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1. 发明申请

US20120149986A1 MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES 有权
标题翻译：使用灵活的轻型结构的医疗设备
公开(公告)号：US20120149986A1
公开(公告)日：2012-06-14
申请号：US13401747
申请日：2012-02-21
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichtlenegger , Jennifer K. Matson , Jean Bishop , Nick YEO , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichtlenegger , Jennifer K. Matson , Jean Bishop , Nick YEO , Hugh Narciso
IPC分类号： A61B1/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

2. 发明申请

US20110077464A1 MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES AND METHODS FOR MANUFACTURING SAME 审中-公开
标题翻译：采用柔性光结构的医疗设备及其制造方法
公开(公告)号：US20110077464A1
公开(公告)日：2011-03-31
申请号：US12890480
申请日：2010-09-24
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61B1/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

3. 发明授权

US08685071B2 Medical apparatus employing flexible light structures 有权
标题翻译：采用柔性灯光结构的医疗器械
公开(公告)号：US08685071B2
公开(公告)日：2014-04-01
申请号：US13401747
申请日：2012-02-21
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

4. 发明申请

US20080269846A1 DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT 审中-公开
标题翻译：用光处理血管的装置
公开(公告)号：US20080269846A1
公开(公告)日：2008-10-30
申请号：US12101069
申请日：2008-04-10
申请人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei Naimushin
发明人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei Naimushin
IPC分类号： A61N5/06 , A61B17/00
CPC分类号： A61N5/0601 , A61B2017/22051 , A61N5/062 , A61N2005/0602 , A61N2005/0652
摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.
摘要翻译：用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括由另一球囊包围的光源。另一种装置是具有两个气囊的导管和在其间延伸的套管。在套管内，导管包括光源和扩张构件。

5. 发明申请

US20100274330A1 DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT 审中-公开
标题翻译：用光处理血管的装置
公开(公告)号：US20100274330A1
公开(公告)日：2010-10-28
申请号：US12831159
申请日：2010-07-06
申请人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei N. Naimushin
发明人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei N. Naimushin
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B2017/22051 , A61N5/062 , A61N2005/0602 , A61N2005/0652
摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.
摘要翻译：用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括由另一球囊包围的光源。另一种装置是具有两个气囊的导管和在其间延伸的套管。在套管内，导管包括光源和扩张构件。

6. 发明授权

US10376711B2 Light generating guide wire for intravascular use 有权
公开(公告)号：US10376711B2
公开(公告)日：2019-08-13
申请号：US11834572
申请日：2007-08-06
申请人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61N1/05 , A61N5/06 , A61B18/22
摘要： Light sources are incorporated into a guidewire for enabling the ability to render light therapy be added to catheters that do not have that capability. In one exemplary embodiment, a solid guidewire includes a conductive core, and light sources are added to compartments formed in a distal end of the guidewire. In another exemplary embodiment, a light source array is included in a distal end of a hollow guidewire. A plurality of openings are formed into the walls of the hollow guidewire surrounding the array, enabling light to pass through the openings. Conductors extend from the array though the hollow center of the guidewire, to a proximal end of the hollow guidewire. The hollow guidewire can be coated with a conductive material, so that the coating on the guidewire serves as a conductor.

7. 发明授权

US07252677B2 Light generating device to intravascular use 有权
标题翻译：发光装置用于血管内使用
公开(公告)号：US07252677B2
公开(公告)日：2007-08-07
申请号：US10799357
申请日：2004-03-12
申请人： Phillip Burwell , Zihong Guo , Jennifer Kristine Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , Zihong Guo , Jennifer Kristine Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B2018/2261 , A61N5/062 , A61N2005/0602 , A61N2005/0652 , A61N2005/1003
摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
摘要翻译：用于照射血管组织部分的光产生装置，以进行光动力疗法。在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。光纤可选地将来自光源的光引导到漫射元件。光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。线性光源元件特别适用于处理容器中组织的细长部分。旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

8. 发明授权

US07730894B2 Photodynamic therapy apparatus and method for vascular tissue treatment 有权
标题翻译：光动力治疗仪和血管组织治疗方法
公开(公告)号：US07730894B2
公开(公告)日：2010-06-08
申请号：US11773555
申请日：2007-07-05
申请人： Phillip Burwell , Zihong Guo , Jennifer Kristine Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , Zihong Guo , Jennifer Kristine Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61B19/00
CPC分类号： A61N5/0601 , A61B2018/2261 , A61N5/062 , A61N2005/0602 , A61N2005/0652 , A61N2005/1003
摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
摘要翻译：用于照射血管组织部分的光产生装置，以进行光动力疗法。在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。光纤可选地将来自光源的光引导到漫射元件。光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。线性光源元件特别适用于处理容器中组织的细长部分。旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

9. 发明授权

US08685005B2 Light delivery system 有权
标题翻译：发光系统
公开(公告)号：US08685005B2
公开(公告)日：2014-04-01
申请号：US12445061
申请日：2007-10-11
申请人： Jonathan S. Dahm , William Louis Barnard , James C. Chen , David B. Shine
发明人： Jonathan S. Dahm , William Louis Barnard , James C. Chen , David B. Shine
IPC分类号： A61B18/18 , A61N5/06 , A61B19/00 , A61N1/30
CPC分类号： A61N5/062 , A61B18/24 , A61N5/0601 , A61N2005/0652
摘要： A light delivery system to provide light treatment to a patient includes a catheter assembly having a plurality of light sources that transmit light towards a target site within a patient. In one embodiment, the light delivery system has a plurality of light sources mounted to a flexible transparent base that extends at least partially through a distal tip of the catheter assembly. The light sources can be wire bonded or mounted in a flip chip arrangement onto the base. In one embodiment to produce the distal tip, an array of light energy sources can be held by an array of holders of a fixture device. A vacuum is applied to secure each light energy source in a corresponding holder. While the vacuum is applied, the energy sources are electrically connected by wire bonding. The vacuum can be reduced or stopped thereby permitting removal of the light energy sources from the fixture device.
摘要翻译：向患者提供光治疗的光递送系统包括具有多个光源的导管组件，所述多个光源向患者内的目标部位透射光。在一个实施例中，光输送系统具有安装到柔性透明基底的多个光源，其至少部分延伸穿过导管组件的远端。光源可以引线键合或以倒装芯片布置安装在基座上。在产生远端的一个实施例中，光能源阵列可以由固定装置的支架阵列保持。施加真空以将每个光能源固定在相应的支架中。当施加真空时，能量源通过引线接合电连接。可以减少或停止真空，从而允许从固定装置移除光能源。

10. 发明申请

US20120209359A1 LOW-PROFILE INTRALUMINAL LIGHT DELIVERY SYSTEM AND METHODS OF USING THE SAME 审中-公开
标题翻译：低剖面内光交付系统及其使用方法
公开(公告)号：US20120209359A1
公开(公告)日：2012-08-16
申请号：US13390319
申请日：2010-08-13
申请人： James C. Chen , William L. Barnard , David B. Shine , Jay Miazga
发明人： James C. Chen , William L. Barnard , David B. Shine , Jay Miazga
IPC分类号： A61N5/06
CPC分类号： A61B5/411 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61B5/415 , A61B5/418 , A61B2017/00057 , A61B2017/003 , A61B2090/374 , A61B2090/3782 , A61N5/0601 , A61N5/062 , A61N2005/063
摘要： A light delivery system to provide light treatment to a patient includes an elongated catheter having a light emitter that transmits light towards a target site within a patient. The catheter is sized and configured to pass through anatomical body structures to reduce or eliminate trauma associated with the delivery procedure. A visualization system of the catheter can assist a user before, during, and/or after performing light therapy. The visualization system includes sensors that provide real-time imaging or feedback.
摘要翻译：向患者提供光治疗的光输送系统包括细长导管，其具有将光发射到患者体内的目标部位的光发射器。导管的尺寸和构造被设计成穿过解剖体部结构以减少或消除与递送过程相关的创伤。导管的可视化系统可以在进行光疗之前，期间和/或之后帮助用户。可视化系统包括提供实时成像或反馈的传感器。

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