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1. 发明授权

US10532132B2 Implantable drug delivery device and methods 有权
公开(公告)号：US10532132B2
公开(公告)日：2020-01-14
申请号：US13910730
申请日：2013-06-05
申请人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
发明人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
IPC分类号： A61L31/06 , A61L31/16
摘要： A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.

2. 发明申请

US20100003297A1 Implantable Drug Delivery Device and Methods of Treating Male Genitourinary and Surrounding Tissues 审中-公开
标题翻译：可植入药物输送装置和处理男性泌尿生殖和周围组织的方法
公开(公告)号：US20100003297A1
公开(公告)日：2010-01-07
申请号：US12538580
申请日：2009-08-10
申请人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
发明人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
IPC分类号： A61K9/00 , A61P43/00
CPC分类号： A61L31/06 , A61K9/0034 , A61L29/06 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/00 , A61M31/002 , C08L83/04 , C08L67/00
摘要： A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.
摘要翻译：提供了一种用于将药物局部控制递送至需要治疗的患者的精囊，前列腺，射精管或输精管的方法。在一个实施例中，该方法包括将可再吸收的药物递送装置植入患者的精囊，前列腺，射精管或输精管内。药物递送装置可以包括容纳至少一个含有至少一种药物的药物储存器的弹性装置主体。在优选的实施方案中，该方法还包括以受控的方式将药物从装置释放，通常直接进入精囊，前列腺，射精管或输精管。

3. 发明申请

US20130324946A1 IMPLANTABLE DRUG DELIVERY DEVICE AND METHODS 审中-公开
标题翻译：可植入药物递送装置和方法
公开(公告)号：US20130324946A1
公开(公告)日：2013-12-05
申请号：US13910730
申请日：2013-06-05
申请人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
发明人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
IPC分类号： A61L31/06 , A61L31/16
CPC分类号： A61L31/06 , A61K9/0034 , A61L29/06 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/00 , A61M31/002 , C08L83/04 , C08L67/00
摘要： A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.
摘要翻译：提供了一种用于将药物局部控制递送至需要治疗的患者的精囊，前列腺，射精管或输精管的方法。在一个实施例中，该方法包括将可再吸收的药物递送装置植入患者的精囊，前列腺，射精管或输精管内。药物递送装置可以包括容纳至少一个含有至少一种药物的药物储存器的弹性装置主体。在优选的实施方案中，该方法还包括以受控的方式将药物从装置释放，通常直接进入精囊，前列腺，射精管或输精管。

4. 发明申请

US20100152704A1 Method for Intravesical Drug Delivery 有权
标题翻译：膀胱内给药方法
公开(公告)号：US20100152704A1
公开(公告)日：2010-06-17
申请号：US12709551
申请日：2010-02-22
申请人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61M25/00 , A61K31/167 , A61K33/04 , A61K31/737 , A61K31/24 , A61K31/407
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

5. 发明授权

US08801694B2 Intravesical drug delivery device 有权
标题翻译：膀胱内药物输送装置
公开(公告)号：US08801694B2
公开(公告)日：2014-08-12
申请号：US11463956
申请日：2006-08-11
申请人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61F2/00 , A61M31/00 , A61L29/16 , A61K9/00 , A61L29/06
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

6. 发明授权

US08182464B2 Method for intravesical drug delivery 有权
标题翻译：膀胱内药物输送方法
公开(公告)号：US08182464B2
公开(公告)日：2012-05-22
申请号：US12709551
申请日：2010-02-22
申请人： Heejin Lee , Karen Danielle Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Danielle Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61M31/00 , A01N43/04 , A01N37/12 , A01N37/44 , A01N43/38 , A01N37/18 , A01N59/02 , A61K31/24 , A61K31/40 , A61K31/16 , A61K33/04
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

7. 发明申请

US20070202151A1 INTRAVESICAL DRUG DELIVERY DEVICE AND METHOD 有权
标题翻译：内窥镜药物递送装置及方法
公开(公告)号：US20070202151A1
公开(公告)日：2007-08-30
申请号：US11463956
申请日：2006-08-11
申请人： Heejin Lee , Karen Daniel , Hong Ho Duc , Michael Cima , Mario Casillo-Ortiz , Steven Floelich , Jordan Dimitrakov
发明人： Heejin Lee , Karen Daniel , Hong Ho Duc , Michael Cima , Mario Casillo-Ortiz , Steven Floelich , Jordan Dimitrakov
IPC分类号： A61F2/02
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

8. 发明申请

US20090220994A1 METHODS FOR DIAGNOSIS OF CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME 审中-公开
标题翻译：慢性前列腺增生症慢性阻塞性肺疾病诊断方法
公开(公告)号：US20090220994A1
公开(公告)日：2009-09-03
申请号：US12393357
申请日：2009-02-26
申请人： Jordan Dimitrakov
发明人： Jordan Dimitrakov
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/342
摘要： The present invention relates to methods for diagnosis of chronic prostatitis/chronic pain pelvic syndrome (CP/CPPS). We have found specific biomarkers that are present in higher concentrations in patients that have chronic prostatitis/chronic pain pelvic syndrome (CP/CPPS) as compared to subjects that have no symptoms of CP/CPPS. In particular, uromodulin (THP), aminopeptidase N (AMPN), dipeptidylpeptidase IV (CD26), neprilysin (NEP), zinc-α-2-glycoprotein (ZA2G) and alkaline phosphatase (ALP) were found to be present at higher concentrations in CP/CPPS patient urine that is voided after prostatic message. Accordingly, the invention is directed to methods for diagnosis of CP/CPPS by monitoring the levels of at least one of these proteins in post-prostatic massage urine, as well as to diagnostic kits designed for diagnosis of CP/CPPS.
摘要翻译：本发明涉及慢性前列腺炎/慢性骨盆综合征（CP / CPPS）的诊断方法。与没有CP / CPPS症状的受试者相比，我们发现具有慢性前列腺炎/慢性骨盆综合征（CP / CPPS）的患者中具有较高浓度的特异性生物标志物。特别地，发现尿调节素（THP），氨基肽酶N（AMPN），二肽基肽酶IV（CD26），尿丙氨酸（NEP），锌-α-2-糖蛋白（ZA2G）和碱性磷酸酶（ALP） CP / CPPS患者尿液在前列腺消息后失效。因此，本发明涉及通过监测前列腺前列腺按摩尿中至少一种蛋白质的水平以及为诊断CP / CPPS而设计的诊断试剂盒来诊断CP / CPPS的方法。

9. 发明授权

US07014652B2 Methods for treating prostatitis 失效
标题翻译：治疗前列腺炎的方法
公开(公告)号：US07014652B2
公开(公告)日：2006-03-21
申请号：US10763856
申请日：2004-01-22
申请人： Iulian Cioanta , Richard Barry Klein , Jordan Dimitrakov
发明人： Iulian Cioanta , Richard Barry Klein , Jordan Dimitrakov
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B2017/00274 , A61B2018/00547 , A61H9/0078 , A61H21/00 , A61H2201/0207 , A61H2201/0214 , A61H2201/0242 , A61H2201/0257 , A61H2201/0292 , A61H2201/10 , A61H2201/5007
摘要： Methods, systems, and computer program products for providing thermal therapies or internal thermal massage therapy for treating prostatitis by expanding and contracting a treatment balloon with inflation media and currently applying heat to a portion of the prostatic urethra.
摘要翻译：方法，系统和计算机程序产品，用于通过用膨胀介质扩张和收缩治疗气球并且目前对前列腺尿道的一部分施加热量来提供热治疗或内部热按摩治疗来治疗前列腺炎。

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