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1. 发明授权

US09125562B2 Catheter-based off-axis optical coherence tomography imaging system 有权
标题翻译：基于导管的离轴光学相干断层成像系统
公开(公告)号：US09125562B2
公开(公告)日：2015-09-08
申请号：US12829267
申请日：2010-07-01
申请人： Maegan K. Spencer , Christopher B. White , Charles W. McNall , Dennis W. Jackson , Michael Zung , Nicholas J. Spinelli , Benjamin Ngo , Evangeline Lumabas , Kin F. Chan , John F. Black , Michael H. Rosenthal , John B. Simpson
发明人： Maegan K. Spencer , Christopher B. White , Charles W. McNall , Dennis W. Jackson , Michael Zung , Nicholas J. Spinelli , Benjamin Ngo , Evangeline Lumabas , Kin F. Chan , John F. Black , Michael H. Rosenthal , John B. Simpson
IPC分类号： A61B5/00 , A61B5/02
CPC分类号： A61B5/0066 , A61B5/0062 , A61B5/0073 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B5/7257
摘要： Catheter-based Optical Coherence Tomography (OCT) systems utilizing an optical fiber that is positioned off-axis of the central longitudinal axis of the catheter have many advantage over catheter-based OCT systems, particularly those having centrally-positioned optical fibers or fibers that rotate independently of the elongate body of the catheter. An OCT system having an off-axis optical fiber for visualizing the inside of a body lumen may be rotated with the body of the elongate catheter, relative to a handle portion. The handle may include a fiber management pathway for the optical fiber that permits the off-axis optical fiber to rotate with the catheter body relative to the handle. The system may also include optical processing elements adapted to prepare and process the OCT image collected by the off-axis catheter systems described herein.
摘要翻译：使用位于导管的中心纵向轴线离轴的光纤的基于导管的光学相干断层扫描（OCT）系统具有优于基于导管的OCT系统的许多优点，特别是具有中心定位的光纤或旋转的光纤独立于导管的细长主体。具有用于可视化体腔内部的离轴光纤的OCT系统可以相对于手柄部分与细长导管的主体一起旋转。手柄可以包括用于光纤的光纤管理路径，其允许离轴光纤相对于手柄与导管主体一起旋转。该系统还可以包括适于制备和处理由本文所述的离轴导管系统收集的OCT图像的光学处理元件。

2. 发明授权

US08998937B2 Methods and devices for cutting tissue 有权
标题翻译：切割组织的方法和装置
公开(公告)号：US08998937B2
公开(公告)日：2015-04-07
申请号：US12431210
申请日：2009-04-28
申请人： John B. Simpson , Michael H. Rosenthal , Himanshu Patel , Gautama B. Venegas
发明人： John B. Simpson , Michael H. Rosenthal , Himanshu Patel , Gautama B. Venegas
IPC分类号： A61B17/32 , A61B17/3207 , A61B17/00 , A61B17/29 , A61B19/00
CPC分类号： A61B17/320783 , A61B1/00087 , A61B1/05 , A61B1/3137 , A61B5/0066 , A61B5/0084 , A61B5/02007 , A61B5/4836 , A61B17/320758 , A61B2017/00685 , A61B2017/2927 , A61B2017/320032 , A61B2017/320064 , A61B2017/320791 , A61B2090/306 , A61B2090/373 , A61B2090/3782
摘要： A method of removing material from a blood flow lumen generally includes providing a device having a cutting element and an opening, advancing the device through the blood flow lumen to a site where material is to be removed, forcing the opening toward a wall of the site where material is to be removed, and moving the cutting element and the opening so that material in the blood flow lumen is cut by the cutting element and directed into the opening for removal as the cutting element and opening are moved through the blood flow lumen. In some embodiments, the device may be deflected or bent to force the opening toward a wall to remove material. The cutting element may be rotatable and may have an axis that is movable, that is not parallel to the longitudinal axis of the device, or both.
摘要翻译：从血流腔中去除材料的方法通常包括提供具有切割元件和开口的装置，将装置通过血流腔前进到要除去材料的部位，迫使开口朝向部位的壁其中要去除材料，并且移动切割元件和开口，使得当切割元件和开口移动通过血流腔时，通过切割元件切割血流腔中的材料并将其引导到用于移除的开口中。在一些实施例中，该装置可能被偏转或弯曲以迫使开口朝向壁以移除材料。切割元件可以是可旋转的并且可以具有可移动的轴线，其不平行于装置的纵向轴线，或两者均可。

3. 发明授权

US08911459B2 Debulking catheters and methods 有权
标题翻译：去污导管和方法
公开(公告)号：US08911459B2
公开(公告)日：2014-12-16
申请号：US13536497
申请日：2012-06-28
申请人： John B. Simpson , Himanshu Patel , Greg Stine , Brett Follmer , Michael H. Rosenthal , Mehrdad Farhangnia
发明人： John B. Simpson , Himanshu Patel , Greg Stine , Brett Follmer , Michael H. Rosenthal , Mehrdad Farhangnia
IPC分类号： A61B17/22 , A61B17/32 , A61B17/00 , A61B17/3207 , A61B10/02 , A61B10/04
CPC分类号： A61B17/320758 , A61B10/04 , A61B17/32075 , A61B17/320783 , A61B2010/0225 , A61B2017/00685 , A61B2017/320032 , A61B2017/320791
摘要： A method of removing material from a blood flow lumen includes providing a device having a cutting element and an opening, the cutting element being movable relative to the opening. The method then includes advancing the device through a patient's vascular system to the blood flow lumen. Finally, the method involves moving the cutting element and the opening relative to the blood flow lumen so that a continuous piece of material is severed by the cutting element and directed into the opening as the cutting element and opening move through the blood flow lumen, the continuous piece of severed material being directed into the device for removal from the patient. The method may include providing a device having a rotatable cutter that, in some embodiments, is not parallel to the longitudinal axis of the device, is movable, has retracted and deployed positions, or any combination thereof.
摘要翻译：从血流腔去除材料的方法包括提供具有切割元件和开口的装置，所述切割元件可相对于所述开口移动。该方法然后包括将装置通过患者的血管系统推进到血流腔。最后，该方法包括相对于血液流动腔移动切割元件和开口，使得当切割元件和开口移动通过血流腔时，连续片材被切割元件切断并引导到开口中，连续切断的材料被引导到装置中以从患者身上取出。该方法可以包括提供具有可旋转切割器的装置，其在一些实施例中不平行于装置的纵向轴线，是可移动的，具有缩回和展开位置或其任何组合。

4. 发明申请

US20140005534A1 DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS 审中-公开
标题翻译：用于预测和预防保留的装置和方法
公开(公告)号：US20140005534A1
公开(公告)日：2014-01-02
申请号：US14019466
申请日：2013-09-05
申请人： Xuanmin HE , John B. SIMPSON , Michael H. ROSENTHAL , John F. BLACK
发明人： Xuanmin HE , John B. SIMPSON , Michael H. ROSENTHAL , John F. BLACK
IPC分类号： A61B5/02 , A61B17/22 , A61F2/06 , A61B5/00 , A61M31/00
CPC分类号： A61B5/02007 , A61B5/0066 , A61B5/0084 , A61B5/4836 , A61B17/22 , A61F2/06 , A61M31/005 , G06T7/0012 , G06T2207/10068 , G06T2207/30101
摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.
摘要翻译：本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

5. 发明申请

US20130123615A1 OCCLUSION-CROSSING DEVICES, ATHERECTOMY DEVICES, AND IMAGING 有权
标题翻译： OCCLUSION-CROSSING DEVICES，ATHERECTOMY DEVICES，AND IMAGING
公开(公告)号：US20130123615A1
公开(公告)日：2013-05-16
申请号：US13675867
申请日：2012-11-13
申请人： Maegan K. SPENCER , John B. SIMPSON , Stephen C. DAVIES
发明人： Maegan K. SPENCER , John B. SIMPSON , Stephen C. DAVIES
IPC分类号： A61B5/00 , A61B17/3207
CPC分类号： A61B34/20 , A61B5/0062 , A61B5/0066 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B6/12 , A61B6/487 , A61B17/00234 , A61B17/320725 , A61B17/320758 , A61B90/37 , A61B90/39 , A61B2017/00296 , A61B2017/22068 , A61B2034/2055 , A61B2034/2065 , A61B2090/306 , A61B2090/3614 , A61B2090/3735 , A61B2217/007 , A61B2562/0233
摘要： Described herein are methods for producing and identifying characteristic (“crescent shaped”) regions indicative of an atherectomy plaque within a vessel, and systems and devices adapted to take advantage of this characteristic region.
摘要翻译：这里描述的是用于产生和识别指示血管内的粥样斑块切除斑块的特征（“新月形”）区域的方法，以及适于利用该特征区域的系统和装置。

6. 发明授权

US08361097B2 Catheter system and method for boring through blocked vascular passages 有权
标题翻译：导管系统和通过阻塞血管通道钻孔的方法
公开(公告)号：US08361097B2
公开(公告)日：2013-01-29
申请号：US13277167
申请日：2011-10-19
申请人： Himanshu N. Patel , John B. Simpson
发明人： Himanshu N. Patel , John B. Simpson
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/32002 , A61B17/22012 , A61B17/32075 , A61B17/320758 , A61B18/1492 , A61B18/24 , A61B2017/00336 , A61B2017/00398 , A61B2017/22094
摘要： A rotating cutting head catheter for passage through chronic total occlusions or other refractory atherosclerotic plaque from diseased arteries is disclosed. The catheter's rotating cutting head is designed to reside safely within an outer protective sheath when not in use. The outer protective sheath contains one or more helical grooves or slots, and the cutting head contains protruding blades or projections that fit into these helical grooves or slots. Application of torque to an inner catheter or wire attached to the cutting head applies spin to the cutting head, and the force of the sheath's helical grooves or slots against the cutting head's protruding blades or projections advances the cutting head outward from the protective sheath. Once extended, the cutting head may now rotate freely. The device may use a guidewire to direct the cutting head to the desired position.
摘要翻译：公开了用于通过慢性完全闭塞或其它难治性动脉粥样硬化斑块从患病动脉穿过的旋转切割头导管。导管的旋转切割头设计成在不使用时安全地驻留在外部保护护套内。外保护套包含一个或多个螺旋槽或槽，并且切割头包含装配到这些螺旋槽或槽中的突出的叶片或凸起。将扭矩施加到附接到切割头上的内导管或线将旋转旋转到切割头，并且护套的螺旋槽或狭槽抵靠切割头的突出的刀片或突起的力将切割头从保护护套向外移动。一旦延伸，切割头现在可以自由旋转。该装置可以使用导丝将切割头引导到期望的位置。

7. 发明申请

US20130013216A1 LIBRARIES AND DATA STRUCTURES OF MATERIALS REMOVED BY DEBULKING CATHETERS 审中-公开
标题翻译：通过清除导管去除的材料的图书和数据结构
公开(公告)号：US20130013216A1
公开(公告)日：2013-01-10
申请号：US13609537
申请日：2012-09-11
申请人： Angela SOITO , John B. SIMPSON
发明人： Angela SOITO , John B. SIMPSON
IPC分类号： G06F19/10
CPC分类号： A61B10/04 , A61B10/0096 , A61B10/02 , A61B10/0266 , A61B17/320725 , A61B17/320758 , A61B17/320783 , A61B90/90 , A61B2017/00778 , A61B2017/320791 , G06Q50/22 , G16H10/40 , G16H10/60 , Y02A90/22 , Y02A90/26
摘要： Material removed by a debulking catheter from a body lumen can be preserved. Materials can be collected from many different patients and/or from multiple procedures on individual patients. Data which describe the properties or qualities of the removed material and/or the patient and/or the patient's family or environment can be stored on computer readable media. The stored data can be used to draw correlations, to stratify groups of patients, to provide risk assessments, to provide diagnoses and/or prognoses. Further tests can be done on the stored materials at later times after the procedures have been completed.
摘要翻译：可以保存通过减压导管从体腔去除的材料。材料可以从许多不同的患者和/或来自多个程序的个体患者收集。描述被去除的材料和/或患者和/或患者家庭或环境的性质或质量的数据可以存储在计算机可读介质上。存储的数据可用于绘制相关性，分层患者组，提供风险评估，以提供诊断和/或预后。在程序完成后的较后时间，可以对存储的材料进行进一步的测试。

8. 发明申请

US20130012411A1 TESTING A PATIENT POPULATION HAVING A CARDIOVASCULAR CONDITION FOR DRUG EFFICACY 审中-公开
标题翻译：测试患有血液病毒的患者人群对药物的影响
公开(公告)号：US20130012411A1
公开(公告)日：2013-01-10
申请号：US13612319
申请日：2012-09-12
申请人： Angela Soito , John B. Simpson
发明人： Angela Soito , John B. Simpson
IPC分类号： A61B10/02 , C40B30/04 , C12Q1/02 , C12Q1/68 , G01N33/53 , G01N33/566
CPC分类号： A61B17/320783 , A61B10/0233 , A61B10/0275 , A61B2010/0225
摘要： Lumenectomy material is tested to determine the efficacy of a test drug in a patient population having a cardiovascular condition. The material is removed from at least a first and a second patient and tested for one or more markers of a cardiovascular condition. The first patient is administered the test drug, and the second patient is administered a placebo. At a later date, more lumenectomy material is removed and tested for the same marker or markers. The presence, absence or amount of the markers is compared in the first patient receiving the drug and the second patient receiving the placebo to determine whether the drug is effective in the patient population. The drugs tested include drugs believed to be effective in treating a cardiovascular condition. The markers used can include any marker that can indicate the effectiveness of the drug being tested.
摘要翻译：测试肿瘤切除术材料以测定具有心血管病症的患者群体中测试药物的功效。从至少第一和第二患者移除材料并测试一种或多种心血管病症的标志物。给予第一名患者试验药物，第二名患者服用安慰剂。在以后，更多的腔切除材料被去除并测试相同的标记或标记。在接受药物的第一个患者和接受安慰剂的第二个患者中比较存在，不存在或量的标记物，以确定药物在患者群体中是否有效。所测试的药物包括被认为有效治疗心血管疾病的药物。所使用的标记物可以包括可以指示待测试药物的有效性的任何标记物。

9. 发明授权

US08226674B2 Debulking catheters and methods 有权
标题翻译：去污导管和方法
公开(公告)号：US08226674B2
公开(公告)日：2012-07-24
申请号：US12757291
申请日：2010-04-09
申请人： John B. Simpson , Himanshu Patel , Greg Stine , Brett Follmer , Michael H. Rosenthal , Mehrdad Farhangnia
发明人： John B. Simpson , Himanshu Patel , Greg Stine , Brett Follmer , Michael H. Rosenthal , Mehrdad Farhangnia
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/320758 , A61B10/04 , A61B17/32075 , A61B17/320783 , A61B2010/0225 , A61B2017/00685 , A61B2017/320032 , A61B2017/320791
摘要： A method of removing material from a blood flow lumen includes providing a device having a cutting element and an opening, the cutting element being movable relative to the opening. The method then includes advancing the device through a patient's vascular system to the blood flow lumen. Finally, the method involves moving the cutting element and the opening relative to the blood flow lumen so that a continuous piece of material is severed by the cutting element and directed into the opening as the cutting element and opening move through the blood flow lumen, the continuous piece of severed material being directed into the device for removal from the patient. The method may include providing a device having a rotatable cutter that, in some embodiments, is not parallel to the longitudinal axis of the device, is movable, has retracted and deployed positions, or any combination thereof. The method may further include forcing the opening toward the wall of the vascular site after the advancing step and before the moving step.
摘要翻译：从血流腔去除材料的方法包括提供具有切割元件和开口的装置，所述切割元件可相对于所述开口移动。该方法然后包括将装置通过患者的血管系统推进到血流腔。最后，该方法包括相对于血液流动腔移动切割元件和开口，使得当切割元件和开口移动通过血流腔时，连续片材被切割元件切断并引导到开口中，连续切断的材料被引导到装置中以从患者身上取出。该方法可以包括提供具有可旋转切割器的装置，其在一些实施例中不平行于装置的纵向轴线，是可移动的，具有缩回和展开位置或其任何组合。该方法还可以包括在推进步骤之后和移动步骤之前迫使开口朝向血管部位的壁。

10. 发明授权

US08062316B2 Catheter system and method for boring through blocked vascular passages 有权
标题翻译：导管系统和通过阻塞血管通道钻孔的方法
公开(公告)号：US08062316B2
公开(公告)日：2011-11-22
申请号：US12108433
申请日：2008-04-23
申请人： Himanshu N. Patel , John B. Simpson
发明人： Himanshu N. Patel , John B. Simpson
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/32002 , A61B17/22012 , A61B17/32075 , A61B17/320758 , A61B18/1492 , A61B18/24 , A61B2017/00336 , A61B2017/00398 , A61B2017/22094
摘要： A rotating cutting head catheter for passage through chronic total occlusions or other refractory atherosclerotic plaque from diseased arteries is disclosed. The catheter's rotating cutting head is designed to reside safely within an outer protective sheath when not in use. The outer protective sheath contains one or more helical grooves or slots, and the cutting head contains protruding blades or projections that fit into these helical grooves or slots. Application of torque to an inner catheter or wire attached to the cutting head applies spin to the cutting head, and the force of the sheath's helical grooves or slots against the cutting head's protruding blades or projections advances the cutting head outward from the protective sheath. Once extended, the cutting head may now rotate freely. The device may use a guidewire to direct the cutting head to the desired position.
摘要翻译：公开了用于通过慢性完全闭塞或其它难治性动脉粥样硬化斑块从患病动脉穿过的旋转切割头导管。导管的旋转切割头设计成在不使用时安全地驻留在外部保护护套内。外保护套包含一个或多个螺旋槽或槽，并且切割头包含装配到这些螺旋槽或槽中的突出的叶片或凸起。将扭矩施加到附接到切割头上的内导管或线将旋转旋转到切割头，并且护套的螺旋槽或狭槽抵靠切割头的突出的刀片或突起的力将切割头从保护护套向外移动。一旦延伸，切割头现在可以自由旋转。该装置可以使用导丝将切割头引导到期望的位置。

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