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1. 发明授权

US08097028B2 Photoreactive system and methods for prophylactic treatment of atherosclerosis 有权
标题翻译：光反应性体系及预防动脉粥样硬化的方法
公开(公告)号：US08097028B2
公开(公告)日：2012-01-17
申请号：US11357358
申请日：2006-02-17
申请人： James C. Chen , Nicholas Yeo , Phillip Burwell , Thomas Wenger
发明人： James C. Chen , Nicholas Yeo , Phillip Burwell , Thomas Wenger
IPC分类号： A61N5/06
CPC分类号： A61K41/0071 , A61N5/0601 , A61N5/062 , A61N2005/0602 , A61N2005/0651 , A61N2005/0661
摘要： The present invention provides a prophylactic light activated treatment method for subjects at risk of a plaque-mediated thrombotic event, such as acute coronary syndromes. In one embodiment, the subject receives a dose of photosensitizer sufficient to result in a concentration of photosensitizer in the neovascularization associated with atherosclerotic disease to permit effective photodynamic therapy. Light of a wavelength that excites the photosensitizer, but that does not to any significant extent penetrate to an adventitial layer of the blood vessel, is applied to the region of the blood vessel. The therapeutic light dose, which may be applied in sequential stages, is sufficient to cause closure of neovasculature leakage and lead to plaque stabilization and reduced adverse clinical outcomes. The present invention further provides light transmission devices and systems useful in carrying out the methods of the present invention.
摘要翻译：本发明为患有斑块介导的血栓形成事件风险的受试者，例如急性冠状动脉综合征提供预防性光活化治疗方法。在一个实施方案中，受试者接受足以导致与动脉粥样硬化疾病相关的新血管形成中的光敏剂浓度以允许有效的光动力疗法的剂量的光敏剂。激发光敏剂的波长的光被施加到血管的区域，而不是任何显着程度的透射到血管的外膜层。可以按顺序施用的治疗光剂量足以引起新血管渗漏的闭合并导致斑块稳定化并减少不良临床结果。本发明还提供了用于实施本发明的方法的光传输装置和系统。

2. 发明申请

US20070038204A1 Photoreactive system and methods for prophylactic treatment of atherosclerosis 有权
标题翻译：光反应性体系及预防动脉粥样硬化的方法
公开(公告)号：US20070038204A1
公开(公告)日：2007-02-15
申请号：US11357358
申请日：2006-02-17
申请人： James Chen , Nicholas Yeo , Phillip Burwell , Thomas Wenger
发明人： James Chen , Nicholas Yeo , Phillip Burwell , Thomas Wenger
IPC分类号： A61B18/18 , A61N5/06
CPC分类号： A61K41/0071 , A61N5/0601 , A61N5/062 , A61N2005/0602 , A61N2005/0651 , A61N2005/0661
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

3. 发明申请

US20120149986A1 MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES 有权
标题翻译：使用灵活的轻型结构的医疗设备
公开(公告)号：US20120149986A1
公开(公告)日：2012-06-14
申请号：US13401747
申请日：2012-02-21
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichtlenegger , Jennifer K. Matson , Jean Bishop , Nick YEO , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichtlenegger , Jennifer K. Matson , Jean Bishop , Nick YEO , Hugh Narciso
IPC分类号： A61B1/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

4. 发明申请

US20110077464A1 MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES AND METHODS FOR MANUFACTURING SAME 审中-公开
标题翻译：采用柔性光结构的医疗设备及其制造方法
公开(公告)号：US20110077464A1
公开(公告)日：2011-03-31
申请号：US12890480
申请日：2010-09-24
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61B1/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

5. 发明申请

US20080269846A1 DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT 审中-公开
标题翻译：用光处理血管的装置
公开(公告)号：US20080269846A1
公开(公告)日：2008-10-30
申请号：US12101069
申请日：2008-04-10
申请人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei Naimushin
发明人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei Naimushin
IPC分类号： A61N5/06 , A61B17/00
CPC分类号： A61N5/0601 , A61B2017/22051 , A61N5/062 , A61N2005/0602 , A61N2005/0652
摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.
摘要翻译：用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括由另一球囊包围的光源。另一种装置是具有两个气囊的导管和在其间延伸的套管。在套管内，导管包括光源和扩张构件。

6. 发明授权

US08685071B2 Medical apparatus employing flexible light structures 有权
标题翻译：采用柔性灯光结构的医疗器械
公开(公告)号：US08685071B2
公开(公告)日：2014-04-01
申请号：US13401747
申请日：2012-02-21
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

7. 发明申请

US20100274330A1 DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT 审中-公开
标题翻译：用光处理血管的装置
公开(公告)号：US20100274330A1
公开(公告)日：2010-10-28
申请号：US12831159
申请日：2010-07-06
申请人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei N. Naimushin
发明人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei N. Naimushin
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B2017/22051 , A61N5/062 , A61N2005/0602 , A61N2005/0652
摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.
摘要翻译：用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括由另一球囊包围的光源。另一种装置是具有两个气囊的导管和在其间延伸的套管。在套管内，导管包括光源和扩张构件。

8. 发明申请

US20070002582A1 Medical apparatus employing flexible light structures and methods for manufacturing same 审中-公开
标题翻译：采用柔性灯结构的医疗器械及其制造方法
公开(公告)号：US20070002582A1
公开(公告)日：2007-01-04
申请号：US11323319
申请日：2005-12-30
申请人： Phillip Burwell , James Chen , Zihong Guo , Steven Daly , David Shine , Gary Lichttenegger , Jennifer Matson , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , James Chen , Zihong Guo , Steven Daly , David Shine , Gary Lichttenegger , Jennifer Matson , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61B1/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

9. 发明申请

US20070142880A1 Light delivery apparatus 审中-公开
标题翻译：发光装置
公开(公告)号：US20070142880A1
公开(公告)日：2007-06-21
申请号：US11594570
申请日：2006-11-07
申请人： William Barnard , Phillip Burwell , James Chen , Julene Christophersen , William Gembala , David Shine
发明人： William Barnard , Phillip Burwell , James Chen , Julene Christophersen , William Gembala , David Shine
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61N5/0601 , A61N5/062
摘要： A light delivery apparatus to provide light treatment to a patient includes a catheter assembly having a light source that transmit light towards a target site within a patient. A balloon surrounds the light source and has a plurality of tissue engaging elements movable between first positions and second positions. In one embodiment, each element extends radially inward in the first position and radially outward in the second position. An insertion tool is used to deliver the light delivery apparatus. During use, the light delivery apparatus is rotationally locked with the insertion tool for improved steering, navigation, and aiming of emitted light.
摘要翻译：为患者提供光治疗的光输送装置包括导管组件，所述导管组件具有将光发射到患者内的目标部位的光源。气囊围绕光源并且具有可在第一位置和第二位置之间移动的多个组织接合元件。在一个实施例中，每个元件在第一位置处径向向内延伸并且在第二位置中径向向外延伸。插入工具用于输送光输送装置。在使用期间，光输送装置与插入工具旋转地锁定，以改善对发射光的转向，导航和瞄准。

10. 发明授权

US07252677B2 Light generating device to intravascular use 有权
标题翻译：发光装置用于血管内使用
公开(公告)号：US07252677B2
公开(公告)日：2007-08-07
申请号：US10799357
申请日：2004-03-12
申请人： Phillip Burwell , Zihong Guo , Jennifer Kristine Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , Zihong Guo , Jennifer Kristine Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B2018/2261 , A61N5/062 , A61N2005/0602 , A61N2005/0652 , A61N2005/1003
摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
摘要翻译：用于照射血管组织部分的光产生装置，以进行光动力疗法。在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。光纤可选地将来自光源的光引导到漫射元件。光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。线性光源元件特别适用于处理容器中组织的细长部分。旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

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