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1. 发明授权

US4975455A New heteroarotinoid compounds 失效
标题翻译：新型类似物类化合物
公开(公告)号：US4975455A
公开(公告)日：1990-12-04
申请号：US336224
申请日：1989-04-11
申请人： Jean-Daniel Brion , Guillaume Le Baut , Patrick Ducrey , Sylvie Piessard-Robert , Claude Cudennec , Genevieve Seurre
发明人： Jean-Daniel Brion , Guillaume Le Baut , Patrick Ducrey , Sylvie Piessard-Robert , Claude Cudennec , Genevieve Seurre
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/04 , C07D311/58
CPC分类号： C07D311/58
摘要： Compounds of general formula (I): ##STR1## in which: R denotes a hydrogen atom, a halogen atom or a hydroxy, lower alkyl, lower alkyloxy, carboxyl, (lower alkyloxy)carbonyl, (lower arylalkyloxy)carbonyl, aminocarbonyl, (lower mono- or dialkyl)aminocarbonyl or (lower arylalkyl)aminocarbonyl group, an aminocarbonyl group N-substituted with a heterocyclic radical, or a thio, (lower alkyl)thio, sulfonyl or (lower alkyl)sulfonyl group,R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms,their isomers, enantiomers, diastereoisomers and also, when R denotes a carboxyl, their addition salts with a pharmaceutically acceptable base and, when R contains a basic group, their addition salts with a pharmaceutically acceptable acid.
摘要翻译：通式（I）的化合物：其中：R表示氢原子，卤素原子或羟基，低级烷基，低级烷氧基，羧基，（低级烷氧基）羰基，（低级芳基烷氧基）羰基，氨基羰基，（低级单或二烷基）氨基羰基或（低级芳基烷基）氨基羰基，被杂环基取代的氨基羰基，或硫代（低级烷基）硫基，磺酰基或（低级烷基）磺酰基，R1，R2，R3 和可以相同或不同的R 4表示任选被一个或多个卤素原子取代的氢原子，卤素原子或低级烷基，低级链烯基，低级烷氧基或低级链烯氧基，它们的异构体，对映体，非对映异构体，以及当R表示羧基时，其与药学上可接受的碱的加成盐，当R含有碱性基团时，其与药学上可接受的酸的加成盐。

2. 发明授权

US4975454A Triene compounds having a chromene structure 失效
标题翻译：具有色烯结构的三烯化合物
公开(公告)号：US4975454A
公开(公告)日：1990-12-04
申请号：US336225
申请日：1989-04-11
申请人： Jean-Daniel Brion , Guillaume Le Baut , Patrick Ducrey , Sylvie Piessard-Robert , Claude Cudennec , Genevieve Seurre
发明人： Jean-Daniel Brion , Guillaume Le Baut , Patrick Ducrey , Sylvie Piessard-Robert , Claude Cudennec , Genevieve Seurre
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/04 , C07D311/58
CPC分类号： C07D311/58
摘要： Compounds of general formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms,R.sub.5 denotes a carboxyl, (lower alkyloxy)carbonyl, (lower alkenyloxy)carbonyl or (lower alkynyloxy)-carbonyl,their isomers, stereoisomers and diastereoisomers, and also their addition salts with a pharmaceutically acceptable base.Medicinal products.
摘要翻译：通式（I）的化合物：其中：R1，R2，R3和R4可以相同或不同，表示氢原子，卤原子或低级烷基，低级烯基，低级烷氧基或低级烯氧基 R 5表示羧基，（低级烷氧基）羰基，（低级链烯氧基）羰基或（低级炔氧基） - 羰基，它们的异构体，立体异构体和非对映异构体，以及它们与药学上的加成盐可接受的基数。药用产品。

3. 发明授权

US5391569A New chromene compounds having a triene side chain 失效
标题翻译：具有三烯侧链的新的色烯化合物
公开(公告)号：US5391569A
公开(公告)日：1995-02-21
申请号：US127804
申请日：1993-09-28
申请人： Jean-Daniel Brion , Guillaume Le Baut , Guillaume Poissonnet , Lucy De Montarby , Larbi Belachmi , Jacqueline Bonnet , Massimo Sabatini , Charles Tordjman
发明人： Jean-Daniel Brion , Guillaume Le Baut , Guillaume Poissonnet , Lucy De Montarby , Larbi Belachmi , Jacqueline Bonnet , Massimo Sabatini , Charles Tordjman
IPC分类号： A61K31/35 , A61K31/352 , A61K31/66 , A61P3/00 , A61P19/10 , A61P29/00 , A61P43/00 , C07D311/12 , C07D311/14 , C07D311/16 , C07D311/18 , C07D311/58 , C07D311/64 , C07D311/70 , C07D311/72 , C07D405/04 , C07D409/04 , C07F9/655 , A61K31/40 , A61K31/445 , A61K31/47
CPC分类号： C07D405/04 , C07D311/58 , C07D311/64 , C07D311/70 , C07D409/04
摘要： A compound selected from those of formula (I): ##STR1## in which the groups R.sub.1 to R.sub.8 are as defined the description. Medicaments.
摘要翻译：选自式（I）的化合物：其中基团R1至R8如说明书所定义。药剂

4. 发明授权

US5393775A Benzopyran compounds 失效
标题翻译：苯并吡喃化合物
公开(公告)号：US5393775A
公开(公告)日：1995-02-28
申请号：US117301
申请日：1993-09-07
申请人： Guillaume Le Baut , Jean-Paul Babingui , Sylvie Robert-Piessard , Pierre Renard , Daniel-henri Caignard , jean-Francois Renaud de la Faverle , Gerard Adam
发明人： Guillaume Le Baut , Jean-Paul Babingui , Sylvie Robert-Piessard , Pierre Renard , Daniel-henri Caignard , jean-Francois Renaud de la Faverle , Gerard Adam
IPC分类号： A61K31/35 , A61K31/352 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/535 , A61K31/54 , A61P3/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D311/58 , C07D311/66 , C07D311/70 , C07D311/72 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04 , C07D498/20 , C07D311/04
CPC分类号： C07D405/12 , C07D311/66 , Y10S514/824 , Y10S514/825
摘要： A compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and n are as defined in the description, its optical isomers, and its addition salts thereof with a pharmaceutically-acceptable acid or base,and medicinal product containing the same for treating a mammal afflicted with a disorder connected with peroxydation processes and biosynthesis of eicosanoids.
摘要翻译：选自式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如说明书中所定义，其光学异构体和其与药学上可接受的酸或碱的加成盐，以及含有它们的药物，用于治疗患有与过氧化作用过程相关的病症的哺乳动物和二十烷酸的生物合成。

5. 发明授权

US5315017A Benzopyran compounds 失效
标题翻译：苯并吡喃化合物
公开(公告)号：US5315017A
公开(公告)日：1994-05-24
申请号：US876763
申请日：1992-05-01
申请人： Guillaume Le Baut , Jean-Paul Babingui , Jacqueline Courant , Jean-Michel Robert , Pierre Renard , Daniel-Henri Caignard , Jean-Francois R. de la Faverie , Gerard Adam
发明人： Guillaume Le Baut , Jean-Paul Babingui , Jacqueline Courant , Jean-Michel Robert , Pierre Renard , Daniel-Henri Caignard , Jean-Francois R. de la Faverie , Gerard Adam
IPC分类号： A61K31/35 , A61K31/352 , A61K31/38 , A61K31/41 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/505 , A61P3/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P37/08 , C07D311/58 , C07D311/66 , C07D311/70 , C07D311/72 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D419/12 , C07D471/04 , C07D491/107 , C07D498/10 , C07D31/04
CPC分类号： C07D405/12 , C07D311/58 , C07D311/66 , C07D311/72 , C07D407/12 , C07D409/12 , C07D413/10 , C07D417/12 , C07D419/12 , C07D471/04
摘要： A compound selected from the group consisting of those of formula I ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, X and n are defined in the description, an optical isomer thereof, and an addition salt thereof with a pharmaceutically-acceptable base or acid.Medicinal product which is useful in treating or in preventing a disorder due to or linked to the phenomena of peroxidation and to the disturbance of the eicosanoid biosynthesis.
摘要翻译：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，X和n在说明书中定义，其光学异构体和其加盐与药学上可接受的碱或酸。可用于治疗或预防由于过氧化现象和类花生酸生物合成紊乱引起的或与之相关的病症的药用产品。

6. 发明申请

US20080027110A1 Indolyl-3-glyoxylic acid derivatives having antitumor action 审中-公开
标题翻译：具有抗肿瘤作用的吲哚基-3-乙醛酸衍生物
公开(公告)号：US20080027110A1
公开(公告)日：2008-01-31
申请号：US11894591
申请日：2007-08-20
申请人： Bernd Nickel , Istvan Szelenyi , Jurgen Schmidt , Peter Emig , Dietmar Reichert , Eckhard Gunther , Kay Brune , Guillaume Le Baut
发明人： Bernd Nickel , Istvan Szelenyi , Jurgen Schmidt , Peter Emig , Dietmar Reichert , Eckhard Gunther , Kay Brune , Guillaume Le Baut
IPC分类号： A61K31/4439 , A61K31/404 , A61K31/444 , A61P35/00 , C07D209/12 , C07D401/12
CPC分类号： A61K31/496 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/444 , A61K31/4709 , C07D209/14 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
摘要翻译：本发明涉及通式I的N-取代的吲哚-3-乙醛酰胺作为抗肿瘤剂和具有抗肿瘤作用的药物组合物的用途，其特征在于其含有至少一种通式1的化合物，如果也适用于生理上可耐受的酸加成盐或N-氧化物的形式。此外，本发明还包括抗肿瘤剂，其包含根据通式1的一种或多种N-取代的吲哚-3-乙醛酰胺作为活性化合物，以及如果合适的话，其生理上可耐受的酸加成盐，以及如果可能的话，N-氧化物和片剂，包衣片剂，胶囊，输注溶液或安瓿，栓剂，贴剂，可通过吸入，悬浮液，霜剂和软膏使用的粉末制剂的药学上可用的载体和/或稀释剂或辅助物质。

7. 发明授权

US5712294A N-pyridyl carboxamides and derivatives 失效
标题翻译： N-吡啶甲酰胺及其衍生物
公开(公告)号：US5712294A
公开(公告)日：1998-01-27
申请号：US450346
申请日：1995-05-25
申请人： Jean-Michel Robert , Odile Rideau , Sylvie Robert-Piessard , Jacqueline Courant , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Jean-Michel Robert , Odile Rideau , Sylvie Robert-Piessard , Jacqueline Courant , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： C07D213/81 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/495 , A61K31/497 , A61P13/02 , A61P13/12 , A61P15/00 , A61P17/00 , A61P19/02 , A61P29/00 , C07D213/75 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
CPC分类号： C07D213/75 , C07D401/12 , C07D413/12
摘要： A compound selected from those of formula (I): ##STR1## where m is equal to 0 or 1 and Het, A, X, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and the ring ##STR2## are defined in the description, and a medicinal product comprising the same for treating an inflammatory disorder.
摘要翻译：选自式（I）的化合物：其中m等于0或1，并且Het，A，X，R，R 1，R 2，R 3，R 4和环定义在描述，以及包含其的用于治疗炎性疾病的药物。

8. 发明授权

US5382593A New 3-(hydroxybenzylidenyl)-indolin-2-ones 失效
标题翻译：新的3-（羟基亚苄基） - 二氢吲哚-2-酮
公开(公告)号：US5382593A
公开(公告)日：1995-01-17
申请号：US94562
申请日：1993-07-20
申请人： Guillaume Le Baut , Marie-Renee Nourrisson , Jean-Francois Renaud de la Faverie , Jean-Guy Bizot Espiard , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Guillaume Le Baut , Marie-Renee Nourrisson , Jean-Francois Renaud de la Faverie , Jean-Guy Bizot Espiard , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/44 , A61K31/4427 , A61P3/00 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P25/04 , A61P29/00 , A61P37/00 , A61P37/08 , C07D209/30 , C07D209/34 , C07D401/04
CPC分类号： C07D401/04 , A61K31/40 , C07D209/30 , C07D209/34
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and X are as defined in the description, its Z and E isomers, its optical isomers, in pure form or in the form of a mixture, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in treating a disorder resulting from or associated with peroxidation phenomena, disturbances in eicosanoid synthesis, or with platelet aggregation disorders.
摘要翻译：本发明涉及选自式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5和X如说明书中所定义，其Z和E异构体，其旋光异构体，其形式为混合物，其与药学上可接受的酸或碱的加成盐，以及含有该药物的药物可用于治疗由二氧化反应现象引起的或与过氧化作用有关的病症，类二十烷酸合成紊乱，或血小板聚集障碍。

9. 发明授权

US06432987B1 Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action 有权
公开(公告)号：US06432987B1
公开(公告)日：2002-08-13
申请号：US09736431
申请日：2000-12-15
申请人： Eckhard Gunther , Peter Emig , Dietmar Reichert , Guillaume Le Baut , Bernd Nickel , Gerald Bacher
发明人： Eckhard Gunther , Peter Emig , Dietmar Reichert , Guillaume Le Baut , Bernd Nickel , Gerald Bacher
IPC分类号： A01N4340
摘要： The invention relates to novel, substituted N-benzyl-indol-3-ylglyoxylic acid derivatives of the following formula and their use for the treatment of oncoses The invention further relates to their physiologically tolerable acid addition salts and if possible their N-oxides. In addition, the invention relates to pharmaceutical preparations containing at least one of the compounds of the abovementioned formula or their salts or N-oxides with physiologically tolerable inorganic or organic acids and, if appropriate, pharmaceutically utilizable vehicles and/or diluents or excipients and also administration forms of the compounds of the abovementioned formula containing at least one of the compounds of this formula or their salts in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments

10. 发明授权

US5470864A .alpha.-amino acid compounds 失效
标题翻译： α-氨基酸化合物
公开(公告)号：US5470864A
公开(公告)日：1995-11-28
申请号：US268289
申请日：1994-06-30
申请人： Muriel Duflos , Sylvie Robert-Piessard , Lucien Welin , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Muriel Duflos , Sylvie Robert-Piessard , Lucien Welin , Guillaume Le Baut , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/44 , A61K31/4418 , A61P3/06 , A61P29/00 , C07D213/75 , C07D213/89 , C07D401/12 , C07F5/02
CPC分类号： C07D213/75 , C07D213/89 , C07D401/12 , C07F5/02 , C07F5/025
摘要： Compounds of the general formula: ##STR1## wherein m, X, Y, A, R.sub.2 and R.sub.3 are defined in the description.
摘要翻译：通式：其中m，X，Y，A，R 2和R 3的化合物在说明书中定义。

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