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1. 发明申请

US20120209359A1 LOW-PROFILE INTRALUMINAL LIGHT DELIVERY SYSTEM AND METHODS OF USING THE SAME 审中-公开
标题翻译：低剖面内光交付系统及其使用方法
公开(公告)号：US20120209359A1
公开(公告)日：2012-08-16
申请号：US13390319
申请日：2010-08-13
申请人： James C. Chen , William L. Barnard , David B. Shine , Jay Miazga
发明人： James C. Chen , William L. Barnard , David B. Shine , Jay Miazga
IPC分类号： A61N5/06
CPC分类号： A61B5/411 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61B5/415 , A61B5/418 , A61B2017/00057 , A61B2017/003 , A61B2090/374 , A61B2090/3782 , A61N5/0601 , A61N5/062 , A61N2005/063
摘要： A light delivery system to provide light treatment to a patient includes an elongated catheter having a light emitter that transmits light towards a target site within a patient. The catheter is sized and configured to pass through anatomical body structures to reduce or eliminate trauma associated with the delivery procedure. A visualization system of the catheter can assist a user before, during, and/or after performing light therapy. The visualization system includes sensors that provide real-time imaging or feedback.
摘要翻译：向患者提供光治疗的光输送系统包括细长导管，其具有将光发射到患者体内的目标部位的光发射器。导管的尺寸和构造被设计成穿过解剖体部结构以减少或消除与递送过程相关的创伤。导管的可视化系统可以在进行光疗之前，期间和/或之后帮助用户。可视化系统包括提供实时成像或反馈的传感器。

2. 发明申请

US20100274330A1 DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT 审中-公开
标题翻译：用光处理血管的装置
公开(公告)号：US20100274330A1
公开(公告)日：2010-10-28
申请号：US12831159
申请日：2010-07-06
申请人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei N. Naimushin
发明人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei N. Naimushin
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B2017/22051 , A61N5/062 , A61N2005/0602 , A61N2005/0652
摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.
摘要翻译：用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括由另一球囊包围的光源。另一种装置是具有两个气囊的导管和在其间延伸的套管。在套管内，导管包括光源和扩张构件。

3. 发明申请

US20080269846A1 DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT 审中-公开
标题翻译：用光处理血管的装置
公开(公告)号：US20080269846A1
公开(公告)日：2008-10-30
申请号：US12101069
申请日：2008-04-10
申请人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei Naimushin
发明人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei Naimushin
IPC分类号： A61N5/06 , A61B17/00
CPC分类号： A61N5/0601 , A61B2017/22051 , A61N5/062 , A61N2005/0602 , A61N2005/0652
摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.
摘要翻译：用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括由另一球囊包围的光源。另一种装置是具有两个气囊的导管和在其间延伸的套管。在套管内，导管包括光源和扩张构件。

4. 发明授权

US08685005B2 Light delivery system 有权
标题翻译：发光系统
公开(公告)号：US08685005B2
公开(公告)日：2014-04-01
申请号：US12445061
申请日：2007-10-11
申请人： Jonathan S. Dahm , William Louis Barnard , James C. Chen , David B. Shine
发明人： Jonathan S. Dahm , William Louis Barnard , James C. Chen , David B. Shine
IPC分类号： A61B18/18 , A61N5/06 , A61B19/00 , A61N1/30
CPC分类号： A61N5/062 , A61B18/24 , A61N5/0601 , A61N2005/0652
摘要： A light delivery system to provide light treatment to a patient includes a catheter assembly having a plurality of light sources that transmit light towards a target site within a patient. In one embodiment, the light delivery system has a plurality of light sources mounted to a flexible transparent base that extends at least partially through a distal tip of the catheter assembly. The light sources can be wire bonded or mounted in a flip chip arrangement onto the base. In one embodiment to produce the distal tip, an array of light energy sources can be held by an array of holders of a fixture device. A vacuum is applied to secure each light energy source in a corresponding holder. While the vacuum is applied, the energy sources are electrically connected by wire bonding. The vacuum can be reduced or stopped thereby permitting removal of the light energy sources from the fixture device.
摘要翻译：向患者提供光治疗的光递送系统包括具有多个光源的导管组件，所述多个光源向患者内的目标部位透射光。在一个实施例中，光输送系统具有安装到柔性透明基底的多个光源，其至少部分延伸穿过导管组件的远端。光源可以引线键合或以倒装芯片布置安装在基座上。在产生远端的一个实施例中，光能源阵列可以由固定装置的支架阵列保持。施加真空以将每个光能源固定在相应的支架中。当施加真空时，能量源通过引线接合电连接。可以减少或停止真空，从而允许从固定装置移除光能源。

5. 发明申请

US20120149986A1 MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES 有权
标题翻译：使用灵活的轻型结构的医疗设备
公开(公告)号：US20120149986A1
公开(公告)日：2012-06-14
申请号：US13401747
申请日：2012-02-21
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichtlenegger , Jennifer K. Matson , Jean Bishop , Nick YEO , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichtlenegger , Jennifer K. Matson , Jean Bishop , Nick YEO , Hugh Narciso
IPC分类号： A61B1/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

6. 发明申请

US20110077464A1 MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES AND METHODS FOR MANUFACTURING SAME 审中-公开
标题翻译：采用柔性光结构的医疗设备及其制造方法
公开(公告)号：US20110077464A1
公开(公告)日：2011-03-31
申请号：US12890480
申请日：2010-09-24
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61B1/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

7. 发明申请

US20100145415A1 LIGHT DELIVERY SYSTEM 有权
标题翻译：光交付系统
公开(公告)号：US20100145415A1
公开(公告)日：2010-06-10
申请号：US12445061
申请日：2007-10-11
申请人： Jonathan S. Dahm , William Louis Barnard , James C. Chen , David B. Shine
发明人： Jonathan S. Dahm , William Louis Barnard , James C. Chen , David B. Shine
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B18/24 , A61N5/0601 , A61N2005/0652
摘要： A light delivery system to provide light treatment to a patient includes a catheter assembly having a plurality of light sources that transmit light towards a target site within a patient. In one embodiment, the light delivery system has a plurality of light sources mounted to a flexible transparent base that extends at least partially through a distal tip of the catheter assembly. The light sources can be wire bonded or mounted in a flip chip arrangement onto the base. In one embodiment to produce the distal tip, an array of light energy sources can be held by an array of holders of a fixture device. A vacuum is applied to secure each light energy source in a corresponding holder. While the vacuum is applied, the energy sources are electrically connected by wire bonding. The vacuum can be reduced or stopped thereby permitting removal of the light energy sources from the fixture device.
摘要翻译：向患者提供光治疗的光递送系统包括具有多个光源的导管组件，所述多个光源向患者内的目标部位透射光。在一个实施例中，光输送系统具有安装到柔性透明基底的多个光源，其至少部分延伸穿过导管组件的远端。光源可以引线键合或以倒装芯片布置安装在基座上。在产生远端的一个实施例中，光能源阵列可以由固定装置的支架阵列保持。施加真空以将每个光能源固定在相应的支架中。当施加真空时，能量源通过引线接合电连接。可以减少或停止真空，从而允许从固定装置移除光能源。

8. 发明授权

US08685071B2 Medical apparatus employing flexible light structures 有权
标题翻译：采用柔性灯光结构的医疗器械
公开(公告)号：US08685071B2
公开(公告)日：2014-04-01
申请号：US13401747
申请日：2012-02-21
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

9. 发明申请

US20120149091A1 SYSTEMS, DEVICES, AND METHODS FOR BIOMASS PRODUCTION 审中-公开
标题翻译：用于生物量生产的系统，设备和方法
公开(公告)号：US20120149091A1
公开(公告)日：2012-06-14
申请号：US11608527
申请日：2006-12-08
申请人： Brian D. Wilkerson , James C. Chen , John Pulse , Andrei Guschin , Michael Weaver
发明人： Brian D. Wilkerson , James C. Chen , John Pulse , Andrei Guschin , Michael Weaver
IPC分类号： C12N1/12 , C12N1/00 , C12M1/02 , C12M1/42
CPC分类号： C12P7/649 , C12M21/02 , C12M31/10 , C12M41/06 , C12M41/36 , C12N1/12 , C12N13/00 , C12P7/6463 , C12P39/00 , Y02E50/13 , Y02E50/343 , Y02P20/134
摘要： Systems, devices, and methods for cultivating biomasses. A bioreactor system is operable for growing photosynthetic organisms. The bioreactor system includes a bioreactor and a lighting system. The lighting system includes one more light-emitting substrates configured to light at least some of a plurality of photosynthetic organisms retained in the bioreactor.
摘要翻译：用于培育生物质的系统，装置和方法。生物反应器系统可用于生长光合生物。生物反应器系统包括生物反应器和照明系统。照明系统包括一个以上的发光基板，其被配置为点亮保留在生物反应器中的多个光合生物中的至少一些光合生物。

10. 发明授权

US08097028B2 Photoreactive system and methods for prophylactic treatment of atherosclerosis 有权
标题翻译：光反应性体系及预防动脉粥样硬化的方法
公开(公告)号：US08097028B2
公开(公告)日：2012-01-17
申请号：US11357358
申请日：2006-02-17
申请人： James C. Chen , Nicholas Yeo , Phillip Burwell , Thomas Wenger
发明人： James C. Chen , Nicholas Yeo , Phillip Burwell , Thomas Wenger
IPC分类号： A61N5/06
CPC分类号： A61K41/0071 , A61N5/0601 , A61N5/062 , A61N2005/0602 , A61N2005/0651 , A61N2005/0661
摘要： The present invention provides a prophylactic light activated treatment method for subjects at risk of a plaque-mediated thrombotic event, such as acute coronary syndromes. In one embodiment, the subject receives a dose of photosensitizer sufficient to result in a concentration of photosensitizer in the neovascularization associated with atherosclerotic disease to permit effective photodynamic therapy. Light of a wavelength that excites the photosensitizer, but that does not to any significant extent penetrate to an adventitial layer of the blood vessel, is applied to the region of the blood vessel. The therapeutic light dose, which may be applied in sequential stages, is sufficient to cause closure of neovasculature leakage and lead to plaque stabilization and reduced adverse clinical outcomes. The present invention further provides light transmission devices and systems useful in carrying out the methods of the present invention.
摘要翻译：本发明为患有斑块介导的血栓形成事件风险的受试者，例如急性冠状动脉综合征提供预防性光活化治疗方法。在一个实施方案中，受试者接受足以导致与动脉粥样硬化疾病相关的新血管形成中的光敏剂浓度以允许有效的光动力疗法的剂量的光敏剂。激发光敏剂的波长的光被施加到血管的区域，而不是任何显着程度的透射到血管的外膜层。可以按顺序施用的治疗光剂量足以引起新血管渗漏的闭合并导致斑块稳定化并减少不良临床结果。本发明还提供了用于实施本发明的方法的光传输装置和系统。

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