738
申请日：2012-08-24
申请人： Mark D. Mitchell , John F. Black , Kurt Mills
发明人： Mark D. Mitchell , John F. Black , Kurt Mills
IPC分类号： A62D1/08 , A62C3/08 , A62C35/02 , A62D1/00
CPC分类号： A62D1/0092 , A62C35/02 , A62D1/00
摘要： A fire suppressant mixture comprising: an organic or supplemental organic fire suppressant compound; a halogen element, and an organic compound, wherein the organic fire suppressant compound, the halogen element and the organic compound are combined such that a boiling point of the mixture is lower than the boiling point of the organic fire suppressant. In some embodiments, the organic fire suppressant compound is FK 5-1-12 and the organic compound is carbon dioxide. In other embodiments, the mixture is supplemented with an additional organic compound such as CF3I or 2,2-Dichloro-1,1,1-trifluoroethane (R123), or an halogen element. In some embodiments an inorganic pressurizing gas, such as nitrogen, is also added.
摘要翻译：一种灭火剂混合物，其包含：有机或补充的有机灭火剂化合物; 卤素元素和有机化合物，其中组合有机灭火剂化合物，卤素元素和有机化合物使得混合物的沸点低于有机灭火剂的沸点。在一些实施方案中，有机灭火剂化合物为FK 5-1-12，有机化合物为二氧化碳。在其它实施方案中，混合物补充有另外的有机化合物如CF 3 I或2,2-二氯-1,1,1-三氟乙烷（R123）或卤素元素。在一些实施方案中，还加入无机加压气体，例如氮气。

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