专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

AU1310295A Method and apparatus for measuring weak magnetic fields 未知
公开(公告)号：AU1310295A
公开(公告)日：1995-07-10
申请号：AU1310295
申请日：1994-12-21
申请人： JAN HENRIK ARDENKJAER LARSEN
发明人： ARDENKJAR-LARSEN JAN HENRIK
IPC分类号： G01R33/24 , G01R33/28 , G01R33/62

2. 发明授权

US06872380B2 Process for preparation of MR contrast agents 有权
标题翻译：制备MR造影剂的方法
公开(公告)号：US06872380B2
公开(公告)日：2005-03-29
申请号：US09990537
申请日：2001-11-16
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61K49/00 , A61K49/18 , C07C67/303 , C07C69/675 , G01R33/28 , G01R33/483 , A61B5/055 , C07C69/02
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述溶液以液滴形式进入含有富氢对氢（对 - 氢）和/或邻 - 氘（o- 2 H 2）的氢气（H 2）和/或邻 - 氘（o- 2 H 2）的室中，由此氢化所述基底以形成氢化显像剂 iii）任选地使所述氢化显像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述成像剂在所述水性介质; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和任选地将所述显像剂的溶液冷冻在所述水性介质中。

3. 发明授权

US06466814B1 Method of magnetic resonance investigation 有权
标题翻译：磁共振研究方法
公开(公告)号：US06466814B1
公开(公告)日：2002-10-15
申请号：US09609153
申请日：2000-06-30
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Lars-Goran Wistrand , Georg Hansson , Ib Leunbach , Stefan Petersson
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Lars-Goran Wistrand , Georg Hansson , Ib Leunbach , Stefan Petersson
IPC分类号： A61B505
CPC分类号： G01R33/5601 , A61K49/08 , A61K49/10 , A61K49/18 , A61K49/1815 , G01R33/282 , G01R33/62
摘要： The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body. The method comprises the step of ex vivo polarization of a high T1 agent. The polarizing agent is optionally separated from the high T1 agent before the high T1 agent is administered to the sample.
摘要翻译：本发明提供一种样品，优选人或非人动物体的磁共振研究方法。该方法包括高T1试剂的离体极化步骤。在将高T1试剂施用于样品之前，任选地将偏振剂与高T1试剂分离。

4. 发明授权

US06311086B1 Overhauser magnetic resonance imaging (ORMI) method comprising ex vivo polarization of a magnetic resonance (MR) imaging agent 有权
标题翻译： Overhauser磁共振成像（ORMI）方法包括磁共振（MR）成像剂的离体极化
公开(公告)号：US06311086B1
公开(公告)日：2001-10-30
申请号：US09460094
申请日：1999-12-13
申请人： Jan Henrik Ardenkjaer-Larsen , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Goran Wistrand , Oskar Axelsson
发明人： Jan Henrik Ardenkjaer-Larsen , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Goran Wistrand , Oskar Axelsson
IPC分类号： A61B505
CPC分类号： A61K49/10 , A61K49/08 , A61K49/18 , A61K49/20 , G01R33/5601 , G01R33/62
摘要： This invention provides a method of MR investigation of a sample, the method comprising: (i) placing in a uniform magnetic field a composition comprising an OMRI contrast agent and an MR imaging agent containing nuclei (MR imaging nuclei) capable of emitting magnetic resonance signals (e.g. the primary magnetic field B0) and capable of exhibiting a T1 relaxation time of 6 s or more (at 37° C. in D2O in a field of 7T); (ii) exposing the composition to a first radiation of a frequency selected to excite electron spin transitions in the OMRI contrast agent; (iii) optionally but preferably separating the whole, substantially the whole, or a portion of said OMRI contrast agent from said MR imaging agent; (iv) administering said MR imaging agent to said sample, (v) exposing the sample to a second radiation of a frequency selected to excite nuclear spin transitions; (vi) detecting magnetic resonance signals from the sample; and (vii) optionally, generating an image or dynamic flow data from the detected signals.
摘要翻译：本发明提供了一种样品的MR研究方法，该方法包括：（i）在均匀的磁场中放置包含OMRI造影剂和含有能够发射磁共振信号的核（MR成像核）的MR成像剂的组合物（例如初级磁场B0），并且能够表现出6秒以上的T1弛豫时间（在7T的场中在D2O中为37℃）; （ii）将组合物暴露于在OMRI造影剂中激发电子自旋跃迁的频率的第一辐射; （iii）任选地但优选地将所述OMRI造影剂的全部，基本上全部或一部分与所述MR成像剂分离; （iv）向所述样品施用所述MR成像剂，（v）将所述样品暴露于选定为激发核自旋转变的频率的第二辐射; （vi）检测来自样品的磁共振信号; 和（vii）可选地，从检测到的信号生成图像或动态流量数据。

5. 发明授权

US06256527B1 Method for determining oxygen concentration 失效
标题翻译：氧浓度测定方法
公开(公告)号：US06256527B1
公开(公告)日：2001-07-03
申请号：US09027560
申请日：1998-02-23
申请人： Ib Leunbach , Jan Henrik Ardenkjaer-Larsen
发明人： Ib Leunbach , Jan Henrik Ardenkjaer-Larsen
IPC分类号： A61B5055
CPC分类号： A61K49/20 , G01R33/281 , G01R33/62
摘要： A method for determining the oxygen concentration of a sample using electron spin resonance enhanced magnetic resonance imaging.
摘要翻译：使用电子自旋共振增强磁共振成像确定样品的氧浓度的方法。

6. 发明申请

US20110270073A1 ELECTRON SPIN RESONANCE IMAGING SCANNER 审中-公开
标题翻译：电子旋转共振成像扫描仪
公开(公告)号：US20110270073A1
公开(公告)日：2011-11-03
申请号：US12769967
申请日：2010-04-29
申请人： Jan-Henrik Ardenkjaer-Larsen , Jonathan Alan Murray , Fraser John Laing Robb , Ralph Eugene Hurd , Victor Taracila
发明人： Jan-Henrik Ardenkjaer-Larsen , Jonathan Alan Murray , Fraser John Laing Robb , Ralph Eugene Hurd , Victor Taracila
IPC分类号： A61B5/055
CPC分类号： G01R33/60 , A61B5/055 , A61B5/14542
摘要： An electron paramagnetic resonance imaging (EPRI) system includes a resistive magnet driven by a power supply such as a power supply module to generate radio frequency signals in a substantially coherent polyphase perfect sequence scheme. The EPRI system further includes image acquisition and processing electronics configured to generate, acquire, quantify and map pO2 information associated with a free radical agent in vivo and having a resonance line width that is sensitive to oxygen and in response to the radio frequency signals without imparting harmful heating effects to a corresponding human or animal body.
摘要翻译：电子顺磁共振成像（EPRI）系统包括由诸如电源模块的电源驱动的电阻磁体，以产生基本上相干的多相完美序列方案中的射频信号。 EPRI系统还包括图像采集和处理电子器件，其被配置为在体内产生，获取，量化和映射与自由基相关的pO2信息，并且具有对氧敏感的谐振线宽度并且响应于射频信号而不赋予对相应的人体或动物体有害的加热效果。

7. 发明授权

US07557573B2 NMR-based methods for detecting ligands, where the ligand or target are hyperpolarized and the NMR-spectrum is compared with a reference spectrum of the ligand or target 有权
标题翻译：用于检测配体的基于NMR的方法，其中配体或靶是超极化的，并且将NMR光谱与配体或靶的参考光谱进行比较
公开(公告)号：US07557573B2
公开(公告)日：2009-07-07
申请号：US10537235
申请日：2003-11-27
申请人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham John Cotton , Klaes Golman , Mark Howard , Mathilde H. Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
发明人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham John Cotton , Klaes Golman , Mark Howard , Mathilde H. Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
IPC分类号： G01V3/00
CPC分类号： G01R33/465 , G01N24/08 , G01N24/088 , G01R33/282 , G01R33/62
摘要： The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.
摘要翻译：本发明涉及包含用于基于NMR的测定中使用的超极化配体或靶的基于NMR的方法。

8. 发明授权

US07102354B2 Methods and devices for hyperpolarising and melting NMR samples in a cryostat 有权
标题翻译：在低温恒温器中超极化和熔解NMR样品的方法和装置
公开(公告)号：US07102354B2
公开(公告)日：2006-09-05
申请号：US11062882
申请日：2005-02-22
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Jan Wolber , Mark Howard
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Jan Wolber , Mark Howard
IPC分类号： G01V3/00 , A61B5/055 , F27B1/09
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup 9 in a strong magnetic field in a polarising means 3a, 3b, 3c in a cryostat 2 and then melted inside the cryostat 2 by melting means such as a laser 8 connected by an optical fibre 4 to the interior of the cryostat.
摘要翻译：本发明涉及在保持高水平偏振的同时熔化固体极化样品的装置和方法。在本发明的一个实施例中，样品在低温恒温器2中的偏振装置3a，3b，3c中的强磁场中在样品保持杯9中极化，然后通过熔化装置熔化在低温恒温器2内作为通过光纤4连接到低温恒温器内部的激光器8。

9. 发明申请

US20060173282A1 Method for the production of hyperpolarized 129xe 有权
标题翻译：生产超极化129xe的方法
公开(公告)号：US20060173282A1
公开(公告)日：2006-08-03
申请号：US10532563
申请日：2003-10-24
申请人： Jan-Henrik Ardenkjaer-Larsen , Lennart Hansson , Haukur Johannesson , Rolf Servin , Lars-Goran Wistrand
发明人： Jan-Henrik Ardenkjaer-Larsen , Lennart Hansson , Haukur Johannesson , Rolf Servin , Lars-Goran Wistrand
IPC分类号： A61B5/05
CPC分类号： A61K51/1206
摘要： The present invention relates to a method for the production of hyperpolarized 129Xe and to a method for the production of a contrast agent.
摘要翻译：本发明涉及一种生产超极化氙的方法和一种制造造影剂的方法。

10. 发明申请

US20050152840A1 Process 有权
标题翻译：处理
公开(公告)号：US20050152840A1
公开(公告)日：2005-07-14
申请号：US11002864
申请日：2004-12-02
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61K49/00 , A61K49/18 , C07C67/303 , C07C69/675 , G01R33/28 , G01R33/483
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供了一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述液滴形式的溶液引入含有富氢对二氢的氢气（H 2 S 2 H 2）的室中，）和/或邻 - 氘（o-2 H 2 H 2），由此氢化所述底物以形成氢化显像剂; iii）任选地使所述氢化成像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述显影剂的溶液在所述水性介质中分离; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和vii）任选地将所述成像剂的溶液冷冻在所述水性介质中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式