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1. 发明申请

US20090176794A1 1H-INDOL-1-YL-UREA COMPOUNDS 审中-公开
标题翻译： 1H-INDOL-1-YL-UREA化合物
公开(公告)号：US20090176794A1
公开(公告)日：2009-07-09
申请号：US12317904
申请日：2008-12-30
申请人： Jean-Daniel Brion , Abdallah Deyine , Alain Le Ridant , Catherine Harpey
发明人： Jean-Daniel Brion , Abdallah Deyine , Alain Le Ridant , Catherine Harpey
IPC分类号： A61K31/4439 , C07D401/02 , C07D403/02 , A61K31/454 , A61K31/506 , A61K31/501 , A61P25/28 , A61P25/16 , A61P25/22 , A61P25/24
CPC分类号： C07D401/12 , C07D209/08 , C07D403/12
摘要： Compounds of formula (I): wherein:R1 and R2, which may be the same or different, represent a hydrogen atom or a linear or branched (C1-C6)alkyl group,R3 represents a hydrogen or halogen atom, a linear or branched (C1-C6)alkyl group, or a linear or branched (C1-C6)alkoxy group,Het represents a pyridyl, pyrimidinyl or piperidyl group, which are optionally substituted by one or more groups selected from halogen, linear or branched (C1-C6)alkyl and linear or branched (C1-C6)alkoxy,—represents a single bond or a double bond,their enantiomers and diastereoisomers, and also addition salts thereof with a pharmaceutically acceptable acid or base.Medicinal products containing the same which are useful in the treatment of depression, anxiety, disorders of memory in the course of aging and/or neurodegenerative diseases, and in the palliative treatment of Parkinson's disease, and for adaptation to stress.
摘要翻译：式（I）化合物：其中：R1和R2可以相同或不同，表示氢原子或直链或支链（C1-C6）烷基，R3表示氢或卤素原子，直链或支链（C 1 -C 6）烷基，或直链或支链（C 1 -C 6）烷氧基，Het表示吡啶基，嘧啶基或哌啶基，其任选被一个或多个选自以下的基团取代：卤素，直链或支链（C1- C6）烷基和直链或支链（C1-C6）烷氧基， - 表示单键或双键，它们的对映体和非对映异构体，以及其与药学上可接受的酸或碱的加成盐。含有它们的药用产品，其可用于治疗抑郁症，焦虑症，老化和/或神经变性疾病过程中的记忆障碍，以及帕金森病的姑息治疗以及适应压力。

2. 发明申请

US20060063801A1 Novel 3-(4-oxo-4h-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same 失效
标题翻译：新的3-（4-氧代-4H-色烯-2-基） - （1H） - 喹啉-4-酮衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US20060063801A1
公开(公告)日：2006-03-23
申请号：US10519208
申请日：2003-06-18
申请人： Jean-Daniel Brion , Lucien Israel , Alain Le Ridant , Catherine Harpey , Cherif Rabhi , El Bachir Kaloun
发明人： Jean-Daniel Brion , Lucien Israel , Alain Le Ridant , Catherine Harpey , Cherif Rabhi , El Bachir Kaloun
IPC分类号： A61K31/4709 , C07D405/02
CPC分类号： C07D405/04 , C07D405/14
摘要： Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or different, each represent a group selected from hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR′ wherein R′ represents an ionised or ionisable group, R5 represents a group selected from alkyl, aryl and heteroaryl, R7 represents a group selected from hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogen-containing or oxygen-containing heterocycle, its optical isomers, hydrates and solvates thereof and addition salts thereof, with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.
摘要翻译：式（I）化合物：

3. 发明申请

US20100105666A1 TRIAZABENZO (A)NAPHTHO(2,1,8-CDE) AZULENE COMPOUNDS. 审中-公开
标题翻译：三氮杂萘（A）萘（2,1,8-CDE）亚苄基化合物。
公开(公告)号：US20100105666A1
公开(公告)日：2010-04-29
申请号：US12448627
申请日：2008-01-04
申请人： Jean-Daniel Brion , Maud Hervet , Anne Moreau , Zafiarisoa Dolor Renko , Alain Le Ridant , Catherine Harpey
发明人： Jean-Daniel Brion , Maud Hervet , Anne Moreau , Zafiarisoa Dolor Renko , Alain Le Ridant , Catherine Harpey
IPC分类号： A61K31/551 , C07D487/22 , A61P25/22 , A61P25/16 , A61P25/24
CPC分类号： C07D471/22
摘要： Compounds of formula (I): wherein: R1 represents hydrogen, (C1-C6)alkyl, (C1-C6)aminoalkyl or (C1-C6)hydroxyalkyl, R2 represents hydrogen, or R1 and R2, together with the carbon atoms carrying them, form a carbon-carbon bond, R3 represents hydrogen, R4 represents hydrogen, methyl or (C3-C6)alkyl, (C1-C6)aminoalkyl, (C1-C6)hydroxyalkyl, aryl-(C1-C6)alkyl or heterocycloalkyl-(C1-C6)alkyl, or R3 and R4 together with the carbon atoms carrying them, form a carbon-carbon bond, R5, R6, R7 and R8 represent hydrogen, or a pair of geminal substituents (R5 and R6 and/or R7 and R8) form an oxo, thioxo or imino group, R9 represents hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, cyano, nitro, (C1-C6)polyhaloalkyl or optionally substituted amino, R10 and R11 represent hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, cyano, nitro, (C1-C6)polyhaloalkyl or optionally substituted amino, n represents an integer between 0 and 4 inclusive, m represents an integer between 0 and 2 inclusive, p represents an integer between 0 and 3 inclusive, X represents a group NR12, R12 represents hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, aryl-(C1-C6)alkyl or (C1-C6)polyhaloalkyl, their enantiomers, diastereoisomers and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.
摘要翻译：式（I）化合物：其中：R1表示氢，（C1-C6）烷基，（C1-C6）氨基烷基或（C1-C6）羟基烷基，R2表示氢，或R1和R2以及携带它们的碳原子（C 1 -C 6）烷基，（C 1 -C 6）羟基烷基，芳基 - （C 1 -C 6）烷基或杂环烷基 - （C 1 -C 6）（C1-C6）烷基或R3和R4与携带它们的碳原子一起形成碳 - 碳键，R5，R6，R7和R8表示氢或一对偕取代基（R5和R6和/或R7 卤素，（C1-C6）烷基，（C1-C6）烷氧基，羟基，氰基，硝基，（C1-C6）多卤代烷基或任意取代的氨基，R10 并且R 11表示氢，卤素，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，羟基，氰基，硝基，（C 1 -C 6）多卤代烷基或任选取代的氨基，n表示0至4的整数， 0和2之间的整数，包括0和2， p表示0〜3的整数，X表示NR12，R12表示氢，（C1-C6）烷基，（C2-C6）烯基，芳基 - （C1-C6）烷基或（C1-C6）多卤代烷基，它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。

4. 发明申请

US20090258883A1 1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds 审中-公开
标题翻译： 1H-吲哚 - 吡啶甲酰胺和1H-吲哚 - 哌啶甲酰胺化合物
公开(公告)号：US20090258883A1
公开(公告)日：2009-10-15
申请号：US11988424
申请日：2006-07-06
申请人： Jean-Daniel Brion , Fabrice Bintein , Rodolphe Razet , Patrick Razon , Zafiarisoa Dolor Renko , Eric Levoirier , Jean-Francois Pujol , Dinah Weissmann , Alain Le Ridant , Catherine Harpey
发明人： Jean-Daniel Brion , Fabrice Bintein , Rodolphe Razet , Patrick Razon , Zafiarisoa Dolor Renko , Eric Levoirier , Jean-Francois Pujol , Dinah Weissmann , Alain Le Ridant , Catherine Harpey
IPC分类号： A61K31/496 , C07D401/12 , A61K31/454 , A61P25/22 , A61P25/16 , A61P25/24 , A61P25/28 , A61K31/4439 , C07D401/14
CPC分类号： C07D401/12
摘要： Compounds of formula (I): wherein: A represents a divalent radical: wherein: Z represents an oxygen atom or a sulphur atom, R6 represents a hydrogen atom, an alkyl, alkenyl, arylalkyl or polyhaloalkyl group or a substituted, linear or branched alkyl chain, represents a single bond or a double bond, R1, R2, R3 and R4 represent a hydrogen or halogen atom, an alkyl, alkoxy, hydroxy, cyano, nitro, polyhaloalkyl or optionally substituted amino group, or a linear or branched alkyl chain substituted by one or more groups, R5 represents a hydrogen atom or an alkyl, aminoalkyl or hydroxyalkyl group, X and Y represent a hydrogen atom or an alkyl group, Ra, Rb, Rc and Rd represent a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, cyano, nitro, polyhaloalkyl, optionally substituted amino group, or a substituted, linear or branched alkyl chain, Re represents a hydrogen atom or an alkyl, arylalkyl or alkenyl group or a substituted, linear or branched alkyl chain, their enantiomers, diastereoisomers, and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.
摘要翻译：式（I）化合物：其中：A表示二价基团：其中：Z表示氧原子或硫原子，R6表示氢原子，烷基，烯基，芳基烷基或多卤代烷基或取代的直链或支链烷基链接，表示单键或双键，R 1，R 2，R 3和R 4表示氢或卤素原子，烷基，烷氧基，羟基，氰基，硝基，多卤代烷基或任选取代的氨基，或直链或支链烷基链被一个或多个基团取代，R 5表示氢原子或烷基，氨基烷基或羟烷基，X和Y表示氢原子或烷基，R a，R b，R c和R d表示氢或卤素原子，烷基，羟基，烷氧基，氰基，硝基，多卤代烷基，任选取代的氨基或取代的直链或支链烷基链，表示氢原子或烷基，芳基烷基或烯基或取代的直链或支链烷基链，它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。

5. 发明授权

US07339061B2 3-(4-oxo-4H-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same 失效
标题翻译： 3-（4-氧代-4H-色烯-2-基） - （1H） - 喹啉-4-酮衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US07339061B2
公开(公告)日：2008-03-04
申请号：US10519208
申请日：2003-06-18
申请人： Jean-Daniel Brion , Lucien Israel , Alain Le Ridant , Catherine Harpey , Cherif Rabhi , El Bachir Kaloun
发明人： Jean-Daniel Brion , Lucien Israel , Alain Le Ridant , Catherine Harpey , Cherif Rabhi , El Bachir Kaloun
IPC分类号： C07D215/38
CPC分类号： C07D405/04 , C07D405/14
摘要： Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or different, each represent a group selected from hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR′ wherein R′ represents an ionised or ionisable group, R5 represents a group selected from alkyl, aryl and heteroaryl, R7 represents a group selected from hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogen-containing or oxygen-containing heterocycle, its optical isomers, hydrates and solvates thereof and addition salts thereof, with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.
摘要翻译：式（I）化合物：其中：R 1，R 2，R 3，R 4，R R 6，R 8，R 9和R 10可以相同或不同，各自表示选自氢，羟基，烷氧基，烷基，芳基烷氧基，烷氧基羰基烷氧基和OR'的基团，其中R'表示电离或可离子基团，R 5表示选自烷基，芳基和杂芳基的基团，R SUB > 7表示选自氢，羟基，烷氧基，烷基和环烷基的基团，或R 7表示含氮或含氧杂环，其光学异构体，水合物和溶剂合物和其加成盐与药学上可接受的酸或碱。含有该药物的药物可用作抗癌剂。

6. 发明申请

US20110160228A1 DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION 审中-公开
标题翻译： DIHYDRO-ISO-CA-4和模拟物：细胞毒素，管状体聚合酶抑制剂
公开(公告)号：US20110160228A1
公开(公告)日：2011-06-30
申请号：US12996488
申请日：2009-06-04
申请人： Mouâd Alami , Samir Messaoudi , Abdallah Hamze , Olivier Provot , Jean-Daniel Brion , Jian-Miao Liu , Jérôme Bignon , Joanna Bakala
发明人： Mouâd Alami , Samir Messaoudi , Abdallah Hamze , Olivier Provot , Jean-Daniel Brion , Jian-Miao Liu , Jérôme Bignon , Joanna Bakala
IPC分类号： A61K31/52 , C07C43/23 , A61K31/09 , A61P35/00 , A61P17/06 , A61K31/36 , C07D317/54 , C07C69/035 , A61K31/222 , A61K31/136 , C07C217/84 , C07C271/22 , A61K31/27 , C07D209/12 , A61K31/404 , A61K31/26 , C07C255/37 , C07D473/34
CPC分类号： C07D215/14 , C07C41/16 , C07C41/18 , C07C41/20 , C07C41/30 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C69/013 , C07C217/80 , C07C217/84 , C07C217/90 , C07C217/92 , C07C229/12 , C07C233/25 , C07C255/37 , C07C271/22 , C07C271/44 , C07C2603/18 , C07D209/12 , C07D213/64 , C07D213/74 , C07D215/38 , C07D307/80 , C07D311/12 , C07D317/54 , C07D473/34 , C07F9/12 , C07C43/215
摘要： The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, —A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, —X represents a nitrogen atom or a CH group, and —Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and —Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a —CN, —SO2NR12R13, —SO2R9, —COOR15 or —COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.
摘要翻译：本发明涉及以下式（I）化合物：其中：-R 1和R 3彼此独立地表示任选被一个或多个氟原子取代的甲氧基，-R 2和R 4彼此独立地表示：氢原子或任选被一个或多个氟原子取代的甲氧基，-A表示选自芳基和杂芳基的环，所述环可以被杂环取代或稠合，-X表示氮原子或 CH基，-Z1表示氢原子或卤素原子，优选氟，-Z2表示氢原子，卤素原子，优选氟，C1〜C4烷基，芳基或-CN，-SO2NR12R13 ，-SO 2 R 9，-COOR 15或-COR 15基团，以及其药学上可接受的盐，其异构体及其前药。

7. 发明授权

US4975455A New heteroarotinoid compounds 失效
标题翻译：新型类似物类化合物
公开(公告)号：US4975455A
公开(公告)日：1990-12-04
申请号：US336224
申请日：1989-04-11
申请人： Jean-Daniel Brion , Guillaume Le Baut , Patrick Ducrey , Sylvie Piessard-Robert , Claude Cudennec , Genevieve Seurre
发明人： Jean-Daniel Brion , Guillaume Le Baut , Patrick Ducrey , Sylvie Piessard-Robert , Claude Cudennec , Genevieve Seurre
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/04 , C07D311/58
CPC分类号： C07D311/58
摘要： Compounds of general formula (I): ##STR1## in which: R denotes a hydrogen atom, a halogen atom or a hydroxy, lower alkyl, lower alkyloxy, carboxyl, (lower alkyloxy)carbonyl, (lower arylalkyloxy)carbonyl, aminocarbonyl, (lower mono- or dialkyl)aminocarbonyl or (lower arylalkyl)aminocarbonyl group, an aminocarbonyl group N-substituted with a heterocyclic radical, or a thio, (lower alkyl)thio, sulfonyl or (lower alkyl)sulfonyl group,R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms,their isomers, enantiomers, diastereoisomers and also, when R denotes a carboxyl, their addition salts with a pharmaceutically acceptable base and, when R contains a basic group, their addition salts with a pharmaceutically acceptable acid.
摘要翻译：通式（I）的化合物：其中：R表示氢原子，卤素原子或羟基，低级烷基，低级烷氧基，羧基，（低级烷氧基）羰基，（低级芳基烷氧基）羰基，氨基羰基，（低级单或二烷基）氨基羰基或（低级芳基烷基）氨基羰基，被杂环基取代的氨基羰基，或硫代（低级烷基）硫基，磺酰基或（低级烷基）磺酰基，R1，R2，R3 和可以相同或不同的R 4表示任选被一个或多个卤素原子取代的氢原子，卤素原子或低级烷基，低级链烯基，低级烷氧基或低级链烯氧基，它们的异构体，对映体，非对映异构体，以及当R表示羧基时，其与药学上可接受的碱的加成盐，当R含有碱性基团时，其与药学上可接受的酸的加成盐。

8. 发明授权

US5602131A EburnanE analogues 失效
标题翻译： EburnanE类似物
公开(公告)号：US5602131A
公开(公告)日：1997-02-11
申请号：US354660
申请日：1994-12-13
申请人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
发明人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
IPC分类号： C07D471/06 , A61K31/435 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D461/00 , C07D471/22 , C07D471/04 , A61K31/44 , A61K31/50 , C07D471/14
CPC分类号： C07D461/00
摘要： A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.
摘要翻译：选自通式（I）的化合物：其中A表示选自以下的二价基团：R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和Z分别为如本说明书中所定义，其异构体和药学上可接受的酸或碱加成盐，以及含有它们的药物，可用于治疗抑郁和焦虑。

9. 发明授权

US5391569A New chromene compounds having a triene side chain 失效
标题翻译：具有三烯侧链的新的色烯化合物
公开(公告)号：US5391569A
公开(公告)日：1995-02-21
申请号：US127804
申请日：1993-09-28
申请人： Jean-Daniel Brion , Guillaume Le Baut , Guillaume Poissonnet , Lucy De Montarby , Larbi Belachmi , Jacqueline Bonnet , Massimo Sabatini , Charles Tordjman
发明人： Jean-Daniel Brion , Guillaume Le Baut , Guillaume Poissonnet , Lucy De Montarby , Larbi Belachmi , Jacqueline Bonnet , Massimo Sabatini , Charles Tordjman
IPC分类号： A61K31/35 , A61K31/352 , A61K31/66 , A61P3/00 , A61P19/10 , A61P29/00 , A61P43/00 , C07D311/12 , C07D311/14 , C07D311/16 , C07D311/18 , C07D311/58 , C07D311/64 , C07D311/70 , C07D311/72 , C07D405/04 , C07D409/04 , C07F9/655 , A61K31/40 , A61K31/445 , A61K31/47
CPC分类号： C07D405/04 , C07D311/58 , C07D311/64 , C07D311/70 , C07D409/04
摘要： A compound selected from those of formula (I): ##STR1## in which the groups R.sub.1 to R.sub.8 are as defined the description. Medicaments.
摘要翻译：选自式（I）的化合物：其中基团R1至R8如说明书所定义。药剂

10. 发明授权

US06350757B1 Beta-carboline compounds 失效
标题翻译： β-咔啉化合物
公开(公告)号：US06350757B1
公开(公告)日：2002-02-26
申请号：US09621742
申请日：2000-07-21
申请人： Solo Goldstein , Guillaume Poissonnet , Jean-Gilles Parmentier , Jean-Daniel Brion , Mark Millan , Anne Dekeyne , Jean Boutin
发明人： Solo Goldstein , Guillaume Poissonnet , Jean-Gilles Parmentier , Jean-Daniel Brion , Mark Millan , Anne Dekeyne , Jean Boutin
IPC分类号： C07D47114
CPC分类号： C07D471/04
摘要： A compound selected from those of formula (I): wherein: represents single or double bond, R1 represents hydrogen, alkyl, —R6-aryl, —R6-cycloalkyl, —R6-heterocycle, —CO2R7—, —COR8, or —CONHR8, wherein R6, R7, and R8 are as defined in the description, R2 represents cyano, mono- or di-alkylaminoalkylaminocarbonyl, —CO2R8, —CONHR8, —NR8R9, —NHCO2R7, or —COR8 wherein R7, R8, and R9 are as defined in the description, R3 and R4 together form (C3-C10)cycloalkyl, R5 represents hydrogen, alkyl, or arylalkyl, Ra, Rb, Rc, Rd, which may be identical or different, represent a group as defined in the description, its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of CNS disorders.
摘要翻译：选自式（I）的化合物：其中：CUSTOM-CHARACTER FILE =“US06350757-20020226-P00900.TIF”ID =“CUSTOM-CHARACTER-00001”>表示单键或双键，R1表示氢，烷基， -R6-芳基，-R6-环烷基，-R6-杂环，-CO2R7-，-COR8或-CONHR8，其中R6，R7和R8如说明书中所定义，R 2表示氰基，单或二烷基氨基烷基氨基羰基，-CO 2 R 8，-CONHR 8，-NR 8 R 9，-NHCO 2 R 7或-COR 8，其中R 7，R 8和R 9如说明书中所定义，R 3和R 4一起形成（C 3 -C 10）环烷基，R 5表示氢，烷基或芳烷基可以相同或不同的R a，R b，R c，R d表示本说明书中定义的基团，其异构体及其药学上可接受的酸或碱加成盐，以及含有该基团的药物，其可用于治疗中枢神经系统疾病。

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