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1. 发明授权

US06574496B1 Magnetic resonance imaging 失效
标题翻译：磁共振成像
公开(公告)号：US06574496B1
公开(公告)日：2003-06-03
申请号：US09572949
申请日：2000-05-18
申请人： Klaes Golman , Oskar Axelsson , Haukur Johannesson
发明人： Klaes Golman , Oskar Axelsson , Haukur Johannesson
IPC分类号： A61B505
CPC分类号： G01R33/5601 , G01R33/56308
摘要： A method of magnetic resonance investigation of a sample by (i) reacting ortho-deuterium enriched hydrogen with a hydrogenatable MR imaging agent precursor to produce a hydrogenated (i.e. deuterated) MR imaging agent; (ii) optionally, subjecting the hydrogenated MR imaging agent to a low magnetic field;(iii) administering the hydrogenated MR imaging agent to the sample; (iv) exposing the sample to radiation of a frequency selected to excite nuclear spin transitions of selected non-zero nuclear spin nuclei in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of the selected non-zero nuclear spin nuclei from the sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from the detected signals.
摘要翻译：通过（i）使富氘氢与可氢化MR显像剂前体反应以产生氢化（即氘代）MR成像剂，对样品进行磁共振研究的方法; （ii）任选地，使氢化MR成像剂经受低磁场;（iii）向该样品施用氢化MR显像剂; （iv）将所述样品暴露于所选择的用于激发所述氢化MR成像剂中选定的非零核自旋核的核自旋跃迁的频率的辐射; （v）从所述样品检测所选择的非零核自旋核的磁共振信号; 和（vi）可选地，从检测到的信号生成图像或生物功能数据或动态流量数据。

2. 发明授权

US07501236B1 NMR spectroscopic in vitro assay using hyperpolarization 有权
标题翻译：使用超极化的NMR光谱体外测定
公开(公告)号：US07501236B1
公开(公告)日：2009-03-10
申请号：US09869629
申请日：1999-12-23
申请人： Peter Knox , Neil Cook , Klaes Golman , Haukur Johannesson , Oksar Axelsson , Jan Henrik Ardenkjaer-Larsen
发明人： Peter Knox , Neil Cook , Klaes Golman , Haukur Johannesson , Oksar Axelsson , Jan Henrik Ardenkjaer-Larsen
IPC分类号： C12Q1/68
CPC分类号： G01R33/281 , C12Q1/6827 , G01N33/58 , C12Q2565/633
摘要： An in vitro assay method which comprises the use of an assay reagent containing at least one NMR active nucleus, and hyperpolarising at least one NMR active nucleus of the assay reagent; and analysing the assay reagent and/or the assay by NMR spectroscopy and/or NMR imaging. The assay reagent may contain an artificially high concentration of an NMR active nucleus.
摘要翻译：一种体外测定方法，其包括使用含有至少一个NMR活性核的测定试剂，以及超极化所述测定试剂的至少一个NMR活性核; 并通过NMR光谱和/或NMR成像分析测定试剂和/或测定。测定试剂可以含有人工高浓度的NMR活性核。

3. 发明申请

US20060173283A1 Method of magnetic resonance imaging 审中-公开
标题翻译：磁共振成像方法
公开(公告)号：US20060173283A1
公开(公告)日：2006-08-03
申请号：US10536480
申请日：2003-11-27
申请人： Oskar Axelsson , Klaes Golman , Sven Mansson , Stefan Petersson
发明人： Oskar Axelsson , Klaes Golman , Sven Mansson , Stefan Petersson
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/7289 , A61K49/06
摘要： The present invention provides methods for passive visualisation of invasive devices by employing a hyperpolarised solution of a high T1 agent having a T1 value of at least 5 seconds at a field strength in the range of 0.001-5 T and a temperature in the range of 20-40° C. Devices and instruments particularly useful for being employed in the methods are also provided as well as use of the methods in imaging, surgery and therapy.
摘要翻译：本发明提供了通过在0.001-5T范围内的场强和20°范围内的温度下使用具有至少5秒的T1值的高T1试剂的超极化溶液来提供侵入性装置的被动可视化的方法 -40°C。还提供了特别可用于方法中使用的装置和仪器以及成像，手术和治疗中的方法的使用。

4. 发明申请

US20050225328A1 Methods and devices for polarised NMR samples 有权
标题翻译：用于极化NMR样品的方法和装置
公开(公告)号：US20050225328A1
公开(公告)日：2005-10-13
申请号：US11062882
申请日：2005-02-22
申请人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
发明人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
IPC分类号： G01N1/44 , G01R33/28 , G01R33/30 , G01R33/62 , G01V3/00 , G01J4/00
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup 9 in a strong magnetic field in a polarising means 3a, 3b, 3c in a cryostat 2 and then melted inside the cryostat 2 by melting means such as a laser 8 connected by an optical fibre 4 to the interior of the cryostat.
摘要翻译：本发明涉及在保持高水平偏振的同时熔化固体极化样品的装置和方法。在本发明的一个实施例中，样品在低温恒温器2中的偏振装置3a，3b，3c中的强磁场中在样品保持杯9中极化，然后通过熔化装置如激光器在低温恒温器2内熔化 8通过光纤4连接到低温恒温器的内部。

5. 发明授权

US06453188B1 Method of magnetic resonance imaging 失效
标题翻译：磁共振成像方法
公开(公告)号：US06453188B1
公开(公告)日：2002-09-17
申请号：US09333910
申请日：1999-06-16
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Goran Wistrand
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Goran Wistrand
IPC分类号： A61B505
CPC分类号： G01R33/5601
摘要： The invention relates to a method of magnetic imaging (MR) of a living sample comprising the steps of hyperpolarizing a hyperpolarizable gas ex-vivo and transferring the nuclear polarization from the hyperpolarized gas to the nuclei of an MR imaging agent, that is not hyperpolarizable, that is exposed to a uniform magnetic field and that is introduced in contact to the hyperpolarizable gas, separating the hyperpolarizable gas from the MR imaging agent, administering the MR imaging agent to the living sample, exciting NMR transitions in the nuclei of the imaging agent and detecting an NMR signal thereof.
摘要翻译：本发明涉及一种活体样品的磁成像（MR）方法，包括以下步骤：离子超极化超极化气体，并将核极化从超极化气体转移到MR成像剂的核，其不是超极化的，暴露于均匀的磁场并且与超极化气体接触引入，将超极化气体与MR成像剂分离，将MR成像剂施用于活体样品，在显像剂的细胞核中激发NMR转变，以及检测其NMR信号。

6. 发明授权

US06574495B1 Para-hydrogen labelled agents and their use in magnetic resonance imaging 有权
标题翻译：对位氢标记的药物及其在磁共振成像中的应用
公开(公告)号：US06574495B1
公开(公告)日：2003-06-03
申请号：US09565450
申请日：2000-05-05
申请人： Klaes Golman , Oskar Axelsson , Haukur Johanneson , Charlotte Olofsson , Sven Mansson , Stefan Petersson
发明人： Klaes Golman , Oskar Axelsson , Haukur Johanneson , Charlotte Olofsson , Sven Mansson , Stefan Petersson
IPC分类号： A61B505
CPC分类号： A61K49/06 , A61K49/08 , A61K49/10 , A61K49/18 , A61K49/1815 , G01R33/5601 , G01R33/62
摘要： The invention provides a method of magnetic resonance investigation of a sample, said method comprising: (i) reacting para-hydrogen enriched hydrogen with a hydrogenatable MR imaging agent precursor containing a non-hydrogen non-zero nuclear spin nucleus to produce a hydrogenated MR imaging agent; (ii) administering said hydrogenated MR imaging agent to said sample; (iii) exposing said sample to radiation of a frequency selected to excite nuclear spin transitions of said non-zero nuclear spin nucleus in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of said non-zero nuclear spin nucleus from said sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from said detected signals.
摘要翻译：本发明提供了一种对样品进行磁共振研究的方法，所述方法包括：（i）将富氢氢与含有非氢非零核自旋核的可氢化MR成像剂前体反应以产生氢化MR成像代理人（ii）将所述氢化MR成像剂施用于所述样品; （iii）将所述样品暴露于所选择的频率的辐射以激发所述氢化MR成像剂中所述非零核自旋核的核自旋跃迁; （v）从所述样品检测所述非零核自旋核的磁共振信号; 和（vi）可选地，从所述检测到的信号生成图像或生物功能数据或动态流量数据。

7. 发明授权

US06278893B1 Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent 有权
标题翻译： MR成像剂离子极化的样品的磁共振成像方法
公开(公告)号：US06278893B1
公开(公告)日：2001-08-21
申请号：US09169148
申请日：1998-10-09
申请人： Jan Henrik Ardenkjær-Larson , Oskar Axelsson , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Göran Wistrand
发明人： Jan Henrik Ardenkjær-Larson , Oskar Axelsson , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Göran Wistrand
IPC分类号： A61B5055
CPC分类号： G01R33/5601 , A61K49/08 , A61K49/10 , A61K49/18 , A61K49/1815 , G01R33/282 , G01R33/62
摘要： The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising the step of ex vivo polarisation of a high T1 agent and wherein the polarising agent is optionally seperated from the high T1 agent before the high T1 agent is administered to the sample.
摘要翻译：本发明提供了一种优选人或非人动物体的样品的磁共振研究方法，所述方法包括高T1试剂的离体极化步骤，其中偏振剂可选地与高 T1试剂前高剂量施用T1试剂。

8. 发明申请

US20060192559A1 Methods and devices for polarized NMR samples 审中-公开
标题翻译：用于极化NMR样品的方法和装置
公开(公告)号：US20060192559A1
公开(公告)日：2006-08-31
申请号：US11191140
申请日：2005-07-28
申请人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
发明人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and methods for melting a solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup in a strong magnetic field in a polarising means in a cryostat and then melted inside the cryostat by melting means such as a laser connected by an optical fibre to the interior of the cryostat.
摘要翻译：本发明涉及用于熔化固体极化样品同时保持高水平偏振的装置和方法。在本发明的一个实施例中，样品在低温恒温器中的偏振装置中的强磁场中的样品保持杯中极化，然后通过诸如通过光纤连接到内部的激光器的熔化装置在低温恒温器内熔化的低温恒温器。

9. 发明授权

US06466814B1 Method of magnetic resonance investigation 有权
标题翻译：磁共振研究方法
公开(公告)号：US06466814B1
公开(公告)日：2002-10-15
申请号：US09609153
申请日：2000-06-30
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Lars-Goran Wistrand , Georg Hansson , Ib Leunbach , Stefan Petersson
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Lars-Goran Wistrand , Georg Hansson , Ib Leunbach , Stefan Petersson
IPC分类号： A61B505
CPC分类号： G01R33/5601 , A61K49/08 , A61K49/10 , A61K49/18 , A61K49/1815 , G01R33/282 , G01R33/62
摘要： The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body. The method comprises the step of ex vivo polarization of a high T1 agent. The polarizing agent is optionally separated from the high T1 agent before the high T1 agent is administered to the sample.
摘要翻译：本发明提供一种样品，优选人或非人动物体的磁共振研究方法。该方法包括高T1试剂的离体极化步骤。在将高T1试剂施用于样品之前，任选地将偏振剂与高T1试剂分离。

10. 发明授权

US06311086B1 Overhauser magnetic resonance imaging (ORMI) method comprising ex vivo polarization of a magnetic resonance (MR) imaging agent 有权
标题翻译： Overhauser磁共振成像（ORMI）方法包括磁共振（MR）成像剂的离体极化
公开(公告)号：US06311086B1
公开(公告)日：2001-10-30
申请号：US09460094
申请日：1999-12-13
申请人： Jan Henrik Ardenkjaer-Larsen , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Goran Wistrand , Oskar Axelsson
发明人： Jan Henrik Ardenkjaer-Larsen , Klaes Golman , Georg Hansson , Ib Leunbach , Stefan Petersson , Lars-Goran Wistrand , Oskar Axelsson
IPC分类号： A61B505
CPC分类号： A61K49/10 , A61K49/08 , A61K49/18 , A61K49/20 , G01R33/5601 , G01R33/62
摘要： This invention provides a method of MR investigation of a sample, the method comprising: (i) placing in a uniform magnetic field a composition comprising an OMRI contrast agent and an MR imaging agent containing nuclei (MR imaging nuclei) capable of emitting magnetic resonance signals (e.g. the primary magnetic field B0) and capable of exhibiting a T1 relaxation time of 6 s or more (at 37° C. in D2O in a field of 7T); (ii) exposing the composition to a first radiation of a frequency selected to excite electron spin transitions in the OMRI contrast agent; (iii) optionally but preferably separating the whole, substantially the whole, or a portion of said OMRI contrast agent from said MR imaging agent; (iv) administering said MR imaging agent to said sample, (v) exposing the sample to a second radiation of a frequency selected to excite nuclear spin transitions; (vi) detecting magnetic resonance signals from the sample; and (vii) optionally, generating an image or dynamic flow data from the detected signals.
摘要翻译：本发明提供了一种样品的MR研究方法，该方法包括：（i）在均匀的磁场中放置包含OMRI造影剂和含有能够发射磁共振信号的核（MR成像核）的MR成像剂的组合物（例如初级磁场B0），并且能够表现出6秒以上的T1弛豫时间（在7T的场中在D2O中为37℃）; （ii）将组合物暴露于在OMRI造影剂中激发电子自旋跃迁的频率的第一辐射; （iii）任选地但优选地将所述OMRI造影剂的全部，基本上全部或一部分与所述MR成像剂分离; （iv）向所述样品施用所述MR成像剂，（v）将所述样品暴露于选定为激发核自旋转变的频率的第二辐射; （vi）检测来自样品的磁共振信号; 和（vii）可选地，从检测到的信号生成图像或动态流量数据。

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