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1. 发明申请

US20100297208A1 SCAFFOLD 有权
标题翻译：脚手架
公开(公告)号：US20100297208A1
公开(公告)日：2010-11-25
申请号：US12300636
申请日：2007-05-10
申请人： Nicholas Fry , Anthony Dagger , David Morsley , Helene Lecomte , Roy Trayhearn , Mark Howard , Sarah Freestone , Brian Thomson , Mark Smith , Rebecca Crallan
发明人： Nicholas Fry , Anthony Dagger , David Morsley , Helene Lecomte , Roy Trayhearn , Mark Howard , Sarah Freestone , Brian Thomson , Mark Smith , Rebecca Crallan
IPC分类号： A61K9/70 , B29C47/00 , C12N5/071 , C12N5/078 , A61K35/12 , A61P17/02
CPC分类号： C12N5/0068 , A61F13/00068 , C12N2533/40
摘要： The present invention relates to scaffolds which can be used as medical devices for guided tissue regeneration and repair, in particular the invention is directed to a scaffold comprising fibres having a mean fibre diameter of between from about 1.2 to 4.0 microns, wherein the fibres comprise a glycolide. The invention further relates to the use of the scaffolds for the selective capture of cell populations for a cell source material.
摘要翻译：本发明涉及可用作导向组织再生和修复的医疗装置的支架，特别是本发明涉及包含平均纤维直径在约1.2至4.0微米之间的纤维的支架，其中纤维包含乙交酯。本发明还涉及支架用于选择性捕获细胞源材料的细胞群体的用途。

2. 发明申请

US20080138414A1 Methods of Regenerating Cartilage 审中-公开
标题翻译：再生软骨的方法
公开(公告)号：US20080138414A1
公开(公告)日：2008-06-12
申请号：US11951676
申请日：2007-12-06
申请人： James Huckle , Sarah Freestone , Kelly Langford , Drew Burdon
发明人： James Huckle , Sarah Freestone , Kelly Langford , Drew Burdon
IPC分类号： A61K35/00 , A61P19/00 , A61K35/28 , A61K35/32
CPC分类号： A61K35/28 , A61K35/32 , A61K2300/00
摘要： The present disclosure relates to methods of regenerating cartilage. In an embodiment, a method includes initiating a release of precursor cells, including bone marrow cells and progenitor cells, into a cartilage defect; and applying a population of exogenous cells to the cartilage defect. The exogenous cells, selected from a group including chondrocytes, synoviocytes, fat pad cells, chondroprogenitor cells, mesenchymal stem cells, and any combination thereof, induce the precursor cells to form cartilage tissue through a release of factors by the exogenous cells. The factors stimulate the precursor cells to form cartilage cells. The cartilage cells then form cartilage tissue. The factors are selected from a group including transforming growth factors, fibroblast growth factors, platelet-derived growth factors, insulin-like growth factors, epidermal growth factors, interleukins, and any combination thereof. Other methods of regenerating cartilage are also disclosed.
摘要翻译：本发明涉及软骨再生的方法。在一个实施方案中，一种方法包括引发前体细胞（包括骨髓细胞和祖细胞）的释放到软骨缺损中; 并将外源性细胞群应用于软骨缺损。选自包括软骨细胞，滑膜细胞，脂肪垫细胞，软骨祖细胞，间充质干细胞及其任何组合的组的外源性细胞通过外源细胞释放因子诱导前体细胞形成软骨组织。这些因素刺激前体细胞形成软骨细胞。然后软骨细胞形成软骨组织。这些因素选自包括转化生长因子，成纤维细胞生长因子，血小板衍生生长因子，胰岛素样生长因子，表皮生长因子，白细胞介素及其任何组合的组。还公开了软骨再生的其它方法。

3. 发明授权

US08338402B2 Scaffold 有权
标题翻译：脚手架
公开(公告)号：US08338402B2
公开(公告)日：2012-12-25
申请号：US12300636
申请日：2007-05-10
申请人： Nicholas Fry , Anthony Dagger , David Morsley , Helene Lecomte , Roy Trayhern , Mark Howard , Sarah Freestone , Brian Thomson , Mark Smith , Rebecca Crallan
发明人： Nicholas Fry , Anthony Dagger , David Morsley , Helene Lecomte , Roy Trayhern , Mark Howard , Sarah Freestone , Brian Thomson , Mark Smith , Rebecca Crallan
IPC分类号： A61K31/585 , A61K31/19 , A61L15/00 , C08G63/08
CPC分类号： C12N5/0068 , A61F13/00068 , C12N2533/40
摘要： The present invention relates to scaffolds which can be used as medical devices for guided tissue regeneration and repair, in particular the invention is directed to a scaffold comprising fibers having a mean fiber diameter of between from about 1.2 to 4.0 microns, wherein the fibers comprise a glycolide. The invention further relates to the use of the scaffolds for the selective capture of cell populations for a cell source material.
摘要翻译：本发明涉及可用作导向组织再生和修复的医疗装置的支架，特别是本发明涉及包含平均纤维直径在约1.2至4.0微米之间的纤维的支架，其中纤维包含乙交酯。本发明还涉及支架用于选择性捕获细胞源材料的细胞群体的用途。

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