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1. 发明授权

US5602131A EburnanE analogues 失效
标题翻译： EburnanE类似物
公开(公告)号：US5602131A
公开(公告)日：1997-02-11
申请号：US354660
申请日：1994-12-13
申请人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
发明人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
IPC分类号： C07D471/06 , A61K31/435 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D461/00 , C07D471/22 , C07D471/04 , A61K31/44 , A61K31/50 , C07D471/14
CPC分类号： C07D461/00
摘要： A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.
摘要翻译：选自通式（I）的化合物：其中A表示选自以下的二价基团：R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和Z分别为如本说明书中所定义，其异构体和药学上可接受的酸或碱加成盐，以及含有它们的药物，可用于治疗抑郁和焦虑。

2. 发明授权

US5622957A Benzopyrrolizinoquinolizinones 失效
标题翻译：苯并吡咯啉喹诺酮类
公开(公告)号：US5622957A
公开(公告)日：1997-04-22
申请号：US433163
申请日：1995-05-03
申请人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
发明人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
IPC分类号： C07D471/06 , A61K31/435 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D461/00 , C07D471/22 , A61K31/475
CPC分类号： C07D461/00
摘要： A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.
摘要翻译：选自通式（I）的化合物：其中A表示二价基团，并且R 1，R 2，R 3，R 4，R 6，R 7，R 8，R 9和Z如描述，其异构体和药学上可接受的酸或碱加成盐，以及含有它们的药物，其可用于治疗抑郁和焦虑。

3. 发明授权

US5776949A 2-(1H) quinolinone compounds 失效
标题翻译： 2-（1H）喹啉酮化合物
公开(公告)号：US5776949A
公开(公告)日：1998-07-07
申请号：US889920
申请日：1997-07-10
申请人： Alex Cordi , Patrice Desos , Jean Lepagnol , Philippe Morain , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Jean Lepagnol , Philippe Morain , Pierre Lestage
IPC分类号： A61K31/47 , A61P9/00 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07D215/36 , C07D401/04 , C07D471/04 , C07D521/00
CPC分类号： C07D231/12 , C07D215/36 , C07D233/56 , C07D249/08 , C07D401/04 , C07D471/04
摘要： A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, which are identical or different, represent hydrogen, halogen, alkyl, nitro, cyano, aminosulfonyl, imidazolyl, or pyrrolyl, or alternatively, when two of them are situated on adjacent carbons, may form with the carbon atoms to which they are attached a benzene ring on C.sub.3 -C.sub.7 cyloalkyl R.sub.4 represents hydroxyl, alkoxy, phenoxy, or amino, their isomers as well as their addition salts with a pharmaceutically-acceptable base, and medicinal products containing the same which are useful as inhibitors of the the pathological phenomena linked to hyperactivation of the neurotransmission pathways by the excitatory amino acids.
摘要翻译：式（I）化合物：其中：R 1，R 2，R 3相同或不同，表示氢，卤素，烷基，硝基，氰基，氨基磺酰基，咪唑基或吡咯基，或者，当它们中的两个位于相邻的碳上时，可以与它们所连接的碳原子一起形成C3-C7环烷基上的苯环R4表示羟基，烷氧基，苯氧基或氨基，它们的异构体以及它们与药学上可接受的碱和含有它们的药物，其可用作与兴奋性氨基酸对神经传递途径的过度活化有关的病理现象的抑制剂。

4. 发明授权

US5026701A Morpholine compounds, compositions and use 失效
标题翻译：吗啉化合物，组成和用途
公开(公告)号：US5026701A
公开(公告)日：1991-06-25
申请号：US603522
申请日：1990-10-25
申请人： Gilbert Regnier , Claude Guillonneau , Jean Lepagnol , Pierre Lestage
发明人： Gilbert Regnier , Claude Guillonneau , Jean Lepagnol , Pierre Lestage
IPC分类号： A61K31/535 , A61P9/08 , A61P25/28 , C07D413/12
CPC分类号： C07D413/12 , Y10S514/878 , Y10S514/879
摘要： New morpholine compounds of the formula: ##STR1## in which: X, bonded to the aromatic nucleus, represents halogen or trifluoromethyl and R' represents hydrogen, (C.sub.1 -C.sub.5)alkyl optionally including a double bond, or aralkyl; in racemic and enantiomeric forms, and physiologically tolerable acid addition salts theroef.These compounds and their physiologically tolerable salts can be used therapeutically especially in the treatment of ischaemic syndromes and cerebral ageing.
摘要翻译：下式的新的吗啉化合物：其中：与芳香核键合的X表示卤素或三氟甲基，R'表示氢，任选地包括双键的（C 1 -C 5）烷基或芳烷基; 外消旋和对映异构体形式，以及生理上可耐受的酸加成盐。这些化合物及其生理上可耐受的盐可用于治疗特别是治疗缺血综合征和脑衰老。

5. 发明授权

US5066651A Pyrrolidone compounds for treating cerebral disorders 失效
标题翻译：吡咯烷酮化合物治疗小脑疾病
公开(公告)号：US5066651A
公开(公告)日：1991-11-19
申请号：US525137
申请日：1990-05-17
申请人： Gilbert Regnir , Alain Dhainaut , Jean Lepagnol , Jean Lepagnol
发明人： Gilbert Regnir , Alain Dhainaut , Jean Lepagnol , Jean Lepagnol
IPC分类号： C07D491/056 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/495 , A61K31/505 , A61K31/535 , A61K31/54 , A61P9/00 , A61P25/28 , C07D207/48 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/06
CPC分类号： C07D401/12 , C07D207/48 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/06
摘要： New pyrrolidone compounds of the formula: ##STR1## in which: R is OR", SR" or N (R.sub.3 R.sub.4)R' is optionally substituted alkyl or aryl, andthe carbon in the 5-position of the pyrrolidone ring, which is substituted by CH.sub.2 R has the R or S configuration.These new compounds and their physiologically tolerable salts may be used therapeutically especially in the treatment of asthenias, ischaemic syndromes and nervous disorders associated with normal or pathological ageing.
摘要翻译：下式的新的吡咯烷酮化合物：其中：R为OR“，SR”或N（R3R4）R'为任选取代的烷基或芳基，吡咯烷酮环的5-位为碳，被CH2R取代有R或S构型。这些新化合物及其生理上可耐受的盐可用于治疗特别是治疗与正常或病理衰老相关的虚弱，缺血综合征和神经障碍。

6. 发明授权

US5536719A Benzothiadiazine compound 失效
标题翻译：苯并噻二嗪化合物
公开(公告)号：US5536719A
公开(公告)日：1996-07-16
申请号：US500609
申请日：1995-07-11
申请人： Alex Cordi , Michael Spedding , Bernard Serkiz , Jean Lepagnol , Patrice Desos , Philippe Morain
发明人： Alex Cordi , Michael Spedding , Bernard Serkiz , Jean Lepagnol , Patrice Desos , Philippe Morain
IPC分类号： A61K31/54 , A61K31/549 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/28 , A61P43/00 , C07B53/00 , C07B57/00 , C07B61/00 , C07D513/04
CPC分类号： C07D513/04
摘要： A compound of formula (I): ##STR1## in the form of its S enantiomer, its addition salts with a pharmaceutically acceptable acid or base and medicinal product containing the same are useful for the treatment or prevention of pathologies associated with dysfunction of glutamatergic neurotransmission.
摘要翻译：式（I）化合物：其S对映异构体形式的其（I）化合物，其与药学上可接受的酸或碱的加成盐和含有其的药物可用于治疗或预防与功能障碍相关的病理学谷氨酸能神经传递。

7. 发明授权

US4859700A 2-(2,3-dihydro-2-oxo-3-benzofuranyl)acetic acid compounds having antihypoxic and nootropic effects 失效
标题翻译：具有抗缺氧和诱导作用的2-（2,3-二氢-2-氧代-3-苯并呋喃基）乙酸化合物
公开(公告)号：US4859700A
公开(公告)日：1989-08-22
申请号：US155352
申请日：1988-02-12
申请人： Gilbert Lavielle , Jean Lepagnol
发明人： Gilbert Lavielle , Jean Lepagnol
IPC分类号： A61K31/34 , A61K31/343 , A61K31/415 , A61P3/00 , A61P25/28 , C07D307/83 , C07D405/06 , C07D405/12 , C07D407/12
CPC分类号： C07D405/12 , C07D307/83 , C07D407/12
摘要： The invention relates to new 2-(2,3-dihydro-2-oxo-3-benzofuranyl)acetic acid compounds of general formula I: ##STR1## in which: R.sub.1 denotes a hydrogen atom, a linear or branched alkyl radical having 1 to 4 carbon atoms or a phenyl radical optionally substituted with a halogen atom or with an alkoxy radical containing 1 to 4 carbon atoms or an alkyl radical having 1 to 4 carbon atoms,R.sub.2 denotes a hydrogen or halogen atom, a hydroxyl radical, an alkyl radical having 1 to 4 carbon atoms or an alkoxy radical containing 1 to 4 carbon atoms,R denotes a hydroxyl radical, a linear or branched alkoxy radical having 1 to 4 carbon atoms, a benzyloxy radical or a radical of general formula A: ##STR2## in which: X and Y, which may be identical or different, each denote a linear or branched alkyl radical containing 1 to 5 carbon atoms, a radical of general formula A.sub.1 (CHZ--COOH)--, in which Z denotes a hydrogen atom, a linear or branched alkyl radical having 1 to 4 carbon atoms, a hydroxyalkyl radical having 1 to 4 carbon atoms, a 4-imidazolylmethylene radical or a benzyl radical optionally substituted with an alkyl radical having 1 to 4 carbon atoms or with a hydroxyl radical; a radical of general formula A.sub.2 (CH.sub.2 W)- in which W denotes a linear or branches dialkylaminomethylene radical having 3 to 9 carbon atoms, a 2-pyrrolidinyl radical optionally substituted with an alkyl radical having 1 to 4 carbon atoms, a benzyl radical, a 1-isochromanyl radical or a 1-isoquinolyl radical, or form, together with the nitrogen to which they are attached, a 2-carboxy-2-pyrrolidinyl radical, a 4-morpholinyl radical, a piperidino radical optionally substituted with a phenyl radical or with an alkoxyphenyl radical having 7 to 10 carbon atoms, or a 1-piperazinyl radical. Medicinal products.
摘要翻译：本发明涉及通式I的新的2-（2,3-二氢-2-氧代-3-苯并呋喃基）乙酸化合物：其中：R 1表示氢原子，直链或支链烷基具有1至4个碳原子的基团或任选被卤素原子或含有1至4个碳原子的烷氧基或具有1至4个碳原子的烷基的苯基，R 2表示氢或卤素原子，羟基，具有1至4个碳原子的烷基或含有1至4个碳原子的烷氧基，R表示羟基，具有1至4个碳原子的直链或支链烷氧基，苄氧基或通式A的基团（A）其中：X和Y可以相同或不同，各自表示含有1至5个碳原子的直链或支链烷基，通式A1（CHZ-COOH） - 的基团，在其中Z表示氢原子，具有1至4个碳原子的直链或支链烷基，羟烷基具有1至4个碳原子的基团，4-咪唑基亚甲基或任选被具有1至4个碳原子的烷基或羟基自由基取代的苄基; 通式A2（CH2W）的基团，其中W表示具有3至9个碳原子的直链或支链二烷基氨基亚甲基，任选被具有1至4个碳原子的烷基取代的2-吡咯烷基，苄基，或与其连接的氮一起形成2-羧基-2-吡咯烷基，4-吗啉基，任选被苯基取代的哌啶子基或具有7至10个碳原子的烷氧基苯基或1-哌嗪基。药用产品。

8. 发明授权

US4782054A Tetrahydroquinoline morpholine compounds, compositions and use 失效
标题翻译：四氢喹啉吗啉化合物，组成和用途
公开(公告)号：US4782054A
公开(公告)日：1988-11-01
申请号：US164103
申请日：1988-03-04
申请人： Gilbert Regnier , Claude Guillonneau , Jean Lepagnol
发明人： Gilbert Regnier , Claude Guillonneau , Jean Lepagnol
IPC分类号： A61K31/535 , A61P9/00 , A61P9/04 , A61P9/10 , A61P25/28 , C07D413/12
CPC分类号： C07D413/12 , Y10S514/878 , Y10S514/879
摘要： Morpholine compounds of the formula: ##STR1## in which R.sub.1 is hydrogen, straight-chain or branched (C.sub.1 -C.sub.6)-alkyl which may contain a double bond, aralkyl which may be substituted, (C.sub.5 -C.sub.6)-cycloalkyl or (C.sub.2 -C.sub.6)-acyl; andR.sub.2 is hydrogen, straight-chain or branched (C.sub.1 -C.sub.6)-alkyl which may contain a double bond, aralkyl which may be substituted, or (C.sub.2 -C.sub.3)-acyl; enantiomers and physiologically tolerable acid salts thereof.These compounds may be used therapeutically especially in the treatment of ischaemic syndromes and of cerebral ageing.
摘要翻译：其中R 1是氢，可以含有双键的直链或支链（C 1 -C 6） - 烷基，可被取代的芳烷基，（C 5 -C 6） - 环烷基或（C 2 -C 6） -C 6） - 酰基; 和R 2是氢，可以含有双键的直链或支链（C 1 -C 6） - 烷基，可被取代的芳烷基或（C 2 -C 3） - 酰基; 对映体和其生理上可耐受的酸盐。这些化合物可以治疗特别用于治疗缺血综合征和脑衰老。

9. 发明授权

US5492913A N-benzylpiperazine compounds 失效
标题翻译： N-苄基哌嗪化合物
公开(公告)号：US5492913A
公开(公告)日：1996-02-20
申请号：US216795
申请日：1994-03-23
申请人： Michel Wierzbicki , Jean Lepagnol , Jean-Paul Tillement , Bernard Testa , Yves Rolland
发明人： Michel Wierzbicki , Jean Lepagnol , Jean-Paul Tillement , Bernard Testa , Yves Rolland
IPC分类号： A61K31/495 , A61P9/10 , A61P25/00 , A61P25/28 , C07D295/08 , C07D295/088 , C07D295/096
CPC分类号： C07D295/096 , C07D295/088 , C07C2101/02
摘要： The compounds are N-(unsubstituted or substituted) N'-benzylpiperazine compounds and pharmaceutically tolerable salts thereof, useful for treating neuronal disorders resulting from the dysfunctioning of oxidative metabolism.A compound disclosed is: N-ethyl N'-(2-hydroxy-3,4- dimethoxybenzyl)-piperazine and its dihydrochloride.
摘要翻译：该化合物是N-（未取代或取代的）N'-苄基哌嗪化合物及其药学上可耐受的盐，可用于治疗由氧化代谢功能障碍引起的神经元病症。所公开的化合物是N' - （2-羟基-3,4-二甲氧基苄基） - 哌嗪及其二盐酸盐。

10. 发明授权

US5459138A Pyridothiadiazines 失效
标题翻译：吡哆噻嗪
公开(公告)号：US5459138A
公开(公告)日：1995-10-17
申请号：US217192
申请日：1994-03-24
申请人： Bernard Pirotte , Pascal de Tullio , Bernard Masereel , Jacques Delarge , Jean Lepagnol , Pierre Renard
发明人： Bernard Pirotte , Pascal de Tullio , Bernard Masereel , Jacques Delarge , Jean Lepagnol , Pierre Renard
IPC分类号： A61K31/54 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D513/04
CPC分类号： C07D513/04
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.4 are as defined in the description,and medicinal products containing the same which is useful for treating a pathology related to dysfunctioning of glutamatergic neurotransmission.
摘要翻译：本发明涉及一种选自式（I）的化合物：其中A，R 1，R 2和R 4如说明书中所定义，其中含有该化合物的医药产品可用于治疗病理学与谷氨酸能神经传递功能障碍有关。

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