专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060173282A1 Method for the production of hyperpolarized 129xe 有权
标题翻译：生产超极化129xe的方法
公开(公告)号：US20060173282A1
公开(公告)日：2006-08-03
申请号：US10532563
申请日：2003-10-24
申请人： Jan-Henrik Ardenkjaer-Larsen , Lennart Hansson , Haukur Johannesson , Rolf Servin , Lars-Goran Wistrand
发明人： Jan-Henrik Ardenkjaer-Larsen , Lennart Hansson , Haukur Johannesson , Rolf Servin , Lars-Goran Wistrand
IPC分类号： A61B5/05
CPC分类号： A61K51/1206
摘要： The present invention relates to a method for the production of hyperpolarized 129Xe and to a method for the production of a contrast agent.
摘要翻译：本发明涉及一种生产超极化氙的方法和一种制造造影剂的方法。

2. 发明授权

US08003077B2 Method for the production of hyperpolarized 129Xe 有权
标题翻译：生产超极化129Xe的方法
公开(公告)号：US08003077B2
公开(公告)日：2011-08-23
申请号：US10532563
申请日：2003-10-24
申请人： Jan-Henrik Ardenkjaer-Larsen , Lennart Hansson , Haukur Johannesson , Rolf Servin , Lars-Goran Wistrand
发明人： Jan-Henrik Ardenkjaer-Larsen , Lennart Hansson , Haukur Johannesson , Rolf Servin , Lars-Goran Wistrand
IPC分类号： A61B5/055 , A61B5/05
CPC分类号： A61K51/1206
摘要： The present invention relates to a method for the production of hyperpolarized 129Xe and to a method for the production of a contrast agent.
摘要翻译：本发明涉及一种生产超极化的129Xe的方法和一种生产造影剂的方法。

3. 发明授权

US07372274B2 Methods and devices configured for dissolving hyperpolarised solid material with a solvent within a cryostat for NMR analyses 有权
标题翻译：配置用于将超极化固体物质溶解在低温恒温器内用于NMR分析的方法和装置
公开(公告)号：US07372274B2
公开(公告)日：2008-05-13
申请号：US10415968
申请日：2001-11-02
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Georg Hansson , Haukur Johannesson , Rolf Servin , Mikkel Thaning , Lennart Hansson
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Georg Hansson , Haukur Johannesson , Rolf Servin , Mikkel Thaning , Lennart Hansson
IPC分类号： G01V3/00 , A61B5/055
CPC分类号： G01R33/282 , G01N1/44 , G01R33/307 , G01R33/5601 , G01R33/62
摘要： The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostat 2 and then brought into solution while still inside the cryostat 2.
摘要翻译：本发明涉及用于溶解固体极化材料同时保持高水平偏振的装置和方法。在本发明的一个实施例中，材料在低温恒温器2中的强磁场中极化，然后在仍然在低温恒温器2内部的同时进入溶液中。

4. 发明申请

US20080061781A1 Multidimensional Nmr Spectroscopy of A Hyperpolarized Sample 有权
标题翻译：超极化样品的多维Nmr光谱
公开(公告)号：US20080061781A1
公开(公告)日：2008-03-13
申请号：US10553381
申请日：2004-04-13
申请人： Rolf Servin , Jan Henrik Ardenkjaer-Larsen , Haukur Johannesson , Maurice Goldman , Jan Wolber
发明人： Rolf Servin , Jan Henrik Ardenkjaer-Larsen , Haukur Johannesson , Maurice Goldman , Jan Wolber
IPC分类号： G01R33/46
CPC分类号： G01R33/4633 , G01R33/62
摘要： The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receives hyperpolarization; performing NMR spectroscopy on the sample with the use of sequences of rf-pulses, wherein the pulse sequences comprises at least two rf-pulses, either on the same nuclei or on different nuclei, and wherein the pulse sequence is adapted for a hyperpolarized sample; and analysing at least two of the NMR spectra to obtain a characterization of the sample, or to obtain an interim result to be used in the NMR spectroscopy step.
摘要翻译：本发明涉及适用于超极化样品的核磁共振（NMR）光谱的方法。所述方法包括使用DNP超极化样品的步骤，其中至少一部分NMR活性核接受超极化; 使用rf脉冲序列对样本进行NMR光谱分析，其中所述脉冲序列包括在同一核上或不同核上的至少两个rf脉冲，并且其中所述脉冲序列适用于超极化样品; 并分析至少两个NMR光谱以获得样品的表征，或获得在NMR光谱步骤中使用的中间结果。

5. 发明授权

US07550970B2 Multidimensional NMR spectroscopy of a hyperpolarized sample 有权
标题翻译：超极化样品的多维NMR光谱
公开(公告)号：US07550970B2
公开(公告)日：2009-06-23
申请号：US10553381
申请日：2004-04-13
申请人： Rolf Servin , Jan Henrik Ardenkjaer-Larsen , Haukur Johannesson , Maurice Goldman , Jan Wolber
发明人： Rolf Servin , Jan Henrik Ardenkjaer-Larsen , Haukur Johannesson , Maurice Goldman , Jan Wolber
IPC分类号： G01V3/00
CPC分类号： G01R33/4633 , G01R33/62
摘要： The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receives hyperpolarization; performing NMR spectroscopy on the sample with the use of sequences of rf-pulses, wherein the pulse sequences comprises at least two rf-pulses, either on the same nuclei or on different nuclei, and wherein the pulse sequence is adapted for a hyperpolarized sample; and analyzing at least two of the NMR spectra to obtain a characterization of the sample, or to obtain an interim result to be used in the NMR spectroscopy step.
摘要翻译：本发明涉及适用于超极化样品的核磁共振（NMR）光谱的方法。所述方法包括使用DNP超极化样品的步骤，其中至少一部分NMR活性核接受超极化; 使用rf脉冲序列对样本进行NMR光谱分析，其中所述脉冲序列包括在同一核上或不同核上的至少两个rf脉冲，并且其中所述脉冲序列适用于超极化样品; 并分析至少两个NMR光谱以获得样品的表征，或获得在NMR光谱步骤中使用的中间结果。

6. 发明授权

US06872380B2 Process for preparation of MR contrast agents 有权
标题翻译：制备MR造影剂的方法
公开(公告)号：US06872380B2
公开(公告)日：2005-03-29
申请号：US09990537
申请日：2001-11-16
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61K49/00 , A61K49/18 , C07C67/303 , C07C69/675 , G01R33/28 , G01R33/483 , A61B5/055 , C07C69/02
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述溶液以液滴形式进入含有富氢对氢（对 - 氢）和/或邻 - 氘（o- 2 H 2）的氢气（H 2）和/或邻 - 氘（o- 2 H 2）的室中，由此氢化所述基底以形成氢化显像剂 iii）任选地使所述氢化显像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述成像剂在所述水性介质; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和任选地将所述显像剂的溶液冷冻在所述水性介质中。

7. 发明申请

US20050152840A1 Process 有权
标题翻译：处理
公开(公告)号：US20050152840A1
公开(公告)日：2005-07-14
申请号：US11002864
申请日：2004-12-02
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61K49/00 , A61K49/18 , C07C67/303 , C07C69/675 , G01R33/28 , G01R33/483
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供了一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述液滴形式的溶液引入含有富氢对二氢的氢气（H 2 S 2 H 2）的室中，）和/或邻 - 氘（o-2 H 2 H 2），由此氢化所述底物以形成氢化显像剂; iii）任选地使所述氢化成像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述显影剂的溶液在所述水性介质中分离; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和vii）任选地将所述成像剂的溶液冷冻在所述水性介质中。

8. 发明授权

US07459144B2 Process for preparation of MR contrast agents 有权
标题翻译：制备MR造影剂的方法
公开(公告)号：US07459144B2
公开(公告)日：2008-12-02
申请号：US11002864
申请日：2004-12-02
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61B5/055 , B01J10/00
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供了一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述液滴形式的溶液引入含有富氢对二氢（p-1H 2）和/或邻 - 氘（o-2H 2）的氢气（H 2）的室中，从而氢化所述底物以形成氢化显像剂; iii）任选地使所述氢化成像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述显影剂的溶液在所述水性介质中分离; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和vii）任选地将所述成像剂的溶液冷冻在所述水性介质中。

9. 发明授权

US07501236B1 NMR spectroscopic in vitro assay using hyperpolarization 有权
标题翻译：使用超极化的NMR光谱体外测定
公开(公告)号：US07501236B1
公开(公告)日：2009-03-10
申请号：US09869629
申请日：1999-12-23
申请人： Peter Knox , Neil Cook , Klaes Golman , Haukur Johannesson , Oksar Axelsson , Jan Henrik Ardenkjaer-Larsen
发明人： Peter Knox , Neil Cook , Klaes Golman , Haukur Johannesson , Oksar Axelsson , Jan Henrik Ardenkjaer-Larsen
IPC分类号： C12Q1/68
CPC分类号： G01R33/281 , C12Q1/6827 , G01N33/58 , C12Q2565/633
摘要： An in vitro assay method which comprises the use of an assay reagent containing at least one NMR active nucleus, and hyperpolarising at least one NMR active nucleus of the assay reagent; and analysing the assay reagent and/or the assay by NMR spectroscopy and/or NMR imaging. The assay reagent may contain an artificially high concentration of an NMR active nucleus.
摘要翻译：一种体外测定方法，其包括使用含有至少一个NMR活性核的测定试剂，以及超极化所述测定试剂的至少一个NMR活性核; 并通过NMR光谱和/或NMR成像分析测定试剂和/或测定。测定试剂可以含有人工高浓度的NMR活性核。

10. 发明授权

US06574496B1 Magnetic resonance imaging 失效
标题翻译：磁共振成像
公开(公告)号：US06574496B1
公开(公告)日：2003-06-03
申请号：US09572949
申请日：2000-05-18
申请人： Klaes Golman , Oskar Axelsson , Haukur Johannesson
发明人： Klaes Golman , Oskar Axelsson , Haukur Johannesson
IPC分类号： A61B505
CPC分类号： G01R33/5601 , G01R33/56308
摘要： A method of magnetic resonance investigation of a sample by (i) reacting ortho-deuterium enriched hydrogen with a hydrogenatable MR imaging agent precursor to produce a hydrogenated (i.e. deuterated) MR imaging agent; (ii) optionally, subjecting the hydrogenated MR imaging agent to a low magnetic field;(iii) administering the hydrogenated MR imaging agent to the sample; (iv) exposing the sample to radiation of a frequency selected to excite nuclear spin transitions of selected non-zero nuclear spin nuclei in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of the selected non-zero nuclear spin nuclei from the sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from the detected signals.
摘要翻译：通过（i）使富氘氢与可氢化MR显像剂前体反应以产生氢化（即氘代）MR成像剂，对样品进行磁共振研究的方法; （ii）任选地，使氢化MR成像剂经受低磁场;（iii）向该样品施用氢化MR显像剂; （iv）将所述样品暴露于所选择的用于激发所述氢化MR成像剂中选定的非零核自旋核的核自旋跃迁的频率的辐射; （v）从所述样品检测所选择的非零核自旋核的磁共振信号; 和（vi）可选地，从检测到的信号生成图像或生物功能数据或动态流量数据。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式