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1. 发明授权

US09125562B2 Catheter-based off-axis optical coherence tomography imaging system 有权
标题翻译：基于导管的离轴光学相干断层成像系统
公开(公告)号：US09125562B2
公开(公告)日：2015-09-08
申请号：US12829267
申请日：2010-07-01
申请人： Maegan K. Spencer , Christopher B. White , Charles W. McNall , Dennis W. Jackson , Michael Zung , Nicholas J. Spinelli , Benjamin Ngo , Evangeline Lumabas , Kin F. Chan , John F. Black , Michael H. Rosenthal , John B. Simpson
发明人： Maegan K. Spencer , Christopher B. White , Charles W. McNall , Dennis W. Jackson , Michael Zung , Nicholas J. Spinelli , Benjamin Ngo , Evangeline Lumabas , Kin F. Chan , John F. Black , Michael H. Rosenthal , John B. Simpson
IPC分类号： A61B5/00 , A61B5/02
CPC分类号： A61B5/0066 , A61B5/0062 , A61B5/0073 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B5/7257
摘要： Catheter-based Optical Coherence Tomography (OCT) systems utilizing an optical fiber that is positioned off-axis of the central longitudinal axis of the catheter have many advantage over catheter-based OCT systems, particularly those having centrally-positioned optical fibers or fibers that rotate independently of the elongate body of the catheter. An OCT system having an off-axis optical fiber for visualizing the inside of a body lumen may be rotated with the body of the elongate catheter, relative to a handle portion. The handle may include a fiber management pathway for the optical fiber that permits the off-axis optical fiber to rotate with the catheter body relative to the handle. The system may also include optical processing elements adapted to prepare and process the OCT image collected by the off-axis catheter systems described herein.
摘要翻译：使用位于导管的中心纵向轴线离轴的光纤的基于导管的光学相干断层扫描（OCT）系统具有优于基于导管的OCT系统的许多优点，特别是具有中心定位的光纤或旋转的光纤独立于导管的细长主体。具有用于可视化体腔内部的离轴光纤的OCT系统可以相对于手柄部分与细长导管的主体一起旋转。手柄可以包括用于光纤的光纤管理路径，其允许离轴光纤相对于手柄与导管主体一起旋转。该系统还可以包括适于制备和处理由本文所述的离轴导管系统收集的OCT图像的光学处理元件。

2. 发明申请

US20110021926A1 CATHETER-BASED OFF-AXIS OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM 有权
标题翻译：基于导管的离轴光学相干成像系统
公开(公告)号：US20110021926A1
公开(公告)日：2011-01-27
申请号：US12829267
申请日：2010-07-01
申请人： Maegan K. SPENCER , Christopher B. White , Charles W. McNall , Dennis W. Jackson , Michael Zung , Nicholas J. Spinelli , Benjamin Ngo , Evangeline Lumabas , Kin F. Chan , John F. Black , Michael H. Rosenthal , John B. Simpson
发明人： Maegan K. SPENCER , Christopher B. White , Charles W. McNall , Dennis W. Jackson , Michael Zung , Nicholas J. Spinelli , Benjamin Ngo , Evangeline Lumabas , Kin F. Chan , John F. Black , Michael H. Rosenthal , John B. Simpson
IPC分类号： A61B6/00
CPC分类号： A61B5/0066 , A61B5/0062 , A61B5/0073 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B5/7257
摘要： Catheter-based Optical Coherence Tomography (OCT) systems utilizing an optical fiber that is positioned off-axis of the central longitudinal axis of the catheter have many advantage over catheter-based OCT systems, particularly those having centrally-positioned optical fibers or fibers that rotate independently of the elongate body of the catheter. An OCT system having an off-axis optical fiber for visualizing the inside of a body lumen may be rotated with the body of the elongate catheter, relative to a handle portion. The handle may include a fiber management pathway for the optical fiber that permits the off-axis optical fiber to rotate with the catheter body relative to the handle. The system may also include optical processing elements adapted to prepare and process the OCT image collected by the off-axis catheter systems described herein.
摘要翻译：使用位于导管的中心纵向轴线离轴的光纤的基于导管的光学相干断层扫描（OCT）系统具有优于基于导管的OCT系统的许多优点，特别是具有中心定位的光纤或旋转的光纤独立于导管的细长主体。具有用于可视化体腔内部的离轴光纤的OCT系统可以相对于手柄部分与细长导管的主体一起旋转。手柄可以包括用于光纤的光纤管理路径，其允许离轴光纤相对于手柄与导管主体一起旋转。该系统还可以包括适于制备和处理由本文所述的离轴导管系统收集的OCT图像的光学处理元件。

3. 发明授权

US09788790B2 Optical coherence tomography for biological imaging 有权
公开(公告)号：US09788790B2
公开(公告)日：2017-10-17
申请号：US12790703
申请日：2010-05-28
申请人： John F. Black , Maegan K. Spencer , Michael Zung , Charles W. McNall , Evangeline Lumabas , Michael H. Rosenthal , John B. Simpson
发明人： John F. Black , Maegan K. Spencer , Michael Zung , Charles W. McNall , Evangeline Lumabas , Michael H. Rosenthal , John B. Simpson
IPC分类号： A61B8/00 , A61B5/00
CPC分类号： A61B5/6852 , A61B5/0066
摘要： Described herein are catheters for use with Optical Coherence Tomography (OCT) that include an optical fiber core having a first refractive index and an interface medium having a second refractive index, where the first and second refractive indexes are mismatched such that receiving electronics configured to receive optical radiation reflected from the reference interface and the target operate in a total noise range that is within 5dB of the shot noise limit. These OCT catheters may include a silicon die mirror having a reflective coating that is embedded in the interface medium. The optical fiber can be fixed at just the distal end of the catheter, and may be managed within a handle that is attached to the proximal end of the catheter body, and is configured to allow rotation of both the catheter body and the optical fiber relative to the handle.

4. 发明申请

US20100305452A1 OPTICAL COHERENCE TOMOGRAPHY FOR BIOLOGICAL IMAGING 有权
标题翻译：光学相关图像生物成像
公开(公告)号：US20100305452A1
公开(公告)日：2010-12-02
申请号：US12790703
申请日：2010-05-28
申请人： John F. Black , Maegan K. Spencer , Michael Zung , Charles W. McNall , Evangeline Lumabas , Michael H. Rosenthal , John B. Simpson
发明人： John F. Black , Maegan K. Spencer , Michael Zung , Charles W. McNall , Evangeline Lumabas , Michael H. Rosenthal , John B. Simpson
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B5/0066
摘要： Described herein are catheters for use with Optical Coherence Tomography (OCT) that include an optical fiber core having a first refractive index and an interface medium having a second refractive index, where the first and second refractive indexes are mismatched such that receiving electronics configured to receive optical radiation reflected from the reference interface and the target operate in a total noise range that is within 5 dB of the shot noise limit. These OCT catheters may include a silicon die mirror having a reflective coating that is embedded in the interface medium. The optical fiber can be fixed at just the distal end of the catheter, and may be managed within a handle that is attached to the proximal end of the catheter body, and is configured to allow rotation of the both catheter body and the optical fiber relative to the handle.
摘要翻译：这里描述的是用于光学相干断层扫描（OCT）的导管，其包括具有第一折射率的光纤芯和具有第二折射率的界面介质，其中第一和第二折射率不匹配，使得接收电子器件被配置为接收从参考接口和目标反射的光辐射在总噪声范围内工作，该噪声范围在散粒噪声极限的5 dB以内。这些OCT导管可以包括具有嵌入在界面介质中的反射涂层的硅模镜。光纤可以固定在导管的远端处，并且可以在附接到导管主体的近端的手柄内管理，并且被配置为允许导管主体和光纤相对的两个旋转到处理。

5. 发明授权

US09498600B2 Atherectomy catheter with laterally-displaceable tip 有权
标题翻译：动脉粥样硬化切除导管具有横向位移尖端
公开(公告)号：US09498600B2
公开(公告)日：2016-11-22
申请号：US12829277
申请日：2010-07-01
申请人： Michael H. Rosenthal , Michael Zung , Nicholas J. Spinelli , Charles W. McNall , John B. Simpson , John F. Black
发明人： Michael H. Rosenthal , Michael Zung , Nicholas J. Spinelli , Charles W. McNall , John B. Simpson , John F. Black
IPC分类号： A61M25/01 , A61M25/00 , A61B17/3207 , A61B17/29
CPC分类号： A61B17/320758 , A61B17/32075 , A61B90/361 , A61B2017/2927 , A61B2017/320064 , A61B2017/320766 , A61B2017/320791 , A61B2090/3614 , A61M25/0074 , A61M25/0133
摘要： Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.
摘要翻译：这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

6. 发明申请

US20110004107A1 ATHERECTOMY CATHETER WITH LATERALLY-DISPLACEABLE TIP 有权
标题翻译： ATHERECTOMY导管与侧向放置提示
公开(公告)号：US20110004107A1
公开(公告)日：2011-01-06
申请号：US12829277
申请日：2010-07-01
申请人： Michael H. Rosenthal , Michael Zung , Nicholas J. Spinelli , Charles W. McNall , John B. Simpson , John F. Black
发明人： Michael H. Rosenthal , Michael Zung , Nicholas J. Spinelli , Charles W. McNall , John B. Simpson , John F. Black
IPC分类号： A61B17/22 , A61B6/00
CPC分类号： A61B17/320758 , A61B17/32075 , A61B90/361 , A61B2017/2927 , A61B2017/320064 , A61B2017/320766 , A61B2017/320791 , A61B2090/3614 , A61M25/0074 , A61M25/0133
摘要： Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.
摘要翻译：这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

7. 发明授权

US08548571B2 Devices and methods for predicting and preventing restenosis 有权
标题翻译：用于预测和预防再狭窄的装置和方法
公开(公告)号：US08548571B2
公开(公告)日：2013-10-01
申请号：US12963536
申请日：2010-12-08
申请人： Xuanmin He , John B. Simpson , Michael H. Rosenthal , John F. Black
发明人： Xuanmin He , John B. Simpson , Michael H. Rosenthal , John F. Black
IPC分类号： A61B1/07 , A61B6/00
CPC分类号： A61B5/02007 , A61B5/0066 , A61B5/0084 , A61B5/4836 , A61B17/22 , A61F2/06 , A61M31/005 , G06T7/0012 , G06T2207/10068 , G06T2207/30101
摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.
摘要翻译：本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

8. 发明申请

US20110263936A1 DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS 有权
标题翻译：用于预测和预防保留的装置和方法
公开(公告)号：US20110263936A1
公开(公告)日：2011-10-27
申请号：US12963536
申请日：2010-12-08
申请人： Xuanmin He , John B. Simpson , Michael H. Rosenthal , John F. Black
发明人： Xuanmin He , John B. Simpson , Michael H. Rosenthal , John F. Black
IPC分类号： A61B1/04
CPC分类号： A61B5/02007 , A61B5/0066 , A61B5/0084 , A61B5/4836 , A61B17/22 , A61F2/06 , A61M31/005 , G06T7/0012 , G06T2207/10068 , G06T2207/30101
摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.
摘要翻译：本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

9. 发明授权

US08998937B2 Methods and devices for cutting tissue 有权
标题翻译：切割组织的方法和装置
公开(公告)号：US08998937B2
公开(公告)日：2015-04-07
申请号：US12431210
申请日：2009-04-28
申请人： John B. Simpson , Michael H. Rosenthal , Himanshu Patel , Gautama B. Venegas
发明人： John B. Simpson , Michael H. Rosenthal , Himanshu Patel , Gautama B. Venegas
IPC分类号： A61B17/32 , A61B17/3207 , A61B17/00 , A61B17/29 , A61B19/00
CPC分类号： A61B17/320783 , A61B1/00087 , A61B1/05 , A61B1/3137 , A61B5/0066 , A61B5/0084 , A61B5/02007 , A61B5/4836 , A61B17/320758 , A61B2017/00685 , A61B2017/2927 , A61B2017/320032 , A61B2017/320064 , A61B2017/320791 , A61B2090/306 , A61B2090/373 , A61B2090/3782
摘要： A method of removing material from a blood flow lumen generally includes providing a device having a cutting element and an opening, advancing the device through the blood flow lumen to a site where material is to be removed, forcing the opening toward a wall of the site where material is to be removed, and moving the cutting element and the opening so that material in the blood flow lumen is cut by the cutting element and directed into the opening for removal as the cutting element and opening are moved through the blood flow lumen. In some embodiments, the device may be deflected or bent to force the opening toward a wall to remove material. The cutting element may be rotatable and may have an axis that is movable, that is not parallel to the longitudinal axis of the device, or both.
摘要翻译：从血流腔中去除材料的方法通常包括提供具有切割元件和开口的装置，将装置通过血流腔前进到要除去材料的部位，迫使开口朝向部位的壁其中要去除材料，并且移动切割元件和开口，使得当切割元件和开口移动通过血流腔时，通过切割元件切割血流腔中的材料并将其引导到用于移除的开口中。在一些实施例中，该装置可能被偏转或弯曲以迫使开口朝向壁以移除材料。切割元件可以是可旋转的并且可以具有可移动的轴线，其不平行于装置的纵向轴线，或两者均可。

10. 发明授权

US08911459B2 Debulking catheters and methods 有权
标题翻译：去污导管和方法
公开(公告)号：US08911459B2
公开(公告)日：2014-12-16
申请号：US13536497
申请日：2012-06-28
申请人： John B. Simpson , Himanshu Patel , Greg Stine , Brett Follmer , Michael H. Rosenthal , Mehrdad Farhangnia
发明人： John B. Simpson , Himanshu Patel , Greg Stine , Brett Follmer , Michael H. Rosenthal , Mehrdad Farhangnia
IPC分类号： A61B17/22 , A61B17/32 , A61B17/00 , A61B17/3207 , A61B10/02 , A61B10/04
CPC分类号： A61B17/320758 , A61B10/04 , A61B17/32075 , A61B17/320783 , A61B2010/0225 , A61B2017/00685 , A61B2017/320032 , A61B2017/320791
摘要： A method of removing material from a blood flow lumen includes providing a device having a cutting element and an opening, the cutting element being movable relative to the opening. The method then includes advancing the device through a patient's vascular system to the blood flow lumen. Finally, the method involves moving the cutting element and the opening relative to the blood flow lumen so that a continuous piece of material is severed by the cutting element and directed into the opening as the cutting element and opening move through the blood flow lumen, the continuous piece of severed material being directed into the device for removal from the patient. The method may include providing a device having a rotatable cutter that, in some embodiments, is not parallel to the longitudinal axis of the device, is movable, has retracted and deployed positions, or any combination thereof.
摘要翻译：从血流腔去除材料的方法包括提供具有切割元件和开口的装置，所述切割元件可相对于所述开口移动。该方法然后包括将装置通过患者的血管系统推进到血流腔。最后，该方法包括相对于血液流动腔移动切割元件和开口，使得当切割元件和开口移动通过血流腔时，连续片材被切割元件切断并引导到开口中，连续切断的材料被引导到装置中以从患者身上取出。该方法可以包括提供具有可旋转切割器的装置，其在一些实施例中不平行于装置的纵向轴线，是可移动的，具有缩回和展开位置或其任何组合。

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