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1. 发明授权

US07557573B2 NMR-based methods for detecting ligands, where the ligand or target are hyperpolarized and the NMR-spectrum is compared with a reference spectrum of the ligand or target 有权
标题翻译：用于检测配体的基于NMR的方法，其中配体或靶是超极化的，并且将NMR光谱与配体或靶的参考光谱进行比较
公开(公告)号：US07557573B2
公开(公告)日：2009-07-07
申请号：US10537235
申请日：2003-11-27
申请人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham John Cotton , Klaes Golman , Mark Howard , Mathilde H. Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
发明人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham John Cotton , Klaes Golman , Mark Howard , Mathilde H. Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
IPC分类号： G01V3/00
CPC分类号： G01R33/465 , G01N24/08 , G01N24/088 , G01R33/282 , G01R33/62
摘要： The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.
摘要翻译：本发明涉及包含用于基于NMR的测定中使用的超极化配体或靶的基于NMR的方法。

2. 发明申请

US20060171891A1 Nmr-based methods for detecting ligands, where the ligand or target are hyperpolarized and the nmr-spectrum is compared with a reference spectrum of the ligand or target 有权
标题翻译：用于检测配体的基于Nmr的方法，其中配体或靶是超极化的，并且将nmr光谱与配体或靶的参考光谱进行比较
公开(公告)号：US20060171891A1
公开(公告)日：2006-08-03
申请号：US10537235
申请日：2003-11-27
申请人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham Cotton , Klaes Golman , Mark Howard , Mathilde Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
发明人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham Cotton , Klaes Golman , Mark Howard , Mathilde Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
IPC分类号： A61B5/055
CPC分类号： G01R33/465 , G01N24/08 , G01N24/088 , G01R33/282 , G01R33/62
摘要： The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.
摘要翻译：本发明涉及包含用于基于NMR的测定中使用的超极化配体或靶的基于NMR的方法。

3. 发明授权

US07102354B2 Methods and devices for hyperpolarising and melting NMR samples in a cryostat 有权
标题翻译：在低温恒温器中超极化和熔解NMR样品的方法和装置
公开(公告)号：US07102354B2
公开(公告)日：2006-09-05
申请号：US11062882
申请日：2005-02-22
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Jan Wolber , Mark Howard
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Jan Wolber , Mark Howard
IPC分类号： G01V3/00 , A61B5/055 , F27B1/09
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup 9 in a strong magnetic field in a polarising means 3a, 3b, 3c in a cryostat 2 and then melted inside the cryostat 2 by melting means such as a laser 8 connected by an optical fibre 4 to the interior of the cryostat.
摘要翻译：本发明涉及在保持高水平偏振的同时熔化固体极化样品的装置和方法。在本发明的一个实施例中，样品在低温恒温器2中的偏振装置3a，3b，3c中的强磁场中在样品保持杯9中极化，然后通过熔化装置熔化在低温恒温器2内作为通过光纤4连接到低温恒温器内部的激光器8。

4. 发明申请

US20050225328A1 Methods and devices for polarised NMR samples 有权
标题翻译：用于极化NMR样品的方法和装置
公开(公告)号：US20050225328A1
公开(公告)日：2005-10-13
申请号：US11062882
申请日：2005-02-22
申请人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
发明人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
IPC分类号： G01N1/44 , G01R33/28 , G01R33/30 , G01R33/62 , G01V3/00 , G01J4/00
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup 9 in a strong magnetic field in a polarising means 3a, 3b, 3c in a cryostat 2 and then melted inside the cryostat 2 by melting means such as a laser 8 connected by an optical fibre 4 to the interior of the cryostat.
摘要翻译：本发明涉及在保持高水平偏振的同时熔化固体极化样品的装置和方法。在本发明的一个实施例中，样品在低温恒温器2中的偏振装置3a，3b，3c中的强磁场中在样品保持杯9中极化，然后通过熔化装置如激光器在低温恒温器2内熔化 8通过光纤4连接到低温恒温器的内部。

5. 发明申请

US20060192559A1 Methods and devices for polarized NMR samples 审中-公开
标题翻译：用于极化NMR样品的方法和装置
公开(公告)号：US20060192559A1
公开(公告)日：2006-08-31
申请号：US11191140
申请日：2005-07-28
申请人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
发明人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and methods for melting a solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup in a strong magnetic field in a polarising means in a cryostat and then melted inside the cryostat by melting means such as a laser connected by an optical fibre to the interior of the cryostat.
摘要翻译：本发明涉及用于熔化固体极化样品同时保持高水平偏振的装置和方法。在本发明的一个实施例中，样品在低温恒温器中的偏振装置中的强磁场中的样品保持杯中极化，然后通过诸如通过光纤连接到内部的激光器的熔化装置在低温恒温器内熔化的低温恒温器。

6. 发明申请

US20100297208A1 SCAFFOLD 有权
标题翻译：脚手架
公开(公告)号：US20100297208A1
公开(公告)日：2010-11-25
申请号：US12300636
申请日：2007-05-10
申请人： Nicholas Fry , Anthony Dagger , David Morsley , Helene Lecomte , Roy Trayhearn , Mark Howard , Sarah Freestone , Brian Thomson , Mark Smith , Rebecca Crallan
发明人： Nicholas Fry , Anthony Dagger , David Morsley , Helene Lecomte , Roy Trayhearn , Mark Howard , Sarah Freestone , Brian Thomson , Mark Smith , Rebecca Crallan
IPC分类号： A61K9/70 , B29C47/00 , C12N5/071 , C12N5/078 , A61K35/12 , A61P17/02
CPC分类号： C12N5/0068 , A61F13/00068 , C12N2533/40
摘要： The present invention relates to scaffolds which can be used as medical devices for guided tissue regeneration and repair, in particular the invention is directed to a scaffold comprising fibres having a mean fibre diameter of between from about 1.2 to 4.0 microns, wherein the fibres comprise a glycolide. The invention further relates to the use of the scaffolds for the selective capture of cell populations for a cell source material.
摘要翻译：本发明涉及可用作导向组织再生和修复的医疗装置的支架，特别是本发明涉及包含平均纤维直径在约1.2至4.0微米之间的纤维的支架，其中纤维包含乙交酯。本发明还涉及支架用于选择性捕获细胞源材料的细胞群体的用途。

7. 发明申请

US20080243029A1 TISSUE HARVESTING 有权
标题翻译：组织收集
公开(公告)号：US20080243029A1
公开(公告)日：2008-10-02
申请号：US12059180
申请日：2008-03-31
申请人： Mark Howard , Mark Smith , Stephen Curran , Graham Smith , Elisabeth Hutson
发明人： Mark Howard , Mark Smith , Stephen Curran , Graham Smith , Elisabeth Hutson
IPC分类号： A61B10/02
CPC分类号： C12N5/0653 , A61B10/025 , A61B10/0283 , A61B17/1635 , A61B17/32002 , A61B17/3205 , A61B2017/00969 , A61B2217/005 , A61M1/00 , A61M1/0056 , A61M2202/0014 , A61M2202/08
摘要： The present disclosure relates to a tissue collection apparatus including a housing defining an inlet and an outlet and a tissue scaffold suitable for disposal within the housing, the tissue scaffold configured to be loaded with the tissue under the application of an aspiration force applied through the tissue collection apparatus.
摘要翻译：本公开涉及一种组织收集装置，其包括限定入口和出口的壳体以及适合于在所述壳体内处置的组织支架，所述组织支架构造为在施加穿过所述组织的抽吸力的情况下装载所述组织收集装置。

8. 发明申请

US20070139040A1 SENSING APPARATUS AND METHOD 有权
标题翻译：感应装置和方法
公开(公告)号：US20070139040A1
公开(公告)日：2007-06-21
申请号：US11677803
申请日：2007-02-22
申请人： Ross Jones , Richard Doyle , Mark Howard , David James , Darran Kreit , Colin Sills
发明人： Ross Jones , Richard Doyle , Mark Howard , David James , Darran Kreit , Colin Sills
IPC分类号： G01B7/30
CPC分类号： G01D5/2073 , D06F39/003 , D06F39/087
摘要： There is described a sensor comprising an excitation winding, a signal generator operable to generate an excitation signal and arranged to apply the generated excitation signal to the excitation winding, a sensor winding electromagnetically coupled to the excitation winding and a signal processor operable to process a periodic electric signal generated in the sensor winding when the excitation signal is applied to the excitation winding by the signal generator to determine a value of a sensed parameter. The excitation signal comprises a periodic carrier signal having a first frequency modulated by a periodic modulation signal having a second frequency, the first frequency being greater than the second frequency. In this way, the sensor is well suited to using digital processing techniques both to generate the excitation signal and to process the signal induced in the sensor windings. In an embodiment, the sensor is used to detect the relative position of two members. In other embodiments, the sensor is used to detect environmental factors such as temperature and humidity.
摘要翻译：描述了一种传感器，其包括激励绕组，信号发生器，其可操作以产生激励信号并被布置成将产生的激励信号施加到激励绕组，电磁耦合到激励绕组的传感器绕组和可操作以处理周期性的信号处理器当激励信号由信号发生器施加到激励绕组以确定感测参数的值时，在传感器绕组中产生的电信号。激励信号包括具有由具有第二频率的周期性调制信号调制的第一频率的周期性载波信号，第一频率大于第二频率。以这种方式，传感器非常适合于使用数字处理技术来产生激励信号并处理在传感器绕组中感应的信号。在一个实施例中，传感器用于检测两个构件的相对位置。在其他实施例中，传感器用于检测诸如温度和湿度的环境因素。

9. 发明申请

US20060125472A1 Position sensing apparatus and method 失效
标题翻译：位置检测装置及方法
公开(公告)号：US20060125472A1
公开(公告)日：2006-06-15
申请号：US10531499
申请日：2003-10-16
申请人： Mark Howard , Colin Sills , Darran Kreit , David James
发明人： Mark Howard , Colin Sills , Darran Kreit , David James
IPC分类号： G01B7/14
CPC分类号： G01D5/2086 , G01D5/2093
摘要： There is described an inductive position sensor in which a signal generator applies a excitation signal to an excitation winding formed on a first member, the excitation winding being electromagnetically coupled to at least two resonant circuits formed on a second member which are spaced from each other along a measurement path. The excitation windings are shaped so that the electromagnetic coupling between the exciting winding and each of the resonators varies along the measurement path. In this way, by applying an excitation signal to the excitation winding, respective different signals are induced in the resonators which depend upon the relative position of the first and second members.
摘要翻译：描述了一种感应位置传感器，其中信号发生器向形成在第一构件上的激励绕组施加激励信号，激励绕组电磁耦合到形成在第二构件上的至少两个共振电路，该谐振电路彼此间隔开测量路径。激励绕组的形状使得励磁绕组和每个谐振器之间的电磁耦合沿测量路径变化。以这种方式，通过向激励绕组施加激励信号，在谐振器中感应出相应的不同信号，这取决于第一和第二部件的相对位置。

10. 发明授权

US06494788B1 Billiard-type game 失效
标题翻译：台球式游戏
公开(公告)号：US06494788B1
公开(公告)日：2002-12-17
申请号：US09580911
申请日：2000-05-26
申请人： Colin Gill , Mark Howard , Gary Wood
发明人： Colin Gill , Mark Howard , Gary Wood
IPC分类号： A63D1500
CPC分类号： A63D15/00
摘要： A billiard type game is provided including a table having a top face and a plurality of pockets. The top face is divided into a plurality of zones, and the plurality of zones include neutral zones being demarcated by a first color marked on the top face. First player zones are demarcated by a second color marked on the top face. Second player zones are demarcated by a third color marked on the top face.
摘要翻译：提供一种台球式游戏，包括具有顶面和多个口袋的桌子。顶面被分成多个区域，并且多个区域包括通过顶面上标记的第一颜色划定的中性区域。第一个玩家区域被标记在顶面上的第二个颜色划定。第二个玩家区域被标记在顶面上的第三个颜色划定。

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