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1. 发明授权

US06350757B1 Beta-carboline compounds 失效
标题翻译： β-咔啉化合物
公开(公告)号：US06350757B1
公开(公告)日：2002-02-26
申请号：US09621742
申请日：2000-07-21
申请人： Solo Goldstein , Guillaume Poissonnet , Jean-Gilles Parmentier , Jean-Daniel Brion , Mark Millan , Anne Dekeyne , Jean Boutin
发明人： Solo Goldstein , Guillaume Poissonnet , Jean-Gilles Parmentier , Jean-Daniel Brion , Mark Millan , Anne Dekeyne , Jean Boutin
IPC分类号： C07D47114
CPC分类号： C07D471/04
摘要： A compound selected from those of formula (I): wherein: represents single or double bond, R1 represents hydrogen, alkyl, —R6-aryl, —R6-cycloalkyl, —R6-heterocycle, —CO2R7—, —COR8, or —CONHR8, wherein R6, R7, and R8 are as defined in the description, R2 represents cyano, mono- or di-alkylaminoalkylaminocarbonyl, —CO2R8, —CONHR8, —NR8R9, —NHCO2R7, or —COR8 wherein R7, R8, and R9 are as defined in the description, R3 and R4 together form (C3-C10)cycloalkyl, R5 represents hydrogen, alkyl, or arylalkyl, Ra, Rb, Rc, Rd, which may be identical or different, represent a group as defined in the description, its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of CNS disorders.
摘要翻译：选自式（I）的化合物：其中：CUSTOM-CHARACTER FILE =“US06350757-20020226-P00900.TIF”ID =“CUSTOM-CHARACTER-00001”>表示单键或双键，R1表示氢，烷基， -R6-芳基，-R6-环烷基，-R6-杂环，-CO2R7-，-COR8或-CONHR8，其中R6，R7和R8如说明书中所定义，R 2表示氰基，单或二烷基氨基烷基氨基羰基，-CO 2 R 8，-CONHR 8，-NR 8 R 9，-NHCO 2 R 7或-COR 8，其中R 7，R 8和R 9如说明书中所定义，R 3和R 4一起形成（C 3 -C 10）环烷基，R 5表示氢，烷基或芳烷基可以相同或不同的R a，R b，R c，R d表示本说明书中定义的基团，其异构体及其药学上可接受的酸或碱加成盐，以及含有该基团的药物，其可用于治疗中枢神经系统疾病。

2. 发明授权

US06399616B1 Pyridine compounds 失效
标题翻译：吡啶化合物
公开(公告)号：US06399616B1
公开(公告)日：2002-06-04
申请号：US09641777
申请日：2000-08-18
申请人： Jean-Louis Peglion , Aimée Dessinges , Christophe Poitevin , Mark Millan , Anne Dekeyne
发明人： Jean-Louis Peglion , Aimée Dessinges , Christophe Poitevin , Mark Millan , Anne Dekeyne
IPC分类号： A61K31496
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： A compound selected from those of formula (I): wherein: W represents optionally substituted naphthyl, n represents an integer from 2 to 3 inclusive, Z represents a single bond, A represents nitrogen, Q represents nitrogen, M, together with the carbon of pyridyl to which it is bonded, represents thieno, furo, pyrrolo or oxopyrrolo, Its optical isomers and pharmaceutically-acceptable acid or base additional salts thereof, and Medicinal products containing the same which are useful in the treatment of CNS disorders. It being understood that “aryl” is phenyl, naphthyl, dihydronaphthyl, or tetrahydronaphthyl.
摘要翻译：选自式（I）的化合物：其中：W表示任选取代的萘基，n表示2〜3的整数，Z表示单键，A表示氮，Q表示氮，M表示与吡咯基，吡咯基或氧吡咯，其光学异构体和药学上可接受的酸或碱的另外的盐，和含有它们的可用于治疗CNS病症的药物。可以理解的是“ 芳基“是苯基，萘基，二氢萘基或四氢萘基。

3. 发明授权

US06486171B2 Piperidine compounds 失效
标题翻译：哌啶化合物
公开(公告)号：US06486171B2
公开(公告)日：2002-11-26
申请号：US10105171
申请日：2002-03-25
申请人： Jean-Louis Peglion , Aimée Dessinges , Christophe Poitevin , Mark Millan , Anne Dekeyne
发明人： Jean-Louis Peglion , Aimée Dessinges , Christophe Poitevin , Mark Millan , Anne Dekeyne
IPC分类号： C07D47104
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： A compound selected from those of formula (I): wherein: W represents optionally substituted naphthyl, or a group of formula Y (wherein) as defined in the description, n represents an integer from 1 to 6 inclusive, Z represents a single bond, oxygen, or optionally substituted nitrogen, A and Q each represent CH or nitrogen, it being understood that A or Q must be N and the other CH, M, together with a carbon of the phenyl to which it is bonded, represents thienyl, furyl, pyrrolyl, or oxopyrrolyl, its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same, which are useful in the treatment of some CNS disorders.
摘要翻译：选自式（I）的化合物：其中：W表示任选取代的萘基，或如说明书中所定义的式Y（其中）的基团，n表示1至6的整数，Z表示单键，氧或任选取代的氮，A和Q各自表示CH或氮，应理解A或Q必须为N，另一个CH，M与其所键合的苯基的碳一起代表噻吩基，呋喃基，吡咯基或氧代吡咯基，其异构体及其药学上可接受的酸或碱加成盐，以及含有它们的药物，其可用于治疗一些CNS障碍。

4. 发明授权

US08247441B2 Chromene compounds, a process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：色烯化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US08247441B2
公开(公告)日：2012-08-21
申请号：US12804355
申请日：2010-07-20
申请人： Guillaume De Nanteuil , Bernard Cimetiere , Anne Dekeyne , Mark Millan
发明人： Guillaume De Nanteuil , Bernard Cimetiere , Anne Dekeyne , Mark Millan
IPC分类号： A61K31/407 , C07D209/58
CPC分类号： C07D491/04
摘要： The invention relates to compounds of formula (I): wherein R1 and R2 together form the following carbon-containing chain: wherein: R3 represents a hydrogen atom or an alkyl group, R4 represents a hydrogen atom or an alkyl, aryl, heteroaryl, 3,4-dioxocyclobutenyl, alkylcarbonyl, cycloalkylcarbonyl, heterocycloalkylcarbonyl, benzoyl, arylsulphonyl or heteroarylsulphonyl group, each of those groups optionally being substituted, or R3 and R4 together with the nitrogen atom carrying them form a 5- to 8-membered ring, the ring thereby formed optionally being substituted. Medicinal products containing the same which are useful in treating conditions requiring a D3 receptor antagonist.
摘要翻译：本发明涉及式（I）化合物：其中R 1和R 2一起形成以下含碳链：其中：R 3表示氢原子或烷基，R 4表示氢原子或烷基，芳基，杂芳基，3 ，4-二氧环戊烯基，烷基羰基，环烷基羰基，杂环烷基羰基，苯甲酰基，芳基磺酰基或杂芳基磺酰基，这些基团任选被取代，或者R3和R4与携带它们的氮原子一起形成5-至8-元环，形成任选地被取代。含有该药物的药物可用于治疗需要D3受体拮抗剂的病症。

5. 发明授权

US5958927A Indanol compounds 失效
公开(公告)号：US5958927A
公开(公告)日：1999-09-28
申请号：US165844
申请日：1998-10-02
申请人： Jean-Louis Peglion , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Anne Dekeyne
发明人： Jean-Louis Peglion , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Anne Dekeyne
IPC分类号： A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P25/00 , A61P25/04 , A61P43/00 , C07D311/18 , C07D319/18 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , A61K31/495 , C07D405/10 , C07D409/10 , C07D411/10
CPC分类号： C07D405/04 , C07D311/18 , C07D319/18 , C07D405/14 , C07D409/04
摘要： A compound of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X-Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid addition salts thereof, and medicinal products containing the same are useful in the treatment of diseases of the central nervous system or of manifestations of pain.

6. 发明申请

US20110021490A1 Chromene compounds, a process for their preparationand pharmaceutical compositions containing them 失效
标题翻译：色烯化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US20110021490A1
公开(公告)日：2011-01-27
申请号：US12804355
申请日：2010-07-20
申请人： Guillaume De Nanteuil , Bernard Cimetiere , Anne Dekeyne , Mark Millan
发明人： Guillaume De Nanteuil , Bernard Cimetiere , Anne Dekeyne , Mark Millan
IPC分类号： A61K31/397 , C07D491/052 , A61K31/407 , C07D401/06 , A61K31/4439 , C07D405/14 , A61K31/506 , A61P25/00
CPC分类号： C07D491/04
摘要： The invention relates to compounds of formula (I): wherein R1 and R2 together form the following carbon-containing chain: wherein: R3 represents a hydrogen atom or an alkyl group, R4 represents a hydrogen atom or an alkyl, aryl, heteroaryl, 3,4-dioxocyclobutenyl, alkylcarbonyl, cycloalkylcarbonyl, heterocycloalkylcarbonyl, benzoyl, arylsulphonyl or heteroarylsulphonyl group, each of those groups optionally being substituted, or R3 and R4 together with the nitrogen atom carrying them form a 5- to 8-membered ring, the ring thereby formed optionally being substituted. Medicinal products containing the same which are useful in treating conditions requiring a D3 receptor antagonist.
摘要翻译：本发明涉及式（I）化合物：其中R 1和R 2一起形成以下含碳链：其中：R 3表示氢原子或烷基，R 4表示氢原子或烷基，芳基，杂芳基，3 ，4-二氧环戊烯基，烷基羰基，环烷基羰基，杂环烷基羰基，苯甲酰基，芳基磺酰基或杂芳基磺酰基，这些基团任选被取代，或者R3和R4与携带它们的氮原子一起形成5-至8-元环，形成任选地被取代。含有该药物的药物可用于治疗需要D3受体拮抗剂的病症。

7. 发明授权

US06784183B2 Diphenylurea compounds 失效
标题翻译：二苯基脲化合物
公开(公告)号：US06784183B2
公开(公告)日：2004-08-31
申请号：US09896278
申请日：2001-06-29
申请人： Gilbert Lavielle , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
发明人： Gilbert Lavielle , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
IPC分类号： A61K31496
CPC分类号： C07D295/135 , C07D209/08 , C07D235/14 , C07D235/30 , C07D319/20 , C07D401/04 , C07D405/04 , C07D405/12
摘要： Compounds of formula (I): and medicinal products containing the same which are useful as dual &agr;2/5-HT2c antagonists.
摘要翻译：式（I）化合物：含有它们的药物，可用作双重α2/ 5-HT2c拮抗剂。

8. 发明授权

US6060487A Indanol compounds 失效
标题翻译：茚满化合物
公开(公告)号：US6060487A
公开(公告)日：2000-05-09
申请号：US273889
申请日：1999-03-22
申请人： Jean-Louis Peglion , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Anne Dekeyne
发明人： Jean-Louis Peglion , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Anne Dekeyne
IPC分类号： A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P25/00 , A61P25/04 , A61P43/00 , C07D311/18 , C07D319/18 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04
CPC分类号： C07D405/04 , C07D311/18 , C07D319/18 , C07D405/14 , C07D409/04
摘要： A compound of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X--Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid addition salts thereof, and medicinal products containing the same are useful in the treatment of diseases of the central nervous system or of manifestations of pain.
摘要翻译：式（I）化合物：其中R1，R2，R3，R4，XY，A，Z和Z'如说明书中所定义，以顺式或反式异构体的形式，各自为外消旋或旋光活性形式，以及其酸加成盐和含有它们的药物可用于治疗中枢神经系统疾病或疼痛的表现。

9. 发明授权

US07026357B2 Diphenylurea compounds 失效
标题翻译：二苯基脲化合物
公开(公告)号：US07026357B2
公开(公告)日：2006-04-11
申请号：US10862546
申请日：2004-06-07
申请人： Gilbert Lavielle , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
发明人： Gilbert Lavielle , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
IPC分类号： A61K31/17 , C07D233/02 , C07D401/00 , C07D211/70 , C07C273/00
CPC分类号： C07D295/135 , C07D209/08 , C07D235/14 , C07D235/30 , C07D319/20 , C07D401/04 , C07D405/04 , C07D405/12
摘要： Compound of formula (I): and medicinal products containing the same are useful as dual α2/5-HT2c antagonist receptors.
摘要翻译：式（I）化合物：含有该化合物的药物可用作双重α2/5-HT 2C拮抗剂受体。

10. 发明授权

US06747032B2 Pyrimidin-4-one compounds 失效
标题翻译：嘧啶-4-酮化合物
公开(公告)号：US06747032B2
公开(公告)日：2004-06-08
申请号：US10125188
申请日：2002-04-18
申请人： Gilbert Lavielle , Thierry Dubuffet , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
发明人： Gilbert Lavielle , Thierry Dubuffet , Olivier Muller , Mark Millan , Anne Dekeyne , Mauricette Brocco
IPC分类号： C07D51900
CPC分类号： C07D471/04
摘要： Compound of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen atom, a halogen atom or a group selected from alkyl, alkoxy, polyhaloalkyl, hydroxy, cyano, nitro and amino, or R1 with R2, R2 with R3, or R3 with R4, together with the carbon atoms carrying them, form an optionally substituted benzene ring or an optionally substituted heteroaromatic ring, X represents an oxygen atom or a methylene group, A represents an alkylene chain, represents an optionally substituted, unsaturated, nitrogen-containing heterocycle and R5 represents an alkyl group, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid, a medicinal products containing the same are useful as a double &agr;2/5-HT2c antagonist.
摘要翻译：式（I）化合物：其中：R 1，R 2，R 3和R 4可以相同或不同，表示氢原子，卤素原子或选自烷基，烷氧基，多卤代烷基，羟基，氰基，硝基和氨基，或R 1与R 2，R 2与R 3或R 3与R 4一起形成任选取代的苯环或任选取代的杂芳环，X表示氧原子或亚甲基，A表示亚烷基链表示任选取代的不饱和的含氮杂环，R5表示烷基，其对映异构体和非对映异构体及其与药学上可接受的酸的加成盐，含有该酸的药物可用作双重α2/ 5 -HT2c拮抗剂。

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